Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: A shift actuator for a transmission includes a drive assembly coupled with a selector interface. A transmission selector operates between a plurality of transmission settings. A threaded actuator is rotationally operated by the drive assembly. A carriage linearly operates along the threaded actuator to define a plurality of actuator positions that correspond to the transmission settings. An actuator arm extends between the carriage and the transmission selector to translate linear operation of the carriage to rotational operation of the transmission selector.

Abstract: A system and a method is provided for assessing motion of a biological tissue of a subject including one or more superficial biological layers and a targeted biological layer. A perturbation unit provide an optical perturbation to the one or more superficial biological layers. An optical signal generator transmits optical signals at one or more near-infrared wavelengths. An optical signal receiver acquires a set of optical signal data preceding, during, or following the optical perturbation at a first acquisition time relative to the optical perturbation. A signal processor determines, using the set of optical signal data, a set of optical characteristics and separates, using the set of optical characteristics, a target optical signal. The signal processor generates a report indicative of a movement of the targeted biological tissue within the subject. The movement of the targeted biological layer is calculated using the target optical signal.

Abstract: Provided herein are hydrogel-hydrocolloid sealant compositions for use as soft-tissue sealants. The compositions can include a cross-linkable electrophilic component; a cross-linkable nucleophilic component; a swellable filler material including gelatin; and, a buffer having a pH in the range of about 9.0 to about 10.0. The compositions can have a first fluid state and a second crosslinked state, and in the crosslinked state, the electrophilic and nucleophilic components can crosslink to form a crosslinked hydrogel network where the swellable filler material including gelatin is disposed within the crosslinked network. Also provided are systems and methods of manufacturing the sealant compositions as well as methods of repairing soft tissue defects including applying the sealant compositions disclosed herein.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: Systems, apparatus, methods and computer-readable storage media facilitating trusted pairing between an implantable medical device (IMD) and an external device are provided. In one embodiment, an IMD includes a housing configured to be implanted within a patient, a memory and circuitry within the housing and a processor that executes executable components stored in the memory.

Abstract: Provided herein are compounds of Formula (I): and forms thereof, including compositions thereof and uses therewith for treating spinal muscular atrophy.

Abstract: A method for storing digital images is presented. The method includes capturing an image using a digital camera system. It also comprises capturing metadata associated with the image or a moment of capture of the image. Further, it comprises storing the metadata in at least one field within a file format, wherein the file format defines a structure for the image, and wherein the at least one field is located within an extensible segment of the file format. In one embodiment, the metadata is selected from a group that comprises audio data, GPS data, time data, related image information, heat sensor data, gyroscope data, annotated text, and annotated audio.

Abstract: A system and method for enhanced automatic monoimaging. Embodiments of the present invention are operable for configuring a first camera based on a configuration determination by a second camera. The method includes capturing a first image with the first camera and determining an optical configuration based on an optical measurement performed by a second camera. In one embodiment, the second camera comprises a lower resolution sensor than a sensor of the first camera. The method further includes sending the optical configuration from the second camera to the first camera and adjusting a configuration of the first camera based on the optical configuration. The method further includes capturing a second image with the first camera. The first image and the second image may be preview images.

Abstract: An apparatus and method for monitoring the application of substances from a dispenser. The apparatus comprising a sensor adapted to detect when a substance is being dispensed from the dispenser and a transmitter in communication with the sensor adapted to transmit a signal in response to the sensor detecting a substance is being dispensed. The apparatus also includes a gps sensor adapted to determine a location, a memory and a processor circuit operable to receive the signal and the location from the gps and send information relating to the locations where the substance has been dispensed to the memory. The method comprises sensing when a substance is being dispensed therefrom through the dispenser, transmitting a signal to a processor circuit in response to the sensing, receiving at a processor circuit the signal and an input representing location and providing a dispensing location to a database.

Abstract: An electronic system for enhancing camera focusing on a portable electronic device is disclosed. The system comprises a body, a bus, and a camera module coupled to the bus and comprising a photosensitive substrate and a lens assembly wherein the lens assembly comprises a lens capable of being selectively moved to a distance from the photosensitive substrate for light focus thereon. Further, it comprises an accelerometer coupled to the bus and configured to generate orientation information, said orientation information indicating contemporaneous orientation of the body with respect to a predetermined reference. It also comprises a memory and a processor coupled to the bus. The memory comprises instructions that when executed implement an autofocus program configured to automatically determine the distance based on: 1) image data captured by said camera module; and 2) the orientation information generated by the accelerometer.

Abstract: A method for storing digital images is presented. The method includes capturing an image using a digital camera system. It also comprises capturing metadata associated with the image or a moment of capture of the image. Further, it comprises storing the metadata in at least one field within a file format, wherein the file format defines a structure for the image, and wherein the at least one field is located within an extensible segment of the file format. In one embodiment, the metadata is selected from a group that comprises audio data, GPS data, time data, related image information, heat sensor data, gyroscope data, annotated text, and annotated audio.

Abstract: An electronic system for enhancing camera focusing on a portable electronic device is disclosed. The system comprises a body, a bus, and a camera module coupled to the bus and comprising a photosensitive substrate and a lens assembly wherein the lens assembly comprises a lens capable of being selectively moved to a distance from the photosensitive substrate for light focus thereon. Further, it comprises an accelerometer coupled to the bus and configured to generate orientation information, said orientation information indicating contemporaneous orientation of the body with respect to a predetermined reference. It also comprises a memory and a processor coupled to the bus. The memory comprises instructions that when executed implement an autofocus program configured to automatically determine the distance based on: 1) image data captured by said camera module; and 2) the orientation information generated by the accelerometer.

Abstract: A system and method for initiating cooperative control over a mobile device configured to capture static images or images contained within a video sequence. The method includes obtaining an instruction on the mobile device from an external source. The method includes initiating an image controller on the mobile device, wherein the image controller controls an image capturing pipeline of the mobile device. The method includes determining that a raw image was captured by the mobile device. The method includes performing an action on the raw image based on the instruction.

Abstract: DNA constructs comprising a first DNA segment that corresponds to at least a portion of a gene in the monolignol biosynthetic pathway, a spacer DNA segment, and a second DNA segment that is complementary to the first DNA segment can be used to reduce or modulate the lignin content in plants. In some embodiments, DNA constructs comprise at least a portion of a gene for 4CL, C3H, CCR, C4H or CCoAOMT. Vascular-preferred and constitutive promoters can be used to drive expression of the constructs.

Abstract: A system and method for enhanced automatic monoimaging. Embodiments of the present invention are operable for configuring a first camera based on a configuration determination by a second camera. The method includes capturing a first image with the first camera and determining an optical configuration based on an optical measurement performed by a second camera. In one embodiment, the second camera comprises a lower resolution sensor than a sensor of the first camera. The method further includes sending the optical configuration from the second camera to the first camera and adjusting a configuration of the first camera based on the optical configuration. The method further includes capturing a second image with the first camera. The first image and the second image may be preview images.

Abstract: A system and method for stereoscopic image capture. The method includes capturing a first image with a first camera and capturing a second image with a second camera. The second camera comprises a lower resolution sensor than a sensor of the first camera. The method further includes determining a third image based on adjusting the first image to a resolution of the lower resolution sensor of the second camera and generating a stereoscopic image comprising the second image and the third image.

Abstract: DNA constructs comprising a first DNA segment that corresponds to at least a portion of a gene in the monolignol biosynthetic pathway, a spacer DNA segment, and a second DNA segment that is complementary to the first DNA segment can be used to reduce or modulate the lignin content in plants. In some embodiments, DNA constructs comprise at a least a portion of a gene for 4CL, C3H, CCR, C4H or CCoAOMT. Vascular-preferred and constitutive promoters can be used to drive expression of the constructs.

Abstract: DNA constructs comprising a first DNA segment that corresponds to at least a portion of a gene in the monolignol biosynthetic pathway, a spacer DNA segment, and a second DNA segment that is complementary to the first DNA segment can be used to reduce or modulate the lignin content in plants. In some embodiments, DNA constructs comprise at least a portion of a gene for 4CL, C3H, CCR, C4H or CCoAOMT. Vascular-preferred and constitutive promoters can be used to drive expression of the constructs.

Abstract: DNA constructs comprising a first DNA segment that corresponds to at least a portion of a gene in the monolignol biosynthetic pathway, a spacer DNA segment, and a second DNA segment that is complementary to the first DNA segment can be used to reduce or modulate the lignin content in plants. In some embodiments, DNA constructs comprise at least a portion of a gene for 4CL, C3H, CCR, C4H or CCoAOMT. Vascular-preferred and constitutive promoters can be used to drive expression of the constructs.