Patents by Inventor Gabriel Nuñez

Gabriel Nuñez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190388483
    Abstract: Provided herein are compositions and methods for the inhibition of enteric infection. In particular, compositions comprising bacteria of the class Clostridia are administered to human and/or animal subjects to prevent or decrease susceptibility to enteric infection.
    Type: Application
    Filed: January 5, 2018
    Publication date: December 26, 2019
    Inventors: Cathym R. Nagler, Gabriel Nunez, Yun-Gi Kim
  • Publication number: 20160031973
    Abstract: Materials and methods are provided for treatment and/or prevention of Staphylococcal diseases and disorders such as infection and dermal inflammation.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Jon Oscherwitz, Kemp Cease, Yumi Nakamura, Tyler Nygaard
  • Publication number: 20080280367
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Application
    Filed: March 26, 2008
    Publication date: November 13, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Patent number: 7375086
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: May 20, 2008
    Assignee: The Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara, Yasunori Ogura
  • Publication number: 20080008652
    Abstract: The present invention relates to methods and compositions for modulating immune responses and adjuvant activity. In particular, the present invention provides methods and compositions for screening for compounds that modulate cryopyrin signaling.
    Type: Application
    Filed: January 10, 2007
    Publication date: January 10, 2008
    Applicant: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Thirumala-Devi Kanneganti
  • Patent number: 7244557
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: July 17, 2007
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara
  • Patent number: 7176019
    Abstract: The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-?B signaling. The present invention thus provides novel targets for drug screening and therapeutics.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: February 13, 2007
    Assignee: The Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara, Akihiro Muto
  • Publication number: 20060292590
    Abstract: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
    Type: Application
    Filed: January 26, 2006
    Publication date: December 28, 2006
    Inventors: Naohiro Inohara, Gabriel Nunez
  • Publication number: 20060160118
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Application
    Filed: January 12, 2006
    Publication date: July 20, 2006
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Patent number: 7060493
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: June 13, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Patent number: 7060442
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: June 13, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nuñez, Naohiro Inohara, Yasunori Ogura
  • Publication number: 20060105413
    Abstract: The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-?B signaling. The present invention thus provides novel targets for drug screening and therapeutics.
    Type: Application
    Filed: December 22, 2005
    Publication date: May 18, 2006
    Inventors: Gabriel Nunez, Naohiro Inohara, Akihiro Muto
  • Patent number: 7041491
    Abstract: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: May 9, 2006
    Assignee: Regents of the University of Michigan
    Inventors: Naohiro Inohara, Gabriel Nuñez
  • Publication number: 20050239105
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Application
    Filed: November 9, 2004
    Publication date: October 27, 2005
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Patent number: 6911532
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: June 28, 2005
    Assignee: The Reagents of the University of Michigan
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nuñez
  • Patent number: 6858391
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction. The present invention also provides Nod2 variant alleles. The present invention further provides methods of identifying individuals at increased risk of developing Crohn's disease.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: February 22, 2005
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura, Judy Cho, Dan L. Nicolae, Denise Bonen
  • Publication number: 20050009065
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
    Type: Application
    Filed: May 14, 2004
    Publication date: January 13, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara
  • Patent number: 6835815
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 28, 2004
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Publication number: 20040253615
    Abstract: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
    Type: Application
    Filed: March 5, 2004
    Publication date: December 16, 2004
    Inventors: Naohiro Inohara, Gabriel Nunez
  • Publication number: 20030199462
    Abstract: The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-&kgr;B signaling. The present invention thus provides novel targets for drug screening and therapeutics.
    Type: Application
    Filed: April 23, 2002
    Publication date: October 23, 2003
    Inventors: Gabriel Nunez, Naohiro Inohara, Akihiro Muto