Abstract: Techniques for improved margin control in a data communication system are disclosed. In one aspect, margin is adjusted in response to a first subpacket error rate. In another aspect, margin is further adjusted in response to an overall packet error rate. In yet another aspect, the first subpacket error rate is adjusted in response to an overall packet error rate. Various other aspects are also presented. These aspects have the benefit of responsive margin control when the overall packet error rate is relatively low, resulting in improved data throughput and increased system capacity.

Abstract: Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular beacon comprises at least one reporter. The probes optionally comprise a protein transduction domain, targeting signal, or a combination thereof. Methods for detecting target polynucleotides using the disclosed probes are also provided.

Abstract: Methods and apparatus are presented for dynamically adjusting parameters of an outer-loop algorithm, which is used to determine the feasibility of a transmission format. The parameters of the outer-loop algorithm are adjusted according to channel conditions. In one embodiment, an erasure-based approach is used to determine whether to incrementally increase or incrementally decrease a margin parameter in the outer-loop algorithm. Once one margin parameter is altered, other margin parameters can be adjusted accordingly.

Abstract: The present invention provides methods for detecting gene expression in normal and cancerous cells. Specifically, provided are methods utilizing molecular beacons (MB) technology combined with fluorescence imaging techniques for detecting, identifying or quantitating the presence of, or alterations in gene expression of, various tumor markers in a sample of cells.

Abstract: Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop molecular beacon probes that hybridize sufficiently near each other on a subject nucleic acid, e.g. mRNA, to generate an observable interaction. The invention also provides lanthanide chelate luminescent resonance energy transfer moieties on linear and stem-loop probes that hybridize sufficiently near each other on a subject nucleic acid to generate an observable interaction. The invention thereby provides detectable signals for rapid, specific and sensitive hybridization determination in vivo. The probes are used in methods of detection of nucleic acid target hybridization for the identification and quantification of tissue and cell-specific gene expression levels, including response to external stimuli, such as drug candidates, and genetic variations associated with disease, such as cancer.

Abstract: A method and apparatus for selecting a favored transmission slot for communicating non-voice data in conjunction with a voice-data communication. The slot, reflecting a favored power level and transmission rate for transmitting the non-voice data on a supplemental channel, is selected based upon the transmission power levels for voice-data transmitted by a base station to a remote station on a fundamental channel. The favored transmission slot is selected without the remote station messaging information to the base station concerning frequency channel or interference information for the supplemental channel.

Abstract: A method and apparatus for selecting a favored transmission slot for communicating non-voice data in conjunction with a voice-data communication. The slot, reflecting a favored power level and transmission rate for transmitting the non-voice data on a supplemental channel, is selected based upon the transmission power levels for voice-data transmitted by a base station to a remote station on a fundamental channel. The favored transmission slot is selected without the remote station messaging information to the base station concerning frequency channel or interference information for the supplemental channel.

Abstract: In a wireless communication system a method for combination transmission of packet data and low delay data. In one embodiment a parallel signaling channel provides a message to receivers indicating a target recipient of packet data. The message also identifies the transmission channels used for packet data transmissions. Each receiver may then selectively decode only packets where the message identifies the receiver as a target recipient. The data packets stored in a buffer are ignored if the target recipient is another mobile unit. In one embodiment, the message is sent concurrently with the data packet on a parallel channel. In one embodiment, the message is punctured into the high rate packet data transmission.

Abstract: Dual nucleic acid probes with resonance energy transfer moieties are provided. In particular, fluorescent or luminescent resonance energy transfer moieties are provided on hairpin stem-loop molecular beacon probes that hybridize sufficiently near each other on a subject nucleic acid, e.g. mRNA, to generate an observable interaction. The invention also provides lanthanide chelate luminescent resonance energy transfer moieties on linear and stem-loop probes that hybridize sufficiently near each other on a subject nucleic acid to generate an observable interaction. The invention thereby provides detectable signals for rapid, specific and sensitive hybridization determination in vivo. The probes are used in methods of detection of nucleic acid target hybridization for the identification and quantification of tissue and cell-specific gene expression levels, including response to external stimuli, such as drug candidates, and genetic variations associated with disease, such as cancer.

Abstract: Apparatus and methods efficiently estimate signal-to-noise ratios of a received signal irrespective of intentional adjustments to transmitting power due to fluctuating data rates. For example, in one embodiment, the variation in power due to the change in data rate is decoupled from environmental sources for variations in power. In one embodiment, the signal to noise ratio is adjusted for the data rate. In another embodiment, another signal is used as a reference for the signal to noise computation. This advantageously permits a system to efficiently and accurately control power in a power control loop for efficient use of spectral bandwidth and for relatively good grade of service (GoS).

Abstract: Probes for detecting a target polynucleotide are provided. One aspect provides a molecular beacon probe set wherein the donor molecular beacon comprises a quantum dot and an acceptor molecular beacon comprises at least one reporter. The probes optionally comprise a protein transduction domain, targeting signal, or a combination thereof. Methods for detecting target polynucleotides using the disclosed probes are also provided.

Abstract: In a wireless communication system a method for combination transmission of packet data and low delay data. In one embodiment a parallel signaling channel provides a message to receivers indicating a target recipient of packet data. The message also identifies the transmission channels used for packet data transmissions. Each receiver may then selectively decode only packets where the message identifies the receiver as a target recipient. The data packets stored in a buffer are ignored if the target recipient is another mobile unit. In one embodiment, the message is sent concurrently with the data packet on a parallel channel. In one embodiment, the message is punctured into the high rate packet data transmission.

Abstract: In a wireless communication system a method for combination transmission of packet data and low delay data. In one embodiment a parallel signaling channel provides a message to receivers indicating a target recipient of packet data. The message also identifies the transmission channels used for packet data transmissions. Each receiver may then selectively decode only packets where the message identifies the receiver as a target recipient. The data packets stored in a buffer are ignored if the target recipient is another mobile unit. In one embodiment, the message is sent concurrently with the data packet on a parallel channel. In one embodiment, the message is punctured into the high rate packet data transmission.

Abstract: An efficient use of communication resources is provided by determining a behavior for selecting the payload size (data rate) of a reverse link transmission from a mobile station to a base station. The mobile station may store a predetermined table including the ratio of the power levels of the traffic channel and pilot channel (TPR), where each entry corresponds to one or more specific sizes of data payload, and consequently a data rate for transmission in a predetermined time frame. The payload size is selected based on an authorized-TPR. The authorized-TPR and a target-TPR are adjusted in accordance with a value of common TPR commands received from the base station. A fast-ramp-up behavior for adjustments of the authorized-TPR is followed when the authorized-TPR is less than the target-TPR. The down TPR commands are ignored in the adjustments of the authorized-TPR to allow following a fast-ramp-up behavior.

Abstract: The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.

Abstract: A method and apparatus for selecting a favored transmission slot for communicating non-voice data in conjunction with a voice-data communication. The slot, reflecting a favored power level and transmission rate for transmitting the non-voice data on a supplemental channel, is selected based upon the transmission power levels for voice-data transmitted by a base station to a remote station on a fundamental channel. The favored transmission slot is selected without the remote station messaging information to the base station concerning frequency channel or interference information for the supplemental channel.

Abstract: A method and apparatus for selecting a favored transmission slot for communicating non-voice data in conjunction with a voice-data communication. The slot, reflecting a favored power level and transmission rate for transmitting the non-voice data on a supplemental channel, is selected based upon the transmission power levels for voice-data transmitted by a base station to a remote station on a fundamental channel. The favored transmission slot is selected without the remote station messaging information to the base station concerning frequency channel or interference information for the supplemental channel.

Abstract: A method and apparatus for selecting a favored transmission slot for communicating non-voice data in conjunction with a voice-data communication. The slot, reflecting a favored power level and transmission rate for transmitting the non-voice data on a supplemental channel, is selected based upon the transmission power levels for voice-data transmitted by a base station to a remote station on a fundamental channel. The favored transmission slot is selected without the remote station messaging information to the base station concerning frequency channel or interference information for the supplemental channel.

Abstract: A method for scheduling packet data transmissions in a wireless communication system wherein a per-user Priority Function (PF) is calculated based on the channel condition and throughput for each user. In one embodiment, the system supports retransmission of data packets and sub-packets, wherein the retransmission information is used to schedule data transmissions. In another embodiment, at each time interval the system updates the priority factor for the user having the highest priority factor in the previous time interval. The priority factors of the other users remain unchanged.

Abstract: Systems and methods for scheduling data transmissions in a wireless communication system using scheduling requests and grants. In one embodiment, a wireless communication system has a base station and one or more mobile stations coupled by a wireless link having forward- and reverse-link channels. The base station is configured to receive requests from the mobile stations, to process the requests independently of a base station controller, to allocate communication link resources among the mobile stations, and, if necessary, to transmit one or more grants to the mobile stations in accordance with the allocation of communication link resources. Each mobile station is configured to transmit data to the base station in accordance with any grants received from the base station.