Patents by Inventor George C. Rovnyak

George C. Rovnyak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mercaptoacyldihydropyrazole carboxylic acid derivatives
    Patent number: 4266065
    Abstract: Compounds having the formula ##STR1## and basic salts thereof, wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R.sub.6 is alkyl or aryl; R.sub.2 is hydrogen, alkyl, trifluoromethyl or pentafluoroethyl;R.sub.3 is hydrogen or alkyl;R.sub.4 is hydrogen, alkyl or arylalkyl;R.sub.5 is hydrogen or alkyl; andn is 0, 1 or 2;have hypotensive activity.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: May 5, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Mercaptoacyldihydropyrazole carboxylic acid derivatives
    Patent number: 4254267
    Abstract: Hypotensive activity is exhibited by compounds having the formula ##STR1## wherein: R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R.sub.5 is alkyl or aryl; R.sub.2 is hydrogen, alkyl, or haloalkyl;R.sub.3 is furanyl, thienyl or pyridyl;R.sub.4 is hydrogen, alkyl or arylalkyl; andn is 0, 1 or 2.
    Type: Grant
    Filed: October 25, 1979
    Date of Patent: March 3, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Mercaptoacyldihydropyrazole carboxylic acid derivatives
    Patent number: 4221804
    Abstract: Hypertension can be treated using compounds having the formula ##STR1## or a basic salt thereof, wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R.sub.5 is alkyl or aryl;R.sub.2 is hydrogen or alkyl;R.sub.3 is aryl;R.sub.4 is hydrogen, alkyl or arylalkyl andn is 0, 1 or 2.
    Type: Grant
    Filed: September 27, 1979
    Date of Patent: September 9, 1980
    Inventor: George C. Rovnyak
  • Mercaptoacylpyrazolidinone carboxylic acid derivatives
    Patent number: 4220791
    Abstract: Compounds having the formula ##STR1## and basic salts thereof, wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R.sub.5 is alkyl or aryl; R.sub.2 is hydrogen or alkyl;R.sub.3 is hydrogen, alkyl, aryl or arylalkyl; andR.sub.4 is hydrogen, alkyl, or arylalkyl;have useful hypotensive activity.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: September 2, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Mercaptoacyldihydropyrazole carboxylic acid derivatives
    Patent number: 4211786
    Abstract: Hypertension can be treated using compounds having the formula or a basic salt thereof, whereinR.sub.1 is hydrogen, alkyl, aryl, arylalkyl or ##STR1## wherein R.sub.5 is alkyl or aryl;R.sub.2 is hydrogen or alkyl;R.sub.3 is aryl;R.sub.4 is hydrogen, alkyl or arylalkyl andn is 0, 1 or 2.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: July 8, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Substituted pyrano[4,3-c]pyrazoles, compositions containing same, and method of use
    Patent number: 4178379
    Abstract: 2,4,6,7-Tetrahydropyrano[4,3-c]pyrazoles are provided having the formula ##STR1## wherein Z is O, S, SO or SO.sub.2 ; R is H, halo, lower alkyl, lower alkoxy, lower alkanoyl, aroyl, cyano or CF.sub.3 ; and R' is H, lower alkyl, aryl-lower alkyl, aryl or halo-lower alkyl. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species is also provided.
    Type: Grant
    Filed: June 7, 1978
    Date of Patent: December 11, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Substituted pyrano[4,3-d]-thiazolo[3,2-a]pyrimidines
    Patent number: 4128648
    Abstract: 2,3,8,9-Tetrahydro-5H,6H-pyrano[4,3-d]thiazolo[3,2-a]pyrimidines of the structure ##STR1## are provided wherein R.sup.1 and R.sup.2 may be the same or different and are hydrogen, lower alkyl, halogen, cyano, carbethoxy, carboxyl, trifluoromethyl or lower alkoxy, and n is 2 or 3, and m is 0 to 2. These compounds are useful in the treatment of auto-immune disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: December 5, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Substituted thiazolo [3,2-a]-thiopyrano[4,3-d]pyrimidines
    Patent number: 4128647
    Abstract: 2,3,8,9-Tetrahydro-5H,6H-thiazolo[3,2-a]thiopyrano[4,3-d]pyrimidines of the structure ##STR1## are provided wherein R is hydrogen, lower alkyl, halogen, acyl, cyano, carboxyl, trifluoromethyl or lower alkoxy, n is 0 or 2 and m is 2 or 3. These compounds are useful in the treatment of auto-immune disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: December 5, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Substituted thiopyrano(4,3-b)pyrans
    Patent number: 4127667
    Abstract: 3,4,7,8-Tetahydro-2H,5H-thiopyrano[4,3-b]pyrans of the structure ##STR1## are provided wherein X is O, S or SO.sub.2, R is hydrogen, halogen, lower alkyl, lower alkoxy, cyano or trifluoromethyl, and R' is carbethoxy, carboxy, alkali metal carboxylate and cyano. These compounds are useful as antiinflammatory agents and anti-hypertensive agents.
    Type: Grant
    Filed: April 5, 1978
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Pyrazolo (1,5-c) quinazoline derivatives and related compounds
    Patent number: 4110452
    Abstract: Compounds are provided having the structure ##STR1## wherein R.sup.1 is alkylamino, dialkylamino, or ##STR2## wherein alkyl in the above groups contains 1 to 4 carbons; R.sup.2 is alkylamino, dialkylamino or ##STR3## wherein alkyl in the above groups contains 1 to 4 carbons; at least one of R.sup.1 and R.sup.2 being alkylamino or dialkylamino; R.sup.3 is hydrogen, lower alkyl, benzyl or phenyl (optionally substituted with R.sup.8), or ##STR4## (wherein R.sup.6 is amino, alkylamino or dialkylamino, and R.sup.7 is alkyl); and R.sup.4, R.sup.5 and R.sup.8 are the same or different and represent hydrogen, lower alkyl, lower alkoxy, alkanoyloxy, benzyloxy, hydroxy, halogen (Cl, Br and F), nitro and trifluoromethyl.
    Type: Grant
    Filed: October 17, 1977
    Date of Patent: August 29, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: George C. Rovnyak, B. Richard Vogt
  • 1,3,Thiazolinyl and 1,3 thiazinyl substituted indolinones
    Patent number: 4053613
    Abstract: Indolinone compounds which exhibit anti-inflammatory activity have the following formula ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, and n are as defined herein.
    Type: Grant
    Filed: September 17, 1975
    Date of Patent: October 11, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: George C. Rovnyak, Venkatachala Lakshmi Narayanan, Rudiger D. Haugwitz
  • Benzylidene pyrano[4,3-c]pyrazoles
    Patent number: 4003890
    Abstract: Compounds having the formula wherein R.sub.1 is hydrogen, hydroxy, alkyl, alkoxy, alkylthio, trifluoromethyl, halogen, nitro, cyano, dialkylamino or alkylsulfinyl; and R.sub.2 is hydrogen, alkyl, aryl, arylalkyl, acyl or an aminoalkylene have useful antiinflammatory activity.
    Type: Grant
    Filed: May 27, 1976
    Date of Patent: January 18, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Substituted indolinones
    Patent number: 4002749
    Abstract: Indolinone compounds which exhibit anti-inflammatory activity have the following formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, ##STR2## and n are as defined herein.
    Type: Grant
    Filed: August 12, 1975
    Date of Patent: January 11, 1977
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • 2,3,3A,4,6,7-Hex ahydro-2-heterocyclicalkyl-3-aryl-7-(arylmethylene)thiopyrano[4,3-c]pyraz oles and analogs thereof
    Patent number: 3994880
    Abstract: Anti-inflammatory activity is exhibited by compounds having the formula ##SPC1##The salts thereof, and the 5-oxide and 5,5-dioxide thereof, wherein A is a straight or branched chain alkylene group; R.sub.1 is hydrogen, alkyl, alkoxy, trifluoromethyl, halogen, nitro, dialkylamino, or alkylsulfinyl; and Z is CH.sub.2, oxygen or N-R.sub.2, wherein R.sub.2 is hydrogen, alkyl, aryl, or arylalkyl.
    Type: Grant
    Filed: April 21, 1976
    Date of Patent: November 30, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John Krapcho, Chester F. Turk, George C. Rovnyak
  • Thiopyrano[4,3-c] pyrazoles
    Patent number: 3979381
    Abstract: Anti-inflammatory activity is exhibited by compounds having the formula ##SPC1##The salts thereof, and the 5-oxide and 5,5-dioxide thereof, wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl, or acyl; and R.sub.2 and R.sub.3 are the same or different and are hydrogen, alkyl, hydroxy, alkoxy, alkylthio, alkylsulfinyl, trifluoromethyl, halogen, acyl, cyano, nitro, or dialkylamino.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: September 7, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • 3A,4,6,7- Tetrahydro-3-phenyl-7-(phenylalkylene)-thiopyrano[4,3-C]pyrazole-2(3H)-al kanamine, and analogs
    Patent number: 3962222
    Abstract: Anti-inflammatory activity and hypotensive activity are exhibited by compounds having the formula ##SPC1##The salts thereof, and the 5-oxide and 5,5-dioxide thereof, wherein A is a straight or branched chain alkylene group; R.sub.1 is hydrogen, alkyl, alkoxy, trifluoromethyl, or halogen; R.sub.2 is hydrogen or alkyl; and R.sub.3 is hydrogen, alkyl, phenyl, or phenylalkyl.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: June 8, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John Krapcho, Chester F. Turk, George C. Rovnyak