Patents by Inventor Garth Powis

Garth Powis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule inhibitors of the pleckstrin homology domain and methods for using same
    Patent number: 9320734
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: April 26, 2016
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
  • SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
    Publication number: 20150126563
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Application
    Filed: January 5, 2015
    Publication date: May 7, 2015
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka MAHADEVAN, Emmanuelle J. MEUILLET, Eugene A. MASH, JR., Vijay M. GOKHALE, Garth POWIS, Shuxing ZHANG
  • Small molecule inhibitors of the pleckstrin homology domain and methods for using same
    Patent number: 8962663
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: February 24, 2015
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gokhale, Garth Powis, Shuxing Zhang
  • Metabolites of wortmannin analogs and methods of using the same
    Patent number: 8586626
    Abstract: Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: November 19, 2013
    Assignee: Arizona Board of Regents, Acting on Behalf of the University of Arizona
    Inventor: Garth Powis
  • Small molecule inhibitors of the pleckstrin homology domain and methods for using same
    Patent number: 8420678
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: April 16, 2013
    Assignees: Board of Regents, The University of Texas System, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Jr., Vijay M. Gohkale, Garth Powis, Shuxing Zhang
  • SINGLE-WALLED CARBON NANOTUBE/BIOACTIVE SUBSTANCE COMPLEXES AND METHODS RELATED THERETO
    Publication number: 20130058984
    Abstract: The present invention includes single-walled carbon nanotube compositions for the delivery of siRNA and methods of making such single-walled carbon nanotube compositions. A single-walled carbon nanotube composition for delivery of siRNA includes a nonfunctionalized single-walled carbon nanotube; and siRNA noncovalently complexed with the nonfunctionalized single-walled carbon nanotube, wherein the siRNA solubilizes such nonfunctionalized single-walled carbon nanotube.
    Type: Application
    Filed: August 7, 2012
    Publication date: March 7, 2013
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Garth Powis, Jeffrey Bartholomeusz, James Tour, Howard Schmidt, Paul Cherukuri, R. Bruce Weisman
  • PALMARUMYCIN BASED INHIBITORS OF THIOREDOXIN AND METHODS OF USING SAME
    Publication number: 20120226031
    Abstract: Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.
    Type: Application
    Filed: February 2, 2012
    Publication date: September 6, 2012
    Inventors: GARTH POWIS, PETER WIPF
  • Palmarumycin based inhibitors of thioredoxin and methods of using same
    Patent number: 8124651
    Abstract: Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: February 28, 2012
    Assignees: The University of Pittsburgh Office of Technology Transfer, Arizona Board of Regents
    Inventors: Garth Powis, Peter Wipf
  • Metabolites of Wortmannin Analogs and Methods of Using the Same
    Publication number: 20110263672
    Abstract: Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.
    Type: Application
    Filed: June 10, 2011
    Publication date: October 27, 2011
    Applicant: Arizona Board of Regents on behalf of the University of Arizona
    Inventor: Garth Powis
  • SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME
    Publication number: 20110144066
    Abstract: Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.
    Type: Application
    Filed: April 14, 2009
    Publication date: June 16, 2011
    Applicants: The Board of Regents of the University of Texas System, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Daruka Mahadevan, Emmanuelle J. Meuillet, Eugene A. Mash, Vijay Gokhale, Garth Powis, Shuxing Zhang
  • Wortmannin Analogs and Methods of Using Same in Combination with Chemotherapeutic Agents
    Publication number: 20110110941
    Abstract: Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 12, 2011
    Applicants: PROLX PHARMACEUTICALS CORP., Arizona Board of Regents on behalf of the University of Arizona, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Garth POWIS, Peter WIPF, Lynn KIRKPATRICK
  • Compositions and Methods for Treating Lung Cancer
    Publication number: 20110092595
    Abstract: Embodiments of the present invention provide compositions and methods for treating lung cancer, including small cell and non-small cell lung cancer that may express HIF-1a by administering a therapeutically effective amount of PX-478.
    Type: Application
    Filed: February 13, 2009
    Publication date: April 21, 2011
    Inventors: Garth Powis, Roy Herbst, Jörg Jacoby
  • Single-Walled Carbon Nanotube/Bioactive Substance Complexes and Methods Related Thereto
    Publication number: 20110045080
    Abstract: The present invention includes single-walled carbon nanotube compositions for the delivery of siRNA and methods of making such single-walled carbon nanotube compositions. A single-walled carbon nanotube composition for delivery of siRNA includes a nonfunctionalized single-walled carbon nanotube; and siRNA noncovalently complexed with the nonfunctionalized single-walled carbon nanotube, wherein the siRNA solubilizes such nonfunctionalized single-walled carbon nanotube.
    Type: Application
    Filed: March 24, 2010
    Publication date: February 24, 2011
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Garth Powis, Jeffrey Bartholomeusz, James Tour, Howard Schmidt, Paul Cherukuri, R. Bruce Weisman
  • Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
    Patent number: 7858657
    Abstract: Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: December 28, 2010
    Assignees: Proix Pharmaceutical Corp., Arizona Board of Regents, Acting on Behalf of The University of Arizona, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Lynn D. Kirkpatrick, Garth Powis, Peter Wipf
  • Metabolites of Wortmannin Analogs and Methods of Using Same
    Publication number: 20100249205
    Abstract: Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.
    Type: Application
    Filed: April 1, 2010
    Publication date: September 30, 2010
    Applicant: ARIZONA BOARD OF REGENTS
    Inventor: Garth Powis
  • Wortmannin analogs and methods of using same
    Patent number: 7776908
    Abstract: Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well, as tumor formation in a subject are described herein.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: August 17, 2010
    Assignees: Arizona Board of Regents, The University of Pittsburgh
    Inventors: Garth Powis, Peter Wipf
  • USES OF THIOREDOXIN
    Publication number: 20100166724
    Abstract: The present invention relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or preventing thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting thioredoxin stimulated cell growth.
    Type: Application
    Filed: January 27, 2010
    Publication date: July 1, 2010
    Inventors: Garth Powis, Lynn Kirkpatrick
  • Metabolites of wortmannin analogs and methods of using the same
    Patent number: 7723375
    Abstract: Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: May 25, 2010
    Assignee: Arizona Board of Regents, acting on behalf of The University of Arizona
    Inventor: Garth Powis
  • METABOLITES OF WORTMANNIN ANALOGS AND METHODS OF USING THE SAME
    Publication number: 20100063129
    Abstract: Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.
    Type: Application
    Filed: December 29, 2006
    Publication date: March 11, 2010
    Inventor: Garth Powis
  • PALMARUMYCIN BASED INHIBITORS OF THIOREDOXIN AND METHODS OF USING SAME
    Publication number: 20090131511
    Abstract: Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.
    Type: Application
    Filed: September 15, 2006
    Publication date: May 21, 2009
    Applicant: UNIVERSITY OF PITTSBURGH
    Inventors: Garth Powis, Peter Wipf