Patents by Inventor Gabriel Nuñez

Gabriel Nuñez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vertebrate apoptosis gene: compositions and methods
    Patent number: 6911532
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: June 28, 2005
    Assignee: The Reagents of the University of Michigan
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nuñez
  • Nod2 nucleic acids and proteins
    Patent number: 6858391
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction. The present invention also provides Nod2 variant alleles. The present invention further provides methods of identifying individuals at increased risk of developing Crohn's disease.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: February 22, 2005
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura, Judy Cho, Dan L. Nicolae, Denise Bonen
  • Modulators of Nod1 signaling
    Publication number: 20050009065
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.
    Type: Application
    Filed: May 14, 2004
    Publication date: January 13, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara
  • Nod2 nucleic acids and proteins
    Patent number: 6835815
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 28, 2004
    Assignee: Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • NOD nucleic acids and polypeptides
    Publication number: 20040253615
    Abstract: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.
    Type: Application
    Filed: March 5, 2004
    Publication date: December 16, 2004
    Inventors: Naohiro Inohara, Gabriel Nunez
  • Methods and compositions for regulating cellular signaling
    Publication number: 20030199462
    Abstract: The present invention related to methods and compositions for modulating cellular signaling. In particular, the present invention relates to PKK and RICK3 proteins. The present invention further relates the to use of PKK and RICK3 proteins in modulating NF-&kgr;B signaling. The present invention thus provides novel targets for drug screening and therapeutics.
    Type: Application
    Filed: April 23, 2002
    Publication date: October 23, 2003
    Inventors: Gabriel Nunez, Naohiro Inohara, Akihiro Muto
  • Modulators on Nod2 signaling
    Publication number: 20030175762
    Abstract: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present invention further provides methods of altering Nod2 signaling.
    Type: Application
    Filed: December 9, 2002
    Publication date: September 18, 2003
    Applicant: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • P53-MEDIATED APOPTOSIS FOR THE THERAPEUTIC TREATMENT OF DISEASES
    Publication number: 20030045485
    Abstract: The invention is directed to a methods of reducing the viability of a proliferating mammalian cells such as cancer cells. In one method cells deficient in p53 activity and in p53 suppressor activity of one or more p53-interacting regulatory proteins cell viability is reduced by increasing the level or activity of p53 in the cell. In another method viability of cells exhibiting p53 activity and p53 suppressor activity of one or more p53-interacting regulatory proteins is reduced by reducing the suppressor activity of the one or more p53-interacting regulatory proteins. Further, cell viability is reduced in cells deficient in p53 activity and exhibiting p53 suppressor activity of one or more p53-interacting regulatory proteins by a method that includes: (a) increasing the level or activity of p53 in the cell, and (b) reducing the suppressor activity of the one or more p53-interacting regulatory proteins.
    Type: Application
    Filed: June 5, 1995
    Publication date: March 6, 2003
    Inventors: MICHAEL F. CLARKE, JAMES J. RYAN, GABRIEL NUNEZ
  • Nod2 nucleic acids and proteins
    Publication number: 20020197616
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction. The present invention also provides Nod2 variant alleles. The present invention further provides methods of identifying individuals at increased risk of developing Crohn's disease.
    Type: Application
    Filed: October 26, 2001
    Publication date: December 26, 2002
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura, Judy Cho, Dan L. Nicolae, Denise Bonen
  • Vertebrate apoptosis gene: compositions and methods
    Publication number: 20020137182
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Application
    Filed: September 12, 2001
    Publication date: September 26, 2002
    Applicant: The Regent of the University of Michigan
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nunez
  • Nod2 nucleic acids and proteins
    Publication number: 20020127673
    Abstract: The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.
    Type: Application
    Filed: October 26, 2001
    Publication date: September 12, 2002
    Inventors: Gabriel Nunez, Naohiro Inohara, Yasunori Ogura
  • Vertebrate apoptosis gene: compositions and methods
    Patent number: 6395510
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: May 28, 2002
    Assignees: ARCH Development Corporation, Board of Regents of The University of Michigan
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nuñez
  • Compositions and methods for identifying apoptosis signaling pathway inhibitors and activators
    Patent number: 6348573
    Abstract: The invention generally relates to compositions and methods for identifying Apoptosis signaling pathway inhibitors and activators.
    Type: Grant
    Filed: April 27, 1998
    Date of Patent: February 19, 2002
    Assignee: The Regents of the University of Michigan
    Inventors: Gabriel Nunez, Naohiro Inohara, Takeyoshi Koseki
  • Vertebrate apoptosis gene: compositions and methods
    Patent number: 6303331
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 16, 2001
    Assignees: Arch Development Corporation, The Regent of the University of Michigan
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nuñez
  • Vertebrate apoptosis gene: compositions and methods
    Patent number: 5834309
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 10, 1998
    Assignee: Arch Development Corporation
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nunez
  • Vertebrate apoptosis gene: compositions and methods
    Patent number: 5646008
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Grant
    Filed: June 22, 1993
    Date of Patent: July 8, 1997
    Assignee: The Regent of the University of Michigan
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nunez