Abstract: Disclosed in the present application are a card-based information displaying method and apparatus, and an information displaying service processing method and apparatus. The card-based information displaying method comprises: determining target information to be displayed and a card type of a first card for displaying the target information; determining whether a configuration version of a client supports the card type of the first card; when it is determined that the configuration version of the client does not support the card type of the first card, determining an association identifier corresponding to the first card, and associating with a second card supported by the configuration version of the client according to the association identifier; and displaying the target information of the client using the second card.

Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: A remote assistance controller serves as an intermediary between a user requesting remote assistance and a remote assistor. A remote assistance policy determines what the remote assistor can see or not see on the requestor's computer system, and may additionally determine allowed or disallowed actions by the remote assistor. The remote assistance policy may be defined by the requesting user, or can be a default policy for the remote assistance controller. The remote assistance controller generates views for the requestor and for the remote assistor. When the remote assistor requests an operation on the requestor's computer system, the remote assistance controller checks the remote assistance policy to determine whether the remote assistor is allowed to perform the requested operation. When the requested operation is allowed according to the remote assistance policy, the remote assistance controller allows the requested operation, and refreshes the views for the requestor and the remote assistor.

Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.

Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.

Abstract: The disclosure relates to a surgical instrument and discloses a flexible drive member, an end-effector, and a surgical instrument. The flexible drive member includes a distal portion, a proximal portion, and a bendable portion therebetween, wherein the bendable portion includes a plurality of wire bundles extending in the length direction of the flexible drive member, and a flexible casing enclosing the plurality of wire bundles. In the technical solutions of the disclosure, the bendable portion is provided with some rigidity and flexibility due to the plurality of wire bundles, and the flexibly casing can fix the plurality of wire bundles relatively and can alleviate friction rate of the surface of the flexible drive member and further improve the rigidity of the flexible drive member.

Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: Disclosed in the present application are a card-based information displaying method and apparatus, and an information displaying service processing method and apparatus. The card-based information displaying method comprises: determining target information to be displayed and a card type of a first card for displaying the target information; determining whether a configuration version of a client supports the card type of the first card; when it is determined that the configuration version of the client does not support the card type of the first card, determining an association identifier corresponding to the first card, and associating with a second card supported by the configuration version of the client according to the association identifier; and displaying the target information of the client using the second card.

Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.

Abstract: The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.

Abstract: Methods and materials involved in assessing samples (e.g., cancer cells) for the status of PINK1-Parkin pathway biomarkers, as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen.

Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.

Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.

Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.

Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.

Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.