Patents by Inventor Georg Frater

Georg Frater has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190119311
    Abstract: The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: wherein: M is a Group 6 metal atom; X is an oxygen atom, ?N—R5, ?N—N(R5)(R5?) or ?N—O—R5, R5 and R5? independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.
    Type: Application
    Filed: October 22, 2018
    Publication date: April 25, 2019
    Inventors: Florian Toth, Georg Frater, Levente Ondi
  • Patent number: 10106566
    Abstract: The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula (I) wherein: M is a Group 6 metal atom; X is an oxygen atom, ?N—R5, ?N—N(R5)(R5?) or ?N—O—R5, R5 and R5? independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: October 23, 2018
    Assignee: XiMo AG
    Inventors: Florian Toth, Georg Frater, Levente Ondi
  • Publication number: 20180022770
    Abstract: A compound of the formula II (I) in which X is substituted pyrrolide with the general structure of (II) in which Ra-Rd are independently selected from H, C1-C4 alkyl, C1-C4 alkoxy, aryl, aryloxy, dialkylamino, diarylamino, halogen, trifluoromethyl, cyano, nitro, sulfonyl and sulfinyl. Y is C1-C6 alkoxy, C1-C10 aryloxy, optionally substituted; R1 is selected from H, C1-C12 alkyl and 5- to 18-membered aryl, optionally substituted; R2 is selected from C1-C12-alkyl, 5- to 18-membered aryl, optionally substituted; R3 is selected from C1-C12 alkyl, 5- to 18-membered aryl, optionally substituted; and 15 124-R11 are independently selected from H, C1-C4 alkyl and halogen. The compounds are particularly effective precursors of metathesis catalysts for the polymerisation of dicyclopentadiene.
    Type: Application
    Filed: March 8, 2016
    Publication date: January 25, 2018
    Inventors: Georg Frater, Henrik Gulyas, Levente Ondi
  • Publication number: 20170037069
    Abstract: The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula (I) wherein: M is a Group 6 metal atom; X is an oxygen atom, ?N—R5, ?N—N(R5)(R5?) or ?N—O—R5, R5 and R5? independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.
    Type: Application
    Filed: April 9, 2015
    Publication date: February 9, 2017
    Inventors: Florian Toth, Georg Frater, Levente Ondi
  • Publication number: 20140330018
    Abstract: The present application provides, among other things, novel compounds and methods for metathesis reactions. In some embodiments, a provided compound has the structure of formula I. In some embodiments, the present invention provides methods for preparing a compound of formula I. In some embodiments, the present invention provides metathesis methods comprising providing a compound of formula I.
    Type: Application
    Filed: May 1, 2014
    Publication date: November 6, 2014
    Applicants: Massachusetts Institute of Technology, Ximo AG
    Inventors: Janos Czirok, Georg Frater, Levente Ondi, Richard Royce Schrock, Florian Toth
  • Publication number: 20100111888
    Abstract: Disclosed are compounds having the ability to modulate, namely to improve, enhance and or modify fragrance compositions due to their ability to inhibit cytochrome P450 enzymes, e.g. CYP2A13 and CYP2B6.
    Type: Application
    Filed: March 20, 2008
    Publication date: May 6, 2010
    Applicant: GIVAUDAN SA
    Inventors: Boris Schilling, Thierry Granier, Georg Frater, Andreas Hanhart
  • Publication number: 20100113460
    Abstract: Disclosed are compounds having the ability to inhibit cytochrome P450 2A6, 2A13, and/or 2B6 and tobacco products comprising them. Also disclosed are pharmaceutical compositions comprising them.
    Type: Application
    Filed: March 20, 2008
    Publication date: May 6, 2010
    Applicant: Givaudan SA
    Inventors: Boris Schilling, Wolf D. Woggon, Antoinette Chougnet, Thierry Granier, Georg Frater, Andreas Hanhart
  • Patent number: 7683190
    Abstract: A method of preparing enatiomerically enriched 3a,6,6,9a-tetramethyl-dodecahydro-naphtho[2,1-b]furan, formula (I), from (E,E)-homofarnesic acid or (E)-monocyclohomofarnesic acid by (a) reacting firstly with a chiral alcohol, (b) reacting the product of (a) with an acid to cause a first cyclization, (c) producing an alcohol by reacting the product of (b) with a reducing agent and (d) causing a second cyclization by reacting the product of (c) with an acid. The product of this process gives a mixture of both enantiomers with one in excess.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: March 23, 2010
    Assignee: Givaudan SA
    Inventors: Georg Frater, Urs Mueller
  • Publication number: 20090022764
    Abstract: The present invention refers to a process for the production of controlled-release aqueous compositions comprising an active ingredient releasably contained within polymeric particles. The polymeric particles are obtainable by ring-opening metathesis polymerisation of a monomer of the general formula (I) wherein R1 and R2 have the same meaning as given in the specification, or a mixture thereof, in an aqueous phase in the presence of a ruthenium catalyst, an emulsifier, and an active ingredient.
    Type: Application
    Filed: August 26, 2005
    Publication date: January 22, 2009
    Applicant: GIVAUDAN SA
    Inventors: Georg Frater, Rita Cannas, Benjamin J. Costa, Jutta Hotz
  • Publication number: 20080064886
    Abstract: A method of preparing enatiomerically enriched 3a,6,6,9a-tetramethyl-dodecahydro-naphtho[2,1-b]furan, formula (I), from (E,E)-homofarnesic acid or (E)-monocyclohomofarnesic acid by (a) reacting firstly with a chiral alcohol, (b) reacting the product of (a) with an acid to cause a first cyclisation, (c) producing an alcohol by reacting the product of (b) with a reducing agent and (d) causing a second cyclisation by reacting the product of (c) with an acid. The product of this process gives a mixture of both enantiomers with one in excess.
    Type: Application
    Filed: July 26, 2005
    Publication date: March 13, 2008
    Applicant: GIVAUDAN SA
    Inventors: Georg Frater, Urs Mueller
  • Patent number: 7135198
    Abstract: A preparation for oral administration, in which plant material is comminuted and treated by mixing thoroughly with an extractant. After mixing, porous inorganic particles are added to the resulting suspension, thoroughly mixed with mixture and dried. The preparation provides a homogeneous distribution of the active ingredient as well as long stability and good bioavailability of the active ingredient.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: November 14, 2006
    Assignee: Bogar AG
    Inventors: Marijkc Frater-Schroder, Georg Frater
  • Patent number: 6951964
    Abstract: The present invention relates to a novel thermo-isomerization method for rapidly and simply producing macrocyclic ketones of the formula Ia or Ib. The macrocyclic ketones are prepared in the gas phase at temperatures above 500° C. rapidly and in a simple manner from alcohols of the formula IIa and IIb directly with a high yield. In the formulae Ia, Ib, IIa and IIb, R1-R5, and n have the meanings given in the description.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: October 4, 2005
    Assignee: Givaudan SA
    Inventors: Georg Frater, Matthias Nagel
  • Patent number: 6844470
    Abstract: A process for the purification of 1,3-diketones comprising reacting a 1,3-diketone with an earth metal or alkaline earth metal complexing agent in an organic solvent, isolating, washing and decomposing the resulting complex, and isolating the purified 1,3-diketone.
    Type: Grant
    Filed: January 24, 2002
    Date of Patent: January 18, 2005
    Assignee: Roche Vitamins Inc.
    Inventors: Georg Frater, Ulrich Huber
  • Publication number: 20040082816
    Abstract: The present invention relates to a novel thermo-isomerization method for rapidly and simply producing macrocyclic ketones of the formula Ia or Ib.
    Type: Application
    Filed: August 22, 2003
    Publication date: April 29, 2004
    Inventors: Georg Frater, Matthias Nagel
  • Publication number: 20040068145
    Abstract: A process for the purification of 1,3-diketones comprising reacting a 1,3-diketone with an earth metal or alkaline earth metal complexing agent in an organic solvent, isolating, washing and decomposing the resulting complex, and isolating the purified 1,3-diketone.
    Type: Application
    Filed: August 1, 2003
    Publication date: April 8, 2004
    Inventors: Georg Frater, Ulrich Huber
  • Patent number: 6627763
    Abstract: The present invention relates to compounds with protected hydroxy groups of formula (I) These compounds are precursors for organoleptic agents, such as fragrances, and masking agents and for antimicrobial agents. When activated, the compounds of formula (I) are cleaved and form one or more organoleptic and/or antimicrobial compounds.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: September 30, 2003
    Assignee: Givaudan SA
    Inventors: Denise Anderson, Georg Fráter, Frank Kumli
  • Patent number: 6569411
    Abstract: Serine carbonates of formula I are precursors for organoleptic compounds, masking agents and antimicrobial agents. Further they are alternative substrates for malodor producing enzymes. The symbols in formula I are defined in claim 1.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: May 27, 2003
    Assignee: The Gillette Company
    Inventors: Georg Frater, Denise Anderson, Frank Kumli, Jens Wittenberg, Virginia Streusand Goldman
  • Publication number: 20030068358
    Abstract: A preparation for oral administration, in which plant material is comminuted and treated by mixing thoroughly with an extractant. After mixing, porous inorganic particles are added to the resulting suspension, thoroughly mixed with mixture and dried. The preparation provides a homogeneous distribution of the active ingredient as well as long stability and good bioavailability of the active ingredient.
    Type: Application
    Filed: September 30, 2002
    Publication date: April 10, 2003
    Applicant: Bogar AG
    Inventors: Marijke Frater-Schroder, Georg Frater
  • Patent number: 6521797
    Abstract: The present invention is an oxime carboxylic acid derivative having the formula I: wherein n is 1 or 0, X is O, R2 and R3 being part of an oxime R2R3C═NOH are individually, substituted or unsubstituted, branched or unbranched alkyl-, alkenyl-, akinyl-, cycloalkyl-, cycloalkenyl-, or aromatic radical and contain less than 30 carbon atoms, and R1 is a substituted or unsubstituted, branched or unbranched alkyl-, alkenyl-, akinyl-, cycloalkyl-, cycloalkenyl-, alkoxyalkyl-, aryloxyaryl-, alkoxyaryl-, aryloxyalkyl-, or aromatic radical, or XnR1 is which are useful as precursors for the delivery of organoleptic compounds, especially for flavors, fragrances and masking agents, and/or antimicrobial compounds.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: February 18, 2003
    Assignee: Givaudan AG
    Inventors: Denise Anderson, Georg Frater
  • Patent number: RE43006
    Abstract: The acrylic acid esters of Formula I are useful for the delivery of organoleptic compounds, especially for flavors, fragrances, masking agents and antimicrobial compounds. They can also deliver fluorescent whitening agents.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: December 6, 2011
    Assignee: Givaudan Roure (International) S.A.
    Inventors: Denise Anderson, Georg Frater