Abstract: There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-? related diseases, such as Alzheimer's disease.

Abstract: An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature. Methods and compositions for making glycoproteins with reduced fucosylation are provided.

Abstract: Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Abstract: A back contact structure includes: a silicon substrate including a back surface including a plurality of recesses disposed at intervals; a plurality of first conductive regions and a plurality of second conductive regions disposed alternately on the back surface of the silicon substrate; a second dielectric layer disposed between the plurality of first conductive regions and the plurality of second conductive regions; and a conductive layer disposed on the plurality of first conductive regions and the plurality of second conductive regions. One of the plurality of first conductive regions and the plurality of second conductive regions is disposed inside the plurality of recesses, respectively, and the other one is disposed outside the plurality of recesses; each first conductive region includes a first dielectric layer and a first doped region which are disposed successively, and each second conductive region includes a second doped region.

Abstract: The disclosure discloses a method for manufacturing a solar cell, a solar module, and a power generation system. The manufacturing method includes the following steps: S1: perforating film layer in a first region and/or a second region of a solar cell where an electrode is to be disposed, thus forming a plurality holes; S2: growing a plurality seed layers on the solar cell, contacting with the first region and/or the second region through the plurality of holes or grooves in S1; and S3: horizontally transporting a to-be-electroplated solar cell on a horizontal electroplating device, to form a cathode on the seed layer, where an anode terminal is disposed in an electroplating liquid in an electroplating bath, and a moving mechanism disposed in the electroplating bath drives the solar cell to move from inlet to outlet, thus achieving electroplating.

Abstract: A conductive contact structure of a solar cell is provided, includes a substrate; a semiconductor region; and an electrode. The semiconductor region is disposed on or in the substrate. The electrode is disposed in the semiconductor region. The electrode includes a seed layer in contact with the semiconductor region. The seed layer includes an alloy material, and includes a main component and an improved component. The main component is one or more metals having an average refractive index lower than 2 and a wavelength in a range of 850-1200 nm, and the improved component includes any one or more of Mo, Ni, Ti, W, Cr, Mn, Pd, Bi, Nb, Ta, Pa, Si, and V.

Abstract: The present inventions provide mammalian cells that comprise multiple Stable Integration Sites. The inventions provide sites introduced genomically into a Genomic Safe Harbor and introduced genomically outside of that particular Genomic Safe Harbor, including but not limited to another Genomic Safe Harbor. Polynucleotides of interest that encode polypeptides or RNAs of interest can be inserted into the Stable Integration Sites provided according to the inventions. The cells and methods of the inventions can be used for the high yield production of any protein, including viral proteins. Additionally, the cells and methods of the inventions are useful for production of viral vectors, such as AAV, antibodies and other proteins.

Abstract: A graphene and in-situ nano-ZrB2 particle-co-reinforced aluminum matrix composite (AMC) and a preparation method thereof are provided. The preparation method includes: heating an aluminum alloy for melting, adding potassium fluoroborate and potassium fluorozirconate to produce ZrB2 particles in-situ, additionally adding a mixture of pre-prepared copper-coated graphene and an aluminum powder, and stirring with an electromagnetic field for uniform dispersion; and ultrasonically treating the resulting melt to improve the dispersion of the in-situ nano-ZrB2 particles and the graphene, casting for molding to obtain a casting, and subjecting the casting to homogenization and rolling for deformation to obtain the graphene and in-situ nano-ZrB2 particle-co-reinforced AMC. The in-situ generation of the reinforcement nano-ZrB2 particles in an aluminum alloy melt increases the number of interfaces in the composite and also increases the dislocation density.

Abstract: A backside-illuminated image sensor includes photodiodes in photodiode regions electrically isolated by filled trenches with openings in a dielectric layer over the photodiodes. The image sensor has a metal grid aligned over the trenches, the metal grid within 80 nanometers of the trenches. The image sensor is formed by: fabricating photodiodes in photodiode regions of a frontside of a silicon substrate with source-drain regions of transistors, the photodiodes electrically isolated by deep trenches, each photodiode within a photodiode region of the substrate; forming the filled trenches in a backside of the semiconductor substrate; forming protective oxide and process stop layers over the backside of the semiconductor substrate; depositing a metal grid over the deep trenches, removing the process stop layer from over photodiode regions; and depositing color filters over the photodiode regions.

Abstract: A method for soldering a solar cell, includes: placing a plurality of back contact cells on a soldering platform, where back surfaces of the back contact cells face away from the soldering platform, and electrodes corresponding to two adjacent back contact cells have opposite polarities in a connection direction of a plurality of to-be-connected ribbons; placing the plurality of to-be-connected ribbons on the electrodes of the plurality of back contact cells by using a first clamping portion, a second clamping portion, and a plurality of third clamping portions, where the first clamping portion, the second clamping portion, and the plurality of third clamping portions respectively correspond to head ends, tail ends, and middle portions of the plurality of ribbons; and heating the plurality of ribbons by using a heater to connect the plurality of ribbons to the plurality of back contact cells.

Abstract: The disclosure relates to the technical field of solar cells, and provides a solar cell and a doped region structure thereof, a cell assembly, and a photovoltaic system. The doped region structure includes a first doped layer, a passivation layer, and a second doped layer that are disposed on a silicon substrate in sequence. The passivation layer is a porous structure having the first doped layer and/or the second doped layer inlaid in a hole region. The first doped layer and the second doped layer have a same doping polarity. By means of the doped region structure of the solar cell provided in the disclosure, the difficulty in production and the limitation on conversion efficiency as a result of precise requirements for the accuracy of a thickness of a conventional tunneling layer are resolved.

Abstract: An image sensor includes a substrate. An array of photodiodes is disposed in the substrate. A plurality of spacers is arranged in a spacer pattern. At least one spacer of the plurality of spacers has an aspect ratio of 18:1 or greater. A buffer layer is disposed between the substrate and the spacer pattern. An array of color filters is disposed in the spacer pattern.

Abstract: Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of <5% as calculated in accordance with ASTM standard D1003-13 and (ii) a U-factor of <0.5 BTU/sf/hr/° F., and a transparent polymer envelope sealed at an internal pressure of ?1 atmosphere, wherein the monolithic silica aerogel slab is encapsulated in the transparent polymer envelope. The monolithic aerogel slab can have a transmittance >94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet.

Abstract: Graphics processing systems and methods are described. A graphics processing apparatus may comprise one or more graphics processing engines, a memory, a memory management unit (MMU) including a GPU second level page table and GPU dirty bit tracking, and a provisioning agent to receive a request from a virtual machine monitor (VMM) to provision a subcluster of graphics processing apparatuses, the subcluster including a plurality of graphics processing engines from a plurality of graphics processing apparatuses connected using a scale-up fabric, provision the scale-up fabric to route data within the subcluster of graphics processing apparatuses, and provision a plurality of resources on the graphics processing apparatus for the subcluster based on the request from the VMM.

Abstract: A low cost biodegradable drinking straw comprising structurally non-altered corn starch mixed with one or more than one improver. The improver comprises a biological enzyme preparation and a colloid preparation. The low cost biodegradable drinking straw is made by providing 98% structurally non-altered corn starch mixed with one or more than one improver to make a biodegradable powder. The edible biodegradable powder is formed into a drinking straw shape and extruded to a drinking straw shape. When the extruded drinking straw shapes are cooled, they are cut into an appropriate drinking straw length. The cut drinking straws are then dried and packaged.

Abstract: A semiconductor device includes a plurality of semiconductor fins, at least one gate stack, a refill isolation, and an air gap. Each of the semiconductor fins extends in an X direction. Two adjacent ones of the semiconductor fins are spaced apart from each other in a Y direction transverse to the X direction. The at least one gate stack has two stack sections spaced apart from each other in the Y direction. The stack sections are disposed over two adjacent ones of the semiconductor fins, respectively. The refill isolation and the air gap are disposed between the stack sections.

Abstract: The embodiment of the present application relates to the technical field of communication and discloses an application request processing method, including: forming an overall service rule in response that two or more different application requests exist for a user on a service, wherein the overall service rule comprises a service rule of each application request. The embodiment of the present application also discloses an application request processing system, electronic device and storage medium. The embodiment of the present application provides an application request processing method, system, electronic device and storage medium that enable multiple application requests for the user on the service to be responded.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: The present application relates to a sulfur-containing isoindoline derivative, and a preparation method therefor and medical use thereof. In particular, the present disclosure relates to a sulfur-containing isoindoline derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and use thereof as a therapeutic agent, particularly use thereof as a Cereblon modulator in the field of treatment of multiple myeloma.

Abstract: Herein provided are cubic boron arsenide (c-BAs) single crystals having an unexpectedly high ambipolar mobility at room temperature, µa, at one or more locations thereof that is greater than or equal to 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, 2500, 2600, 3000, 4000, 5000, 6000, 7000, 8000, 9000, or 10000 cm2V-1s-1, wherein the ambipolar mobility is defined as: µa = 2µeµh/(µe + µh), wherein µe is electron mobility and µh is hole mobility, and having a room temperature thermal conductivity at the one or more locations thereof that is greater than or equal to 1000 Wm-1K-1. Methods of making and using the c-BAs single crystals are also provided.