Patents by Inventor George Church

George Church has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted polypeptide degradation
    Publication number: 20050152888
    Abstract: This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.
    Type: Application
    Filed: December 3, 2004
    Publication date: July 14, 2005
    Applicant: President and Fellows of Harvard College
    Inventors: George Church, Daniel Janse
  • Characterization of individual polymer molecules based on monomer-interface interactions
    Patent number: 6015714
    Abstract: A method for sequencing a nucleic acid polymer by (1) providing two separate, adjacent pools of a medium and an interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage from one pool to the other pool of only one nucleic acid polymer at a time; (2) placing the nucleic acid polymer to be sequenced in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the nucleic acid polymer passes through the channel so as to sequence the nucleic acid polymer.
    Type: Grant
    Filed: June 16, 1998
    Date of Patent: January 18, 2000
    Assignees: The United States of America as represented by the Secretary of Commerce, The Regents of the University of California
    Inventors: Richard Baldarelli, Daniel Branton, George Church, David W. Deamer, Mark Akeson, John Kasianowicz
  • Characterization of individual polymer molecules based on monomer-interface interactions
    Patent number: 5795782
    Abstract: A method is disclosed for characterizing a linear polymer molecule by measuring physical changes across an interface between two pools of media as the linear polymer traverses the interface and monomers of the polymer interact with the interface, where the physical changes are suitable to identify characteristics of the polymer.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: August 18, 1998
    Assignees: President & Fellows of Harvard College, The Regents of the University of California
    Inventors: George Church, David W. Deamer, Daniel Branton, Richard Baldarelli, John Kasianowicz
  • Selective oxidation of 1,2-diphenyl-4-(2-phenylthio)ethyl)-3,5-pyrazolidinedione to the sulfinyl compound
    Patent number: 4288602
    Abstract: Herein is described a process for oxidizing 1,2-diphenyl-4-[2-(phenylthio)ethyl]-3,5-pyrazolidinedione with peroxymonosulfuric acid to obtain 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: September 8, 1981
    Assignee: American Home Products Corporation
    Inventors: George A. Church, Chih H. Chou