Patents by Inventor Gary L. Nelsestuen

Gary L. Nelsestuen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified factor VII or factor VIIa polypeptides
    Patent number: 9493757
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: November 15, 2016
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 9266931
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: December 9, 2013
    Date of Patent: February 23, 2016
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • FACTOR IX VARIANTS
    Publication number: 20150337284
    Abstract: Variants of factor IX with increased membrane binding affinity, and the use of such variants for treating factor IX deficiency, are described.
    Type: Application
    Filed: September 30, 2013
    Publication date: November 26, 2015
    Inventors: Gary L. Nelsestuen, Stephen Barrett Harvey
  • High molecular weight derivatives of vitamin K-dependent polypeptides
    Patent number: 9050372
    Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: June 9, 2015
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
    Publication number: 20150010530
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 8, 2015
    Inventor: Gary L. Nelsestuen
  • Nucleic acids encoding modified vitamin K-dependent polypeptides
    Patent number: 8809016
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: August 19, 2014
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
    Publication number: 20140113330
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: December 9, 2013
    Publication date: April 24, 2014
    Applicant: Regents of the university of Minnesota
    Inventor: Gary L. Nelsestuen
  • MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
    Publication number: 20140038282
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: March 27, 2012
    Publication date: February 6, 2014
    Inventor: Gary L. Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 8642738
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: February 4, 2014
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • High molecular weight derivatives of vitamin K-dependent polypeptides
    Patent number: 8632771
    Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: January 21, 2014
    Assignees: Regents of the University of Minnesota, The United States of America as represented by Department of Veterens Affairs
    Inventors: Gary L. Nelsestuen, Ronald Bach, Matthew Stone, Stephen Barrett Harvey
  • Modified vitamin K-dependent polypeptides
    Patent number: 8628769
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: January 14, 2014
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 8415457
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: April 9, 2013
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 8415458
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: April 9, 2013
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 8168754
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: May 1, 2012
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L Nelsestuen
  • MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
    Publication number: 20120087906
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: December 19, 2011
    Publication date: April 12, 2012
    Inventor: Gary L. Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 8101382
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: January 24, 2012
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 8048990
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: November 1, 2011
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L Nelsestuen
  • MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
    Publication number: 20110027258
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: September 8, 2010
    Publication date: February 3, 2011
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: Gary L. Nelsestuen
  • MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
    Publication number: 20110021430
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: September 8, 2010
    Publication date: January 27, 2011
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: Gary L. Nelsestuen
  • MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES
    Publication number: 20100311658
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: April 29, 2010
    Publication date: December 9, 2010
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: Gary L. Nelsestuen