Abstract: Composite fabrication system and associated methods. In one embodiment, a composite fabrication system comprises a molding tool that includes a forming surface at least partially disposed within a constrained space, and a foamable material that expands inside of the constrained space to form an expanded material that presses a layup of one or more composite layers against the molding tool. The composite fabrication system further comprises a curing device configured to cure the layup to form a composite part, and a cutting wire embedded in the constrained space that is heated and configured to cut the expanded material into pieces that are removable from the constrained space.

Abstract: A method for performing online convex optimization is provided. The method includes receiving, from two or more worker nodes, a local decision vector and local data corresponding to each of the two or more worker nodes. The method includes performing a multi-step gradient descent based on the local decision vector and the local data received from the two or more worker nodes. Performing the multi-step gradient descent includes determining a global decision vector and corresponding global information. The method includes sending, to each of the two or more worker nodes, the global decision vector and corresponding global information.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.

Abstract: Methods of recovering and/or recycling expanded polymer tooling, the methods including collecting expanded polymer tooling, reducing the collected expanded polymer tooling into smaller particles, treating the reduced expanded polymer tooling in order to yield an at least partially purified recovered polymer composition, and then collecting the at least partially purified recovered polymer composition. The at least partially purified recovered polymer composition can then be used to form new expandable polymer tooling.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: A method includes receiving a set of training utterances each including a non-synthetic speech representation of a corresponding utterance, and for each training utterance, generating a corresponding synthetic speech representation by using a voice conversion model. The non-synthetic speech representation and the synthetic speech representation form a corresponding training utterance pair. At each of a plurality of output steps for each training utterance pair, the method also includes generating, for output by a speech recognition model, a first probability distribution over possible non-synthetic speech recognition hypotheses for the non-synthetic speech representation and a second probability distribution over possible synthetic speech recognition hypotheses for the synthetic speech representation.

Abstract: The present disclosure seeks to reduce the effects of rotational and linear acceleration experienced by the body of a user in response to an impact force. Modular disengaging systems of the present disclosure are generally suitable for coupling to protective equipment to provide a disengaging motion between various layers such that the effects of the impact force to the body of the user are reduced. Generally described, the modular disengaging systems of the present disclosure include layers configured to facilitate relative lateral motion therebetween upon an impact force.

Abstract: A method includes receiving training data that includes unspoken text utterances, un-transcribed non-synthetic speech utterances, and transcribed non-synthetic speech utterances. Each unspoken text utterance is not paired with any corresponding spoken utterance of non-synthetic speech. Each un-transcribed non-synthetic speech utterance is not paired with a corresponding transcription. Each transcribed non-synthetic speech utterance is paired with a corresponding transcription. The method also includes generating a corresponding synthetic speech representation for each unspoken textual utterance of the received training data using a text-to-speech model. The method also includes pre-training an audio encoder on the synthetic speech representations generated for the unspoken textual utterances, the un-transcribed non-synthetic speech utterances, and the transcribed non-synthetic speech utterances to teach the audio encoder to jointly learn shared speech and text representations.

Abstract: A method includes receiving audio data corresponding to an utterance and generating a pair of positive audio data examples. Here, each positive audio data example includes a respective augmented copy of the received audio data. For each respective positive audio data example, the method includes generating a respective sequence of encoder outputs and projecting the respective sequence of encoder outputs for the positive data example into a contrastive loss space. The method also includes determining a L2 distance between each corresponding encoder output in the projected sequences of encoder outputs for the positive audio data examples and determining a per-utterance consistency loss by averaging the L2 distances. The method also includes generating corresponding speech recognition results for each respective positive audio data example. The method also includes updating parameters of the speech recognition model based on a respective supervised loss term and the per-utterance consistency loss.

Abstract: A water filter includes a housing, a spoiler unit, a power generation unit, a sterilization unit and a purification unit. The housing includes an input portion, an output portion and a first thread portion. The spoiler unit is provided in the housing and corresponds to the input portion. The power generation unit is provided in the housing and is coupled to the spoiler unit. The sterilization unit is provided in the housing and is electrically connected to the power generation unit, and includes a sterilization light source. The purification unit is provided in the housing and corresponds to the output portion and the sterilization unit, and includes a plurality of purification particles. Thus, the water filter is enabled to be coupled to a faucet using the first thread portion, allowing tap water to flow toward the direction from the input portion to the output portion.

Abstract: Generally described, aspects of the disclosed subject matter are directed to impact mitigating membranes. In accordance with aspects of the present disclosure, the impact mitigating membranes generally include a laminar core having a first lamina and a second lamina coupled to the first lamina and configured to shift relative to the first lamina to dissipate kinetic energy resulting from an oblique impact force. The laminar core may include a lubricating layer or self-lubrication between the lamina to reduce friction. In general, the laminar core is surrounded by first and second encapsulating layers positioned adjacent each lamina. An anchoring attachment coupled to one or more of the first and second encapsulating layer and associating with the laminar core constrains relative lateral motion between the laminar core and the first and second encapsulating layers.

Abstract: The present disclosure generally relates to a suspension-based impact test system for testing impact of a testing object against an impacting object. The impact test system includes components to couple the testing object to a suspension arm through a coupling member, and the suspension arm interfaces a motion-guiding mechanism. The impact test system generally includes a detachment mechanism for releasing the testing object from the suspension arm when initiated by a release system. The testing object releases from the constraints such that the testing object can move freely just prior to contacting the impacting object.

Abstract: The present disclosure seeks to reduce the effects of rotational and linear acceleration experienced by the body of a user in response to an impact force. Modular disengaging systems of the present disclosure are generally suitable for coupling to protective equipment to provide a disengaging motion between various layers such that the effects of the impact force to the body of the user are reduced. Generally described, the modular disengaging systems of the present disclosure include layers configured to facilitate relative lateral motion therebetween upon an impact force.

Abstract: An impact diverting mechanism having a top layer and a bottom layer is provided. The two layers are connected such that the top layer is configured to move in relation to the bottom layer when impacted, and therefore is able to divert impact and reduce rotational and linear acceleration on the bottom layer. The impact diverting mechanism may be attached to, or configured to attach to, an object in need of protection, such as a helmet.

Abstract: An impact diverting mechanism having a top layer and a bottom layer is provided. The two layers are connected such that the top layer is configured to move in relation to the bottom layer when impacted, and therefore is able to divert impact and reduce rotational and linear acceleration on the bottom layer. The impact diverting mechanism may be attached to, or configured to attach to, an object in need of protection, such as a helmet.

Abstract: The invention relates to (S)-3?-methyl-abscisic acid, and esters thereof, and methods of using and making these compounds.

Abstract: An impact diverting mechanism having a top layer and a bottom layer is provided. The two layers are connected such that the top layer is configured to move in relation to the bottom layer when impacted, and therefore is able to divert impact and reduce rotational and linear acceleration on the bottom layer. The impact diverting mechanism may be attached to, or configured to attach to, an object in need of protection, such as a helmet.

Abstract: The invention relates to (S)-3?-methyl-abscisic acid, and esters thereof, and methods of using and making these compounds.

Abstract: A radio signal receiving system for providing a signal to a transceiver includes a signal retrieving module and a signal processing module. The signal retrieving module retrieves a radio signal through one of a conducting wire in an electrical outlet, a conducting wire in a vehicular cigarette lighter, and a metallic vehicular casing. The radio signal receiving system operates without any conventional self-contained antenna and includes a radio signal receiving carrier which is either made from a conventional conducting wire or made of a metal to thereby enhance the efficiency of signal reception.