Patents by Inventor George Cotsarelis

George Cotsarelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180280475
    Abstract: The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 4, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: George Cotsarelis, Oh Sang Kwon
  • Patent number: 9889082
    Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analog or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: February 13, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: George Cotsarelis, Luis Garza
  • Publication number: 20170209475
    Abstract: This invention is directed to compositions for promoting wound healing and regeneration and methods of use thereof. In one aspect, methods for promoting wound healing in a subject are provided, the methods comprising: administering a therapeutically effective amount of a DNA methyl transferase inhibitors (DNMT) to the subject. In another aspect, methods for reducing scarring during healing of a skin wound are provided, the methods comprising: administering a therapeutically effective amount of a DNMT inhibitor.
    Type: Application
    Filed: July 21, 2015
    Publication date: July 27, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANNIA
    Inventors: George COTSARELIS, Jen-Chih HSIEH, Ying ZHENG
  • Patent number: 9700502
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: July 11, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: George Cotsarelis, Mayumi Ito
  • Patent number: 9642789
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: May 9, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: George Cotsarelis, Mayumi Ito
  • Publication number: 20160346186
    Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.
    Type: Application
    Filed: August 24, 2015
    Publication date: December 1, 2016
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: George COTSARELIS, Luis Garza
  • Publication number: 20160310395
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Application
    Filed: November 19, 2015
    Publication date: October 27, 2016
    Inventors: George COTSARELIS, Mayumi Ito
  • Patent number: 9254293
    Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analog or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: February 9, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: George Cotsarelis, Luis Garza
  • Patent number: 9220926
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: December 29, 2015
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: George Cotsarelis, Mayumi Ito
  • Publication number: 20150216934
    Abstract: The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
    Type: Application
    Filed: October 3, 2014
    Publication date: August 6, 2015
    Inventors: GEORGE COTSARELIS, OH SANG KWON
  • Publication number: 20150072963
    Abstract: The invention relates to compositions and methods for regulating hair growth. Specifically, the invention relates to regulating hair growth by regulating the activity one of the prostaglandin D2 (PGD2) receptors, DP-2 (GPR44). Compositions and methods for regulating hair growth include inhibiting hair growth by administering a DP-2 agonist, or stimulating hair growth by administering a DP-2 antagonist.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 12, 2015
    Inventors: George Cotsarelis, Garret Fitzgerald, Luis Garza
  • Patent number: 8871711
    Abstract: The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: October 28, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: George Cotsarelis, Oh Sang Kwon
  • Patent number: 8252749
    Abstract: The invention features methods, kits, and compositions for generating new hair follicles and growing hair on a subject.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: August 28, 2012
    Assignees: Follica, Inc., The Trustees of the University of Pennsylvania
    Inventors: David Steinberg, Kevin Pojasek, Stephen Prouty, George Cotsarelis, Mayumi Ito
  • Publication number: 20120156228
    Abstract: The invention features methods, kits, and compositions for generating new hair follicles and growing hair on a subject.
    Type: Application
    Filed: September 9, 2011
    Publication date: June 21, 2012
    Applicants: Follica, Inc., The Trustees Of The University of Pennsylvania
    Inventors: David Steinberg, Kevin Pojasek, Stephen Prouty, George Cotsarelis, Mayumi Ito
  • Publication number: 20120121693
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Application
    Filed: December 15, 2011
    Publication date: May 17, 2012
    Inventors: George COTSARELIS, Mayumi Ito
  • Publication number: 20110282267
    Abstract: The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
    Type: Application
    Filed: November 11, 2009
    Publication date: November 17, 2011
    Inventors: George Cotsarelis, Oh Sang Kwon
  • Publication number: 20110152746
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Application
    Filed: October 14, 2010
    Publication date: June 23, 2011
    Inventors: George COTSARELIS, Mayumi Ito
  • Publication number: 20110092421
    Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.
    Type: Application
    Filed: October 14, 2010
    Publication date: April 21, 2011
    Inventors: GEORGE COTSARELIS, MAYUMI ITO
  • Publication number: 20110021599
    Abstract: This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.
    Type: Application
    Filed: June 15, 2007
    Publication date: January 27, 2011
    Inventors: George Cotsarelis, Luis Garza
  • Publication number: 20100120768
    Abstract: The invention features methods, kits, and compositions for generating new hair follicles and growing hair on a subject.
    Type: Application
    Filed: September 27, 2007
    Publication date: May 13, 2010
    Inventors: David Steinberg, Kevin Pojasek, Stephen Prouty, George Cotsarelis, Mayumi Ito