Abstract: One aspect of the present disclosure is directed to a device for providing light to the surface of a subject, comprising an array of a plurality of light emitting modules, wherein the plurality comprises four light emitting modules, each module of the plurality is flexibly connected to another module of the plurality, and two of the modules of the plurality comprise a polygonal perimeter having 4, 5, or 6 major sides, a light source, and a longest apex-to-apex dimension for a module of 5-50 millimeters, and, optionally, a non-adherent member configured to be adjacent to the subject.

Abstract: One aspect of the present disclosure is directed to a device for providing light to the surface of a subject, comprising an array of a plurality of light emitting modules, wherein the plurality comprises four light emitting modules, each module of the plurality is flexibly connected to another module of the plurality, and two of the modules of the plurality comprise a polygonal perimeter having 4, 5, or 6 major sides, a light source, and a longest apex-to-apex dimension for a module of 5-50 millimeters, and, optionally, a non-adherent member configured to be adjacent to the subject.

Abstract: One aspect of the present disclosure is directed to a device for providing light to the surface of a subject, comprising an array of a plurality of light emitting modules, wherein the plurality comprises four light emitting modules, each module of the plurality is flexibly connected to another module of the plurality, and two of the modules of the plurality comprise a polygonal perimeter having 4, 5, or 6 major sides, a light source, and a longest apex-to-apex dimension for a module of 5-50 millimeters, and, optionally, a non-adherent member configured to be adjacent to the subject.

Abstract: One aspect of the present disclosure is directed to a device for providing light to the surface of a subject, comprising an array of a plurality of light emitting modules, wherein the plurality comprises four light emitting modules, each module of the plurality is flexibly connected to another module of the plurality, and two of the modules of the plurality comprise a polygonal perimeter having 4, 5, or 6 major sides, a light source, and a longest apex-to-apex dimension for a module of 5-50 millimeters, and, optionally, a non-adherent member configured to be adjacent to the subject.

Abstract: One aspect of the present disclosure is directed to a device for providing light to the surface of a subject, comprising an array of a plurality of light emitting modules, wherein the plurality comprises four light emitting modules, each module of the plurality is flexibly connected to another module of the plurality, and two of the modules of the plurality comprise a polygonal perimeter having 4, 5, or 6 major sides, a light source, and a longest apex-to-apex dimension for a module of 5-50 millimeters, and, optionally, a non-adherent member configured to be adjacent to the subject.

Abstract: A system for photodynamic therapy is provided that includes a light delivery device that delivers the illumination necessary to perform photodynamic therapy. The light delivery device includes one or more etched fibers arranged to illuminate a selective region of a body for photodynamic therapy. An illumination device is coupled to the light delivery device to provide the necessary illumination to the light delivery device.

Abstract: A light-based therapy device is provided that includes a controller mechanism that produces power and control signals to enable operation of one or more medical devices. An implantable light delivery device (IM-LDD) is coupled to the controller mechanism that receives the power and the control signals to enable a light source to emit sufficient illumination. The light source is implanted within body cavities enabling energy at one or more wavelengths to reach and provide therapy treatment to a selected region.

Abstract: A therapeutic light delivery system is provided that includes one or more fiber optic arrays that channels illumination from an illumination device. An optics module coupled to the one or more fiber optic arrays that provides the illumination to the one or more fiber optic arrays. A control module coupled to the optics module that controls the illumination to the one or more fibers. The illumination comprises a plurality of therapeutic illumination patterns and wavelengths.

Abstract: A light-based therapy device is provided that includes a controller mechanism that produces power and control signals to enable operation of one or more medical devices. An implantable light delivery device (IM-LDD) is coupled to the controller mechanism that receives the power and the control signals to enable a light source to emit sufficient illumination. The light source is implanted within body cavities enabling energy at one or more wavelengths to reach and provide therapy treatment to a selected region.

Abstract: A method of performing a medical procedure (e.g., a cardiac bypass procedure) on a patient comprises introducing at least one medical instrument into a patient (e.g., percutaneously), conveying control signals from a remote controller to a drive unit, and operating the drive unit in accordance with the control signals to actuate at least one tool respectively located on the medical instrument(s) to transversely secure a first anatomical vessel (e.g., a blood vessel) to a sidewall of a second anatomical vessel (e.g., another blood vessel). In one method, the control signals are conveyed from the remote controller to the drive unit in response to user commands. The user commands may be movements made at a user interface that correspond to movements of the medical instrument(s).

Abstract: Systems and methods are providing for treating a patient with continuous low irradiance photodynamic therapy. A disclosed method includes applying a photosensitizer to the patient; applying a conformable skin facing light applicator to the patient; and providing continuous low irradiance photodynamic therapy through the light applicator. A disclosed system includes a light applicator having a fiber optic cloth. The light applicator is conformable so that it can be worn against a patient's skin and the fiber optic cloth has a two dimensional surface that emits light in a direction toward a patient's skin. In this aspect, the power of the light emitted from the two dimensional surface in a direction toward a patient's skin is less than or equal to about 5 mW/cm2.

Abstract: A drive mechanism for use with an elongated medical implement comprises a motor, a first pulley mechanically coupled to the motor, and a second pulley. The drive mechanism further comprises a connector mechanically coupled to the second pulley. The connector is configured for laterally receiving the medical implement. The drive mechanism further comprises a belt wrapped around the first and second pulleys to transmit force from the motor to the connector. A robotic medical system comprises a user interface configured for receiving at least one command, a drive mechanism including a motor and a connector configured for laterally receiving the medical implement, and an electrical controller configured for directing the motor to cause the drive mechanism to move the medical implement within at least one degree-of-freedom.

Abstract: Systems and methods are providing for treating a patient with continuous low irradiance photodynamic therapy. A disclosed method includes applying a photosensitizer to the patient; applying a conformable skin facing light applicator to the patient; and providing continuous low irradiance photodynamic therapy through the light applicator. A disclosed system includes a light applicator having a fiber optic cloth. The light applicator is conformable so that it can be worn against a patient's skin and the fiber optic cloth has a two dimensional surface that emits light in a direction toward a patient's skin. In this aspect, the power of the light emitted from the two dimensional surface in a direction toward a patient's skin is less than or equal to about 5 mW/cm2.

Abstract: A system for photodynamic therapy is provided that includes a light delivery device that delivers the illumination necessary to perform photodynamic therapy. The light delivery device includes one or more etched fibers arranged to illuminate a selective region of a body for photodynamic therapy. An illumination device is coupled to the light delivery device to provide the necessary illumination to the light delivery device.

Abstract: A medical system includes first and second medical probes in an arrangement and configured for insertion into a lumen or vessel of a patient, the first medical probe having indicia, and a detector is fixedly coupled to the second medical probe and configured for insertion into and advancement through the lumen or vessel along with the second medical probe, wherein the detector detects passage of the indicia as the first and second medical probes are moved relative to each other within the lumen or body vessel. An electromechanical driver is coupled to, and operable to move the first and second medical probes. A system controller is configured for directing the electromechanical driver to move the first and second medical probes relative to each other within the lumen or body vessel based on signals received from the detector when the detector is positioned within the lumen or body vessel.

Abstract: A medical system comprises a first medical probe having indicia, and a second medical probe in a coaxial arrangement with the first medical probe. The second medical probe has a detector (e.g., an optical detector) configured for detecting a passage of the indicia as the first and second medical probes are moved relative to each other. In one embodiment, the first medical probe is an inner medical probe, and the second medical probe is an outer medical probe. The medical system further comprises an electromechanical driver coupled to the first and second medical probes, and a controller configured for directing the electromechanical driver to move the first and second medical probes relative to each other, and for receiving signals from the detector indicating the relative movement between the first and second medical probes.

Abstract: A method of performing a medical procedure on a patient comprises introducing a medical instrument into a patient (e.g., percutaneously), conveying control signals from a remote controller to a drive unit, and operating the drive unit in accordance with the control signals to actuate the tool located on the medical instrument to secure a stent to an anatomical vessel (e.g., a blood vessel, such as an abdominal aorta). The tool may be a sewing tool that is controlled to stitch the stent to the anatomical vessel. In one method, the control signals are conveyed from the remote controller to the drive unit in response to user commands. The user commands may be movements made at a user interface that correspond to movements of the medical instrument.

Abstract: A robotic medical system for use with an intravascular catheter that delivers fluid within an anatomical vessel is provided. The robotic medical system comprises a user interface configured for receiving at least one command, an electromechanical driver configured for being coupled to the catheter, a fluid delivery controller coupled to the catheter, and an electric controller configured for directing the electromechanical driver to mechanically move the catheter within at least one degree-of-freedom and for directing the fluid delivery controller to deliver fluid to the catheter in response to the at least one command. The robotic medical system may further comprise a source of fluid and a fluid line configured for coupling the source of fluid to the catheter, and a manifold configured for fluidly interfacing with the catheter, in which case, the manifold has a fluid inlet port coupled to the fluid line.

Abstract: A robotic medical system and method of performing a medical procedure are provided. The robotic medical system comprises a user interface configured for receiving commands, an electromechanical driver configured for being coupled to outer and inner catheters having proximal and distal balloons, a balloon controller configured for being coupled to the proximal and distal balloons, and an electric controller configured for directing the electromechanical driver to linearly translate the outer and inner catheters relative to each other and for directing the balloon controller to inflate and deflate the proximal and distal balloons in response to the command(s). The method may comprise inflating and deflating the proximal and distal balloons, and linearly translating the inner and outer catheters relative to each other in a specified sequence to move the inner and outer catheters along the anatomical vessel.

Abstract: A robotic medical system comprises a user interface configured for receiving at least one command, a first drive mechanism configured for receiving the outer medical implement, a second drive mechanism configured for receiving the inner medical implement, a linear drive arrangement (e.g., one of a drive screw drive arrangement, a rack and pinion drive arrangement, and a belt/pulley drive arrangement) mechanically coupled to the first and second drive mechanisms, and a motor array. The robotic medical system further comprises an electric controller configured for directing the motor array to cause the first drive mechanism to axially rotate the outer medical implement, to cause the second drive mechanism to axially rotate the inner medical implement, and to cause the linear drive mechanism to linearly translate the first and second drive mechanisms relative to each other in response to the at least one command.