Abstract: The present invention relates to a novel compounds that can be used as anti-inflammatory, immunomodulatory and antiproliferatory agents. In particular, the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehyrogenase (DHODH).

Abstract: Prioritization of fragmented messages in an ORB is achieved by intercepting the flow of message data within the ORB, marking the current data stream location and issuing sufficient read commands to gather the message header and control area information. Then classification for priority can be performed using the data in the control area to classify the request. The classification information is stored for the message for later use by queuing and prioritization processes and the data stream marker is reset to the original location. When the queuing and prioritization processes are ready to dispatch the message, the message can be sent on to the higher levels of processing within the ORB where the higher levels of message processing code will process the message, totally unaware of the fact that the message has been classified and/or queued or prioritized prior to delivery to the higher level.

Abstract: The present invention relates to novel compounds that can be used as antiinflammatory, immunomodulatory and antiproliferatory agents. In particular the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehydrogenase (DHODH).

Abstract: The present invention relates to a novel compounds that can be used as anti-inflammatory, immunomodulatory and antiproliferatory agents. In particular, the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehyrogenase (DHODH).

Abstract: A method and apparatus for securing hypertext transfer protocol sessions authenticates a user's credentials before creating a session. The present invention then associates the session with the credentials. Subsequent requests are submitted with the session ID and the user credentials to be associated with the session. Therefore, an unauthorized user that has obtained a session ID cannot gain access to sensitive content associated with the session without possessing the valid credentials.

Abstract: The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C?O, C?S, C?NH, (C?O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal diseases and to diseases where the inhibition of intracellular protein-degradation pathways is of benefit.

Abstract: The invention relates to compounds having the Formula (I) or a salt, or a physiologically functional derivative, or a prodrug thereof, wherein Z is carbonyl or sulfonyl; R1 is alkyl, alkenyl, alkynyl, aryl, H, halogen, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl or heteroaryl; R2 is H, OH, —CH2—SO2-alkyl, —CH2—SO2-cycloalkyl, —CH2—SO2-aryl, —CH2—SO2-heteroaryl, alkylamine, alkenylamine, alkynylamine, cycloalkylamine, arylamine, heteroarylamine, aryl, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heteroaryl or a linear or branched alkyl, alkenyl, alkynyl, which can optionally be substituted by one or more substituents R3; R3 is H, alkyl, alkenyl, alkynyl, cycloalkyl, —CO2R4, —CONHR4, —CONR4R4, —CR4O, —SO2R4, —NR4—CO—R4, alkoxy, alkylthio, —OH, —SH, —O-aryl, —O-cycloalkyl, —S-aryl, —S-cycloalkyl, hydroxyalkyl, halogen, haloalkyl, haloalkoxy, CN, NO2, hydroxyalkylamine, aminoalkyl, alkylamine, aryl or heteroaryl; R4 is H, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkylthio, —O-aryl,

Abstract: The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.

Abstract: The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.

Abstract: The invention relates to compounds having the Formula (I) 1

Abstract: The present invention relates to novel compounds that can be used as antiinflammatory, immunomodulatory and antiproliferatory agents. In particular the invention refers to new compounds which inhibit dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehydrogenase (DHODH).

Abstract: The invention relates to the use of a compound of the Formula (I) 1

Abstract: The invention relates to new diphenylurea having the formula (I) 1

Abstract: A dynamic topic partitioning messaging system. The messaging system can include a message server; one or more topics stored in the message server; one or more subtopics associated with at least one of the topics in the message server; and, a dynamic topic partitioning system configured to partition the topics into the subtopics. Notably, the message server can be Java message service (JMS) compliant. In that regard, the message server can reside in a single process address space. For example, the process address space can be a Java virtual machine (JVM).

Abstract: The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.

Abstract: Treatment of Protozoan Infections with new diphenylurea derivatives.