Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: A feed roller is formed with a generally cylindrical outer surface having raised portions arranged in a pattern that extends circumferentially around the surface. The raised portions are formed in distinct shapes. Preferably the distinct shapes are chevron shapes that retain dough between successive chevron shapes. The roller preferably has an annular ridge which prevents dough from escaping axially off the edge of the roller. In use, dough is feed between the feed roller and a mold roller. Some of the dough is retained on the outer cylindrical surface of the feed roller to provide a smooth surface for inserting the rest of the dough in mold cavities located in the mold roller.

Abstract: A roller is provided with replaceable shells formed of panels. The roller includes a shaft extending in a longitudinal direction. A center flange and two end flanges are mounted on the shaft and extend radially outward from the shaft at axially spaced locations. Between each end flange and one side of the center flange, a replaceable shell is provided. Preferably, multiple additional center flanges and replaceable shells are mounted on the shaft between the end flanges. An internal pin system is employed to ensure no screws are visible while holding the shell panels in place.

Abstract: An apparatus and method for determining the position of a ring magnet fixed to a rotating device includes locating the ring magnet proximate to a sensor that is sensitive to magnetic polarities. The ring magnet includes a plurality of magnetic pole pairs of opposite magnetic polarities, having at least one pole pair larger than at least three other pole pairs. The sensor produces an output signal for each pole pair that represents a period when a pole pair is detected by the sensor as the ring magnet is rotated by the device. The output signals from the sensor are coupled to a digital circuit that differentiates the three smaller pole pairs from the at least one larger pole pair to determine the position of the ring magnet.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: The invention provides energy recovery or heat pump system comprising a plurality of Shape-Memory Alloy (SMAs) or Negative Thermal Expansion (NTE) elements arranged to define a core and housed in an immersion chamber. A first fluid can be introduced into the chamber provides a first temperature change to activate the core from a first state to a second state and a second fluid is introduced at a second temperature to activate the core from the second state to the first state. A controlled gas is inserted into the chamber between the first fluid and the second fluid. The advantage of the invention is that increased efficiency and power production from the SMA/NTE engine is achieved, or increased CoP within the SMA/NTE heat pump. By eliminating energy destruction via the mixing of fluids, the power production cycle can either operate faster, which means the same quantity of SMA/NTE material can produce more power, or a lower number of NTE strands can be used to create the same power that allow mixing to occur.

Abstract: Embodiments of the present disclosure describe a snowmobile including an engine mounted on the chassis, a drive track in contact with the chassis, and a drive train, operatively interconnecting the engine with the drive track for delivering propulsive power to the drive track. The drive train includes a driveshaft, comprising a tubular driveshaft including two or more interior channels, the channels positioned in a substantially longitudinal orientation, two or more sprocket driving features on an exterior surface of the tubular driveshaft, and one or more fitting components, positioned at one or more distal ends of the driveshaft.

Abstract: The invention provides an energy recovery system comprising a plurality of Shape-Memory Alloy (SMAs) or Negative Thermal Expansion (NTE) elements arranged to define a core and housed in an immersion chamber. A first fluid is introduced into the chamber and provides a first temperature change to activate the core from a first state to a second state and a second fluid is introduced at a second temperature to activate the core from the second state to the first state. A gas is inserted into the chamber between the first fluid and the second fluid. The advantage of the invention is that increased efficiency and power production from the SMA/NTE engine is achieved.

Abstract: Embodiments of the present disclosure describe a snowmobile including an engine mounted on the chassis, a drive track in contact with the chassis, and a drive train, operatively interconnecting the engine with the drive track for delivering propulsive power to the drive track. The drive train includes a driveshaft, comprising a tubular driveshaft including two or more interior channels, the channels positioned in a substantially longitudinal orientation, two or more sprocket driving features on an exterior surface of the tubular driveshaft, and one or more fitting components, positioned at one or more distal ends of the driveshaft.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: The present invention is directed to wall box for hemodialysis interface having two isolated zones. The first zone is a clean interface zone having sources of purified water and dialysis fluids. The second zone is a waste interface zone comprising waste connectors and a waste drain.

Abstract: An assembly of a thermal probe and a probe fitting arranged to measure the temperature of a fluid medium flowing in a passage of the probe fitting. The assembly comprises a temperature sensing assembly that produces a resistance which varies with the temperature. A connector assembly that is connected to the temperature sensing assembly that transmits the resistance to external circuitry. A non-metallic housing includes a sensor portion incasing the temperature sensing assembly and a connector portion housing the connector assembly. A probe receptacle attached to the probe fitting is arranged to receive the sensor portion of the thermal probe, positioning the temperature sensing assembly in the passage to sense the temperature of the fluid medium flowing in the passage.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: The present disclosure relates to compounds of formula (I?) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders, including hemoglobinopathies, sickle cell disease and beta-thalassemia.

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: The present disclosure relates to compounds of formula (I?) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.