Abstract: Provided herein is a method for predicting the probability of having or developing a non-fusion, wherein said method comprises determining the frequency of a subpopulation of CD8+ T cells selected from CD8+CD57+, CD8+CD28? and CD8+CD57+CD28? in a sample obtained from a patient. Also provided herein is a system for predicting the probability of having or developing a non-fusion.

Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.

Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.

Abstract: A biomaterial, particularly for tissue regeneration, includes an open, porous bioresorbable first material portion and a second material portion that is stiffer than the first material portion, wherein the volume fraction of the stiffer material is less than 30% of the total volume of the biomaterial, and the structural stiffness of the second material portion is at least 10 times greater than that of the first material portion.

Abstract: A biomaterial, particularly for tissue regeneration, includes an open, porous bioresorbable first material portion and a second material portion that is stiffer than the first material portion, wherein the volume fraction of the stiffer material is less than 30% of the total volume of the biomaterial, and the structural stiffness of the second material portion is at least 10 times greater than that of the first material portion.

Abstract: The present invention relates to a method for predicting the probability of having or developing a non-fusion, wherein said method comprises determining the frequency of a subpopulation of CD8+ T cells selected from CD8+CD57+, CD8+CD28? and CD8+CD57+CD28? in a sample obtained from a patient. The invention further relates to a system for predicting the probability of having or developing a non-fusion.

Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.

Abstract: The present invention relates to a therapeutic substance and/or medicament and methods relating to the use of said substance and/or medicament for skeletal muscle regeneration using mesenchymal stem cells (MSCs) which can be applied directly or shortly after muscle damage or injury.

Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.

Abstract: A component for an arrangement at an implant includes a sensor detecting a measurement variable and generating measuring data corresponding to the detected measurement variable; telemetry device transmitting data; a data transmission connection between the sensor and the telemetry device for the transmission of the measuring data therebetween; and an assembly arrangement detachably mounting the component in an implant recess of the implant wherein the component is configured to be insertable through an implant recess of an implant positioned over a target portion of a bone so that the component extends through the opening toward an outer periphery of the target portion of the bone.

Abstract: The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.

Abstract: A guide body is designed to receive longitudinal fixation elements such as wires nails, pegs or screws which are to be anchored within bone. The guide body includes a top surface, a bottom surface, and a number of openings connecting the top surface with the bottom surface. The central axes of at least two of the openings are transverse to each other. The guide body permits the insertion of fixation elements at various angles with respect to each other. The guide body may prevent fixation elements which extend into the intramedullary region or the spongiosa from being displaced either in the proximal or in the distal direction.

Abstract: The present invention relates to a therapeutic substance and/or medicament and methods relating to the use of said substance and/or medicament for skeletal muscle regeneration using mesenchymal stem cells (MSCs) which can be applied directly or shortly after muscle damage or injury.

Abstract: The invention refers to a component for arrangement at an implant as well as a method for the assembling of an implant arrangement. The component comprises a basic component, at least one sensor arranged in the basic component for the detection of a measurement variable and for the generation of measuring data for the detected measurement variable, a telemetry device arranged in the basic component for transmitting and receiving data and a data transmission connection between the at least one sensor device and the telemetry device for the transmission of data between the at least one sensor device and the telemetry device, whereby the data comprise the measuring data. At the basic component, assembly means for mounting the basic component in an implant recess are formed.

Abstract: The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.

Abstract: The invention relates to a device comprising: i) a sample-receiving unit (20), said sample-receiving unit (20) comprising a cavity (24) for receiving sample material, means (22) for applying pressure in a regulatable and/or controllable fashion to sample material located in the cavity, and an outlet (25), said outlet (25) being disposed and designed in such a way that, by actuating the means (22) for applying pressure in a regulatable and/or controllable fashion, components of the sample material can be transferred from the cavity (24) through the outlet (25) and directly to an analysis unit (30) connectable to the outlet (25); and ii) an analysis unit (30), said analysis unit (30) comprising an inlet (31), a first filter (32), a reservoir (33) and an analysis track (35), said inlet (31) being designed to be connectable to an outlet (25) of the sample-receiving unit (20) such that components of the sample material can be fed from the sample-receiving unit (20) directly to the analysis unit (30), said first fi

Abstract: The invention relates to an osteosynthesis implant (1) that preferably consists of a bioresorbable plastic material. The inventive implant receives the longitudinal fixation elements (10) to be anchored in the bone, especially in the form of wires, nails, pins or screws. The openings destined to receive the fixation elements (10) do not completely extend through the implant (1) like in conventional bone plates or intramedullary nails but are degenerated to indents (2) in the surface of the implant (1) so that they may serve as a guide for the fixation elements (10) to be guided through the implant (1). The inventive implant (1) allows insertion of the fixation elements (10) in the bone diverging angles and crossing one another, so that the fixation elements (10) extending intramedullarly or in the spongiosa are primarily prevented from migrating in a proximal or distal direction.

Abstract: The present invention concerns a method of detecting information relevant to the characterization of joint movements, wherein markers fitted on both sides of a body joint are used for the analysis of joint movements and wherein the method includes: determining a mean marker configuration and determining time-dependent discrepancies from the mean configuration, wherein an orthogonal distance regression is carried out for determining a mean marker configuration and wherein markers fitted on a respective side of the body joint are used; carrying out a weighted orthogonal distance regression using the time-dependent discrepancies from the mean configuration for weighting, wherein markers fitted on a respective side of the body joint are used; and solving a linear equalization problem using items of information which were determined by carrying out the weighted orthogonal distance regression.

Abstract: The invention relates to an osteosynthesis implant (1) that preferably consists of a bioresorbable plastic material. The inventive implant receives the longitudinal fixation elements (10) to be anchored in the bone, especially in the form of wires, nails, pins or screws. The openings destined to receive the fixation elements (10) do not completely extend through the implant (1) like in conventional bone plates or intramedullary nails but are degenerated to indents (2) in the surface of the implant (1) so that they may serve as a guide for the fixation elements (10) to be guided through the implant (1). The inventive implant (1) allows insertion of the fixation elements (10) in the bone diverging angles and crossing one another, so that the fixation elements (10) extending intramedullarly or in the spongiosa are primarily prevented from migrating in a proximal or distal direction.

Abstract: The invention relates to a hand-held medical instrument, in particular a hand-held surgical or dental instrument, comprising a component that generates mechanical vibrations during operation, and a particle damping element which has at least one hollow space that is designed to receive the mechanical vibrations and is filled at least in part with a plurality of granular particles which dampen the mechanical vibrations by means of dissipative shocks between the granular particles and/or between the granular particles and a wall surrounding the hollow space.