Abstract: The present invention provides a conjugate and preparation method thereof, a pharmaceutical composition comprising the conjugate and use of the pharmaceutical composition in the manufacture of a medicament for the treatment or prevention of a disease.

Abstract: The present invention provides methods for increasing the sensitivity of tumor cells to a TCR-engineered T cells (TCR-T) therapy comprising genetically modifying the tumor cells to express an haplotype, for example an HLA haplotype, different from the haplotype endogenous to the tumor cells.

Abstract: In various examples, sensor configuration for autonomous or semi-autonomous systems and applications is described. Systems and methods are disclosed that may use image feature correspondences between camera images along with an assumption that image features are locally planar to determine parameters for calibrating an image sensor with a LiDAR sensor and/or another image sensor. In some examples, an optimization problem is constructed that attempts to minimize a geometric loss function, where the geometric loss function encodes the notion that corresponding image features are views of a same point on a locally planar surface (e.g., a surfel or mesh) that is constructed from LiDAR data generated using a LiDAR sensor. In some examples, performing such processes to determine the calibration parameters may remove structure estimation from the optimization problem.

Abstract: Disclosed herein are modified Clostridial Botulinum neurotoxin (BoNT) polypeptides with a modified protease domains of Clostridial Botulinum serotype A1 or A2. Modifications include substitution amino acid mutations, isolated modified protease domains, chimeric molecules, pharmaceutical compositions, and methods of using the same are also disclosed.

Abstract: Methods of mitigating line bending during feature fill include deposition of a nucleation layer having increased roughness. In some embodiments, the methods include depositing two or more metal nucleation layers.

Abstract: Disclosed are a viewing angle adjustment film structure, a manufacturing method thereof, and a display device, including a base, an isotropic optical material layer, and a liquid crystal layer stacked in sequence. The isotropic optical material layer is provided with grooves, the liquid crystal layer fills the grooves, and light enters from the liquid crystal layer and then exits through the isotropic optical material layer. Director of liquid crystal molecules in the liquid crystal layer is changed according to an external applied voltage or a change of an electric field, so as to adjust a viewing angle of the light emitted from the isotropic optical material layer.

Abstract: Embodiments of a microelectronic assembly includes: an interposer comprising a first portion in contact along an interface with a second portion; a first integrated circuit (IC) die embedded in a dielectric material in the first portion of the interposer; and a second IC die coupled to the first portion of the interposer opposite to the second portion, wherein: the second portion comprises a glass substrate with a channel within the glass substrate, a portion of the channel has an opening at the interface, a conductive pad in the first portion is exposed in the opening, and the conductive pad is coupled to a circuit in at least one of the first IC die or the second IC die.

Abstract: Methods and systems for image-based abnormal event detection are disclosed. An example method includes obtaining a sequential set of images captured by a camera; generating a set of observed features for each of the images; generating a set of predicted features based on a portion of the sets of observed features that excludes the set of observed features for a last image in the sequential set of images; determining that a difference between the set of predicted features and the set of observed features for the last image in the sequential set of images satisfies abnormal event criteria; and in response to determining that the difference between the set of predicted features and the set of observed features for the last image in the sequential set of images satisfies abnormal event criteria, classifying the set of sequential images as showing an abnormal event.

Abstract: In various examples, sensor configuration for autonomous or semi-autonomous systems and applications is described. Systems and methods are disclosed that may use image feature correspondences between camera images along with an assumption that image features are locally planar to determine parameters for calibrating an image sensor with a LiDAR sensor and/or another image sensor. In some examples, an optimization problem is constructed that attempts to minimize a geometric loss function, where the geometric loss function encodes the notion that corresponding image features are views of a same point on a locally planar surface (e.g., a surfel or mesh) that is constructed from LiDAR data generated using a LiDAR sensor. In some examples, performing such processes to determine the calibration parameters may remove structure estimation from the optimization problem.

Abstract: Methods, systems, and apparatus, including an apparatus for managing user data according to user consent settings are described. In some aspects, a method includes determining that a request for transmission by a client device to a recipient will include user data of a user of the client device. In response determining that the request will include the user data, the method includes requesting, from a consent management module of the client device, current user consent settings specified by the user which define at least one of (i) user data that can be transmitted from the client device, (ii) how user data transmitted from the client device can be used or (iii) which recipients can receive and retain user data from the client device. The method further includes receiving, from the consent management module, the current user consent settings and generating request data according the current user consent settings.

Abstract: A thin film transistor includes a gate electrode embedded in an insulating layer that overlies a substrate, a gate dielectric overlying the gate electrode, an active layer comprising a compound semiconductor material and overlying the gate dielectric, and a source electrode and drain electrode contacting end portions of the active layer. The gate dielectric may have thicker portions over interfaces with the insulating layer to suppress hydrogen diffusion therethrough. Additionally or alternatively, a passivation capping dielectric including a dielectric metal oxide material may be interposed between the active layer and a dielectric layer overlying the active layer to suppress hydrogen diffusion therethrough.

Abstract: A user equipment (UE) configured for multi-beam operation in a fifth-generation new radio (5G-NR) system may decode a physical downlink control channel (PDCCH). When a DCI format for a configured grant (CG) based small data transmission (SDT) (CG-SDT) is detected and a transport block (TB) is received in a corresponding physical downlink shared channel (PDSCH), the UE may assume that a demodulation reference signal (DM-RS) antenna port associated with PDCCH receptions and a DM-RS antenna port associated with PDSCH receptions are quasi co-located (QCL) with a synchronization signal/physical broadcast channel (SS/PBCH) associated with a physical uplink shared channel (PUSCH) resource for the CG-SDT. During the CG-SDT, the UE may encode a PUCCH for transmission using a same spatial domain transmission filter as a last PUSCH transmission.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for detecting errors in a client device and its associated applications while preserving the privacy of the user of the device. Methods can include obtaining and blinding contextual application data for an application on a device. Data regarding the application's digital certificate and device trustworthiness data are obtained and provided to a trust assessment server along with the blinded data. This server can provide indications that the device is trustworthy and the application is authentic, and can digitally sign the blinded data. The digital signature can be validated and the unblinded contextual application data can be obtained. If the unblinded data matches the contextual application data, the application can provide the digital signature, the indications, and the unblinded contextual application data to an error detection server, which in turn can indicate the application does not have errors.

Abstract: A battery includes a cathode, a lithium metal anode, and an electrolyte. The electrolyte includes lithium difluoro(oxalato)borate (LiDFOB) salt and a solvent mixture. The solvent mixture includes a first organic solvent having a cyclic carbonate and a second organic solvent having a linear ester or a linear carbonate.

Abstract: The present application discloses a sealing valve (10), including a guiding tube (1), comprising a first end (11) configured to be inserted into an outer packaging bottle and a second end configured to be connected to an anesthesia vaporizer (12); the outer peripheral surface of the first end (11) is provided with a convex ring (111) protruding toward the inner wall of the outer packaging bottle and abutting against the inner wall of the outer packaging bottle; and a pushing rod (2) configured to be arranged in the guiding tube (1) and slidable along an axial direction of the guiding tube (1) to connect the anesthesia vaporizer with the outer packaging bottle or to block between the anesthesia vaporizer and the outer packaging bottle.

Abstract: The present disclosure relates to a detection method and system for an underground space by joint use of fixed sensors and unmanned aerial vehicle (UAV) movement detection. The detection system includes underground space sensor nodes and an underground space UAV. The underground space sensor nodes are configured to perform fixed monitoring based on an adaptive optimal layout strategy for an underground structural space. The underground space UAV is configured to calculate a first virtual force, and realize movement detection by means of a virtual force-guided path planning algorithm. The underground space UAV is configured to calculate the first virtual force based on the electronic telescopic anti-collision bars, a second virtual force based on a static perception probability and a third virtual force based on structural evolution knowledge, and realize a fixed node-guided UAV flight detection mode by means of the virtual force-guided path planning algorithm.

Abstract: Provided are a sampling clock phase mismatch error estimation method and apparatus, and a storage medium. This sampling clock phase mismatch error estimation method includes: a proportional relation between an estimation operator of a modular square subtraction method corresponding to each frequency interval of multiple frequency intervals and a sampling clock phase mismatch error of a time-interleaved analog to digital converter (TIADC) is acquired; a slope and an offset value of a fitting proportion line segment are counted; and a slope of a proportion line segment corresponding to a real-time estimation frequency is converted, and an offset value corresponding to the real-time estimation frequency is estimated through an interpolation according to a counted slope and a counted offset value, and the actual value of the sampling clock phase mismatch error is estimated according to a converted slope and an offset value estimated through the interpolation.

Abstract: Systems and methods are provided to determine an estimated location of a user equipment (UE). For instance, a UE can provide a positioning request to a node while the UE is in a radio resource control idle (RRC_IDLE) or inactive (RRC_INACTIVE) state. The positioning request can be implemented in a random access channel (RACH) message A (MsgA). The UE can then receive a positioning response from the node. The positioning response can be implemented in a RACH message B (MsgB).

Abstract: A user equipment (UE) configured for operation in a 5th generation (5G) new radio (NR) system (5GS) (5G NR) in which a multi-transmission time interval (TTI) DCI schedules multiple physical downlink shared channels (PDSCHs), generates a Type-1 HARQ-ACK codebook for candidate PDSCH reception occasions corresponding to an uplink slot. The UE determines a set of downlink (DE) slots for the multiple scheduled PDSCHs and a set of a Start and Length Indicator Values (SLIVs) for the DE slots based on configured slot timing values (K1) and a configured time domain resource allocation (TDRA) table.

Abstract: Various embodiments herein are directed to multi-Transmission Time Interval (TTI) scheduling for data transmission for system operating above the 52.6 GHz carrier frequency. Other embodiments may be disclosed and/or claimed.