Abstract: A method of analyzing a molecule is disclosed. A lipid bilayer is formed such that it divides a first reservoir characterized by a first reservoir osmolarity from a second reservoir characterized by a second reservoir osmolarity. An electrolyte solution is flowed to the first reservoir that tends to make a first change to a ratio of the first reservoir osmolarity to the second reservoir osmolarity. A voltage is applied across the lipid bilayer, wherein the lipid bilayer is inserted with a nanopore, and wherein a net transfer of ions between the first reservoir and the second reservoir tends to make a second change to the ratio of the first reservoir osmolarity to the second reservoir osmolarity, and wherein the first change to the ratio and the second change to the ratio tends to counter-balance each other.

Abstract: Disclosed here are methods useful for incorporating protein into lipid bilayers using voltage induced insertion. The methods presented herein can decrease time and costs associated with incorporation of proteins into naturally derived or artificially created lipid bilayers. A method for incorporating a protein capable of translocating a ligand also is disclosed herein.

Abstract: The general concept of using a nanopore for DNA sequencing is to electrophoretically drive a polymer (e.g. single stranded DNA) through a nanopore under aqueous conditions, and identify each individual monomer (e.g. nucleotide) of the strand as it passes through the sensitive region of the nanopore based on its characteristic current modulation.

Abstract: Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR).

Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.

Abstract: Disclosed here are methods useful for incorporating protein into lipid bilayers using voltage induced insertion. The methods presented herein can decrease time and costs associated with incorporation of proteins into naturally derived or artificially created lipid bilayers. A method for incorporating a protein capable of translocating a ligand also is disclosed herein.

Abstract: A hardware-based file system includes multiple linked sub-modules that perform functions ancillary to client data handling. Each sub-module is associated with a metadata cache. A doubly-rooted structure is used to store each file system object at successive checkpoints. Metadata is stored within an object and/or as a separate object. Provisions are made for allocating sparse objects. A delayed write feature is used for writing certain objects into non-volatile storage. Checkpoints can be retained as read-only versions of the file system. Modifications to the file system are accomplished without affecting the contents of retained checkpoints. The file system can be reverted to a retained checkpoint. Multiple file servers can be interconnected as a cluster, and each file server stores requests from another file server. Interconnections between file servers can be dynamically modified. A distributed locking mechanism is used to control access to file system objects stored by the file servers.

Abstract: A network-attached system, device, and method supports multiple storage tiers. Data may be migrated between storage tiers, for example, based on a data migration policy.

Abstract: A filesystem-aware storage system locates and analyzes host filesystem data structures in order to determine storage usage of the host filesystem. To this end, the storage system might locate an operating system partition, parse the operating system partion to locate its data structures, and parse the operating system data structures to locate the host filesystem data structures. The storage system manages data storage based on the storage usage of the host file system. The storage system can use the storage usage information to identify storage areas that are no longer being used by the host filesystem and reclaim those areas for additional data storage capacity. Also, the storage system can identify the types of data stored by the host filesystem and manage data storage based on the data types, such as selecting a storage layout and/or an encoding scheme for the data based on the data type.

Abstract: A dynamically expandable and contractible fault-tolerant storage system employs a virtual hot spare that is created from unused storage capacity across a plurality of storage devices. This unused storage capacity is available if and when a storage device fails for storage of data recovered from the remaining storage device(s). On an ongoing basis, the storage system may determine the amount of unused storage capacity that would be required for the virtual hot spare (e.g., based on the number of storage devices, the capacities of the various storage devices, the amount of data stored, and the manner in which the data is stored) and generate a signal if additional storage capacity is needed for a virtual hot spare.

Abstract: A dynamically upgradeable fault-tolerant storage system permits a storage device to be replaced with a larger storage device. Data stored redundantly across multiple storage devices is reproduced on the replacement device, and the additional storage space on the replacement device is made available for redundantly storing additional data.

Abstract: A storage system condition indicator and method provides a visual display representing the operating condition of a set of storage devices. Various operating conditions may be defined based on available storage capacity and capacity to store data redundantly. One or more indicators may be used to represent the operating condition of the set of storage devices. The indicator(s) may be used to indicate whether additional storage capacity is recommended and, in a storage array, which slot in the array should be updated with additional storage capacity.

Abstract: A dynamically expandable and contractible fault-tolerant storage system permits variously sized storage devices. Data is stored redundantly across one or more storage devices if possible. The layout of data across the one or more storage devices is automatically reconfigured as storage devices are added or removed in order to provide an appropriate level of redundancy for the data to the extent possible. A hash-based compression technique may be used to reduce storage consumption. Techniques for freeing unused storage blocks are also disclosed.

Abstract: An apparatus in one embodiment handles service requests over a network, wherein the network utilizes a protocol. In this aspect, the apparatus includes: a network subsystem for receiving and transmitting network service requests using the network protocol; and a service subsystem, coupled to the network subsystem, for satisfying the network service requests. At least one of the network subsystem and the service subsystem is hardware-implemented; the other of the network subsystem and the service subsystem may optionally be hardware-accelerated. A variety of related embodiments are also provided, including file servers and web servers.

Abstract: A method and system for canceling extraneous signals in a nuclear quadrupole resonance (NQR) system used for the detection of explosives and drugs. A specimen is irradiated with a specific sequence of electromagnetic pulses, referred to as a spin-locked inversion mid-echo (SLIME) pulse sequence with each pulse having a specified phase and duration. The pulses are separated by specified time intervals. The SLIME pulse sequence has a single excitation pulse. As a result of the characteristics of the SLIME pulse sequence, if the target substance to be detected is present in the specimen, sets of oppositely-phased NQR echo signals are generated from the target substance. NQR echo signals of one phase are subtracted from NQR echo signals having the opposite phase, rendering a cumulative echo signal, and simultaneously subtracting out the same-phase extraneous signal.

Abstract: The resin content of an organic resin-matrix composite material is measured nondestructively by nuclear magnetic resonance. A specimen of the composite material is placed into a constant magnetic field and subjected to a radio-frequency magnetic field pulse. The response of the material is indicative of the amount of organic resin that is present. The response may be used as a feedback signal to control the operation of a manufacturing machine.