Abstract: Aspects of regional vehicle assembly and distribution are disclosed. A system of regional vehicle assembly and distribution includes a regional site, an assembly point, and a distribution point. A method comprises aggregating confirmed vehicle orders from the distribution point arranging the manufacturing and assembling at regional sites of primary vehicle structures and exterior and interior components based on the type of the confirmed vehicle orders and arranging the delivery to the assembly point of the primary vehicle structures and exterior and interior components. The method further includes instructing the assembly point to assemble a vehicle associated with the confirmed vehicle order.

Abstract: A sustainable and compact green energy harvesting, storage and monetization ecosystem. Various energy capturing devices (e.g., solar, wind, water, kinetic) are utilized to capture sustainable and renewable energy that is captured in portable energy storage devices (e.g., battery packs). The energy from the battery packs is collected by an energy collection, storage and distribution facility that may store the energy for future use and/or utilize the energy to mine/purchase cryptocurrencies, provide energy for industry, provide charging stations, and/or sell energy back to the grid. Customers are paid for the energy they provide in various types of currencies based on their contract with the system. The ecosystem is small, sustainable, green, scalable, environmentally friendly, and easy to use for anyone, anywhere.

Abstract: Described herein are compositions and methods useful for the depletion of CD45+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. The compositions and methods described herein can be used to treat a disorder, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for allogeneic hematopoietic stem cell transplant therapy and to improve the engraftment of allogeneic hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

Abstract: Fuel injectors having a fuel-air heat exchange system and methods thereof for use in a gas turbine engine. The fuel-air heat exchanger allows heat transfer between a flow of cooling air used to cool components of the engine and a flow of fuel used to drive the engine to transfer heat to the flow of fuel and cool the cooling air.

Abstract: A multi-layer time-interleaving (TI) device and method of operation therefor. This device includes a plurality of TI layers configured to receive a plurality of input clock signals and to output a plurality of output clock signals, each of which can be configured to drive subsequent devices. The layers include at least a first and second layer including a fine-grain propagation device and a barrel-shifting propagation device configured to retime the plurality of input clock signals to produce divided output clock signals. The device can include additional barrel-shifting propagation devices to time interleave an initial two layers to produce one or more additional layers. Using negative phase stepping, the plurality of output clock signals is produced with optimal timing margin and synchronized on a single clock edge.

Abstract: Fuel injectors having a fuel-air heat exchange system and methods thereof for use in a gas turbine engine. The fuel-air heat exchanger allows heat transfer between a flow of cooling air used to cool components of the engine and a flow of fuel used to drive the engine to transfer heat to the flow of fuel and cool the cooling air.

Abstract: Disclosed are methods and compositions relating to the treatment of autoimmune diseases using anti-CD45 antibody drug conjugates (ADCs).

Abstract: Techniques for monitoring dispensed liquid include an intelligent spout that incorporates an IMU (Inertial Measurement Unit) for tracking its own orientation and movement in three-dimensional space. The spout has its own processor, memory, and wireless networking components, which support local data processing, data logging, and bi-directional wireless communication. Communication may be carried out with a server, with other spouts of like kind, and/or with other devices.

Abstract: The invention provides anti-CD45 antibody drug conjugates (ADCs), and methods of use thereof. In one embodiment, the invention provides methods of depleting a population of CD45+ cells from a subject, by administration of an anti-CD45 ADC provided herein. In some embodiments, the ADCs include a cytotoxin containing a benzodiazepine moiety, for example. a pyrrolobenzodiazepine (PBD) or an indolinobenzodiazepine (IGN) moiety.

Abstract: A multi-layer time-interleaving (TI) device and method of operation therefor. This device includes a plurality of TI layers configured to receive a plurality of input clock signals and to output a plurality of output clock signals, each of which can be configured to drive subsequent devices. The layers include at least a first and second layer including a fine-grain propagation device and a barrel-shifting propagation device configured to retime the plurality of input clock signals to produce divided output clock signals. The device can include additional barrel-shifting propagation devices to time interleave an initial two layers to produce one or more additional layers. Using negative phase stepping, the plurality of output clock signals is produced with optimal timing margin and synchronized on a single clock edge.

Abstract: The invention provides methods of depleting CD45+ cells in human patients undergoing chimeric antigen receptor (CAR) immunotherapy in order to promote acceptance of CAR expressing immune cells. Anti-CD45 antibody drug conjugates (ADCs) are administered as a conditioning regimen to a human patient receiving autologous or allogeneic CAR expressing immune cells such that the CAR expressing immune cells are accepted by the human patient. Compositions and methods of the invention can be used in combination with CAR therapy to treat a variety of pathologies, including autoimmune diseases and cancer.

Abstract: Described herein are compositions and methods useful for the depletion of CD117+ or CD45+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. The compositions and methods described herein can be used to treat a disorder, for instance, by depleting a population of CD117+ or CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for allogeneic hematopoietic stem cell transplant therapy and to improve the engraftment of allogeneic hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

Abstract: A multi-layer time-interleaving (TI) device and method of operation therefor. This device includes a plurality of TI layers configured to receive a plurality of input clock signals and to output a plurality of output clock signals, each of which can be configured to drive subsequent devices. The layers include at least a first and second layer including a fine-grain propagation device and a barrel-shifting propagation device configured to retime the plurality of input clock signals to produce divided output clock signals. The device can include additional barrel-shifting propagation devices to time interleave an initial two layers to produce one or more additional layers. Using negative phase stepping, the plurality of output clock signals is produced with optimal timing margin and synchronized on a single clock edge.

Abstract: Techniques for monitoring dispensed liquid include an intelligent spout that incorporates an IMU (Inertial Measurement Unit) for tracking its own orientation and movement in three-dimensional space. The spout has its own processor, memory, and wireless networking components, which support local data processing, data logging, and bi-directional wireless communication. Communication may be carried out with a server, with other spouts of like kind, and/or with other devices.

Abstract: Aspects of regional vehicle assembly are disclosed. A system of regional vehicle assembly includes a regional site, an assembly point-of-sale, and a sales/service point-of-sale. A method comprises aggregating confirmed vehicle orders from the points-of sale; arranging the manufacturing and assembling of a primary vehicle structure and an exterior and interior component at the regional site, based in part on the type of the confirmed vehicle orders, and arranging the delivery of the primary vehicle structure and exterior and interior components to the assembly point-of sale. The method can further include coordinating the assembly point-of-sale to assemble the confirmed vehicle orders.

Abstract: A lithographic apparatus includes a clamp (406) configured to receive an object (402). The clamp defines at least one channel (408) configured to pass a fluid at a first fluid temperature. The lithographic apparatus also includes a chuck (404) coupled to the clamp. The chuck (404) defines at least one void (464) configured to thermally insulate the chuck from the clamp.

Abstract: A gas turbine engine vane or blade comprises a plurality of micro-structures disposed on an internal surface of the outer wall. The micro-structures may comprise an array of fins having a thickness of less than 0.002?, for example. Cooling air may be impinged upon the surface and routed through at least one flow channel to convectively cool the outer wall. Additionally or alternatively, micro-channels may be disposed along a suction side wall and pressure side wall of the vane or blade to convectively cool the respective walls. An embodiment of a vane or blade in accordance with the present invention may be constructed from a plurality of thin metal foils, stacked and bonded together.

Abstract: A lithographic apparatus includes a clamp (406) configured to receive an object (402). The clamp defines at least one channel (408) configured to pass a fluid at a first fluid temperature. The lithographic apparatus also includes a chuck (404) coupled to the clamp. The chuck (404) defines at least one void (464) configured to thermally insulate the chuck from the clamp.

Abstract: A transceiver for fiber optic communications. The transceiver can include a transmitter module having a transmitter host interface configured to receive an input host signal; a transmitter framer configured to frame the input host signal and to generate a framed host signal; and a transmitter coder configured to encode the framed host signal to generate an encoded host signal for transmission over a communication channel. The transceiver can also include a receiver module having a bulk chromatic dispersion, fiber length estimation, and coarse carrier recovery circuit configured to equalize a digital input ingress signal to generate an equalized ingress signal; a receiver framer configured to frame the equalized ingress signal to generate a framed ingress signal; and a receiver host interface configured to output the framed ingress signal. The receiver host interface is compatible with a framing protocol of the receiver framer.

Abstract: A lithographic apparatus includes a clamp (406) configured to receive an object (402). The clamp defines at least one channel (408) configured to pass a fluid at a first fluid temperature. The lithographic apparatus also includes a chuck (404) coupled to the clamp. The chuck (404) defines at least one void (464) configured to thermally insulate the chuck from the clamp.