Patents by Inventor George C. Rovnyak

George C. Rovnyak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzoic acid derivatives and related compounds as antiarrhythmic agents
    Patent number: 6624309
    Abstract: Benzoic acid derivatives of the formula where X is oxygen, sulfur, —NH, —NR1, —N—CN, —N—OR1 or —N—NO2; Y is a single bond, —C═C—, or —NH; R1 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclo, or (heterocyclo)alkyl; and R2 is aryl or heterocyclo. The compounds of formula I are useful in the treatment of arrhythmia.
    Type: Grant
    Filed: September 25, 2002
    Date of Patent: September 23, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: John Lloyd, George C. Rovnyak, Philip D. Stein, Saleem Ahmad, Karnail S. Atwal, Thomas J. Caulfield, Michael A. Poss
  • Benzoic acid derivatives and related compounds as antiarrhythmic agents
    Publication number: 20020137968
    Abstract: Benzoic acid derivatives of the formula I 1
    Type: Application
    Filed: October 10, 2001
    Publication date: September 26, 2002
    Inventors: John Lloyd, George C. Rovnyak, Philip D. Stein, Saleem Ahmad, Karnail S. Atwal, Thomas J. Caulfield, Michael A. Poss
  • 4-arylamino-benzopyran and related compounds
    Patent number: 5837702
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH.sub.2 --, --C(O)--, --O--, --S-- or --N(R.sup.8)-- where R.sup.8 is hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl, and R.sup.1 to R.sup.7 are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: November 17, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: George C. Rovnyak, Karnail S. Atwal, Dinos P. Santafianos, Charles Z. Ding
  • Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
    Patent number: 5414017
    Abstract: Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R.sub.3 is hydrogen, acyl, or benzyl; and R.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, phenyl-alkylene, heterocyclic-alkylene, etc. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • Trifluoromethyl mercaptan and mercaptoacyl derivatives and method of using same
    Patent number: 5414013
    Abstract: Compounds of the formula ##STR1## wherein Z is ##STR2## proline, pipecolic acid, an indolecarboxylic acid or an isoquinolinecarboxylic acid. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: May 9, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • Aryl urea (thiourea) and cyanoguanidine derivatives
    Patent number: 5374643
    Abstract: Novel compounds useful, for example, in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or --NCN and the R groups are as defined herein.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: December 20, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail S. Atwal, George C. Rovnyak
  • Chromanyl substituted indole potassium channel openers
    Patent number: 5310932
    Abstract: Novel compounds are disclosed having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are as defined herein.
    Type: Grant
    Filed: September 11, 1991
    Date of Patent: May 10, 1994
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, George C. Rovnyak
  • 3,3,3-trifluoro-2-mercaptomethyl-N-tetrazolyl substituted propanamides and method of using same
    Patent number: 5223516
    Abstract: Compounds of the formula ##STR1## wherein Y can be tetrazolyl are disclosed. These compounds are useful as cardiovascular agents.
    Type: Grant
    Filed: April 24, 1991
    Date of Patent: June 29, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
  • 2-thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters
    Patent number: 5202330
    Abstract: Pyrimidine compounds of the formula ##STR1## wherein X is sulfur or oxygen, Y is R.sub.11 or --O--R.sub.1, and R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents, particularly anti-hypertensive agents, due to their calcium entry blocking vasodilator activity.
    Type: Grant
    Filed: January 5, 1987
    Date of Patent: April 13, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, George C. Rovnyak, Spencer D. Kimball
  • Dihydropyrimidine macrocyclic lactones useful as calcium antagonists and agonists
    Patent number: 5143915
    Abstract: A compound of the formula ##STR1## (symbols defined in the specification), its 3,4-dihydropyrimidine tautomer form and pharmaceutically acceptable salts thereof have calcium entry blocking activity. A process of preparation, pharmaceutical composition and method of using the compound to reduce blood pressure are also provided.
    Type: Grant
    Filed: July 25, 1990
    Date of Patent: September 1, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: George C. Rovnyak, Spencer D. Kimball
  • Dihydropyrimidine lactone derivatives
    Patent number: 5103006
    Abstract: Novel compounds of the formula ##STR1## wherein X is sulfur or oxygen, R.sub.2 is aryl or heterocyclo and R.sub.1 is as defined herein, are disclosed. Compounds of formula I possess calcium channel activating activity.
    Type: Grant
    Filed: August 21, 1990
    Date of Patent: April 7, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: George C. Rovnyak, Spencer D. Kimball
  • Benzazepine and benzothiazepine derivatives
    Patent number: 4902684
    Abstract: Vasodilating activity is exhibited by compounds having the formula ##STR1## wherein X can be --S--or --CH.sub.2 --; andR.sub.2 is ##STR2##depending upon the definition of X.
    Type: Grant
    Filed: May 22, 1989
    Date of Patent: February 20, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David M. Floyd, John T. Hunt, Spencer D. Kimball, John Krapcho, Jagabandhu Das, George C. Rovnyak, Joel C. Barrish
  • 1,2,3,4-Tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo (or oxo)-5-pyrimidinecarboxylic acids and esters
    Patent number: 4855301
    Abstract: Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;R is hydrogen, alkyl, cycloalkyl, aryl, or arylalkyl and R.sub.1 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, ##STR2## or halo substituted alkyl, or R and R.sub.1 taken together with the nitrogen atom to which they are attached are 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl or 1-pyrrolidinyl, 1-piperidinyl, or 1-azeipinyl substituted with alkyl, alkoxy, alkylthio, halo, trifluoromethyl or hydroxy;R.sub.2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, ##STR3## or halo substituted alkyl; R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, ##STR4## or halo substituted alkyl; R.sub.4 is aryl or heterocyclo;R.sub.5 and R.sub.6 are each independently hydrogen, alkyl, --(CH.sub.2).sub.q --aryl or --(CH.sub.2).sub.
    Type: Grant
    Filed: February 9, 1987
    Date of Patent: August 8, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, George C. Rovnyak
  • Pyrimidinecarboxylic acid derivatives
    Patent number: 4753946
    Abstract: Pyridine compounds of the formula ##STR1## wherein R.sub.4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents due to their calcium entry blocking vasodilator activity.
    Type: Grant
    Filed: April 8, 1987
    Date of Patent: June 28, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Karnail Atwal, George C. Rovnyak
  • Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors
    Patent number: 4555579
    Abstract: Angiotensin converted enzyme inhibitor activity if exhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is hydrogen, aryl, or heteroaryl; R.sub.2 is hydrogen, amino, alkanoylamino, arylcarbonylamino, or heteroarylcarbonylamino;R.sub.3 is hydrogen, alkyl, or aminoalkyl;R.sub.4 and R.sub.5 are the same or different and each is hydrogen, alkyl, halogen, aryl, arylalkyl, hydroxy, alkoxy, alkylthio, aryloxy, arylthio, or cycloalkyl, or R.sub.4 and R.sub.5 taken together are oxo, ethylenedithio or propylenedithio;one of R.sub.6 and R.sub.7 is ##STR2## and the other is hydrogen, alkyl or arylalkyl; R.sub.8 is hydrogen, alkl or aryl;R.sub.9 is hydrogen or alkyl;n is 0 or an integer of 1 to 8;m is 0 or 1; andA is --(CH.sub.2).sub.p --wherein p is 0 or 1, --NH--, or --O--.
    Type: Grant
    Filed: March 24, 1983
    Date of Patent: November 26, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Bis-amidine indene ketones, compositions containing same and method of use
    Patent number: 4371543
    Abstract: Bis-amidine indene ketones are provided having the structure ##STR1## wherein R is hydrogen, lower alkyl or aryl; and R.sup.1 is hydrogen, lower alkyl, halogen, carboxy, trifluoromethyl, lower alkoxy, hydroxy or acyl, and acid-addition salts thereof. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species are also provided.
    Type: Grant
    Filed: June 5, 1981
    Date of Patent: February 1, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Phosphinylalkanoyl substituted 4,5-dihydropyrazole-5-carboxylic acid derivatives and hypotensive method and composition
    Patent number: 4371526
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: August 21, 1981
    Date of Patent: February 1, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Bis-(amidine phenyl)cyclohexanecarboxylic acid ketones, compositions containing same and method of use
    Patent number: 4341797
    Abstract: Bis-(amidine phenyl)cyclohexanecarboxylic acid ketones are provided having the structure ##STR1## wherein R is hydrogen, lower alkyl or aryl and n is 0, 1 or 2, and acid-addition salts thereof. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species are also provided.
    Type: Grant
    Filed: June 5, 1981
    Date of Patent: July 27, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Bis-amidine ketones, compositions containing same and method of use
    Patent number: 4325958
    Abstract: Bis-amidine ketones are provided having the structure ##STR1## wherein X is S, SO.sub.2, O or NR.sup.1 ; R is hydrogen, lower alkyl or aryl; and R.sup.1 is hydrogen, lower alkyl, acyl, aroyl or aryl-lower alkyl, and acid-addition salts thereof. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species are also provided.
    Type: Grant
    Filed: June 5, 1981
    Date of Patent: April 20, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Dihydropyrazole-5-carboxylic acid and analogs
    Patent number: 4322541
    Abstract: Compounds having the formula ##STR1## wherein R.sub.3 and R.sub.5 each is independently hydrogen or alkyl are useful intermediates for the preparation of mercaptoacylamino acids having hypotensive activity.
    Type: Grant
    Filed: August 22, 1980
    Date of Patent: March 30, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak