Patents by Inventor Geert Jannes

Geert Jannes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220018856
    Abstract: The present invention provides an improvement of sensitivity in immunological measurement of tau protein. Specifically, the present invention provides an antibody conjugate comprising two or more kinds of anti-tau protein antibodies bound to a carrier.
    Type: Application
    Filed: November 21, 2019
    Publication date: January 20, 2022
    Applicant: FUJIREBIO INC.
    Inventors: Geert JANNES, Martine DAUWE, Yuichi ISHII, Ryo OKADA
  • Patent number: 9273361
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: March 1, 2016
    Assignees: FUJIREBIO EUROPE N.V., ROCHE DIAGNOSTICS GMBH
    Inventors: Hilde De Henau, Joachim Van Crombruggen, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Patent number: 8945850
    Abstract: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: February 3, 2015
    Assignees: Fujirebio Europe N.V., Roche Diagnostics GmbH
    Inventors: Sofie Claeys, Geert Jannes, Gerd Haberhausen, Thomas Emrich, Lia Verdoodt
  • Publication number: 20130130258
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Application
    Filed: January 23, 2013
    Publication date: May 23, 2013
    Inventors: Hilde DE HENAU, Joachim Van Crombruggen, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Patent number: 7741461
    Abstract: The current invention relates to the field of detection and identification of clinically important fungi. More particularly, the present invention relates to species specific probes originating from the Internal Transcribed Spacer (ITS) region of rDNA for the detection of fungal species such as Candida albicans, Candida parapsilosis, Candida tropicalis, Candida kefyr, Candida krusei, Candida glabrata, Candida dubliniensis, Aspergillus flavus, Aspergillus versicolor, Aspergillus nidulans, Aspergillus fumigatus, Cryptococcus neoformans and Pneumocystis carinii in clinical samples, and methods using said probes.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: June 22, 2010
    Assignees: Innogenetics N.V., Enterprise Ireland, National University of Ireland Galway
    Inventors: Terry Smith, Majella Maher, Cara Martin, Geert Jannes, Rudi Rossau, Marjo Van der Weide
  • Publication number: 20090191558
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S rRNA genes, to be used for the specific detection and/or identification of Serratia species, in particular of Serratia marcescens, Serratia ficaria and/or Serratia fonticola, in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Serratia species, in particular Serratia marcescens, Serratia ficaria and/or Serratia fonticola, using said new nucleic acid sequences derived from the ITS region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Serratia species in a sample.
    Type: Application
    Filed: December 9, 2008
    Publication date: July 30, 2009
    Applicants: Innogenetics, N.V., Roche Diagnostics GmbH
    Inventors: Geert JANNES, Wouter Mijs, Thomas Emrich, Gerd Haberhausen
  • Publication number: 20090148830
    Abstract: The present invention relates to a method for the detection of acute respiratory tract infection (ARI) comprising the simultaneous amplification of several target nucleotide sequences present in a biological sample by means of a primer mixture comprising at least one primer set from each one of the following gene regions: the F1 subunit of the fusion glycoprotein gene for RSV, the hemagglutininneuraminidase gene for PIV-1, the 5? noncoding region of the PIV-3 fusion protein gene, 16 S rRNA sequence for M. pneumoniae, 16 S rRNA sequence for C. pneumoniae, the 5? noncoding region for enterovirus, the non-structural protein gene from influenza A, the non-structural protein gene from influenza B, and the hexon gene for adenoviruses. This multiplex RT-PCR method is particularly preferred because it allows to determine the presence of the following microorganisms which infect the respiratory tract of mainly children in one amplification step: RSV, parainfluenza virus, M. pneumoniae, C.
    Type: Application
    Filed: April 10, 2008
    Publication date: June 11, 2009
    Applicant: INNOGENETICS N.V.
    Inventors: Geert Jannes, Heinz-Josef Schmitt
  • Publication number: 20090098558
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribionucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
    Type: Application
    Filed: October 16, 2008
    Publication date: April 16, 2009
    Applicants: INNOGENETICS N.V., ROCHE DIAGNOSTICS GmbH
    Inventors: Geert Jannes, Wouter Mijs, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20090068651
    Abstract: Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved, comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the relevant part of the antibiotic resistance genes present in said sample with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least one of the rpoB gene probes, as specified in table 2, under the appropriate hybridization and wash conditions; (iv) detecting the hybrids formed in step (iii); (v) inferring the Mycobacterium antibiotic resistance spectrum, and possibly the Mycobacterium species involved from the differential hybridization signal(s) obtained in step (iv).
    Type: Application
    Filed: June 27, 2007
    Publication date: March 12, 2009
    Applicant: INNOGENETICS N.V.
    Inventors: Hans De Beenhouwer, Francoise Portaels, Lieve Machtelinckx, Geert Jannes, Rudi Rossau
  • Publication number: 20090017456
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Application
    Filed: March 10, 2008
    Publication date: January 15, 2009
    Applicants: INNOGENETICS N.V., ROCHE DIAGNOSTICS GMBH,
    Inventors: Hilde DE HENAU, Joachim Van Crombruggen, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20080199878
    Abstract: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
    Type: Application
    Filed: April 18, 2008
    Publication date: August 21, 2008
    Applicants: INNOGENETICS N.V., ROCHE DIAGNOSTICS GMBH
    Inventors: Sofie Claeys, Geert Jannes, Gerd Haberhausen, Thomas Emrich, Lia Verdoodt
  • Patent number: 7390623
    Abstract: The present invention relates to 16S-23S rRNA spacer sequences from Staphylococcus aureus and their use in a method for detection and/or identification of Staphylococcus aureus . The invention further relates to a method for detection and identification of Staphylococcus aureus in a sample, involving the steps of: (i) optionally releasing, isolating and/or concentrating the polynucleic acids present in the sample; (ii) optionally amplifying the 16S-23S rRNA spacer region, or a part thereof, with at least one primer pair; (iii) detecting the presence of a 16S-23S rRNA spacer sequence; and (iv) identifying the Staphylococcus aureus present in the sample from the nucleic acid(s) detected in the sample.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: June 24, 2008
    Assignee: Innogenetics N.V.
    Inventors: Geert Jannes, Rudi Rossau, Hugo Van Heuverswyn
  • Patent number: 7252936
    Abstract: Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved, comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the relevant part of the antibiotic resistance genes present in said sample with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least one of the rpoB gene probes, as specified in table 2, under the appropriate hybridization and wash conditions; (iv) detecting the hybrids formed in step (iii); (v) inferring the Mycobacterium antibiotic resistance spectrum, and possibly the Mycobacterium species involved from the differential hybridization signal(s) obtained in step (iv).
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: August 7, 2007
    Assignee: Innogenetics N.V.
    Inventors: Hans De Beenhouwer, Fran├žoise Portaels, Lieve Machtelinckx, Geert Jannes, Rudi Rossau
  • Publication number: 20060240427
    Abstract: The present invention is directed to a method for identification of a Gram positive pathogenic bacterium comprising an amplification step with at least a first set of amplification primers capable of amplifying a preselected nucleic acid sequence region from a first predetermined sub-group of pathogenic Gram positive bacteria, and a detection step with at least a first hybridization reagent capable of specifically detecting a preselected nucleic acid sequence region from the first predetermined sub-group of pathogenic Gram positive bacteria, said detection step comprising steps monitoring whether hybridization has occurred at a preselected temperature, said occurrence of hybridization being indicative for at least the genus of a pathogenic organism present in the sample, and monitoring temperature dependence of hybridization, said temperature dependence being indicative for at least the species of the pathogenic Gram positive bacterium.
    Type: Application
    Filed: December 2, 2003
    Publication date: October 26, 2006
    Applicants: ROCHE MOLECULAR SYSTEMS, INC., INNOGENETICS, N.V.
    Inventors: Gerd Haberhausen, Thomas Emrich, Rudi Rossasu, Geert Jannes, Daniel Vos
  • Publication number: 20060134618
    Abstract: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 22, 2006
    Inventors: Hilde De Henau, Joachim Van Crombruggen, Geert Jannes, Thomas Emrich, Geert Jannes, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20060115819
    Abstract: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Staphylococcus species, in particular of S. aureus, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Staphylococcus species in a sample.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 1, 2006
    Inventors: Sofie Claeys, Geert Jannes, Gerd Haberhausen, Thomas Emrich, Lia Verdoodt
  • Publication number: 20060099618
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region, between the 16S and 23S rRNA genes, to be used for the specific detection and/or identification of Serratia species, in particular of Serratia marcescens, Serratia ficaria and/or Serratia fonticola, in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Serratia species, in particular Serratia marcescens, Serratia ficaria and/or Serratia fonticola, using said new nucleic acid sequences derived from the ITS region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Serratia species in a sample.
    Type: Application
    Filed: September 29, 2005
    Publication date: May 11, 2006
    Applicants: Innogenetics, N.V., Roche Diagnostics GmbH
    Inventors: Geert Jannes, Wouter Mijs, Thomas Emrich, Gerd Haberhausen
  • Publication number: 20050176048
    Abstract: The present invention relates to new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Proteus species, in particular of Proteus mirabilis, Proteus vulgaris and/or Proteus penneri in a biological sample. The present invention relates also to a method for the specific detection and/or identification of Proteus species, in particular Proteus mirabilis, Proteus vulgaris and/or Proteus penneri, using said new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Proteus species in a sample.
    Type: Application
    Filed: February 4, 2005
    Publication date: August 11, 2005
    Inventors: Geert Jannes, Wouter Mijs, Gerd Haberhausen, Thomas Emrich
  • Publication number: 20050164243
    Abstract: The current invention relates to the field of detection and identification of clinically important fungi. More particularely, the present invention relates to species specific probes originating from the Internal Transcribed Spacer (ITS) region of rDNA for the detection of fungal species such as Candida albicans, Candida parapsilosis, Candida tropicalis, Candida kefyr, Candida krusei, Candida glabrata, Candida dubliniensis, Aspergillus flavus, Aspergillus versicolor, Aspergillus nidulans, Aspergillus fumigatus, Cryptococcus neoformans and Pneumocystis carinii in clinical samples, and methods using said probes.
    Type: Application
    Filed: October 19, 2004
    Publication date: July 28, 2005
    Inventors: Terry Smith, Majella Maher, Cara Martin, Geert Jannes, Rudi Rossau, Marjo Van der Weide
  • Publication number: 20050142575
    Abstract: The present invention relates to 16S-23S rRNA spacer sequences from Staphylococcus aureus and their use in a method for detection and/or identification of Staphylococcus aureus. The invention further relates to a method for detection and identification of Staphylococcus aureus in a sample, involving the steps of: (i) optionally releasing, isolating and/or concentrating the polynucleic acids present in the sample; (ii) optionally amplifying the 16S-23S rRNA spacer region, or a part thereof, with at least one primer pair; (iii) detecting the presence of a 16S-23S rRNA spacer sequence; and (iv) identifying the Staphylococcus aureus present in the sample from the nucleic acid(s) detected in the sample.
    Type: Application
    Filed: July 21, 2004
    Publication date: June 30, 2005
    Applicant: INNOGENETICS N.V.
    Inventors: Geert Jannes, Rudi Rossau, Hugo Van Heuverswyn