Abstract: Muconic acid is a molecule that can be converted into direct replacement chemicals for incumbent petrochemicals and performance-advantaged bioproducts. Disclosed herein are Pseudomonas putida KT2440 that are engineered to convert glucose and xylose, the primary carbohydrates in lignocellulosic hydrolysates, to muconic acid using a model-guided strategy to maximize the theoretical yield. Using adaptive laboratory evolution (ALE) and metabolic engineering in a strain engineered to express the D-xylose isomerase pathway, we demonstrated that mutations in the heterologous D-xylose:H+ symporter (XylE), increased expression of a major facilitator superfamily transporter (PP_2569), and overexpression of aroB encoding the native 3-dehydroquinate synthase, enable efficient muconic acid production from glucose and xylose simultaneously. Using the rationally engineered strain, we produced 33.7 g/L muconate at 0.18 g/L/h and a 46% molar yield (92% of the maximum theoretical yield).

Abstract: A method includes accessing a first dataset including aerial imagery data and infrared data, accessing a second dataset including property boundary data, and identifying property boundaries associated with a geographic area. A plurality of models is applied to the datasets to identify and compute information of interest. Based on the first dataset and constrained by the property boundaries, a building detection model can be applied to identify a building, and a vegetation detection model can be applied to identify one or more areas of vegetation. An estimated distance can be determined between each of the areas of vegetation and the building as separation data, which can be compared to a defensible space guideline to determine a defensible space adherence score. A wildfire risk map can be generated, including the defensible space adherence score associated with the geographic area.

Abstract: A system includes a processing device and memory device storing instructions that result in accessing a first dataset including aerial imagery data and infrared data, accessing a second dataset including property boundary data, and identifying property boundaries associated with a geographic area. A plurality of models is applied to the datasets to identify and compute information of interest. Based on the first dataset and constrained by the property boundaries, a building detection model can be applied to identify a building, and a vegetation detection model can be applied to identify one or more areas of vegetation. An estimated distance can be determined between each of the areas of vegetation and the building as separation data, which can be compared to a defensible space guideline to determine a defensible space adherence score. A wildfire risk map can be generated, including the defensible space adherence score associated with the geographic area.

Abstract: A method includes receiving an input histology image, processing, using a cell classification model, the input histology image to generate one or more lymphocyte density maps within the input histology image, and performing morphological image processing on the one or more lymphocyte density maps to identify one or more TLS regions within the input histology image. Each TLS region is represented by a respective cluster of lymphocyte cells. For each corresponding TLS region of the one or more TLS regions identified in the input histology image, the method also includes extracting, from the respective cluster of lymphocyte cells, a respective set of TLS features, and processing, using a TLS classification model, the respective set of TLS features to classify the corresponding TLS region as one of a first TLS maturation state, a second TLS maturation state, or a third TLS maturation state.

Abstract: Certain aspects of the present disclosure provide techniques electric vehicle charging management. In one example, a method includes: detecting a connection between an electric vehicle supply equipment and an electric vehicle; receiving image data depicting an electric vehicle charging scene; determining one or more candidate vehicles in the image data; for each respective candidate vehicle of the one or more candidate vehicles in the image data, determining one or more vehicle characteristics associated with the respective candidate vehicle; associating one candidate vehicle of the one or more candidate vehicles with the electric vehicle based on one or more vehicle characteristics associated with the one candidate vehicle; determining if a user account is associated with the one candidate vehicle associated with the electric vehicle; and determining a charging authorization decision for the electric vehicle.

Abstract: This invention is directed to a compound of formula (I): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).

Abstract: The present disclosure provides, in an aspect, computer-implemented method for generating data associated with a vehicle event, the method including obtaining vehicle event data for a vehicle event associated with a vehicle; identifying a parameter associated with the vehicle event; emulating the parameter based on simulating the vehicle event with the vehicle event data and a model of the parameter, and extrapolating parameter data based on the simulated vehicle event.

Abstract: The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.

Abstract: A rooftop tent frame and exterior assembly for a rooftop or truck bed of a vehicle comprises one or more frame assemblies; a moon roof supported by the one or more frame assemblies and positionable between a retracted position where the moon roof is adjacent to the rooftop of the vehicle, and a deployed camping position where at least part of the moon is elevated relative to the roof top of the vehicle, wherein the rooftop tent frame and exterior assembly is configured to contact the rooftop of the vehicle.

Abstract: A dynamically deployable, low visibility pneumatic cofferdam for flood mitigation is disclosed. The cofferdam includes a first planar component, a second planar component, an inflatable hermetic airbag sandwiched therebetween, and connection members attached to the first planar component, a second planar component to form a cofferdam unit. The connection members are adjustable to apply and maintain a desired amount of pressure on the airbag to enable a watertight seal to be formed. The cofferdam units may be sized and designed to sealingly mate adjacent cofferdam units in a variety of configurations to form watertight seals. The cofferdam units may also be sized and designed to attach to seawalls, flood walls, sidewalks, or other infrastructure. When in a deployed state, the height of the cofferdam may be adjusted to a desired height to provide flood mitigation. When in an undeployed state, the cofferdam remains in a substantially flat and unobtrusive position.

Abstract: A system includes a processing device and memory device storing instructions that result in accessing a first dataset including aerial imagery data and infrared data, accessing a second dataset including property boundary data, and identifying property boundaries associated with a geographic area. A plurality of models is applied to the datasets to identify and compute information of interest. Based on the first dataset and constrained by the property boundaries, a building detection model can be applied to identify a building, and a vegetation detection model can be applied to identify one or more areas of vegetation. An estimated distance can be determined between each of the areas of vegetation and the building as separation data, which can be compared to a defensible space guideline to determine a defensible space adherence score. A wildfire risk map can be generated, including the defensible space adherence score associated with the geographic area.

Abstract: A dynamically deployable, low visibility pneumatic cofferdam for flood mitigation is disclosed. The cofferdam includes a first planar component, a second planar component, an inflatable hermetic airbag sandwiched therebetween, and connection members attached to the first planar component, a second planar component to form a cofferdam unit. The connection members are adjustable to apply and maintain a desired amount of pressure on the airbag to enable a watertight seal to be formed. The cofferdam units may be sized and designed to sealingly mate adjacent cofferdam units in a variety of configurations to form watertight seals. The cofferdam units may also be sized and designed to attach to seawalls, flood walls, sidewalks, or other infrastructure. When in a deployed state, the height of the cofferdam may be adjusted to a desired height to provide flood mitigation. When in an undeployed state, the cofferdam remains in a substantially flat and unobtrusive position.

Abstract: A method includes accessing a first dataset including aerial imagery data, accessing a second dataset including property boundary data, and identifying property boundaries associated with a geographic area. A plurality of artificial-intelligence (AI) models are applied to the datasets to identify and compute information of interest. Based on the first dataset and constrained by the property boundaries, a building detection model can be applied to identify a building footprint, and a tree detection model can be applied to identify one or more trees. An estimated distance can be determined between each of the trees and a nearest portion of the building footprint as separation data, which can be compared to a defensible space guideline to determine a defensible space adherence score. A wildfire risk map can be generated, including the defensible space adherence score associated with the geographic area.

Abstract: A security system for a building includes a plurality of lock modules. Each lock module is associated with a particular door and has an unlocked position and a locked position. Each lock module includes a lock bar, an actuator, and a controller. The lock bar has a first position that allows the particular door to open and a second position that extends from a door frame, a wall, or a floor surface adjacent to the particular door to prevent the particular door from opening. The actuator moves the lock bar between the first and second positions. The controller is operably connected to the actuator and transmits a door status signal that uniquely identifies the particular door. A lock module command signal received by the plurality of lock modules directs the plurality of lock modules to reposition to either the unlocked position or the locked position.

Abstract: Methods of shaping a glass sheet are described comprising heating the glass sheet to a temperature for shaping; positioning the glass sheet on a shaping support; shaping the glass sheet on the shaping support, wherein during the shaping of the glass sheet at least one portion of the glass sheet is deliberately cooled. In preferred embodiments, the shaping of the glass sheet involves press bending a heat softened glass sheet between a lower shaping support and an upper shaping member, and wherein during the shaping of the glass sheet on the shaping support only a portion of the major surface of the glass sheet facing the lower shaping support is cooled by directing one or more jet of air onto said portion.

Abstract: A furnace includes a gas burner exposed to a heat-exchange tube. An inducer is fluidly coupled to the heat-exchange tube and configured to induce draft air through the heat-exchange tube. A regulator is fluidly coupled to the gas burner. A rollout shield is disposed adjacent to the gas burner. A rollout switch is disposed in the rollout shield. The rollout switch is electrically coupled to the regulator. At least one vent is formed through the rollout shield adjacent to the rollout switch. The vent provides a path for a rollout flame to the rollout switch. The at least one vent is disposed on at least two sides of the rollout switch.

Abstract: This invention is directed to a compound of formula (1): wherein R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising the compound, intermediates and processes for making said compounds, and the use of the compound to treat allergic and/or inflammatory disorders, particularly disorders such as allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD) and age-related macular degeneration (AMD).