Patents by Inventor Gan Zhang

Gan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treatment using substituted imidazo[1,2b]pyridazine compounds
    Patent number: 9795611
    Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: October 24, 2017
    Assignee: Array BioPharma, Inc.
    Inventors: Steven W. Andrews, Julia Haas, Yutong Jiang, Gan Zhang
  • BOUVARDIN DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20170218025
    Abstract: The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.
    Type: Application
    Filed: August 10, 2016
    Publication date: August 3, 2017
    Inventors: Tin Tin SU, Mara N. GLADSTONE, Gan ZHANG, Tarek SAMMAKIA
  • Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    Patent number: 9676783
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: June 13, 2017
    Assignee: Array BioPharma, Inc.
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
  • Method of Treatment Using Substituted Imidazo[1,2b]Pyridazine Compounds
    Publication number: 20170112849
    Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.
    Type: Application
    Filed: January 9, 2017
    Publication date: April 27, 2017
    Inventors: Steven W. Andrews, Julia Haas, Yutong Jiang, Gan Zhang
  • Method of Treatment Using Substituted Imidazo[1,2b]Pyridazine Compounds
    Publication number: 20170114068
    Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.
    Type: Application
    Filed: January 9, 2017
    Publication date: April 27, 2017
    Inventors: Steven W. Andrews, Julia Haas, Yutong Jiang, Gan Zhang
  • METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS
    Publication number: 20170114067
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Application
    Filed: January 5, 2017
    Publication date: April 27, 2017
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
  • Heterocyclic Hydroxamic Acids as Protein Deacetylase Inhibitors and Dual Protein Deacetylase-Protein Kinase Inhibitors and Methods of Use Thereof
    Publication number: 20170081343
    Abstract: The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.
    Type: Application
    Filed: May 14, 2015
    Publication date: March 23, 2017
    Applicant: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Gan Zhang, Daniel Chuen-Fong Chan, Anthony D. Piscopio
  • FLEXIBLE DRIVE MEMBER, END-EFFECTOR, AND SURGICAL INSTRUMENT USING THE SAME
    Publication number: 20160296231
    Abstract: The disclosure relates to a surgical instrument and discloses a flexible drive member, an end-effector, and a surgical instrument. The flexible drive member includes a distal portion, a proximal portion, and a bendable portion therebetween, wherein the bendable portion includes a plurality of wire bundles extending in the length direction of the flexible drive member, and a flexible casing enclosing the plurality of wire bundles. In the technical solutions of the disclosure, the bendable portion is provided with some rigidity and flexibility due to the plurality of wire bundles, and the flexibly casing can fix the plurality of wire bundles relatively and can alleviate friction rate of the surface of the flexible drive member and further improve the rigidity of the flexible drive member.
    Type: Application
    Filed: June 23, 2016
    Publication date: October 13, 2016
    Inventors: Yongfeng WANG, Gan Zhang
  • Bourvadin derivatives and therapeutic uses thereof
    Patent number: 9452215
    Abstract: The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: September 27, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, SUVICA, INC.
    Inventors: Tin Tin Su, Mara N. Gladstone, Gan Zhang, Tarek Sammakia
  • Method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds
    Patent number: 9447104
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: September 20, 2016
    Assignee: Array BioPharma, Inc.
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
  • Method of Treatment Using Substituted Imidazo[1,2b]Pyridazine Compounds
    Publication number: 20160251357
    Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.
    Type: Application
    Filed: December 30, 2015
    Publication date: September 1, 2016
    Inventors: Steven W. Andrews, Julia Haas, Yutong Jiang, Gan Zhang
  • Macrocyclic compounds useful as inhibitors of histone deacetylases
    Patent number: 9422340
    Abstract: The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: August 23, 2016
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Andrew J. Phillips, Dana Ungermannova, Christopher G. Nasveschuk, Gan Zhang
  • METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS
    Publication number: 20160228441
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Application
    Filed: September 4, 2015
    Publication date: August 11, 2016
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
  • Method of treatment using substituted imidazo[1,2B]pyridazine compounds
    Patent number: 9227975
    Abstract: Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic disease in a mammal, which comprise administering to said mammal a therapeutically effective amount of a compound of Formula I in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: January 5, 2016
    Assignee: Array BioPharma, Inc.
    Inventors: Steven W. Andrews, Julia Haas, Yutong Jiang, Gan Zhang
  • CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF
    Publication number: 20150343016
    Abstract: The present invention describes the use of translation inhibitors for the treatment of cancer and other disorders. Described herein are translation-inhibiting compounds, and methods of using those compounds for the treatment of cancer and other disorders. In some aspects the compounds inhibit translation elongation at the ribosome. In some aspects the compounds are used alone or in combination with known therapies.
    Type: Application
    Filed: December 24, 2014
    Publication date: December 3, 2015
    Inventors: Tin Tin Su, Gan Zhang
  • Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compounds
    Patent number: 9127013
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: September 8, 2015
    Assignee: Array BioPharma, Inc.
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
  • BOURVADIN DERIVATIVES AND THERAPEUTIC USES THEREOF
    Publication number: 20150238562
    Abstract: The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.
    Type: Application
    Filed: February 21, 2013
    Publication date: August 27, 2015
    Inventors: Tin Tin SU, Mara N. GLADSTONE, Gan ZHANG, Tarek SAMMAKIA
  • METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a] PYRIMIDINE COMPOUNDS
    Publication number: 20150133429
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Application
    Filed: January 14, 2015
    Publication date: May 14, 2015
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
  • Macrocyclic Compounds Useful as Inhibitors of Histone Deacetylases
    Publication number: 20150010541
    Abstract: The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
    Type: Application
    Filed: May 29, 2014
    Publication date: January 8, 2015
    Applicant: The Regents of the University of Colorado, A Body Corporate
    Inventors: Xuedong Liu, Andrew J. Phillips, Dana Ungermannova, Christopher G. Nasveschuk, Gan Zhang
  • METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS
    Publication number: 20150005499
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Application
    Filed: September 18, 2014
    Publication date: January 1, 2015
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang