Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.

Abstract: An integrated semiconductor device is provided. The integrated semiconductor device includes a first semiconductor structure having a first IC, and a second semiconductor structure stacked above the first semiconductor structure and having a second IC. The second semiconductor structure has a first surface facing the first semiconductor structure and a second surface facing away from the first semiconductor structure. The integrated semiconductor device also includes a thermal dissipation structure having a first portion partially through the first IC and a second portion fully through the second semiconductor structure and exposed at the second surface of the second semiconductor structure. The second portion may be outside of the second IC.

Abstract: The present invention belongs to the technical field of liquid crystal materials, and in particular relates to a liquid crystal composition with good frequency dependence and a liquid crystal display element or liquid crystal display containing the liquid crystal composition. The liquid crystal composition of the present invention comprises a compound represented by Formula I, a compound represented by Formula II and a compound represented by Formula III, wherein the mass percentage content of the compound represented by Formula I is not less than 30%. The liquid crystal composition provided by the present invention has an appropriate optical anisotropy, an appropriate dielectric anisotropy, especially a relatively low rotational viscosity, a good low-temperature mutual solubility and a good reliability, especially good frequency dependence.

Abstract: The present invention belongs to the technical field of liquid crystal materials, and in particular relates to a negative liquid crystal composition and a liquid crystal display element or liquid crystal display containing the liquid crystal composition. The present invention discloses a negative dielectric nematic liquid crystal composition, comprising a compound represented by Formula I, one or more compounds represented by Formula II, and one or more compounds represented by Formula III. The liquid crystal composition has a relatively low rotational viscosity (?1), a high clearing point (Cp), a good solubility and a high stability to heat and light (VHR) on the basis of maintaining an appropriate optical anisotropy (?n), and can be used for developing a liquid crystal display element or liquid crystal display with a low cell thickness, a wide temperature for display, and a fast response.

Abstract: Some implementations described herein include systems and techniques for fabricating a multi-dimension through silicon via structure in a three-dimensional integrated circuit device. The multi-dimension through silicon via structure includes a first columnar structure having a first width and a second columnar structure including a second width that is greater relative to the first width. The first columnar structure may include a low electrical capacitance and be configured for electrical signaling within the three-dimensional integrated circuit device. The second columnar structure may be configured to provide power to integrated circuitry of the three-dimensional integrated circuit device and also be configured to conduct heat through the three-dimensional integrated circuit device for thermal management of the three-dimensional integrated circuit device. Additionally, a pattern including the second columnar structure may be used for alignment purposes.

Abstract: An integrated circuit (IC) device includes a substrate. The IC device includes a multi-layer interconnect structure disposed over a first side of the substrate. The multi-layer interconnect structure includes a plurality of metal layers. The IC device includes a first portion of a through-substrate via (TSV) disposed over the first side of the substrate. The first portion of the TSV includes a plurality of conductive components belonging to the plurality of metal layers of the multi-layer interconnect structure. The IC device includes a second portion of the TSV that extends vertically through the substrate from the first side to a second side opposite the first side. The second portion of the TSV is electrically coupled to the first portion of the TSV.

Abstract: The present application relates to a substrate, an LED light source assembly and manufacturing methods therefor. The substrate includes a first substrate and a second substrate which are arranged in a stacked manner. Electrode soldering regions on the front side of the first substrate and corresponding first conductive regions on the back side of the first substrate are electrically connected; and second conductive regions on the front side of the second substrate and corresponding third conductive regions on the back side of the second substrate are electrically connected, where the corresponding first conductive regions and the corresponding second conductive regions are electrically connected.

Abstract: The present invention belongs to the technical field of liquid crystal materials, and in particular relates to a liquid crystal composition with good frequency dependence and a liquid crystal display element or liquid crystal display containing the liquid crystal composition. The liquid crystal composition of the present invention comprises a compound represented by Formula I, a compound represented by Formula II and a compound represented by Formula III, wherein the mass percentage content of the compound represented by Formula I is not less than 30%. The liquid crystal composition provided by the present invention has an appropriate optical anisotropy, an appropriate dielectric anisotropy, especially a relatively low rotational viscosity, a good low-temperature mutual solubility and a good reliability, especially good frequency dependence.

Abstract: The present invention belongs to the technical field of liquid crystal materials, and in particular relates to a liquid crystal composition and a liquid crystal display element or liquid crystal display containing the liquid crystal composition. The liquid crystal composition of the present invention is characterized in that the liquid crystal composition comprises more than or equal to 30% of a compound represented by Formula I, and also comprises one or more compounds represented by Formula II and one or more compounds represented by Formula III. The liquid crystal composition of the present invention has a high refractive index, a high clearing point and also a low rotational viscosity, and is mainly used for the display of a projector with a relatively high working temperature and a low cell thickness.

Abstract: The present invention belongs to the technical field of liquid crystal materials, and in particular relates to a negative liquid crystal composition and a liquid crystal display element or liquid crystal display containing the liquid crystal composition. The present invention discloses a negative dielectric nematic liquid crystal composition, comprising a compound represented by Formula I, one or more compounds represented by Formula II, and one or more compounds represented by Formula III. The liquid crystal composition has a relatively low rotational viscosity (?1), a high clearing point (Cp), a good solubility and a high stability to heat and light (VHR) on the basis of maintaining an appropriate optical anisotropy (?n), and can be used for developing a liquid crystal display element or liquid crystal display with a low cell thickness, a wide temperature for display, and a fast response.

Abstract: A liquid crystal composition, a liquid crystal display element and a liquid crystal display comprising the liquid crystal composition belong to the field of liquid crystal display. The liquid crystal composition comprises a compound represented by formula I with a mass content of 1-10% as the first component, a compound represented by formula II with a mass content of 1-20% as the second component, more than two compounds represented by formula III as the third component, more than three compounds represented by formula IV as the fourth component, and one or more polymerizable compounds as the fifth component, the crystal composition has low rotational viscosity and low ?1/K33 on the basis of maintaining appropriate optical anisotropy. When applied to liquid crystal display elements or liquid crystal displays, the liquid crystal display has a fast response speed.

Abstract: A positive dielectric anisotropic liquid crystal composition includes one or more compounds of formula I and one or more compounds of formula II: wherein R1 represents cyclopropyl, cyclobutyl or cyclopentyl, R2, R3 and R4 are as defined in the specification, and a liquid crystal display device. The liquid crystal composition has positive dielectric properties, a high charge retention ratio, a low rotary viscosity, a fast response time, and especially a high transmittance, and is suitable for manufacturing a TFT-LCD with a high transmittance and a fast response.

Abstract: A liquid crystal composition, a liquid crystal display element and a liquid crystal display comprising the liquid crystal composition belong to the field of liquid crystal display. The liquid crystal composition of the present disclosure comprises a compound represented by formula I, a compound represented by formula II, one or more compounds represented by formula III, one or more compounds represented by formula IV and more than three compounds represented by formula V. The liquid crystal composition has low rotational viscosity ?1 and high stability to heat and light on the basis of maintaining appropriate optical anisotropy ?n, which can realize fast response of liquid crystal display.

Abstract: A dielectric negative liquid crystal composition, a liquid crystal display element and a liquid crystal display containing the liquid crystal composition belong to the field of liquid crystal display. The liquid crystal composition of the present disclosure includes a compound represented by formula I, a compound represented by formula II, two or more compounds represented by formula III and one or more compounds represented by formula IV. The liquid crystal composition of the present invention has high dielectric anisotropy, high elastic constant K, low rotational viscosity, can be used to develop large dielectric, fast response liquid crystal display elements or liquid crystal displays.

Abstract: A liquid crystal composition, a liquid crystal display element and a liquid crystal display comprising the liquid crystal composition belong to the field of liquid crystal display. The liquid crystal composition of the present disclosure comprises a compound represented by formula I, a compound represented by formula II, one or more compounds represented by formula III, one or more compounds represented by formula IV and more than three compounds represented by formula V. The liquid crystal composition has low rotational viscosity ?1 and high stability to heat and light on the basis of maintaining appropriate optical anisotropy ?n, which can realize fast response of liquid crystal display.

Abstract: A dielectric negative liquid crystal composition, a liquid crystal display element and a liquid crystal display containing the liquid crystal composition belong to the field of liquid crystal display. The liquid crystal composition of the present disclosure includes a compound represented by formula I, a compound represented by formula II, two or more compounds represented by formula III and one or more compounds represented by formula IV. The liquid crystal composition of the present invention has high dielectric anisotropy, high elastic constant K, low rotational viscosity, can be used to develop large dielectric, fast response liquid crystal display elements or liquid crystal displays.

Abstract: A compound represented by formula I, a negative liquid crystal composition comprising such a compound, and a liquid crystal display element or liquid crystal display comprising the compound or liquid crystal composition are provided. The compound represented by formula I contains two hydroxy groups. In an ODF process for a panel, due to an intermolecular force between the hydroxyl groups and the surface of the panel (a glass surface or an ITO electrode surface), the compound is spontaneously aligned, in a standing manner, on the panel glass or transparent ITO electrode substrate, causing liquid crystal molecules similar to the compound represented by formula ITO be vertically aligned, and UV light irradiation, a polymer layer with a rough surface is formed on the substrate by means of polymerization, and achieves the effects of PI insulation and vertical alignment of the liquid crystal molecules.

Abstract: A liquid crystal composition, a liquid crystal display element and a liquid crystal display comprising the liquid crystal composition belong to the field of liquid crystal display. The liquid crystal composition comprises a compound represented by formula I with a mass content of 1-10% as the first component, a compound represented by formula II with a mass content of 1-20% as the second component, more than two compounds represented by formula III as the third component, more than three compounds represented by formula IV as the fourth component, and one or more polymerizable compounds as the fifth component, the crystal composition has low rotational viscosity and low ?1/K33 on the basis of maintaining appropriate optical anisotropy. When applied to liquid crystal display elements or liquid crystal displays, the liquid crystal display has a fast response speed.

Abstract: Disclosed are a liquid crystal composition, a liquid crystal display element, and a liquid crystal display, said liquid crystal composition comprising one or more compounds represented by formula I, one or more compounds represented by formula II, one or more compounds represented by formula III and one or more compounds represented by formula IV, The liquid crystal composition of the present invention has a good stability to light and heat and a lower viscosity, and can attain a wider refractive index and a high clearing point (a wide service temperature range), and in particular, the liquid crystal composition has a high light transmittance, thus allowing a display device to have a high brightness or an energy saving effect.

Abstract: Provided are a polymerizable composition of a polymerizable compound represented by formula I and a polymerizable compound represented by formula II, a liquid crystal composition formed by combining this polymerizable composition with a specific liquid crystal component, particularly a PSVA liquid crystal composition suitable for display or TV applications, and a PSA-IPS liquid crystal composition for an IPS mode; in particular, the polymerizable liquid crystal composition has a good solubility, and an adjustable rate of polymerization and morphology after polymerization; furthermore, a “material system” formed from the selected polymerizable component and liquid crystal component has a low rotary viscosity and good photoelectric properties, and has a high VHR after (UV) photoradiation, this avoiding the problems of the occurrence of afterimages in final displays, etc.