Abstract: Systems for processing a workpiece are disclosed herein. The systems may include: a laser cutting head configured to produce a laser beam spot pattern comprising a plurality of laser beam spots, where at least two laser beam spots of the plurality of laser beam spots being disposed within the laser beam spot pattern symmetrically from a centerline defined by a cutting path for processing the workpiece. Methods of processing a workpiece are disclosed herein. The methods may include emitting, by a laser cutting head, a laser beam spot pattern comprising at least two laser beam spots, each disposed within the laser beam spot pattern and symmetrically positioned away from a centerline of a processing path of the workpiece; and removing portions of the workpiece using the laser beam spot pattern along the cutting path of the workpiece.

Abstract: A laser processing head for directing a laser beam includes two reflectors and a sole lens element. The first reflector disposed in a housing's interior reflects the laser beam from a source to the second reflector, which then reflects the laser beam toward a process zone for a workpiece. The single lens element is disposed in the housing's interior between the reflectors. The lens element can be moved to adjust a focal position of the laser beam beyond the housing's outlet. To reduce contamination, one or more nozzles are configured to direct purge gas across one or more of the first reflector, the second reflector, and the lens element, while one or more collection areas disposed in the interior are configured to collect contamination directed from the purge gas.

Abstract: An electric motor, more particularly a permanent magnet-excited synchronous motor, is disclosed. In order to draw sufficient energy from a stator winding of a stator of the electric motor and also in order to be able to detect reliable measurement data from a rotor of the electric motor, it is proposed for the energy-harvesting device and the measuring device to be provided on the rotor, wherein the energy-harvesting device has at least one electrode for drawing electrical energy from an electrical field that forms as a counter electrode between this electrode and an end turn, which electrode extends in a circumference direction of the rotor and is positioned next to an end surface of the rotor.

Abstract: A laser material processing head, such as a remote welding head, has an output with a protective optic configured to pass an emitted laser to a working area. The protective optic, such as a cover slide of the output, protects other optics inside the head and is a replaceable, spare part. To prevent at least some debris expelled from the working area from reaching the protective optic, a nozzle is mounted to the head adjacent to the protective optic. The nozzle has an inlet and an outlet for the gas. The outlet has a curvilinear profile configured to fan a cross-jet of the gas in the plane between the protective optic and the working area. The profile of the nozzle reduces the amount of gas needed to divert the debris from the protective optic.

Abstract: A dispensing device includes a housing having at least one pressure chamber, having a supply opening for the supply of liquid into the pressure chamber and having a multiplicity of conduits between the pressure chamber and an external side of the housing, there being situated in each of the conduits a tube, the first end of which protrudes into the pressure chamber and the second end of which protrudes out of the housing on the external side.

Abstract: A laser processing head for directing a laser beam includes two reflectors and a sole lens element. The first reflector disposed in a housing's interior reflects the laser beam from a source to the second reflector, which then reflects the laser beam toward a process zone for a workpiece. The single lens element is disposed in the housing's interior between the reflectors. The lens element can be moved to adjust a focal position of the laser beam beyond the housing's outlet. To reduce contamination, one or more nozzles are configured to direct purge gas across one or more of the first reflector, the second reflector, and the lens element, while one or more collection areas disposed in the interior are configured to collect contamination directed from the purge gas.

Abstract: The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.

Abstract: A composite pane having electrically controllable optical properties, includes an outer pane and an inner pane that are joined to one another via a thermoplastic intermediate layer, wherein a functional element having electrically controllable optical properties is embedded in the intermediate layer, the functional element including an active layer between a first carrier film and a second carrier film, wherein the intermediate layer contains a first thermoplastic material and the carrier films contain a second thermoplastic material, and wherein the first carrier film and the second carrier film are fused together along at least one region of the side edge of the functional element.

Abstract: In order to satisfy a need for a high reliability mortality risk prediction method and device while minimizing the efforts to be taken by the patient and health personnel, the present invention provides a method for assessing a mortality risk of a cardiac patient based on respiratory sinus arrhythmia, said method comprising the following steps. Step A: Computing the mean respiratory sinus arrhythmia during inhalation and/or exhalation for a plurality of breathing cycles of said patient. Step B: Assessing the mortality risk of said patient based on said computation. A device for performing said method is also disclosed.

Abstract: The invention relates to a method for estimating the physical condition of a person by evaluating several parameters of the cardiovascular system by means of measurement signals in order to estimate the functionality of control of the cardiovascular system by the autonomous nervous system. Only one measurement signal, which contains information about the heart beat sequence and the force of contraction of the heart, is used to evaluate the parameters. The measurement signal is preferably the photoplethysmographic signal (PPG signal), which is used to detect the pulse rate and oxygen saturation of the tissue.

Abstract: A method and a system for rapid kinetic fluorescence measurement in high-throughput screening with high time-resolution includes providing a microtiter plate having a transparent base and multiple assay wells, a dispensing system arranged above the microtiter plate for simultaneously adding liquid into multiple assay wells, an illumination system beneath the microtiter plate for illuminating the multiple assay wells simultaneously through the transparent base, a detection system for detecting electromagnetic radiation from the multiple assay wells simultaneously through the transparent base, adding 0.

Abstract: A composite pane having electrically controllable optical properties, includes an outer pane and an inner pane that are joined to one another via a thermoplastic intermediate layer, wherein a functional element having electrically controllable optical properties is embedded in the intermediate layer, the functional element including an active layer between a first carrier film and a second carrier film, wherein the intermediate layer contains a first thermoplastic material and the carrier films contain a second thermoplastic material, and wherein the first carrier film and the second carrier film are fused together along at least one region of the side edge of the functional element.

Abstract: An electromagnetic wave sensor for determining an interstitial fluid parameter in vivo comprises an implantable housing, and a sensor component hermetically encapsulated within the implantable housing. The sensor component comprises an electromagnetic wave transmitter unit configured to emit an electromagnetic wave signal in a frequency range between 300 MHz and 3 THz penetrating the implantable housing and penetrating an interstitial fluid probe volume, an electromagnetic wave receiver unit configured to receive the electromagnetic wave signal modified by the interstitial fluid probe volume, and a transceiver unit configured to transmit radio frequency signals related to the electromagnetic wave signal modified by the interstitial fluid probe volume. A system for determining an interstitial fluid parameter in vivo comprises the electromagnetic wave sensor and an external reader.

Abstract: A device for the electrochemical processing of a metal workpiece, including a plurality of electrodes that by way of respective linear drive units are movable in a linear manner relative to the workpiece from an initial position to a terminal position, the electrodes having a reproduction face that is directed toward the workpiece, wherein at least three electrodes are provided, the electrodes being disposed so as to be offset around the circumference of the workpiece and by way of the reproduction faces of the electrodes during the entire readjustment movement from the initial position to the terminal position engaging across one another in portions so as to be in contact, and by way of the reproduction faces of the electrodes delimiting a fluid duct that in a closed manner encircles the circumference of the workpiece.

Abstract: A method and a system for rapid kinetic fluorescence measurement in high-throughput screening with high time-resolution includes providing a microtiter plate having a transparent base and multiple assay wells, a dispensing system arranged above the microtiter plate for simultaneously adding liquid into multiple assay wells, an illumination system beneath the microtiter plate for illuminating the multiple assay wells simultaneously through the transparent base, a detection system for detecting electromagnetic radiation from the multiple assay wells simultaneously through the transparent base, adding 0.

Abstract: The invention relates to a dispensing device comprising a housing having at least one pressure chamber, having a supply opening for the supply of liquid into the pressure chamber and having a multiplicity of conduits between the pressure chamber and an external side of the housing, there being situated in each of the conduits a tube, the first end of which protrudes into the pressure chamber and the second end of which protrudes out of the housing on the external side.

Abstract: The present disclosure relates to compositions and methods useful for the production of recombinant glycoproteins in filamentous fungal cells, such as Trichoderma cells, wherein at least 90% (mol %), preferably at least 95% of the total neutral N-glycans of said produced recombinant glycoprotein are mammalian-like N-glycans. More specifically, the invention provides a filamentous fungal cell comprising i. one or more mutations that reduces or eliminates one or more endogenous protease activity compared to a parental filamentous fungal cell which does not have said mutation(s); ii. a polynucleotide encoding a heterologous catalytic subunit of oligosaccharyl transferase; iii. a recombinant polynucleotide for increasing ?1, 2 mannosidase activity;and, iv. a recombinant polynucleotide encoding said heterologous glycoprotein.

Abstract: A method for producing of a metal component that is electrochemically machined to remove material, wherein an electrode is positioned adjacent to and, by a duct gap, spaced from a component portion to be machined, and in the presence of an electrolyte a current and a voltage are applied to the electrode and the component. The electrode is moved toward the component from an initial position to a terminal position. In a first operating mode material is removed using a permanently applied current and voltage, a constant electrolyte flow through the duct gap, and a constant advancement of the electrode from the initial position toward the component while maintaining a first gap width. Upon achieving a predetermined removal depth, a changeover to a second operating mode occurs and the electrode is moved cyclically between a non-operating position and an operating position having a second gap width smaller than the first gap width.

Abstract: A device for the electrochemical processing of a metal workpiece, including a plurality of electrodes that by way of respective linear drive units are movable in a linear manner relative to the workpiece from an initial position to a terminal position, the electrodes having a reproduction face that is directed toward the workpiece, wherein at least three electrodes are provided, the electrodes being disposed so as to be offset around the circumference of the workpiece and by way of the reproduction faces of the electrodes during the entire readjustment movement from the initial position to the terminal position engaging across one another in portions so as to be in contact, and by way of the reproduction faces of the electrodes delimiting a fluid duct that in a closed manner encircles the circumference of the workpiece.

Abstract: An antenna array having a plurality of antenna elements is disclosed. The antenna array comprises: a plurality of transceiver modules; an active antenna element subset of the plurality of antenna elements, wherein the active antenna element subset comprises at least one active antenna element being actively coupled to an associated transceiver module of the plurality of transceiver modules; and at least one passively combined sub-array of at least two antenna elements of the plurality of antenna elements. A method for generating antenna patterns with the antenna array is also disclosed.