Patents by Inventor George B. Sigal

George B. Sigal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular recognition at surfaces derivatized with self-assembled monolayers
    Patent number: 6472148
    Abstract: An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: October 29, 2002
    Assignee: President and Fellows of Harvard College
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides
  • Molecular recognition at surfaces derivatized with self-assembled monolayers
    Publication number: 20020042074
    Abstract: An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Application
    Filed: July 25, 2001
    Publication date: April 11, 2002
    Applicant: President and Fellows of Harvard College
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides
  • Molecular recognition at surfaces derivatized with self-assembled monolayers
    Patent number: 6322979
    Abstract: An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: November 27, 2001
    Assignee: President and Fellows of Harvard College
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides
  • Methods and apparatus for improved luminescence assays using microparticles
    Patent number: 6319670
    Abstract: The present invention relates to methods, reagents and compositions, for conducting electrochemiluminescence binding assays which improve one or more characteristics of the assay or the instruments used to conduct the assay. The method is achieved using microparticles that include electrically conductive material. The electrically conductive material has one or more copies of an assay ligand immobilized an its outer surface and a plurality of electrochemiluminescent moieties immobilized an its outer surface. The assay ligand may be linked to the electrochemiluminescent moiety.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: November 20, 2001
    Assignee: Meso Scale Technology LLP
    Inventors: George B. Sigal, Jacob N. Wohlstadter, Satyanarayana Gudibande, Mark T. Martin, James L. Wilbur
  • Assays for measuring nucleic acid damaging activities
    Patent number: 6214552
    Abstract: A method for assaying a sample for a nucleic acid damaging activity using at least one singular double-stranded nucleic acid with at least one electrochemiluminescent label, and a method for measuring an inhibitor of a nucleic acid damaging activity with at least one singular double-stranded nucleic acid using at least one electrochemiluminescent label, are disclosed.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: April 10, 2001
    Assignee: IGEN International, Inc.
    Inventors: Jeffrey A. Heroux, George B. Sigal, Reid W. von Borstel
  • Molecular recognition at surfaces derivatized with self-assembled monolayers
    Patent number: 6197515
    Abstract: An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: March 6, 2001
    Assignee: Harvard University
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides
  • Molecular recognition at surfaces derivatized with self-assembled monolayers
    Patent number: 5620850
    Abstract: An article suitable for use as a biosensor includes a species of a formula X--R--Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: April 15, 1997
    Assignee: President and Fellows of Harvard College
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides