Patents by Inventor Gary M. Lee

Gary M. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7893276
    Abstract: The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: February 22, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Gary M. Lee, Jiang Zhu
  • Publication number: 20100280256
    Abstract: The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20.
    Type: Application
    Filed: June 1, 2010
    Publication date: November 4, 2010
    Inventors: Gary M. Lee, Jiang Zhu
  • Publication number: 20100249411
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Inventors: Wenxue Wu, Hongbiao Liao, David J.S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Patent number: 7745626
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: June 29, 2010
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Patent number: 7745634
    Abstract: The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: June 29, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Humberto Bartolome Arzeno, Gary M. Lee, Michael Martin, Keshab Sarma, Jiang Zhu
  • Publication number: 20090012304
    Abstract: The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones 20.
    Type: Application
    Filed: May 30, 2008
    Publication date: January 8, 2009
    Inventors: Humberto Bartolome Arzeno, Gary M. Lee, Michael Martin, Keshab Sarma, Jiang Zhu
  • Patent number: 6992189
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: January 31, 2006
    Assignee: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Patent number: 6872826
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: March 29, 2005
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Patent number: 6801518
    Abstract: An asynchronous serial crosspoint switch is word synchronized to each of a number of transceiver circuits. The crosspoint switch circuit generates both a master bit clock and a master word clock signal. A transceiver circuit recovers the master bit clock signal from an incoming high-speed serial data stream using a clock and data recovery circuit. The recovered bit clock signal is used as a timing signal by which data is serialized and transmitted to the crosspoint switch circuit. The data stream transmitted to the switch circuit is frequency locked to the master bit clock signal, such that the serial data stream need only be phase adjusted with a data recovery circuit. To recover word timing, the switch circuit issues alignment words to the transceivers during link initialization. The transceivers perform word alignment and establish a local word lock. Alignment words are then reissued to the switch circuit using the local word clock.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: October 5, 2004
    Inventors: John P. Mullaney, Gary M. Lee
  • Patent number: 6700886
    Abstract: An asynchronous serial crosspoint switch is word synchronized to each of a number of transceiver circuits. The crosspoint switch circuit generates both a master bit clock and a master word clock signal. A transceiver circuit recovers the master bit clock signal from an incoming high-speed serial data stream using a clock and data recovery circuit. The recovered bit clock signal is used as a timing signal by which data is serialized and transmitted to the crosspoint switch circuit. The data stream transmitted to the switch circuit is frequency locked to the master bit clock signal, such that the serial data stream need only be phase adjusted with a data recovery circuit. To recover word timing, the switch circuit issues alignment words to the transceivers during link initialization. The transceivers perform word alignment and establish a local word lock. Alignment words are then reissued to the switch circuit using the local word clock.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: March 2, 2004
    Assignee: Vitesse Semiconductor Corporation
    Inventors: John P. Mullaney, Gary M. Lee
  • Publication number: 20040024217
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: February 5, 2004
    Applicant: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Publication number: 20030208074
    Abstract: In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: November 6, 2003
    Applicant: Schering Corporation
    Inventors: Wenxue Wu, Hongbiao Liao, David J. S. Tsai, David R. Andrews, Dinesh Gala, Gary M. Lee, Martin Lawrence Schwartz, Timothy L. McAllister, Xiaoyong Fu, Donal Maloney, Tiruvettipuram K. Thiruvengadam, Chou-Hang Tann
  • Publication number: 20020075845
    Abstract: An asynchronous serial crosspoint switch is word synchronized to each of a number of transceiver circuits. The crosspoint switch circuit generates both a master bit clock and a master word clock signal. A transceiver circuit recovers the master bit clock signal from an incoming high-speed serial data stream using a clock and data recovery circuit. The recovered bit clock signal is used as a timing signal by which data is serialized and transmitted to the crosspoint switch circuit. The data stream transmitted to the switch circuit is frequency locked to the master bit clock signal, such that the serial data stream need only be phase adjusted with a data recovery circuit. To recover word timing, the switch circuit issues alignment words to the transceivers during link initialization. The transceivers perform word alignment and establish a local word lock. Alignment words are then reissued to the switch circuit using the local word clock.
    Type: Application
    Filed: February 12, 2002
    Publication date: June 20, 2002
    Inventors: John P. Mullaney, Gary M. Lee
  • Publication number: 20020061016
    Abstract: An asynchronous serial crosspoint switch is word synchronized to each of a number of transceiver circuits. The crosspoint switch circuit generates both a master bit clock and a master word clock signal. A transceiver circuit recovers the master bit clock signal from an incoming high-speed serial data stream using a clock and data recovery circuit. The recovered bit clock signal is used as a timing signal by which data is serialized and transmitted to the crosspoint switch circuit. The data stream transmitted to the switch circuit is frequency locked to the master bit clock signal, such that the serial data stream need only be phase adjusted with a data recovery circuit. To recover word timing, the switch circuit issues alignment words to the transceivers during link initialization. The transceivers perform word alignment and establish a local word lock. Alignment words are then reissued to the switch circuit using the local word clock.
    Type: Application
    Filed: January 14, 2002
    Publication date: May 23, 2002
    Applicant: Vitesse Semiconductor Corporation
    Inventors: John P. Mullaney, Gary M. Lee
  • Patent number: 6377575
    Abstract: An asynchronous serial crosspoint switch is word synchronized to each of a number of transceiver circuits. The crosspoint switch circuit generates both a master bit clock and a master word clock signal. A transceiver circuit recovers the master bit clock signal from an incoming high-speed serial data stream using a clock and data recovery circuit. The recovered bit clock signal is used as a timing signal by which data is serialized and transmitted to the crosspoint switch circuit. The data stream transmitted to the switch circuit is frequency locked to the master bit clock signal, such that the serial data stream need only be phase adjusted with a data recovery circuit. To recover word timing, the switch circuit issues alignment words to the transceivers during link initialization. The transceivers perform word alignment and establish a local word lock. Alignment words are then reissued to the switch circuit using the local word clock.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: April 23, 2002
    Assignee: Vitesse Semiconductor Corporation
    Inventors: John P. Mullaney, Gary M. Lee
  • Patent number: 6078194
    Abstract: A method and apparatus for reducing power consumption by gallium arsenide integrated circuits divides the integrated circuit into higher and lower frequency sections. The high frequency sections require a substantial portion of the system clock period to resolve their longest combinatorial paths. The lower frequency sections require a relatively small portion of the system clock period to resolve their longest combinatorial logic paths. The combinatorial logic paths of each of such lower frequency sections are designed using logic gates which are capable of being decoupled from the chip power supply by way of a power enable input. Edge triggered memory circuits such as flip-flops are also designed using the reduced power logic gates, except for their cross-coupled outputs so that they may retain their state.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: June 20, 2000
    Assignee: Vitesse Semiconductor Corporation
    Inventor: Gary M. Lee
  • Patent number: 5670666
    Abstract: Disclosed are a process and intermediates of the formulae ##STR1## wherein X.sup.- is halide, BF.sub.4.sup.-, R.sup.3 SO.sub.3.sup.-, wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl, CF.sub.3, C.sub.1 -C.sub.6 alkylphenyl or phenyl, and Q is a group of the formula ##STR2## wherein R is C.sub.1 -C.sub.6 alkyl; useful for preparing benzazepine intermediates of the formula ##STR3## These benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: September 23, 1997
    Assignee: Schering Corporation
    Inventors: Donald Hou, Richard W. Draper, Gary M. Lee, Janet L. Mas
  • Patent number: 5502186
    Abstract: Disclosed are a process and intermediates of the formula ##STR1## wherein R is --CH.sub.3 or --C(O)--OR.sup.1, and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5 ; or the formula ##STR2## wherein: R.sup.2 is H or OH, R is --C(O)OR.sup.1 and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5, or where R.sup.2 is H, R can also be CH.sub.3 ; for preparing benzazepine intermediates of the formula ##STR3## The benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: March 26, 1996
    Assignee: Schering Corporation
    Inventors: Donald Hou, Richard W. Draper, Gary M. Lee, Janet L. Mas
  • Patent number: 5463051
    Abstract: Disclosed are a process and intermediates of the formulae ##STR1## wherein X.sup.- is halide, BF.sub.4.sup.-, R.sup.3 SO.sub.3.sup.-, wherein R.sup.3 is C.sub.1 -C.sub.6 alkyl, CF.sub.3, C.sub.1 -C.sub.6 alkylphenyl or phenyl, and Q is a group of the formula ##STR2## wherein R is C.sub.1 -C.sub.6 alkyl; useful for preparing benzazepine intermediates of the formula ##STR3## These benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: October 31, 1995
    Assignee: Schering Corporation
    Inventors: Donald Hou, Richard W. Draper, Gary M. Lee, Janet L. Mas, Ingrid Mergelsberg
  • Patent number: 5461147
    Abstract: Disclosed are a process and intermediates of the formula ##STR1## wherein R is --CH.sub.3 or --C(O)--OR.sup.1, and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5 ; or the formula ##STR2## wherein: R.sup.2 is H or OH, R is --C(O)OR.sup.1 and R.sup.1 is C.sub.1 -C.sub.6 alkyl or --CH.sub.2 C.sub.6 H.sub.5, or where R.sup.2 is H, R can also be CH.sub.3 ; for preparing benzazepine intermediates of the formula ##STR3## The benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: October 24, 1995
    Assignee: Schering Corporation
    Inventors: Donald Hou, Richard W. Draper, Gary M. Lee, Janet L. Mas