Patents by Inventor Gary L. Nelsestuen

Gary L. Nelsestuen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified vitamin K-dependent polypeptides
    Patent number: 6693075
    Abstract: The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: February 17, 2004
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • Compositions for producing factor Xa
    Publication number: 20030232075
    Abstract: Compositions that include tissue factor incorporated into lipid vesicles are described, as well as compositions that include enzymes other than factor VIIa that directly activate factor X to Xa in solution without directly supporting thrombin generation. Such compositions do not produce thrombogenic levels of thrombin in human patient and can be used to increase clot formation in patients in need thereof.
    Type: Application
    Filed: May 6, 2003
    Publication date: December 18, 2003
    Applicant: University of Minnesota, a Minnesota corporation
    Inventor: Gary L. Nelsestuen
  • Methods for detecting activity of clottings factors
    Publication number: 20030211460
    Abstract: Whole blood assays and kits are described for evaluating dosage of factor VIIa or activated protein C, as well as for monitoring responsiveness to factor VIIa or activated protein C.
    Type: Application
    Filed: December 30, 2002
    Publication date: November 13, 2003
    Inventor: Gary L. Nelsestuen
  • High molecular weight derivatives of vitamin k-dependent polypeptides
    Publication number: 20030211094
    Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.
    Type: Application
    Filed: December 30, 2002
    Publication date: November 13, 2003
    Inventor: Gary L. Nelsestuen
  • Factor VIIa compositions
    Publication number: 20030186862
    Abstract: Compositions that include a factor VIIa polypeptide and a factor X polypeptide are described. Such compositions are free of thrombogenic levels of active clotting factors, other than factor VIIa, and can be used to increase clot formation in a mammal.
    Type: Application
    Filed: April 2, 2002
    Publication date: October 2, 2003
    Inventor: Gary L. Nelsestuen
  • Modified Vitamin K-dependent polypeptides
    Publication number: 20030100506
    Abstract: The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: November 18, 2002
    Publication date: May 29, 2003
    Inventor: Gary L. Nelsestuen
  • High molecular weight derivatives of vitamin K-dependent polypeptides
    Patent number: 6423826
    Abstract: Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: July 23, 2002
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Publication number: 20010018414
    Abstract: The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Application
    Filed: March 12, 2001
    Publication date: August 30, 2001
    Applicant: Regents of the University of Minnesota, a Minnesota corporation
    Inventor: Gary L. Nelsestuen
  • Modified vitamin K-dependent polypeptides
    Patent number: 6017882
    Abstract: The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: January 25, 2000
    Assignee: Regents of the University of Minnesota
    Inventor: Gary L. Nelsestuen