Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.

Abstract: An optical device includes a first optically dimmable switch for providing a first transmittance while the first optically dimmable switch is in a first state and providing a second transmittance distinct from the first transmittance while the first optically dimmable switch is in a second state distinct from the first state. The optical device also includes a dynamic heat source thermally coupled with the first optically dimmable switch. The dynamic heat source is at a first temperature at a first time and is at a second temperature distinct from the first temperature at a second time mutually exclusive from the first time. The optical device may operate as an optical dimming device, which may be used in head-mounted display devices or as dimmable windows or shutters.

Abstract: An interface assembly comprises a nasal mask that includes a seal having a rolling portion. The rolling portion of the seal rolls over a portion of a clip that secures the seal to a frame. The frame has a ball and socket connection to a connector. The connector comprises an elbow having integrally formed exhaust holes and a swivel.

Abstract: Techniques for validating or determining trajectories for a vehicle are discussed herein. A trajectory management component can receive status and/or error data from other safety system components and select or otherwise determine safe and valid vehicle trajectories. A perception component of a safety system can validate a trajectory upon which the trajectory management component can wait for selecting a vehicle trajectory, validate trajectories stored in a queue, and/or utilize kinematics for validation of trajectories. A filter component of the safety system can filter out objects based on trajectories stored in a queue. A collision detection component of the safety system can determine the collision states based on trajectories stored in a queue or determine a collision state upon which the trajectory management component can wait for selecting or otherwise determining a vehicle trajectory.

Abstract: A cable gland sealing member comprising: a sleeve (19) arranged to be slidably received within a passage (9) defined in a body (5) of a cable gland, the sleeve (19) arranged to receive a settable sealing material for forming a seal to a cable passing through the sleeve, wherein the sleeve (19) is defined by an annular side wall extending along an axial length; wherein an outer surface (71) of the sleeve (19) includes a tapered portion (95) such that the external diameter of the sleeve (19) widens in the tapered portion (95); and wherein the outer surface (71) of the sleeve (19) is arranged to form a seal with the cable gland body (5). A cable gland is also disclosed using such a sealing member.

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

Abstract: Techniques for secure fast channel change in live content streaming are described. In some embodiments, during content preparation, a packager and/or an encoder encrypts media content items at both the service level (e.g., by encrypting a first portion of the plurality of segments with a service level access key unique to a service) and the channel level (e.g., by encrypting a second portion of the plurality of segments with a channel level access key unique to a channel associated with the service). On the receiving end, a client device (e.g., a media player) requests a service level access key prior to content acquisition. As such, a client can join any channel on a segment protected with the service level key without waiting for a license for that channel first, and the channel license can be acquired in parallel with the content acquisition during channel switching.

Abstract: According to examples, a tunable visible light source may include a periodically poled lithium niobate (PPLN) waveguide and a control mechanism to optimize the phase-matching of the PPLN waveguide in response to an input signal with a varied wavelength. The control mechanism may include an electro-optic (EO) tuning mechanism, a microheater-based thermo-optic (TO) control mechanism, and/or an acousto-optic (AO) control mechanism. The control mechanisms may, respectively, generate an electric field, heat, or an acoustic wave to affect a change in refractive index of the PPLN waveguide and thereby optimize the conversion efficiency to maximize the output power of the output wavelength of the PPLN waveguide as the input wavelength is tuned.

Abstract: A method of chromatically-corrected image demosaicing for a sensor with a colour filter array (CFA) such as a Bayer filter array. The demosaicing makes use of local chromatic aberration correction data to determine chromatically-corrected pixel positions for spatial interpolation. In implementations a chromatically-corrected quadratic adjustment is also applied.

Abstract: A method for assembling an LED apparatus using an epitaxial layered structure comprising a first-type doped semiconductor layer, a second-type doped semiconductor layer, and an active layer between the doped semiconductor layers. The method involves depositing a conductive layer adjacent to and in ohmic contact with the first-type doped semiconductor layer. After forming a pattern masked layer on the conductive layer to expose one or more unprotected mask regions, the unprotected mask region(s) are processed to form a micropixellated structure having micropixel contact areas that are electrically isolated from each other. The method further involves placing a first contact pad over the micropixellated structure to overlap the micropixel contact areas and form a first electrode shared by a set of micro-LEDs. The micropixellated structure is also electrically coupled to a second contact pad that forms a second electrode shared by the set of micro-LEDs.

Abstract: Techniques for rapid video on demand (VOD) media content breach response are described. In some embodiments, during content preparation, a server generates an encrypted media content item by generating a first encrypted portion using a first key derived from a first seed that is of a first type and generating a second encrypted portion using a second key derived from a second seed that is of a second type. In some embodiments, the server classifies the first portion in a first category (e.g., a prioritized category) and the second portion in a second category (e.g., a non-prioritized category). During a breach response, the server repairs the encrypted media content item by re-encrypting portions in the first category, e.g., re-encrypting the first encrypted portion using a replacement key derived from a replacement seed that is of the first type, and updating encryption metadata.

Abstract: Techniques for a trusted system for secure content distribution and trusted recording of content consumption are described. In some embodiments, the trusted system transcodes and transcrypts a media content item using a key obtained from a content provider and one or more keys based on an entitlement from a service provider to generate an encrypted media content item. The trusted system further receives a request to provide the media content item to a client device. The trusted system also obtains a signed audit token recording the request upon an authorization by the service provider based on the entitlement and a confirmation by the content provider, where the signed audit token is signed by the content provider and the service provider. The trusted system additionally provides the one or more keys for decrypting the encrypted media content item and reports the signed audit token.

Abstract: Techniques for secure fast channel change in live content streaming are described. In some embodiments, during content preparation, a packager and/or an encoder encrypts media content items at both the service level (e.g., by encrypting a first portion of the plurality of segments with a service level access key unique to a service) and the channel level (e.g., by encrypting a second portion of the plurality of segments with a channel level access key unique to a channel associated with the service). On the receiving end, a client device (e.g., a media player) requests a service level access key prior to content acquisition. As such, a client can join any channel on a segment protected with the service level key without waiting for a license for that channel first, and the channel license can be acquired in parallel with the content acquisition during channel switching.

Abstract: Disclosed is a method for displaying a health registry-issued vaccination certification of a user on a user-mobile device, said method comprising the steps of: coupling the user-mobile device to a health registry over a network for display of a health registry-issued vaccination certification for the user; and outputting a visual display from the user-mobile device certifying the user's vaccination status.

Abstract: Embodiments of the present disclosure generally relate to light emitting diodes LEDs and methods of manufacturing the LEDs. The LEDs include a mesa-structure that improves light extraction of the LEDs. Furthermore, the process for forming the LEDs refrains from using physical etching to a quantum well active region of the LEDs to prevent compromising performance at the quantum well sidewall.

Abstract: Systems and Methods are disclosed for real-time decryption of a health registry-issued certificate for signaling a user vaccination and/or test status on a user device comprising the steps of: coupling a first user mobile device to a health registry for real-time decryption of a health registry-issued health certificate over a network; outputting on the first user mobile device at least one of an audible output, visual output, vibrational output, and/or textual output based on a pre-defined signaling protocol to signal a user vaccination status based on a token derived from the real-time decrypted health certificate; and decoding a device identifier/tag or token from the first user mobile device by a second user mobile device, fixed access device, or hand-held scanner, signaling to a second user a first user vaccination status based on a pre-defined signaling protocol and the tag/token.

Abstract: Techniques for secure fast channel change in live content streaming are described. In some embodiments, during content preparation, a packager and/or an encoder encrypts media content items at both the service level (e.g., by encrypting a first portion of the plurality of segments with a service level access key unique to a service) and the channel level (e.g., by encrypting a second portion of the plurality of segments with a channel level access key unique to a channel associated with the service). On the receiving end, a client device (e.g., a media player) requests a service level access key prior to content acquisition. As such, a client can join any channel on a segment protected with the service level key without waiting for a license for that channel first, and the channel license can be acquired in parallel with the content acquisition during channel switching.