METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS, AND HAIR REMOVAL

Info

Publication number: 20200101000
Type: Application
Filed: Dec 17, 2018
Publication Date: Apr 2, 2020
Applicant: The Trustees of the University of Pennsylvania (Philadelphia, PA)
Inventors: George Cotsarelis (Berwyn, PA), Mayumi Ito (New York, NY)
Application Number: 16/222,705

Abstract

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

Description

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 14/946,512, filed on Nov. 15, 2015, which is a continuation of U.S. patent application Ser. No. 13/327,611, filed on Dec. 15, 2011, which is a continuation of U.S. patent application Ser. No. 11/887,104, filed Sep. 25, 2007, which is a National Phase Application of PCT International Application PCT/US06/11319, filed Mar. 28, 2006, claiming priority to U.S. Provisional Patent Applications 60/665,857 and 60/683,293, filed 29 Mar., 2005, and 23 May, 2005, respectively. Additionally, this application relates to U.S. patent application Ser. Nos. 12/904,822 and 12/904,981, both filed on Oct. 14, 2010. All of the above-identified applications are incorporated by reference herein in their entirety.

FIELD OF INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

BACKGROUND OF THE INVENTION

Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias.

SUMMARY OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

In one embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting the epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge.

FIG. 2: BrdU labeling of HF following epidermal abrasion. HF at progressive stages of development are depicted in the left, center, and right panels.

FIG. 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction.

FIG. 4. Appearance of hair germs 12 days after wound induction. Arrow indicates hair germ.

FIG. 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels.

FIG. 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: HF at a further developmental stage.

FIG. 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development.

FIG. 8. Induction of several markers of embryonic HF development, Lef1 (left panel), wingless/int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads.

FIG. 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels.

FIG. 10. Induction of HF markers S100A3 (left panel; tissue section parallel to HF axis) and S100A6 (right panel; cross-sectional view of follicle) by EDIHN.

FIG. 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction.

FIG. 12. Schematic of whole-mount EDIHN assay.

FIG. 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50×. Right panel: higher magnification: 400×.

FIGS. 14A-14B. FIG. 14A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as panel but viewed under white light; right panel: tissue sections. FIG. 14B. Neogenesis HF proceed to next hair cycle.

FIG. 15. Schematic of creation of new HF by EDIHN.

FIG. 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top panel: macroscopic examination; bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis.

FIG. 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10× magnification. Inserts: 80× magnification.

FIG. 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K17 staining of the epidermis. Main panels: 10× magnification. Inserts: 80× magnification.

FIG. 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately following wounding. Right panel: 10 days following wounding.

FIGS. 20A-20B. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. FIG. 20A. Top panel: lower left panel AP staining of the dermis; lower right panel: K17 staining of the epidermis. FIG. 20B. Graphical representation of enhancement of EDIHN by depilation.

FIGS. 21A-21B. FIG. 21A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days after induction of an excisional wound. Arrows indicate new HF. FIG. 21B.

Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S100A6 (first, second, and fourth rows) or S100A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17 d post wounding was included as a control (top left panel).

FIGS. 22A-22C. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (FIG. 22A). Mean values and standard errors of the up-regulated transcripts in non-activated (“bs-line”) and activated (“expt”) samples and fold-changes and differences between non-activated and activated values are depicted. (FIG. 22B). Raw data for up-regulated transcripts in non-activated and activated cells. “Ctrl” denotes non-activated and “High-dep” denotes activated cells. (FIG. 22C). Additional information about up-regulated transcripts.

FIGS. 23A-23B. Pigmented hair follicle neogenesis observed in the skin of Dkk1-expressing mice following EDIHN FIG. 23A. 3.2× magnification. FIG. 23B. 8× magnification.

FIG. 24. Control mice lacked pigmented HF.

FIGS. 25A-25D. EGF inhibits HF formation by EDIHN. FIG. 25A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4×. FIG. 25B. High magnification view (10×) of skin depicted in (FIG. 25A). FIG. 25C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4×. FIG. 25D. Higher magnification view (10×) of skin depicted in (FIG. 25D).

FIGS. 26A-26B. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. FIG. 26A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area in each panel. FIG. 26B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 μm.

FIGS. 27A-27C. FIG. 27A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. FIG. 27B. Quantiation of experiment with 4 week old mice. FIG. 27C. Quantiation of experiment with 3 week old mice.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for generating a new HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor.

In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the compound or factor.

In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a precursor cell that is capable of differentiation into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a precursor cell that is capable of differentiation into a hair follicle cell, thereby treating an AGA in a scalp.

In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention.

“Contacting” as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention.

“Promotes a differentiation” refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to increasing the number of cells per unit area of skin that will differentiate. In another embodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention.

“Uncommitted epidermal cell” refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell.

The “HF cell” that results from the differentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administered in a solution. In another embodiment, the compound or factor is administered in a cream. In another embodiment, the compound or factor is administered in an ointment. In another embodiment, the compound or factor is administered in a slow release formulation. In another embodiment, the compound or factor is administered in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administered by any other method known in the art. Each possibility represents a separate embodiment of the present invention.

The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention.

As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12.

In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR® (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, N.Y.). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a β-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a β-catenin protein. In another embodiment, the compound or factor is an activator of a β-catenin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the β-catenin protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the present invention provides a use of (a) a β-catenin protein; (b) a nucleotide encoding a β-catenin protein; or (c) a compound or factor that activates a β-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the β-catenin protein, nucleotide, compound or factor.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF-bp1. Each possibility represents a separate embodiment of the present invention.

Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as “eda”; in another embodiment, as “ectodermodysplasin protein.”) In another embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as “edar”). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the eda protein of methods and compositions of the present invention has the sequence:

MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAA LHSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGP PGPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGT RENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFI YSQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVK MVHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_001005609, NM_001005610, NM_001005611, NM_001005612, NM_001005613, NM_001005614, NM_001005615, AF040628, AF061194, AF061193, AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the edar protein of methods and compositions of the present invention has the sequence:

MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPC GPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRAT VLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVG ATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAI AIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFS EKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPEL CLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPF DCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDR ISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275).

In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_021783; NM_022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence:

MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLN ETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGL EFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKR SCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L38518 and NP_000184. In another embodiment, the Hedgehog protein has any other Hedgehog sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-beta1 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta1 protein. In another embodiment, the compound or factor is an activator of a TGF-beta1 protein. In another embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta1 protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the TGF-beta1 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_000660. In another embodiment, the TGF-beta1 protein has any other TGF-beta1 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a mesenchymal cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention.

The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence:

MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCE VVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAG CTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRN YVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKH FKNCTSIS GDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFE NLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTS GQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEG EPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNT LVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIG LFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLI TQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT PQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWE LMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFS K MARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTS RTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYIN QSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSP AHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank Accession No: NM_005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_201282, NM_201283, NM_201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The EGF of methods and compositions of the present invention has, in another embodiment, the sequence:

MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGT NYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAIN WINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRAD LDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHN LFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDD TWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCT LGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVL ERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANS QDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERL IEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKR LFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGS KRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVV VHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGG EVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDA TCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDID ECQLGVHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSE CPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKV IVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSC PQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSS DKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank Accession No: NM_001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence:

MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQL S KKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPA LVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTD CLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAG GMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLV RAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQL LYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMS EDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGY GQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, AF130085, AB062292, Z19054, and NP_001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence:

MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIG EGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAAC TQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNL HNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVR ASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASG CDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession No: BC008811; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_004625, D83175, U53476, and NP_004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wnt1 protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt10b protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention.

As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention.

As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258-273. Each possibility represents a separate embodiment of the present invention.

As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject.

In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered simultaneously. Each possibility represents a separate embodiment of the present invention.

In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1-273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth. In another embodiment, the wnt pathway is stimulated before the hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention.

In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention.

In one embodiment, an RNA molecule of the present invention encodes a protein that plays a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development.

In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell.

In another embodiment of methods and compositions of the present invention, a composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention.

In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject.

In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject.

In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the minoxidil.

In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject.

In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkk1 protein. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor.

In another embodiment, a composition or method of the present invention is utilized on human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest.

An “inhibitor” utilized in methods and compositions of the present invention is, in another embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention.

The step of disrupting the epidermis in methods of the present invention is performed, in another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term “abrading” refers to an act of creating an abrasion. In another embodiment, “abrading” refers to rubbing. In another embodiment, “abrading” refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo-genesis. In another embodiment, the epidermal layer is disrupted.

In one embodiment, “abrasion” has the same meaning as “abrading.” In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, “abrasion” refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of “abrading” and “abrasion” represents a separate embodiment of the present invention.

As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well.

In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth.

“EDIHN,” in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; (d) measuring a second HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples).

In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo.

In one embodiment, the methods of the present invention of testing a compound are repeated using a plurality of subjects, until a statistically significant sample has been tested.

In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a “chamber” to introduce drugs and or cells into the reepithelialized area. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention.

The subject of methods of the present invention, is, in another embodiment, a human. As provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the subject is an adult. In one embodiment, “adult” refers to an age greater than about 18 years. In another embodiment, “adult” refers to an age greater than about 20 years. In another embodiment, “adult” refers to an age greater than about 25 years. In another embodiment, “adult” refers to an age greater than about 30 years. In another embodiment, “adult” refers to an age greater than about 35 years. In another embodiment, “adult” refers to an age greater than about 40 years. In another embodiment, “adult” refers to an age greater than about 45 years.

In another embodiment, the subject is elderly. In one embodiment, “elderly” refers to an age greater than about 45 years. In another embodiment, “elderly” refers to an age greater than about 50 years. In another embodiment, “elderly” refers to an age greater than about 55 years. In another embodiment, “elderly” refers to an age greater than about 60 years. In another embodiment, “elderly” refers to an age greater than about 65 years. In another embodiment, “elderly” refers to an age greater than about 70 years.

In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art.

In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention.

In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for inducing pigmentation of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wnt1. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt10a. In another embodiment, the Wnt protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject.

In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of a Dkk1 protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkk1 protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkk1 protein several days before generation of the follicle. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention.

In another embodiment, “several” refers to about 1 day. In another embodiment, “several” refers to about 2 days. In another embodiment, “several” refers to about 3 days. In another embodiment, “several” refers to about 5 days. In another embodiment, “several” refers to about 7 days. In another embodiment, “several” refers to about 10 days. In another embodiment, “several” refers to about 12 days. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each possibility represents a separate embodiment of the present invention.

“Disrupting” an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the epidermal layer need be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO₂laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal disruption comprises a burn treatment.

In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art.

In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, “mechanical means” refers to abrading. In another embodiment, the term refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to an electrical process or the use of an electrical current. In another embodiment, the term refers to electoporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption comprises chemical treatment. In another embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art.

Each method or type of method of epidermal disruption represents a separate embodiment of the present invention.

In another embodiment, epidermal trauma is utilized in a method of the present invention.

Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention.

In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention.

In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention.

In one embodiment, “following” refers to a period of time of about 2 days. In another embodiment, “following” refers to a period of time of about 3 days. In another embodiment, “following” refers to a period of time of about 4 days. In another embodiment, “following” refers to a period of time of about 5 days. In another embodiment, “following” refers to a period of time of about 7 days. In another embodiment, “following” refers to a period of time of about 10 days. In another embodiment, “following” refers to a period of time of about 2 weeks. In another embodiment, “following” refers to a period of time of about 3 weeks. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction.

In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the topical retinoid induces resting (telogen) HF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the additional step (depilation or administration of a retinoid) is performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation-promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell capable of inducing an epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/int (wnt). In another embodiment, the factor is a Noggin protein. In another embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation.

In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell.

In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention.

In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an HF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil®. In another embodiment, the anti-androgen compound is dutasteride. In another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti-androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti-androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention.

In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of the skin is treated. Each possibility represents a separate embodiment of the present invention.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom.

In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2′Z,3′E)-6-bromoindirubin-3′-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a separate embodiment of the present invention.

In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present invention.

In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention.

The terms “homology,” “homologous,” etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the alignment are well known in the art.

In another embodiment, the term “homology,” when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence.

In another embodiment, “homology” refers to identity of greater than 70%. In another embodiment, “homology” refers to identity of greater than 75%. In another embodiment, “homology” refers to identity of greater than 80%. In another embodiment, “homology” refers to identity of greater than 82%. In another embodiment, “homology” refers to identity of greater than 85%. In another embodiment, “homology” refers to identity of greater than 87%. In another embodiment, “homology” refers to identity of greater than 90%. In another embodiment, “homology” refers to identity of greater than 92%. In another embodiment, “homology” refers to identity of greater than 95%. In another embodiment, “homology” refers to identity of greater than 97%. In another embodiment, “homology” refers to identity of greater than 98%. In another embodiment, “homology” refers to identity of greater than 99%. In another embodiment, “homology” refers to identity of 100%.

Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software packages available, via established methods. Some of these packages may include the FASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention.

In another embodiment, the present invention provides a kit, comprising a tools and/or a compound suitable for performing a method of the present invention.

In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention.

Pharmaceutical Compositions

In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof; and a pharmaceutically acceptable carrier. Each possibility represents a separate embodiment of the present invention.

The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention.

In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule.

In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier.

In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time.

For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil.

In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration.

EXPERIMENTAL DETAILS SECTION Example 1 Depilation and Epidermal Abrasion Causes De Novo Hair Follicle Formation Materials and Experimental Methods Depilation and Epidermal Abrasion

Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, N.Y.), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm)²cm of the inter-follicular epidermis were removed by careful abrasion with a felt wheel mounted on a Dremel Moto-tool (Racine, Wis.). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis.

Immunohistochemistry

Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections were cut and stained, where applicable, with antibodies.

BrdU Labeling

The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2′-deoxyuridine (BrdU) every 12 hours for a total of four injections.

Results

An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of follicle neogenesis were present (FIG. 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in FIG. 2, the proliferation pattern was similar to developing follicles in the embryo.

These findings demonstrate that (a) disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50-day-old mice are in the second telogen stage of the hair cycle).

Example 2 Induction of a Large Excisional Wound, but not a Small Punch Wound, Causes De Novo Hair Follicle Formation Materials and Experimental Methods Punch Wound and Excisional Wound Induction

The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical scissors.

Results

To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (FIG. 3, left panel). No follicles were evident at this time point (FIG. 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (FIG. 4). Several markers were used to verify that the observed structures were HF. The structures exhibited staining with anti-keratin 17 (K 17), an HF marker (FIG. 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (FIG. 6; HF at earlier and later stages are depicted in the left and right panels, respectively).

The HF generated by wound induction were further characterized by morphological comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (FIG. 7). In addition, several markers of embryonic HF development, namely Lef1, wingless/int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (FIG. 8). Additional BrdU staining (FIG. 9) and staining for HF markers S100A3 and S100A6 (FIG. 10; left panel: tissue section parallel to HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development.

These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle).

Example 3 EDIHN-Induced Hair Follicles Generate Hairs

At 25 and 45 days after wound induction, wound sites contained new hairs (FIG. 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10).

These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs.

Example 4 EDIHN Hair Follicles Retain the Ability to Enter into Cyclical Hair Growth Materials and Experimental Methods BrdU Labeling

50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase).

Whole Mounting and Immunofluorescence

HF whole mounts were obtained by incubating fresh skin with EDTA (20 mM in PBS) at 37° C. overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in FIG. 12) and were imaged using a Leica confocal microscope.

Results

To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were observed (FIG. 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K15 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in FIG. 14A, eGFP-expressing cells were observed in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. (panel is same as panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties.

To determine whether EDIHN-induced HF cycle normally, mounts were prepared from additional mice at 35, 38 and 45 days after wounding. As depicted in FIG. 14B, the EDIHN-induced HF entered the resting phase, telogen, and then re-entered a new anagen stage.

In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN-induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K15-eGFP). This model is shown schematically in FIG. 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need.

Example 5 EDIHN-Induces New Hair Follicles in Mice at the Telogen Stage of the Hair Cycle

To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of new HF. As depicted in FIG. 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in FIG. 17, dermal papilla cells were detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (FIG. 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was consistent over three separate experiments, as depicted in Table 1.

TABLE 1 Results of three separate experiments performed on 21-day-old mice. Sample Expt 1 Expt 2 Expt 3 Avg of expts Std dev of expts 1 24 70 55 2 29 52 25 3 27 85 53 4 102 25 80 5 53 27 23 Average 47 51.8 47.2 48.67 2.71 Std dev 32.8 26.3 23.7

The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding.

Example 6 In Adult Mice, Induction of Anagen Increases the Efficiency of EDIHN

The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN.

TABLE 2 Efficiency of HF formation by EDIHN in adult mice at various stages of the hair cycle. Wound Days after Mice exhibiting Age size wound EDIHN Hair cycle 3 wk 1 cm 20 25/25 (100%) Telogen 4 wk 1 cm 20 5/5 (100%) Early anagen 5 wk 1 cm 20 1/2 (50%) Anagen 8 wk 1.5 cm 30 16/35 (46%) Telogen 14 wk 1.5 cm 30 1/2 (50%) N/A* 20 wk 1.5 cm 30 2/2 (100%) N/A* *The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20- week-old mice contained a mixture of telogen and anagen HF.

To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in FIG. 19, the wounds closed similarly whether or not they were preceded by depilation. As depicted in FIG. 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold.

The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only forming new HF, but also of activating anagen in pre-existing HF in the telogen stage.

Example 7 EDIHN-Induces New Hair Follicles in Human Skin Materials and Experimental Methods Grafting

Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting.

Results

To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (FIG. 21A; arrows indicate new HF) by hematoxylin and eosin staining of paraffin embedded tissue sections.

In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S100A6 or S100A4 (FIG. 21B).

The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin.

Example 8 Molecular Pathways Activated During HF Stem Cell Activation Materials and Experimental Methods Isolation and Activation of HF Stem Cells

K15-eGFP mice were depliated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 μg (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, Calif.) array MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated “bs-line” and activated (“expt”) samples.

Results

To identify molecular pathways up-regulated during HF stem cell activation, activated HF stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up-regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up-regulation of the transcripts and further information about them is provided in FIG. 22.

TABLE 3 RNA transcripts up-regulated during HF stem cell activation. 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uguuuaacucagcguauuuuauggaugaaagcuaaauacagauauuuggcaucucuaaggu ggaaugagcccacuccacacacugauaaaauucaugcauaguuuuaaaugaacauuaauaaa cucauguugucuu 9 U04443 gaauucaaggaggcuuuccagcuguuugaccgaacaggugauggcaagauccuguacagcc aguguggggaugugaugcgggcccugggccagaacccuaccaacgccgaggugcucaaggu ucuaggaacccccaagagugaugagaugaaugugaagguacuggacuuugagcacuuccug cccaugcugcagaccguggcgaagaacaaggcccagggaaccuacgaggauuauguugaagg ccuucguguguuugacaaggaaggaaauggcaccgucaugggugcugaaauccgucauguc cuagucacacugggcgagaagaugacagaggaagaaguagagaugcuaguggcagggcaug aggacagcaaugguugcaucaacuaugaagcauuugugaggcauauccugucggggugacg ggcccgauggggcggagcucguccggauggugcugaauggcugagacauucuguaucccga gucuguucccugcccagugugauuucuguguggcuccagacgcuccccugucacagcaccu ugucccauuugguuucuuuggaugauguuugccuucaccaaauaaaauuugcucucuuugc cc 10 Y07836 caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucaggg auggauuuugcccacauguaccaaguguacaaguccaggcggggaauaaaacggagcgaa gacagcaaggaaacuuacaaacugccgcaccggcugauugagaaaaagagacgugaccgg 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guuuguuugcaugguguccagcuuuguuucuucucugucaucaccaccuucaggcaaauaguugaccaaccacuggccug ugucuguccacccuccaaagcccaggccaccuuucuguuuucugaaauacugauccuuccuccugaauacaucccuccuug uuccuagcuucaagacugcugccucaaauagggauagagcaaguccccgcugcagguugugcuagaugggauggagaaauu aucuucauuugauacagagcaaguagauugucucgagagaaaaguuagcaugcgugguaugauuuguaaguaaagaugga agagagagagagagagagagagagagagagagagagagagagagagguagccauaucuaacagccuacuuaccaaagacccc aggccucucugcuuggcaugccuccuuucuguccauccucugaaccccagagauuagugagauuugaauaauuaaaucauu uucagagugaaggggguuaaugcagggucugugcuaggggaggguuuuagcuuuugguaacugaagauuuuuucaugga aaaagucuucguguucaaugugccuagaacugauaacuaaacagcugacauuugucggggacagauauggugugaaacuau gaaaauauaagcaaaaucuucacuuggaacaugaaacuauuucacuuagaaaauaaucgaaggacccgagguguugccugg guugccaguuucuuucguggcugggcaggaacuagugagguugaggggcagugucuguaaguagcugcuaagaggugca uuuccagaugaagcccuuggggaacaucugccagggauccgcaugguguuggcuccauccauugcuuuaguuuccuccuu ggauuguguagaaacuuggcuucccaugguuuugaaccuuccaugccuucuuugcuuuguggccacccagccugccuagu gcugccuaggaagcucuuacccaccugauuucuucugacauuucuuucuuuggccuuuuuuucuuucuccggacaugcag cuaguugccugaguguaucaagagcacccaggacuugcugcuguccaggccuguuccucccccaguauccgugggugugg aagagcuguguagcuucaggaagcagagccaggugccaccuuucuguggcuuccagauccucccuaccuccaacucaugug ccucugucacagugauuucaggaaagcuugguagacccucuagcaacaucucgguucagaaagucucucugguuugugag uuaacagcucagcuaagugcuguuuugucucagugaguuaaccacugaaugcgaggguugguuguugaucugucucggug ugugucggaguagacagcauaugcacuucucccugugcgcuuugcaagguaauguggcuuuggcugauccaugcaggcag guagugguacagugcugcugaaaggaagaaguuccccauuuuaucuguuaaaacaccagagacaugggcaagugcuaaugg accucacuucaggaagagggucugcuuccugaagccagugugugaugaaaagugacugagaccugauaucuaaggugagac cugauaccuaacacucugucacacaguccagggccaacagugcuauaggaaagucuagaagaaaacaucacaucaguauuuu agaaccaucaaccaucucuugucccuauagcccaauccagaggccugguuuuuagaacuggcuguguaaggugccaaacac ucaguucacuuguagaaucagagccuuuuuuccccccuauguuaauugaacacgcgcucugagcuguuuuguugaaguag aaaaucucauagaaaaaucacuguagaucuacugaccuauagcccucuggaaaugccuuugagaugguuuuacuuuucuag gucauagaugccugauuauaaagaugaacaauaaaaucagcuuucuuucuuucucuucugaucuuauuccccagaucugau ucaggccauguuccaaagcaaggcuacauugagguccuggugucuuuaaguaaaggacaucuuucagauccucucaaagaa ggauuuauaacaguuuccagaugaauguacuaauagcuuugggugccuuaucucuuuccuaaucuguagugccugugagc ucagucucacuccuucccuuagcccggagaccccuuagaucgagugggaauagucaagaggcuggcuggagagucaucagu acauugguuugcagaaaucuuuuacaggcuacauuuuggaauuuuuuuuuuuuuaguaagugaucaaauuuggugggaa guaauucgaguguauucgauuguauugucguccucguuaucauugucaaacauguuauagacggcaguuggcacuggggc ugcuaaucucuggguguagucucugaaacuguagcuccagugagguggugugaaagguuagcaaagccaccaucugcugg ugcuccagccaaggugccucuuagccacugaauugcuauguuauccuuucucuuguaacaaacccaccccagagauaaagcc uuuaaucaacccaagaaacuccugggcuaaguaucugacagucucacaucucaacagugugaauuaaguguccauagcauca gcucaggaggacacucugggagagugcugacaaaaaaggguuauuaauacugaccuacuacuucaagggcaguucugaggu gauuagagcuuuuuuuaaaaaccaaguauuuggggauccucagcagagguauucauacagacucccaaagaacuauauaug uuccugagaccaucguuuagucuacauugcucuucccagagacugacagauaugaccagucaaagugcaagacuaccuaccc acugccaugaaaaccauugcaggaaaccuuucccuuccugaaugagauuuuuuuuuucccuuuuuaugugggguaauuau uugugacccaaguguaauuuggaugauuuccauuaauaucaacucuugaagccuacuuguacugauugagauuguauuug uuccuaauaaaaguggaucugguuguacuguc 12 V00756 accacuugcagacaaaugaauuccuucgaaauguauuugagguuggacccccugugaugcu ugaugcugcaacacuuaaaaccaugaagauuucucguuuugaaaggcauuuauauaacucu gcagcuuucaaagcucgaacaaaagcucgaagcaaaugccgagauaagagagcagauguugg agaauucuuguagaugucugaauuugauggcuguuuucuaaucucuuccuuuauuauuau uuuugcuacuucuaauguauauaagcuuuuagagacaguuuuuuaucuuggucaacuuaaa uaauuuuugauguagggguggguuguauuuuaauuuaauguacaguguuacaaauuaaug aguucuuuauucucuguaaaaauaacugguaaccacaaauaaaguguuugugauguuuggu cgu 13 Y14296 auguccgcggccgccuacauggacuucguggcugcccagugucugguuuccaucuccaacc gcgccgccgugccggagcacgggggcgcuccggaagccgagcggcugcgacuaccugagcg cgaggugaccaaggaacacggugacccgggggacaccuggaaggauuauugcacgcugguc acuaucgccaagagcuuguuggaccucaacaaauaccgacccauccagacccccucggugug cagcgacagucuggagagucccgaugaggauauaggauccgacagcgacgugaccaccgaau cugggucgaguccuucccacagcccggaggagagacaggauucuggcagcgcgcccagccca cucucccuccuccacucuggaguggcuucgaaggggaaacacgccuccgaaaagaggcacaa gugccccuacaguggcugugggaaagucuauggaaaauccucccaucuuaaagcccauuaca gagugcauacaggugaacggcccuuucccugcacguggccagacugccuuaaaaaguucuc gcgcucggaugagcugacccgccacuaccggacccacacuggggaaaagcaguuccguugcc cacugugugagaagagauucaugaggagugaccaucucaccaagcaugcccggcgucacacc guguuccaucccagcaugaucaagagaucaaaaaaggcucuugccugccccuugugaggug cuccccauggcagccaggcagagauggguccccggaaggacagagcucccaggaaacagacu gacacauggaaaucugccacagcagaggcgcgcuggccacaggaggucacugcuucuuugg ccaauauucugauaucucccugcacuguuuccaaaaagcacaugguagcccuaaggucaaag ucaacauuugguccccuugcagaggcaacucugaaccgucucugacugaagauucagacug gugguguacauacgucunacugggugaguugaccccuggccucccacagugcagaaccacu cucuugaaucacauuaacuuuugagauuuaaaaaaaacccaaacccaacccnncaaaacncca ganacaccgaaacucuggauccucgaugcuugcugacucucagaauugnuunuucuucuca nuuaugcaagcnagagcacaccuacuccagcaugauuugucaucuaaagacuugaaaacaaa acaacaacaacanaaaguuacuuauagucaauggauaagcagaguccgaauuuacacuaauc aagacagaccuucgaggggucacgauaaguccggaacuuucaaaccuugcuucguaugaau uguacuaucugaacauaaacugcacuuuuauuuucuaauaccgagggugaauacgguaaau acaugcuuugaggguagaanccgacggucuguuuggcaccacguuauaaucugcunnuuuu aacgaguaccaccuuggagggcaggcaaauaaaugcuuuuggguauuuucuccuuuguuuu ugacaaaugcugcggaugggggaucgggaucggaggggagugcuuuuaaagauaauaaaaa augagguaaauaauuuuaacuuaugaauuuguuugaauuc 14 X16490 gagauugaaacaauggaagaacuuuccauggcaaacaccauguuugcccucaaucuccuu aagcagauagaaaaaucaaacucuacccagaacaucuuuaucucuccauggagcaucuca ucaacauuggccauaguucuccucggugcuggggguaacacugaacagcagauggccaaa gugcugcaguuuaaugaaauuggcaguuaugguaucaccacaagaaacccagagaacuuc aguggcugugauuucgcacaacagauacagaaggaaaauuauccuagugcuauuuuacagg cacaagcaggagauaaaauccauucagccuucuccucucucagcucaacaaucaacaca ccacagggggauuauuuguuagaaagugcaaacaagcuguuuggagagaagucugcaagau ucaaagaagaauacauccaacucucuaagaaauauuacucaacagaaccagaagcagug gacuuccuugaaugugcugaagaagcuagggaaaagauuaauucuugggucaagacucaaa ccaaaggugaaaucccaaaccugcuacccgaagguucuguagaugaagacaccaagauggug cuggugaaugcugucuacuucaaaggaaaguggaaaacuccauuugagaagaaacuuaaug ggcuuuauccuuuccgugugaacucgcaugagagcauaccuguccagaugauguuccucca ugcaaagcugaacauuggauacauaaaggaccugaagacucagauccuagaacuuccgcaua cuggaaacaucagcaugcuccuguugcuucccgaugagauugaggacgcauccacuggcuu ggaauugcuggaaagugaaauaaacuuugccaacuucaacaaguggaucagcaaagacacac uggaugaagaugauguuguggucuacauucccaaguucaaacuggcacaaagcuacgaacu caaguccauucuucaaagcaugggcauggaggaugccuucaacaagggcaaggccaacuucu caggaaugucugagaggaaugaccuuuuucuuucugagguguuccaucaagccagcgugga ugucaccgaggagggcacuguggcagcuggugggacuggggcaguuaugacaggaagaacu ggccaugguggcccacaguuuguggccgaucaucccuuucuuuucuuuaucauggacaaaa uuacccacacgauacuauuuguugguagauucuccucacccuaaaaggggaagaccuauuuc cacaugagguuuuguagcaugaacuauaagccucagaauugcaucuucaagugccaaaagu uuaaauacuuucuuacacauuuuuauacuucugcuauacacuaaauauaaccuaaaagcaau uguauagcagucuucagugcuuacaguauaacucuauuaaugauuuuguuuccuaaaguca gaugaugucuauuuaguucauccuuauuacugcuuugucuuuauaacuuuaguuuuuaca guguuauuuauuguuuauauaaugguuguuuuacaaauuguuguccucuguuuaaugaaa cuguaacacuacagaagcagaaaauuagauaauuuucuauuuaaagaaaaucagccauuuaa uuuaauaaugaaggaaaaauaugagucuuccauacuuucccaugauauucacccagaaaaaa uguacuuaacaaaagacauguuauaucucuaucauuauauaucauauguacguaucugcaac ucaucuauaauuaggacuacaucauaaguaagcaugcuuacuuacacacugcuaucuguug uauaaaacuuagcaauccuuauuuguuaguuaucuuucuaucacuguaacaaaauaccuga gauaauaaaguucaaagauuuauuuugaaaaaaaaaaaa 15 AW120868 uuuuuuuuuuuuuuunuaagaauuaacuuuuauuuuugcuuaguuuuauuaaaaaaauaa auaugucauaaagcuuuuguuuccuuuagggagaaaaaaaaggaacaaguuccauaaaauca aacaagcaaugguaacaugucuuaacuugaaaacaacuggggucacugguuuacaaguuaua acugaaugaaugacugccacaguugcccauuuccuccugccaauggcagcaaacaacaggau caacuagggcaaaauaaauaauuguguggaagcccuga 16 C78850 aacuaaacuuccuuguaacuuuugagaacucagcucugguacuuuuucaugccuugcaaaa uggcguuanugcagcuagcuugcuaanccuuaugguggggucuuucauuccccccucuuuc uggaaacugnauaaaaucauuuauucacgugauucuauuucuucuggaucuauugauuuga guuggugauacuguugggucanaaccagggccuguu 17 D67076 Sequence below. gcagcuccgagcuaggugcuaucgcaaggccagagcgcacagcccggcggagagagcagauccuugcucagaucgagucaa aucgggccaaggcggaggacgaagaguccaggcuccuauucuggacuuguuccccagcuccgggggcgcuucuagguccu gcagcagccagcagugcggagccaccaacucggugcuggaaugaaaaaauucccgcgcgccagugcagaaucuuucuaagu gacccggagcuucgggugcuagcucugcacgaacuuucccaucaaagugaucgugaauuuuaagcaucaggagcaggccag cgaagcucuacgcgucuaaacgucuauccagaccaagaguucucugcggugcagggugcggugccaugcagccaaaagucc cuuuuggggucacgcaagcagaagcccugcuccgacaugggggacguccagcgggcagcgagaucucggggcucucugucc gcacacaugcuguugcugcuccucgcuuccauaacaaugcugcuaugugcgcggggcgcacacgggcgccccacggaggaa gaugaggagcugguccugcccucgcuggagcgcgccccgggccacgauuccaccaccacacgccuucgucuggacgccuuu ggccagcagcuacaucugaaguugcagccggacagcgguuucuuggcgccuggcuucacccugcagacuguggggcgcag ucccggguccgaggcacaacaucuggaccccaccggggaccuggcucacugcuucuacucuggcacggugaacggugaucc cggcucugccgcagcccucagccucugugaaggugugcguggugccuucuaccuacaaggagaggaguucuucauucagcc agcgccuggaguggccaccgagcgccuggccccugccgugcccgaggaggagucauccgcacggccgcaguuccacauccu gaggcgaaggcggcggggcaguggcggcgccaagugcggcgucauggacgacgagacccugccaaccagcgacucgcgacc cgagagccagaacacccggaaccaguggccugugcgggaccccacgccucaggacgcgggaaagccaucaggaccaggaagc auaaggaagaagcgauuuguguccagcccccguuauguggaaaccaugcucguagcugaccaguccauggccgacuuccac ggcagcggucuaaagcauuaccuucuaacccuguucucgguggcagccagguuuuacaagcaucccagcauuaggaauuca auuagccuggugguggugaagaucuuggucauauacgaggagcagaagggaccagaaguuaccuccaaugcagcucucacc cuucggaauuucugcagcuggcagaaacaacacaacagccccagugaccgggauccagagcacuaugacacugcaauucugu ucaccagacaggauuuauguggcucccacacgugugacacucucggaauggcagauguuggaaccguaugugaccccagca ggagcugcucagucauagaagaugaugguuugcaagccgccuucaccacagcccaugaauugggccauguguuuaacaugc cgcacgaugaugcuaagcacugugccagcuugaauggugugaguggcgauucucaucugauggccucgaugcucuccagc uuagaccauagccagcccuggucaccuugcagugccuacauggucacguccuuccuagauaauggacacggggaauguuug auggacaagccccagaauccaaucaagcucccuucugaucuucccgguaccuuguacgaugccaaccgccagugucaguuua cauucggagaggaauccaagcacugcccugaugcagccagcacauguacuacccuguggugcacuggcaccuccgguggcu uacuggugugccaaacaaaacacuucccuugggcagauggcaccagcuguggagaagggaaguggugugucaguggcaag ugcgugaacaagacagacaugaagcauuuugcuacuccuguucauggaagcuggggaccauggggaccguggggagacug cucaagaaccuguggugguggaguucaauacacaaugagagaaugugacaacccagucccaaagaacggagggaaguacug ugaaggcaaacgaguccgcuacagguccuguaacaucgaggacuguccagacaauaacggaaaaacguucagagaggagcag ugcgaggcgcacaaugaguuuuccaaagcuuccuuugggaaugagcccacuguagaguggacacccaaguacgccggcguc ucgccaaaggacaggugcaagcucaccugugaagccaaaggcauuggcuacuuuuucgucuuacagcccaagguuguagau ggcacucccuguaguccagacucuaccucugucugugugcaagggcagugugugaaagcuggcugugaucgcaucauaga cuccaaaaagaaguuugauaaguguggcguuuguggaggaaacgguuccacaugcaagaagaugucaggaauagucacuag uacaagaccuggguaucaugacauugucacaauuccugcuggagccaccaacauugaagugaaacaucggaaucaaagggg guccagaaacaauggcagcuuucuggcuauuagagccgcugaugguaccuauauucugaauggaaacuucacucuguccac acuagagcaagaccucaccuacaaagguacugucuuaagguacagugguuccucggcugcgcuggaaagaauccgcagcuu uaguccacucaaagaacccuuaaccauccagguucuuaugguaggccaugcucuccgacccaaaauuaaauucaccuacuuu augaagaagaagacagagucauucaacgccauucccacauuuucugagugggugauugaagaguggggggagugcuccaag acaugcggcucagguuggcagagaagaguagugcagugcagagacauuaacggacacccugcuuccgaaugugcaaaggaa gugaagccagccaguaccagaccuugugcagaccuuccuugcccacacuggcaggugggggauuggucaccauguuccaaa acuugcgggaaggguuacaagaagagaaccuugaaaugugugucccacgaugggggcguguuaucaaaugagagcuguga uccuuugaagaagccaaagcauuacauugacuuuugcacacugacacagugcaguuaagaggcguuagaggacaagguagc guggggaggggcugauacacugagugcaagaguacuggagggauccagugagucaaaccaguaagcagugagguguggca aggagguguguguaggggauacauagcaaaggagguagaucaggacacuacccugccaguuacauucugauaagguaguu aaugaggcacaguagcaucugaaagaccauacagagcacuaaggagccccaaagcacuauuaguaucucuuuucuuauaucu aucgcccaaauaauuuucagagucuggcagaagcccuguugcacuguacuaacuagauacuucuuaucacaaagauuggga aaggcaaagcagaaagaugguaagacuggguuucaaacaaggcuugguuucaaucacuggaggcaaggaggaggggacaaa caagaucauuauucgaagucgcugguugcugugguuuuacggaagguugaugcaucauuccuaucaacagugaaaaguuc agcuuguucaacgugacagaaaggcucaucuccgugaaagagcuccugauuucuucuuacaccaucucaguucuuaacuau aguucauguugagguagaaacaauucaucuauuuauaaaauguacauuggaaaaaaaaagugaaguuuaugagguacacau aaaaacugaaggaaacaaugagcaacaugccuccugcuuugcuuccuccugagguaaaccugccuggggauugagguuguu uaagauuauccauggcucacaagaggcaguaaaauaauacauguugugccagaguuagaaugggguauagagaucaggguc ccaugagauggggaacauggugaucacucaucucacaugggaggcugcugcag 18 M61007 ccgcgggcccgcguucaugcaccgccugcuggccugggacgcagcaugccucccgccgcc gcccgccgccuuuagacccauggaaguggccaacuucuacuacgagcccgacugccuggc cuacggggccaaggcggcccgcgccgcgccgcgcgcccccgccgccgagccggccauugg cgagcacgagcgcgccaucgacuucagccccuaccuggagccgcucgcgcccgccgcgga cuucgccgcgcccgcgcccgcgcaccacgacuuccucuccgaccucuucgccgacgacua cggcgccaagccgagcaagaagccggccgacuacgguuacgugagccucggccgcgcggg cgccaaggccgcgccgcccgccugcuuuccgccgccgccucccgccgcgcucaaggcgga gccgggcuucgaacccgcggacugcaagcgcgcggacgacgcgcccgccauggcggccgg uuucccguucgcccugcgcgccuaccugggcuaccaggcgacgccgagcggcagcagcgg cagccuguccacgucgucgucguccagcccgcccggcacgccgagccccgccgacgccaa ggccgcgcccgccgccugcuucgcggggccgccggccgcgcccgccaaggccaaggccaa gaagacgguggacaagcugagcgacgaguacaagaugcggcgcgagcgcaacaacaucgc ggugcgcaagagccgcgacaaggccaagaugcgcaaccuggagacgcagcacaaggugcu ggagcugacggcggagaacgagcggcugcagaagaagguggagcagcugucgcgagagcu cagcacccugcggaacuuguucaagcagcugcccgagccgcugcuggccucggcgggcca cugcuagcgcggcgcgguggcguggggggcgccgcggccaccgugcgcccugccccgcgc gcuccggccccgcgcgcgcgcccggaccaccgugcgugcccugcgcgcaccugcaccugc accgaggggacaccgcgggcacaccgcgggcacgcgcggcgcacgcaccugcacagcgca ccggguuucgggacuugaugcaauccggaucaaacguggcugagcgcguguggacacggg acuacgcaacacacguguaacugucuagccgggcccugaguaaucaccuuaaagauguuc cugcgggguuguugauguuuuugguuuuguuuuuguuuuuuguuuuguuuuguuuuuu uuuuuggucuuauuauuuuuuuuguauuauauaaaaaaguucuauuucuaugagaaaaga gg cguauguauauuuugagaaccuuuuccguuucgagcauuaaagugaagacauuuuaauaa acuuuuuuggagaauguuuaaaagccaaaaaaaaaa 19 C85523 aaaauguagaaggcaagauuuaauaaggcagcaacaugaaagcacacagaccagagcucu ggggucgaaauaaagcagcaacauggaagcacacagagcucuggggucgaaacucauaca ccuuagcacaggguagaggagucucgacggucanccagaauuuuucacaggcuuauauag uaaaacucaaagggggagaacugggcagggaaaguacaaguuuacaucacuagggaguuc ugccaaaggacaanggguucunucagaggaaucuacguaacuaaggngucauguccuauc aaggnaucuacguaacuaaggagucauguccuaucauuuggcaauguacccggnucuuuu gagguuguuccggagggncuuauucucaaaauguuuuucagauuggaagggguggguunc cgguaaaaaguucuguuuucaaagaggcnguaauuuucuauucuucauuccccauucucc uguaaguauucnnaucuuagaauuucagaaguccauauucncuauguggggaauaacugg cuuuaacccnaucuuuaaaauggggg 20 AW122030 uuuuuuuuuuuuuuuuuaugaaacaguuuuguucagcccaugacuuugugcaugacuguc guccguucuagucaccugugcucuccaucuacugccuuuuaaagcugcgucaugagaagg aucuacacguuccaccaugacucucguuucuugccacaaguagaagaaaugguugauucu uugcuuuucgguuaggccguuaaacaaaacucagucacaccccugccuuccacccucaaa cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua uacauugcugaggucuuuuucugguuguucauguaucaguguuuucaaccucgugccg 21 U57524 Sequence below. gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucac caccccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaagu cauuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcg gugccccucuuugaccccuugguggagucagauguagcacggucgcccccaaagcguuucuaaauuaauagucacuuaguu cuuaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugagguc uuuaugacccaccuagggccuccuguuugccugaucuccuaagagacaaaugggaggaucagauuccauagcgggaggugu cugggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuuucuguuuccucuuccauuuguagacucca cuccacuuggcugugaucaccaaccagccaggaauugcugaggcacuucugaaagcuggcugugauccugagcuccgagac uuucgaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcaca ccccagcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggagggag agagauggggccacuugagucuuaaacuccgaacguauacaaaguucagacacugugaucuuuuuaaaaaguuuucuccuc gaugccuauaugauauucacucagaacccagauucugaguucuucaaaacugaugauguuugugguuguccucaagacaau agacaugaguugugugaggauugaaacacguaguacaguuuuugucuuccuccuccaggccacacgugucugcaccuagcc ucuacucacggcuaccuggccaucguggagcacuuggugacuuugggugcugaugucaacgcucaggugaguacaucucc cuuccaccuaaucucuguugggcuggcucugauggugagcagguuuccagaugcagccguaaacuaacgccugauugcuu uugguuucaggagcccugcaauggccggacagcccuccaccuugcgguggaccugcagaauccugaccugguuucgcucuu guugaaauguggggcugaugucaacaggguaaccuaccaaggcuacucccccuaccagcuuaccuggggccgcccaaguac ccggauacagcagcagcugggccagcugacccuggaaaaucuccagaugcuacccgagagcgaggaugaggagagcuauga cacggagucagaauucacagaggaugaggugaguguuccuccccucagcacgcugacggcuguucuagggcugcuuugga ucagagggauuucaguuguuuaacuucucagacucggcuugcaaagcaggaucccaagaauuugucucugguuuguuuua agagcuuacccuuuugguugaggaaugagggaauucuagaaauugaacccaggccuuagcacauggugauaagcacacguu caaccauuaagcuccacccccucaauagcuuagacuuuuuuuuuuuuuaaggaaagaauagguaagggaaacuccuacagc cuggugcccuuguucuauuuggguuaaggagaaaaagagcccaagaauaggaguuauuucagcagcagcucuccccuuauc ccaaugucuuggugaaguucuaggaauuuaauaugucuuuuuccccucucuuguuuuagcugcccuaugaugacugugug uuuggaggccagcgucugacauuauaaguggaaaguggcaaaaaagaauguggacuuguauauuuguacaaauagaguuu uauuuuucuaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaguauacuuagcaccacaccacacagcgccuagacccaggc auuuuacuggggugauucggcuguugucuuugugaaauccgggg 22 U05809 cucucggucacugccggucgcuuccugagccgcugcuggcucugugucucuguccucagc guucucuuccucguccucguccuaccacgccauggaagguuaccauaagccagaucagca gaagcuccaggcccugaaggacacagccaaucgccugcgcaucagcuccauccaggccac caccgcggcaggcucaggccaccccacaucaugcugcagcgcugccgagaucauggcugu ccuguuuuuccauaccaugcgcuacaaggcccuggauccccgaaacccucacaaugaucg cuuugugcucucuaagggccaugcagcucccauuuuauaugcagucugggcugaagcugg cuuccugcccgaggccgagcugcugaaccugaggaagaucagcucugacuuggacgggca uccugucccgaaacaagccuucaccgauguggccacuggcucccugggccagggccuggg agcugcuugcgggauggcauacacaggcaaauacuuugacaaagccagcuaccgagucua uugcaugcugggagacggggaggucuccgagggcuccgucugggaggccauggccuuugc uggaauuuacaagcuggacaaccucguugccauuuuugacaucaaccgccugggccagag cgacccagccccgcugcagcaccagguggacaucuaccagaagcgcugugaggccuuugg cuggcacaccaucaucguggacggacacagcguggaggagcugugcaaggccuuugguca ggccaagcaccaaccaacagccaucaucgccaagaccuucaagggccgagggaucacagg gauugaagacaaggaggcguggcacgggaagccccuccccaaaaacauggccgagcagau uauccaggagauuuacagccagguucagagcaaaaagaagauccuggccacgcccccuca ggaggaugccccauccguggacauugcuaacauccgaaugccuacgccacccagcuacaa agugggggacaagauagccacccggaaggccuauggacuggcccucgcuaagcugggcca cgccagugaccguaucauugcccuggauggagacaccaagaauuccaccuucucggagcu cuucaaaaaggagcacccagaccgguucauugagugcuacauugccgagcaaaacauggu gagcauugccgugggcugugccacacgugaccggacagugcccuucugcaguacuuucgc ggccuucuucacacgggccuucgaccagauucgcauggccgccaucucugagagcaacau caaccucuguggcucccacugugguguguccauuggggaagacgggcccucucagauggc ccucgaagaccuggccauguuccggucaguccccauguccaccgucuuuuacccaagcga uggaguugcaacagagaaggcaguggaguuagcagccaacacaaagggcauuugcuucau ccggaccagccgcccagagaaugccauuauuuauagcaacaaugaggauuuccaggucgg ccaagccaaggugguccugaagagcaaggaugaccaagugacagugaucggggcuggugu aacucugcaugaggccuuggcugcugcagagagucuaaagaaagauaagaucagcauccg ggugcuggaucccuucacuaucaagccccuggacaggaaacucauccuagacucugcccg agcaaccaaaggcaggauccucaccguggaggaccacuacuacgaagguggcauaggaga ggcagugucugcugccguagugggugaaccuggagugacggucacucgccuggcugucag ccaaguaccacgaaguggcaagccagcugagcuacugaagauguucgguauugacaagga cgccauugugcaagcugugaaaggccuugucaccaagggcuagggagggcaugggaugcu gggugggugaacuacacauuccagggagguucuggcagagguggcgaagguguacugagu ggggagguaaauauauguuuug 23 AW212475 uuaacggugucauaaauaaguaauauaacuuuauuaaaaugaaaagacaauauucaaaau aaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggagaucagug cauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuuuaaauag cucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacaug 24 V00835 ugaguucucguaaacuccagagcagcgauaggccguaauaucggggaaagcacuauaggg acaugauguuccacacgucacaugggucguccuauccgagccagucgugccaaaggggcg gucccgcugugcacacuggcgcuccagggagcucugcacuccgcccgaaaagugcgcucg gcucugccaggacgcggggcgcgugacuaugcgugggcuggagcaaccgccugcugggug caaacccuuugcgcccggacucguccaacgacuauaaagagggcaggcuguccucuaagc gucaccacgacuucaacguccugaguaccuucuccucacuuacuccguagcuccagcuuc accagaucucggaauggaccccaacugcuccugcuccaccgguaagacucccgauccuug gucuuuagaauaccaaguugggaccgcagagcggaauccccgaguuguagaggcuuggcg ggaauaggcaccuuuaguuggcgauucauuccgguucuuucuagaauccgcucuugcaaa agccuucauuaguuacgaguauugucgaacggguccuuuggcgggguuggggcuaggauu uagacgcgcaaauguccgguuccugaucacccaguuaguggggacaucuggguugagucc caggcauuacuaaacuuacugugaauugcuugaauuaagaaagaggugaaggaccuuuau gucuugggacucaaagacauaaucccugacuuaaccugugaggagaaaaguggggcuagg cucccugcagcuccgaggaggacuuagugaacugagccgggacucgugguguuggccacu gcuguaaugcugccucccucaugcugucuucuuucuccucccaggcggcuccugcacuug caccagcuccugcgccugcaagaacugcaagugcaccuccugcaagaagagugaguuggg acaccuuggguggcggcuaaggcuaggggcggggaacuccuacaaaacuggcucugagaa auguccuuugcuucccggaggccauuguauugucucggggacagaacuauacagagaacu auuuaaaaaaaccgaggucuucucuguuggggacaggaagcagaggucuucagccaggcu gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg aacagcgcugccaccacguguaaauaguaucggaccaacccagcgucuuccuauacaguu ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug 25 AV374868 gcggcacgaugugucuucggguggcuuuuuuuuuuuuguuuugaauaauguuuacaauuu cccucaaucacuuuuauagaaauccaccuccaggccccccccuuuccccacuuaggccuu cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc acauauauuuauauuuauaaucagaaaagaaacauuucaguaauuuauaauaaaagagca cuauuuuuuaacg 26 M21285 See above (same Accession Number). 27 U74683 acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuuggg agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga agcaacagaagaaaagguagugguacaccuuaagaaguuggauacugccuacgacgagcu gggcaauuccgggcauuuuacccucauuuacaaccaaggcuucgagauuguguugaauga cuacaaaugguuugcguuuuucaaguaugaagucagaggccacacagcuaucaguuacug ccaugagaccaugacuggguggguccaugaugugcugggccggaacugggcuugcuuugu uggcaagaagguggaaagucacauugagaagguuaauaugaaugcagcacaucuuggagg ucuccaggaaagauauucugaaagacucuacacucacaaccacaacuuugugaaggccau caauaccguucagaagucuuggacugcaacugcauauaaggaauaugagaaaaugagccu gcgagaucugauaaggagaaguggccacagccaaaggaucccaaggcccaaaccugcccc gaugacugaugaaauacagcaacaaauuuuaaauuugccagaaucuugggacuggagaaa cguccaaggcgucaauuauguuagcccuguucgaaaccaagaaucuuguggaagcugcua cucauuugccucuauggguaugcuagaagcaagaauucguauauuaaccaacaauucuca gacaccaauccugaguccucaggagguuguaucuugcagccccuaugcccaagguuguga ugguggauucccauaccucauugcagggaaguaugcccaagauuuuggggugguggaaga aagcugcuuucccuacacagccaaagauucuccaugcaaaccaagggagaauugccuccg uuacuauucuucugacuacuacuaugugggugguuucuaugguggcugcaaugaagcccu gaugaagcuugagcuggucaaacauggacccauggcaguugccuuugaaguccacgauga cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc cuucgagcugacaaaucaugcuguuuugcuugugggcuauggaagagauccaguuacugg gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga gugauuuagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca ucuuuaaagaauuuugucuuugaacuuaaaaccauccuugauuuuuuucuuuuaauaucu uccccaucaacuacugaacuacuuuucuuuuuaaaguacuugguuaaguaauacuuuuau gagcagugguucaguuguccaauauuuuuugcaggucaucuacaaugcaaccagauguuu caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa ucaguaccauagucuuucuauguguguuuacaagaauuuuugucaccuacuucuucccuu agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa 28 X61800 gagcucgaucccuguuccgccuuugcuaugucugaaggcguccugcuuugcgcgugucgg ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac cccagucccuccccgcuccgucuccgacccacuggggccggggcgggcgugcgcgucagc uggggcuagaaaaggcggcgguccggcccggcgaggugacagccaacuuggacgccaggu ccggccgacgccgccaugagcgccgcgcuuuucagccuggacagcccggugcgcggcaca cccuggcccacagaacccgcggccuucuacgagccaggcaggguggacaagcccggccga gggcccgagccaggggaacugggggagcugggcuccacgacuccugccauguacgacgac gagagcgccaucgacuucagcgccuacauugacuccauggccgccgugcccacccuagag cugugccacgacgaacucuucgccgaccucuucaacagcaaccacaaagcggccggcgcg ggcggccuggagcugcugcagggcggcccuacgcgacccccggguguggggucugucgcu agggggccgcucaagcgcgaacccgacuggggcgacggcgacgcgccgggcucccugcug ccggcgcaaguggcggugugcgcgcagacaguggugagcuuggcggccgcggcucagccc acuccacccacuucgccggagccuccucgaggcagcccggggccgagccucgcgcccggc acaguccgagaaaagggcgcgggcaagagggguccggaccgcggcagcccggaguaccgg cagcggcgcgagcgcaacaacaucgcugugcgcaagagccgcgacaaggccaagcgccgc aaccaggagaugcagcagaagcugguggaguugucggccgagaacgagaagcugcaucag cgcguggagcagcucacccgggaccuggcuggccuccggcaguucuucaaaaaacugccc agcccgccuuuccugccgcccaccggcgccgacugccgguaacgcgcggcgugggccuuu gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag agaagcuauauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc uuauuaccauugcagcuaagguacauuuguagaaaagacauuuccgacagacuuuuguag auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaagaauaa gaauaagaauaaagaagcauuuaaaucgcaaaaaaaaa 29 U20735 Sequence below. uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaa agcaggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugccaacuggccgcugccga ccgucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagc ccggggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuauc acgacgacucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaaacuccugaaacccac cuuggcgcucaaccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcagugggg caggcagcuacuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucg uccccaacagcaacggcgugaucacgacgacgcccacgccuccgggacaguacuuuuacccccguggggguggcagcggug gagguacagggggcggcgucaccgaggagcaggagggcuuugcggacgguuuugucaaagcccuggacgaccugcacaag augaaccacgugacgccccccaacgugucccugggcgccagcggggguccccaggccggcccagggggcgucuaugcuggu ccggagccgccucccgucuacaccaaccucagcaguuacucuccagccucugcacccucuggaggcuccgggaccgccgugc ggacugggagcucauacccgacggccaccaucagcuaccucccacaugcaccacccuuugcgggcggccacccggcacagcu ggguuugagucguggcgcuuccgccuuuaaagaggaaccgcagaccguaccggaggcacgcagccgcgacgccacgccgcc ugugucccccaucaacauggaagaccaggagcgcaucaaaguggagcgaaagcggcugcggaacaggcuggcggccaccaa gugccggaagcggaagcuggagcgcaucgcgcgccuggaggacaaggugaagacacucaaggcugagaacgcggggcuguc gagugcugccggucuccuaagggagcaaguggcgcagcucaagcagaaggucaugacccaugucagcaacggcugccaguu gcugcuaggggucaagggacacgccuucugagagccucccuugccccauacggacacccccagccuugaaggcugggcgcc ugccccccacuggggugaggggggcaggcgaugggcacccgccaaaaggccuggggcgcagcucacacacuggacuccggc ccgcccgccugcgcccaguccuuccaccucgagguuuacauggcccccuuccagcguauuuuguauguuuuuuuuuucug caaagagacugaauucauauugaauauaauauauuuguguauuuaacaggagggagaagggggcugucgcggcggagcug gccgccgcuugguacucagcugcggggauacuagggagggaccuccgcccccugcccucccccucugcauaguacugugga gaagaaacacgacuucgugucuaaagucuauuuuaagauguguuuguguguguguguuugacuuuuuauugaaucuauu uaagua 30 U19118 Sequence below gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagaguc cuuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacugga gcaaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccucc ugggucacugguauuugaggauuuugcuaaccugacacccuuugucaaggaagagcugagauucgccauccagaauaaaca ccucugccaucggauguccucugcgcuggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucuga ggcggccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaa aaaggagaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugagga gcugaagaaugagaaacagcauuugauauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacg gacaccggaagacgagaggaaccucuuuauccaacagauaaaagaaggaacauugcagagcuaagcagagguggcacggagg caauuggggaguucuuacugaauccuccuuuuccaccccacacccugaagccauuggaaaacuggcuuccugugcacuucu agaaucccagcagccaagagccguuggggcaggagggccuguggugaccuacugcauugacccacucugcccccgagugaa ccguggagcaggcaggagcauccuuugucucaccaauuccaggauuuaggccuuaucaucccggccagucucagaugaccu agcuggccccaggcugggguccuaugcaaagcaggaucccacuaaugggauucaggcagaagugucuaccuugauaggugg ggugggaccacauccuccacuguggcugacaacgcccuuccaagggaauauggaaugagaacauucauuauugagguuguc caauggccaggguaugcuuucuagaaaauaugcuguucugucccagaaugacugugcauaggguauccguuucagagccu gguguugugcuauuuagauguuugucuugcacaacauuggcaugauuuuuccgggaguuucaucagaucugauuucuga gagucuggggaucugccaugguggaaagugccccucaaaagcauuuguguggccacaugaacuggcuggcaccaggggag ugaaacuggcugaugaccagcugagccacuuugugccaacagaggauggacgacaccuuucccuguacccacugcagagga agaacccugggcacagcagcuuuguccuuggcuacaaacuguuacaacgucacacaaugaaggcacaaaguccaacuuucaa aggguguaggacuccauacucagugacagggcaggaagagccaaagauaaccacagccacagccuguggagaccaggguug gaagccaggugcagggccaggcaucugcauugugggauguuaauggcacuuuugucuuguagcuauuuugagauguggu ccagagcauuucagcugggagaucucccucuggccaccaggacucuggcuacuguuaaaauccugauguuucuguggaauc cucaguguuuaaucccacucaauaguaucauuacaguuuucuguaagagaaaauauuacuuauuuaucccaguauuccuag ccugucaacauaauaaauaucggaacaaaaccuggua 31 AW049031 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uucauccucucugaaaguuuuaaaccaggaaaggaaaacguuccauggaauccaucuucca cauggugaugagucacaugaacuccaacauucugaagccgcuugacauacaugaguccau c aucucuuaggacaucauacuggcaagugaugauauaggucuuagguaaaugaugcaauau auugucauuggccaacagagggcaugccuucacaucuaugaacccuggauacuuuugagc cagcucagaacuaccaggagugggauuuuuguaaacgggacuuuucuuguaucucucagg gagcaaggaacuccaauucacaaacuguaacaaguggcuagauuccauggguacauguug guuga 44 AJ001418 Sequence below. gagcacccgggacccugggaccacaacgcacuugcucccucucgaccgcgcuccugacccgcagcccucgccaacccuacgg auccuaaccaccgccagccuaggugggcgucaggaugaaggcagcccgcuucgugaugcgcagcgccagcucgcugagcag cgccagccugguccccagggaggucgagcuguucucccgcuacagcccguccccgcuguccaugaagcagcugcuggacuu ugguucagaaaaugccugugaaagaacguccuuugcuuuucugcggcaagagcugcccguccgccuggccaauauccugaa ggagauugacauccugccugaccgcuuagugaacacuccuucggugcagcuggugaagagcugguauauccagagccugau ggauuugguggaguuccaugagaagagcccagaagaccagaaagcccugucagaguuuguagacacgcuggucaaaguucg aaacagacaucauaauguggucccuacaauggcucaaggcauccuggaguauaaagacaccugcacaguggaccccguuacc aaucaaaaucuucaguauuuuuuagaccgguuuuacaugaaccgcauuucuacucggaugcucaugaaucagcacauccuc auauucagugacucaaagacgggaaacccaagccacauuggaaguaucgacccaaacugugaugugguagcaguaguccaa gaugccuuugagugugcaaagaugcucugcgaccaguauuaucuaacaucgccagaauuaaaccucacacaagucaaugga aaauuuccaggccaaccaauccacauuguguacguuccuucacaccuucaccacaugcucuucgaacucuucaagaaugcca ugagggccacggucgagcaucaagaaaaccguccuuccuugaccccaguagaggccacugucgucuugggaaaagaagacc uuacaaucaagauuucugaccgaggaggcgguguuccucugaggauuacugaccgccucuuuaguuacacguacuccacug cuccaacaccugugauggacaauucccggaaugccccuuuggcugguuuugguuauggcuugccaauuucucgucucuac gccaaguauuuucaaggagaucugaaucucuacucuaugucagguuaugggacagacgcuaucaucuacuuaaaggcuuua ucuucugagucuguagaaaagcucccagucuuuaacaagucagccuucaaacauuaucagaugagcuccgaagcugaugac ugguguaucccaagcagggaaccgaagaaccuggcgaaggagaagcuggcagugugaagcggaugacgccugacauuuuac gggaucaaagugggucuguggcauugcugcuucgugaauguguguggacucuaguuuccgcaaaacaacgcaacacaaaac caagcaagcaaaacacaaacacgaguacaaaccuugaccugaugagggacagagcuugguuggaugacccgggagaagucag ggcagggcuccaggggauaacagguguccugcuucuccuuuggcaaugcaaaaugacuccugacuguuccaaauacugaaa agaagucugccucugaguuacagcucuuucucaacaaguacagaguuugaggcuugcaguugcaacagcuggauguuugg ugguucuugcugccagccaaauaaauugguguuuagugaacauuuucaguguuuccccgccaugcaaagcuuggcgccuu gggagaaauguguguaaauguacauuguauagguauuagugugcucuagaaaggacaggauggaaggaaucaaagcacuu uaucgagcuuguggcugagcauugcagccuaugugcaaacccagaggaaaaguaucucugucaagacagcuccaguaucau gcagcuuuuuauguuugcacucaaaaagccagugccuucuggcuggugccgaggcuugggugaaauguuaaauaugcacu gaccucagaaagucgaguucaaaagggagauaaaauugccaaagugauccaaggauugugcauguugggaaacccauauga gagaaaggauucucauacuuagaacuuuccuaugaagaaauggugguaaacuuucucuaccuagaaguaguggaaauuuca aggucaucuuaaaaaagaugugcguuguauauuuuaacuacauucucuacacucuaacauuaacauaucuauucaaauuug ucuaguugccaauugucuucagagugugaaaauuuaaauccuucuugaaguaucuuucgugagaguaguauggaaguaaa acguucucauaucaggaggaugucauuugugaagcauggggacaucaugaacuagugaugugcgugaggcuugggaggcu gaaggguaaggaucagcgggaggccauccauguaggagagagaauuaaaacgaggagcgagggaagcaauggagagaggga agcaagaaaggaaccagaaggcuggcaucauccuauuucccacaggcuaacccaagggaugcucugugccuuuccugggga gggaagggggugaacugguagauuugaaagcaguauggcuucuucugugggucucccucuuacuagacaaggugaaauga uaauucgugucaaauuaaugugaaauuuuuuuccugcauuguaauauuaugaggccugagucgcaguugaguuugaaauu uguauuuaauuucacagugaccuagagcuaaggugcucccgguuguggcaauaggagccacaaguauuuucuuucuuucu uucguucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuuccuuccuuccuuccuuccuuccuuccuuc cuuccuuccuuccuucuuccuuuccuuuucuuuucucuucucuucuuuucuuuuuucuguuucuuuuucuuuuuuugca uuguagauguuguccuuaaaagaucagggcagugacuuucacagcaggacuuugacucccacauugguugaucacacaaaa cugucagcauuuggguaaucugauguauaguuguuuuguugcugauguuuccauugaaauuucagcucugaguuugugc acaugaauacuuacuuguguuuaccaaaggucuaaggcauuugguuacuuaacccaaauauccugaacugugcguaaagua auagagaaaagcuuuagggucucaauagugucaccuguguaaaucaaaucaaaauagccuucccuauuauuuaugaaccca ugggagacuuuaaacucuuguagauagaugcuaaaugcccaggcccacuuaacuuauuaaugugugaauuacauuuaugu uuuuaguuuauaugcaaagaauugugauaauuuuauaauaaauauuuuuauuauaauagu 45 AI838080 uuuucuuuuuuuuuuuucuucucuuuuuucugccaccaacagcacugugcaguuuauua accauucauguacaguagccaucuggggagauugggacagaauugggaucgcaaagugga uagauauucagcaucuaauggguuggcagaagccgccauauacucuucacaaauaucuuc c acagucaauacagaacuagccauuaucccagcacaccgauuugugc 46 AF072127 agccaggagccucgccccgcagcugcacagagagcaaggguauaggcacuaacuuguuug cagagaccccaucaccuucgggagcucaggugcgcaccuugcaaacuccacuuucugcau cugccacugagcccgcgggagccucggaaagagccauggccaacgcggggcugcagcugc uggguuucauccuggcuucucugggauggaucggcuccaucgucagcacugcccugcccc aguggaagauuuacuccuaugcuggggacaacaucgugaccgcucaggccaucuacgagg gacuguggauguccugcguuucgcaaagcaccgggcagauacagugcaaagucuucgacu ccuugcugaaucugaacaguacuuugcaggcaacccgagccuugaugguaauuggcaucc ugcuggggcugaucgcaaucuuuguguccaccauuggcaugaagugcaugaggugccug g aagaugaugaggugcagaagauguggauggcugucauugggggcauaauauuuuuaauu u caggucuggcgacauuaguggccacagcaugguauggaaacagaauuguucaagaauucu augaccccuugacccccaucaaugccagguaugaauuuggccaggcccucuuuacuggcu gggccgcugccucccucugccuucugggagguguccuacuuuccugcuccuguccccgga aaacaaccucuuacccaacaccacggccuuaucccaagccaacaccuucuagugggaaag acuaugugugacagaggcaaaggaagagaucuuccuggagcaaauacaaaauggacauug aaccuaggauugacauuaacgccuuagacuguugaugaugguuaucggaacugugguaga acagaaggaagcauauuuuuauacauccccauggcuaugcaggccuuggcug 47 X80417 Sequence below. cggcacgagcggccacugaccgagaagugcccccgccuggagucagccugggggcaggccaggguccaccagaccc cgggaugaccgcagccagucgggccaaccccuacagcaucguaucaucagaggaggacgggcugcaccugguuacca ugucaggcgccaacgguuuuggcaauggcaaggugcauacacggcgccggugccgcaaccgcuucgucaagaagaa cggucagugcaacauugaauucgccaacauggacgagaagucacaacgcuaccuggcugacauguuuaccacgugu guggacauccgcuggcgcuacaugcugcucaucuucucucuggccuuucuugccuccugguuguuguuuggcauc aucuucugggucauugcugucgcccacggggaccuggagccagccgagggccguggccguacacccugugugcugc agguccacggcuucauggcagccuuucucuucuccauugagacacagaccaccauuggcuacgggcuacgcugugu gacugaagagugcccgguggcugucuucauggugguggcgcaguccauugugggcugcaucauugacuccuucau gaauggugccaucauggccaagauggcacggcccaagaagcgcgcacagacucugcuuuucagccauaaugccgug guggcucugcgugacggcaagcucugccucauguggcgcgugggcaaccugcguaagagucacaucguggaggccc augugcgggcccagcucaucaagcccagggucacagaggagggugaguacaucccacuggaccagauugacaucga ugucggcuuugacaagggccuagaccguaucuuccugguaucacccaucaccaucuugcacgagauugaugaggcc agcccacuguuuggcauuagccgucaggaccuugagacagacgacuuugagauuguggucauccuggagggcaugg uagaggccacagccaugaccacacaggcucgcaguuccuaccuggcuaacgagauccuguggggccaccgcuuugag ccagugcucuucgaagagaagaaccaguacaagauugacuauucacacuuccacaagaccuacgaggugccaucuac accccgcugcagcgccaaggaccugguggagaacaaguuccuccugcccagcgccaacucuuucugcuaugagaacg agcuggccuuccugaucagagaugaggaggacgaggugucuaccgaccgggauguccgcaccccucagcccgagca ugacuuugacagacugcaggccagcagcgcugcccuugugcggcccuacagacgggagucggagauuugaaugccc uuggcuuagaugcagcaccacccugaccacaauaggucccaugucccuugggggccugcguuugagcagagcaggc cgaaagccucgggucacagacucaguagcaucuuagucuuuuucauguuuuuucgcaguagcuugggaaaguugg cgggagcguggauggcccaaaugacuggcucacggccucggaggcugauguauacccaugggcaaggaggugacuu cuugggguaggguugcucaggaguuagggacucugcuggaggccuuaggugcaggucccaaccccggugggagga ggcuguguauguacacuucauugguuuuuaacuugggcaagacuguuuacaaaccaaaacaaacaaacaaacaauc caaaaaaaaaaaaaaaaaaaaaaaaaaaa 48 AI847051 uuuuuuuuuuuuuuguuccuuuuuuggaauucccaaagcugguuuuaauuucaaaaaau uaugaggucucuucccacacuggggauaaugggaugggauagcccaaacuauuaucccag u ucaaccccagccugguccaaacaccauuacugucacugggcccugucauuucacc 49 U09504 uccucguccucgucuguuccaucuucuccaaauagcucuaacugugaugccaacggcaau cccaagaacgcugauaucucuagcaucgaugguguucugaagagugaccgcacagauugu ccugugaaaacaggcaaaaccagugcuccuggcaugacuaagagucacaguggaaugaca aaauuuaguggcaugguucuacuguguaaagucuguggggauguggcaucaggauucca c uauggaguucaugcuugugaaggcuguaaggguuucuuucggaggagcauucagcaaaa c auccaguauaagaagugccugaagaaugagaacuguuccaucaugaggaugaacaggaac cggugccagcagugccgcuuuaagaagugucugucuguggggaugucacgagaugcugu u cgauuuggccgaauuccuaagcgugaaaaacagagaaugcuaauugaaaugcaaagugca augaagaccaugaugaacacccaguucaguggccaccugcagaaugacaccuuagcagaa cagcaugaucagucagcacuaccagcucaggaacagcugcggcccaagucccagcuggag caagaaaacaucaaaaacacuccuucugauuuugcaaaggaggaagugauugguauggug accagagcccacaaggauaccuuucuguauaaucaggaacaucgagaaaacucaucugag agcaugccaccucagagaggagaacggauucccaggaacauggagcaauauaauuuaaau caagaccaucguggcagugggauucacaaccacuuccccuguagugagaggcagcaacau cucaguggacaguacaaagggaggaacauaaugcauuacccaaacggccaugccguuugu auugcaaauggacacuguaugaacuucuccagugcuuauacucaaagagucugugauaga auuccaguagguggauguucucagacugagaacagaaauaguuaccugugcaacacugga gggaggaugcaucugguguguccuaugagcaagucuccauauguggacccucagaagucu ggacaugaaaucugggaagaauuuucaaugaguuuuaccccagcaguaaaagagguggug gaauuugcaaagaggauuccuggcuuccgagaucugucucagcaugaucaggucaaucug uuaaaagcugggacuuuugagguuuuaaugguacgauuugcuucauuauuugaugcaaa g gaacggaccgucaccuuucuaagugguaagaaguacaguguggaugaccugcacucaaug ggagcaggggaucugcucagcucuauguuugaguucagugagaagcugaaugcccuccag cucagugaugaggaaaugagcuuguucacagcaguuguucugguaucugcagaucgauc u ggaauugaaaaugucaacucaguggaggcuuugcaggaaacacucauccgugcacuaagg accuuaauaaugaaaaaccauccaaaugaggccuccauuuuuacaaaauuacuucuaaag uugccagaucuucgaucuuuaaacaacaugcacucugaggaacucuuggccuuuaaaguu cauccuuaa 50 U22033 auggcguuacuggaucugugcggugccgcucgggggcagcggcccgagugggcugcccu g gaugcgggaagcgggggucgcucggacccgggacacuacaguuucuccgcgcaagcuccg gagcucgcacuuccccggggaaugcagcccaccgcauuccugagguccuuugguggugac caggaaaggaauguucaaauugagauggcccacggcacaaccacacucgccuucaaguuc cagcauggcgucaucguggcuguggacuccagggccacugcagggaguuacauuagcucc uuaaggaugaacaaagugaucgagauuaacccuuaccugcuuggcaccaugucugguugu gcagccgacugccaguacugggagaggcuguuggccaaggagugcagguuguauuaucu u cggaauggggaacgcaucuccgugucugcagcauccaagcugcuuuccaacaugaugcug caguaccgggggaugggccucuccaugggcagcaugaucuguggcugggacaagaaggga ccaggacuuuacuacguagaugacaaugggacucggcucucgggacagauguuuuccacu ggcagcgggaacaccuaugccuacggggugauggacagugguuaccggcaggaccucagu ccugaagaggccuacgaccuuggccgcagagcuauugcuuaugcuacccacagagacaac uauucuggaggagucgucaacauguaccacaugaaggaagacgguugggugaaaguggag aguuccgaugucagugaccugcuguacaaguaccgagaggccgcucuguga 51 AF033034 Sequence below. auuccaggaguuccagcugcuggagaggacuguguagaagguaaccuaccccaucucucuuacuucgucucuagaugggag cagacaaguacauauagccugcuuggagcgaggacuuugaaaggcugagacuugcguccacucugagggcaacuaguccag acucugacaggucagcauuuccugacugggugcacugaaugccaagcaccagaggucugucaccuuccgacauuggaccaa gagagucccagagacccucaaagacacaggaacagagguguccuuugggugagagaccugugcccugccaagccucucagc cccuagaaaggcggcagggcugaguagcugagugugugcaacuugggagcagccugauuucagugcuugucaccugugag ggcaaaggcagcaugcuuaaugccaucaguccuacucuucucacccguggaacagacgcauaacugaccuuuuuucgugac cacuauuagggugcauuuaaaaaucaaucucucucuuuucugcuccucuuucuccaccuucccucaugugugugucugug uguguguguuucugugugugugugcgugcaccauacagguauaugugccaugacaugugugcaggucaguagacagccu ugguugucagucccugccuucuacuuuguucaaggcagggucuauucuuuauuauugacugcuauccagguacaccaaga caguuggccugugagguuccagggagucuccugucucuggcccccaucuuauagcaggaguugugagauuucagaaaugu gcacccacaucuagcuuuauuuggcaucuuggcacccaaacuuggguucucaugcuuuccaagcaaggacuucacccacug aaccaucucaccagcuccacuauggcgguuuucugaaacugaagggaguggggagaaggcgcugagugugaacgggucug gaaggcggguauaaccuuuaaggcuggcugguucugagagaggaaagccggcuugugucccauucaggugccaggugcag caucaaauguggcuccacccaacggucaguaacuccgcagacagcaccgugguuaacugccucacagagggggcccagggac cuaguuccuuaaagcccacuuaguuuugagagacgacauggaggggcaagcccagcccuguccagcugcauucacacgagg cccuucuccuccgaggacccuaccuuuguguuuaguggcugaggcuguguggcucugcuugaagcucuggcuaucaggaa ggaccuggcccaccggcuggcaggacaaacuggcccagugaaggcacuguccggucuccugguggaucacaaggaaagggg cguggcauguccagauuugaacccuggaugccucuucccaggguaggaagucuaagggucaacaugaauaggugagggug gugguggaaagaaucugcaugcaaaaucaggcacucaugucugacaucgucaaacacuauauuuauguagauuuauauggg ggugaggcuuggggagcacuuguauuuuugugugcaauugcaagagcuuccuccacauugcaguguuaaauaucauaugg ugcuggaccaaccaucucuggaacgagggugaggguuugguacccgugacuaugguucucuguguaguagaaacggcuuc uugggaagagagaggaagugcuuugaaaugcauccucucuuguuucauucugcaucauggccagguuucucugcacaaag augcaauagacauucaggaaaauaagcgcauugcaagaugucaaaagucaugaaaaaugaaaagcaaggucacugcagcugg gguguaguguggcuguagaagcacguuuaugauguacagguuccgggagagggaggaagagagagggagggaaggaggaa uggaggaagagagggagagggagcaagagaggggggagggagggaggggagaagggagagagagagagaagaaagagagg gagggaagaaggaauggaggaagagagagaaagaggggaagaaagagagggagggaaggagggguggaggaagagagagg ugugagggauggagggacagagagggagggaaggagaaauggaggaagagagaaacagagagauggaggaagagagaaaa gucaccaauuauuuuucuccccagucgcccccugcccucacaccaaggguacccccacuuuucuuucacucaugcacacaca cuacacccaauguuuagguaacacauguagggcaggcagagccuuugugaaugugcuugguaguuuucugccuuacuucu aaauaaccaaucacacggaugccacaggguuccuuuagacuguccagggcuccggggcucuuagacuguucccaauguggg ugucacaugcaaacaguaagcaccuucuuguuuguggugcccaggaugcugcagguacuagaaauuccugcacagaccuuu gcuacuucuacacagacuuacccuuuaaaacauuuaauuauauguuuuuuucagcauaaagaucuauuuugauuauuuuua guugcguguaugggugugugccugugugugauuguguaauugucuguaugggaguguaagugccuacagaggcaucgga uccccuggagcugccguuacaaguaagggacugggacucagaccugagugguuuggaugagcagugaaugagcgugguga gccaucccaccaugcccuauaaacacuuucaagaggacuuugcuggguauggucaaguugucccccugcgacagccacccca acuugccauccucauuuacuguacuggaagcagcaaccaccucugcaauuuugcacaagaaccugagagucugaaagacuu uuguuggcacuggccuguguuccacugggguggacacauuaaucuaaaagcuaagaagcucacuucagcuuugccaggcaa ccagcacguuugagcacaacgguguagccaggaagggugugugggaauuuugaugcuaguuuuucuuuaauuagguugag agugaaaucauggucuguaugcauccaacaacuuaauccaaaaaguugguugcacggcuccuggaagguuuaccggcaagg aaccugucccauuuuguaaguaggugggacuggagaguugccaagaagccccccucccugcccccuuccuccuggcagauu cugcuuaaaaugagugugguucacugcagaauagugucaccugucuucagaugucuaaagacauaagaaaggccuagccag cuaagucagaaaaggggacuuuccggugggaaugcauuuuccagucucuaggagaagucuuuauccaaauaaaauuagcau agugguggagucacugccagggcgcuggugcggaagcacagcccagagccgaggacguggccauccuccuuccucugaugc aaaguguucucuauccccaguuaccaugagcaauaucaguagcaucgugaaccgggcccgugaugccuuuaacucaggcaa gacucgaccgcugcaguuccggguugagcagcuggaggcguugcagcgcaugauc 52 AA960603 uuuuuuuuuccaaaaaauuuuauugggggaaacuacaaaacauuuacaguacaauguuua cagucacaauuuguagugaacugauuccccaaaauauauuacaacucaaguugacuuaau cuuguuacauucaaaaaccuacuucugucaaaguaguccagagugcacacgcggugcucc aacuguaccuacauacaaacuaaacaacugcucauuuaucugccauccaggaaagccgga gacauuccugccucuuuacauugaaaaauaauaguacaaguuuuuggacugucauugaac aaggcauauucauguaccaccaacauuuc 53 U47737 Sequence below. ggugauccuccaggaccuaagguuucgguauuaucuucggggccucuucacccggaggugagucugcugagcccgaccuc agguguucacucgucacgcgagggccuggccacggcggggaagcacugggagagagcgggaggccuugaccgcagcgugu aggaucuggggucccggcgcucugcucccgggugcagagugguuggagcaugcgaggcccucugcagcgugcucuguucc uaccaucaccccacccccaccccaguccuuccugcacguuucuggagaggcaaaggccccugcugagccuucacuggguacc ccuaucucgacuccacuugucugcuugggaucuccaaagggggauacacccucguaaacuagagcaggaggcuggggggug gggguagggguagggucugaccaguuagauugaggcuggacccuccccagagugaggagcgggaagcucuuugucuuauc caggauuuugcauaucaaugcugagguucuggugauuaaguagggucccuggcuagcggggguaaccugaacaaccuucc uccgcuggccgcuagccaauagacaccuggcuuccgcggaugagcccuuugaguuuguggagguguuccucaggucccca gggcccugccccguugccugcagauguguggacagacaaaacauuggacucguuuuccaaccacuucaccccuuccuucgc uaguccuccgguggacgaugggaugccucauugacuuguuuguggcugugcaugccagagcuuccuagcagacagcucag ggcuccaucguuccuaaaucccacuguguaacgaaaaaaaaaaaaacaaaaacaacaacaacaacaacaacaaaaacaaaacca gaaaugaggacaggcccagcugggcuuggcacugaacuuggccaccuggagcuuuggcuacccacuacaagaugucagcaa gucucaggauagaagaggccuaaggccaguccuggaagauaccaaaacuucaccuccucuauaccccguuccucuaggagaa cuguaagccaccuuugucucugggacgccccucucccacucaacagauggcaccagucaucuuccuccucaagaggccagug guauucaaaauaggauauugaaaccaagcaagcugguccucuccucuacccuaugccaaagacuucugcccaaagggcccag aaaagucccauagccaucuggcuggcuagugugcugacugcuacaggugucaguguccccagcgagcagguaguggagug gaggugucuucuuguggaaauggguccugagccucuaccuuguacagaaaggaauuagugaagcccagaggccuccagccc gugucucugccacaagagagaggggguggggguggggcuguauuugguucccagggcucagggaagguuuucgguucau gcaugcucauuuaucugaccacugucuuaaccccaggacaaccacuuaacuguccacuuccauaucagaguucuugguucc ccuuuacuucgucuauggagccccugaguuugggaagggguauuaacugaaagguaccauuagaugaacuuggagaaaga uuuguaggugccacgggagauuucagguaaaagcucuuuuaauaauuggcuacaauagcagcaggaggaggccaggaauu cugagguagagauuugauuagcagcacguggagcaaaggagacuucugacuccuacagguuucagaaaguggggagaggc ucucagaugaauggcuuggacugugagguaaguguuaguguagcacgagacuagcuuaaggcuguacaaauuguccgucu gauuggugcauugggccagguagacacuagauaagcaauugggccuuaacucgaguugucuuaauggcuacccccagggca gcagggagucaauacugcucuccugucuggggccugaaugcugaaaccaucuacaaaggggacauaaggcauauuggggag guguagagugggccaggcccagggucugcugguaucuaugccaggauccugaguggugguggcguagccugucuuuuaac caacugccucucucacaguaggcuucuuuggcuugcgaaccuucagcagaugucugccacuuccaacaugagagucuuccu gccugugcuguuggcagcccuucugggcauggagcaagguauggagcucugagauaacccugcagccugguccuccuccu gaucucucauucuuucuccugaguagaugcccagggcuccuccugagccagcccuccuaggaacgucuggccuucccaccu ccuacucucuagccaacugaccuaguuccccugaugcugugcuggcccagcuacaccuuugucaccucguguugacuuuag ccacuccaguaccaaagucugaagucaguugucauuggcuggcuuuuuucccugacccagggcugagcaugcuguugcuu cuugucaguggguuggggaucaagggccccacuggaaagucaccuuacccuggaaggcuuccccaggcaauaggcaggugu caccuacagcauugucccuuuugcaguucauucccugaugugcuucucauguaccgaucagaagaacaauauaaacugccu guggccaguuucaugccaggagaaagaccauuacuguaucacguuaucugccgcugcgggcuuuggugaguagcugccug uuucccuagccagggccagggaccugcggggcuuuccccauuuccugcuacccugucugucuguccccucauccucacuuu ccaugcagggaaugucaaccuuggcuacacccugaacaagggcugcuccccgaucugccccagugaaaaugucaaucucaau cucgguguggcguccgugaacagcuacugcugccaaagcuccuucugcaacuucagcgcagcuggccucggacuucgugcc aguaucccacuacugggccuuggacuccugcuuagcuuguuggcucugcugcagcugagccccugaccaucccccaugugu ucuccauauccccccagcucaggaaaagcccagcuccuuuuaggucccaggggacccuaggaaccuucagcuccuccugggu gugucuaguucccccuccacacucucucaacgucagggcuaaguaccaaacucacccauaccugcucuguugaagugguac uggcuacccuugcuuccagagccaauccuauaaccucccuuggggaaccagcgaaggggugaagaucuccuuggagucuca agaguaccagagucagcgccgaaucuuguggacacacugacaaggaugucuaauccaaauagauguauaucugugugcuca guguaucccugugugaaugaagccacuuggauucuggggugggcaaagaagaccugaaaagauucuacagcagaaggccug ugucgccaccaaaaccccucccccugguaucauuguacccaccuuguacucuguucaggaggcugcccauggaggacugcc accccuccagaugaaggcucccacuacccgaugcaguugagucccauccugcccucucugcccacacuggcuuccugcugcu auucuagugccucaaauaaaccguucacacccuu 54 L00039 cuuccucccucuacagaagaagagcaagaagaugaggaagaaauugauguggugucugug gagaagaggcaaaccccugccaagaggucggagucgggcucaucuccauuccgaggccac agcaagccuccgcacagcccacugguccucaagaggugccacgucuccacucaccagcac aacuacgccgcaccccccuccacaaggaaggacuauccagcugccaagagggccaaguug gacaguggcaggguccugaagcagaucagcaacaaccgcaagugcuccagccccaggucc ucagacacggaggaaaacgacaagaggcggacacacaacgucuuggaacgucagaggagg aacgagcugaagcgcagcuuuuuugcccugcgugaccagaucccugaauuggaaaacaac gaaaaggcccccaagguagugauccucaaaaaagccaccgccuacauccuguccauucaa gcagacgagcacaagcucaccucugaaaaggacuuauugaggaaacgacgagaacaguug aaacacaaacucgaacagcuucgaaacucuggugcauaaacugaccuaacucgaggagga gcuggaaucucucgugagagcuaaggagaacgguuccuucugacagaacugaugcgcugg aauuaaaaugcaugccaaagccuaaccucacaaccuuggcuggggcuuugggacuguaag cuucagccauaauuuuaacugcucaacuaaauaguauaaaagaacuuuuuuuuaugcuuc ccacucuuuuuucuuuuuccuuuuaacagauuuguauuuaauuguuuuuuuaaaaaauc g uuaaaaucuauccaauuuuccauguaaauagggccuugaaauguaaacaacuuuaauaaa acguuuauaacaguuacaaaagauuuuaagacauguaccauaauuuuuuuu 55 D21099 gugggacgggccccccucgaggucgacccacgcguccgggaguacccccgaccuuggcug cgugcugacucgcuuccuucugccugcccaggcuugcacuccccggggaucugccucugc aucucuugccuucgcuguuguuucccucucuguccagcuccccucccgcucucgcccugg agaauggcucagaaggagaacgccuacccguggcccuacggcucaaagacgucucagucu ggccugaacacguugucccagagaguccuacggaaggagccugccacgacaucugcgcuu gcucucgugaacugguccaacagccaguccacagcugccccuggccagaaguuggcugag aacaagagucagggcuccacugccucgcaaggaucccagaacaagcagccuuucacuauu gacaacuuugagauugggcguccuuugggcaaaggcaaauuuggaaacguguacuuggc u cgggagaagaagagccguuucaucguggcacucaagauccucuucaagucucagauugag aaggaggggguagagcaccagcuucgccgagagaucgaaauccaggcgcaccugaaacau cccaacauccuucaacucuacaacuacuucuacgaccagcagaggaucuacuuaauccug gaauacgccccucgcggggaacucuacaaggaacugcagaagagucggaccuucgaugag cagcggacugccacgaucauggaggaacugucagaugcccugaccuacugccacaagaag aagguaauucacagagacauaaagccggagaaccugcuguuaggucugcagggagaacug aagauugcagacuuuggcuggucggugcaugccccaucccugaggaggaagaccaugugc ggcacgcuggacuaucugcccccagagaugauugaggggcgcaugcauaaugaaauggua gaucuauggugcaucggggugcucugcuaugaacugaugguggggaacccccccuucga g agcccuagccacagugagacguaucgucggauugucaagguggaccugaaguuccccucu ucugugccuucgggcgcccaggaccucaucuccaagcugcucaaacauaaccccuggcaa cggcugccccuggcggagguugcagcucacccuuggguccgggccaacucaaggaggguu cugccucccucugcccuuuagccugcuccuugguuuuuugucccugucauuuuucagug u ucuuuguaugucuguguauguguucugagaaggggugggaacuggaaacuauuccuagc uccaguucuaggggaucugaucucucuucugaccucuacaggcaaaauuaggcaccccug u ggugcacauauaugcacgccaaacacaugaaguuacaaacaaacaacaaacacacagaua gugcuggagagauggcucggcaguuaaaagcacuggcugcucuucccaggaaccuagaac ucaauucuagcacuacauggugcucacggccacugucuguaacacccaguccuggggaau cuggggccuucgagccucugcaggcacuaggcauggaugugguauacauguaugcaggca aaacacccaugcacugacuuuuaagaaacccucuagucugauuccuuucaauuugucaaa uguugaauguuauuuuuaaaauauuauaagccauuuaauacaauuuuucuuugaaacaug guauagccuagucugucuuaaauucagaaaaauuaugaagaacaacauuuuauaauaaag ucuuaaauguuucauguuuuug 56 AF026481 Sequence below. uugccuaggaagggcgcgucgucucucugcucguccggcugugacggggaagggucccgcugcguuuuggucacugugag uaccaaguuugggggauccccgagggacucucgagagcucauuuuagggaugcaggggcuacuccccggugguagagagc uuucuaguuggcaggagguuucguauguggaggaggccagcuuaggcagaaagcacauguucucagagaugaggacaaga cuaagaccgucuaaucccugaucuuuaccuuccggcccgcugaccugggccuggaugcuaaagcccucugcuuucgucuaa acagcgcuaaauaguaaacaguauugccuaagauaaaugcggauuauuacccgauucagugucgggaaaaggcagcuagga gagagcggcuggcacgugguaagcacacgguaaguuucgguuaaauuaaaacaaccauccguugagcaucucuuagcaagc uccuuccacccuucaaacaaucagugauagugcgucuguuucacugauuagggagcuaaggcuccaacagcagcaaaggaa cuaauccgccucugaucaacauggcguuucuuacagggcauuccuuauacgcuuucccacgugcguaacaggaaucgggug uucccggguuuuguuuuguuguuguuguuuuuguuuuguuuucuuagugaaagaggcagggugggcuccaggccgcug aggauuaauaaagagauucuaugaggaggaaauaacaggcaggugguaugaucgaggcaaggcccugaggaaggcuuggg uggggugaguagaaccagagccggaaguccacucagcagccuggggcacuuaaagcuucugcuggggcaaaugguaaggcg gcguaaggucacauuccuuucauuucuuccagacucaggaggagaccacaccuuccggagaaccaggccugaaccgaggua cuauuuuguagcucucagaagccaggacucugcaacacuguuugcugccuguggaucuucuauauucacagugucccagu ugcuucugaucuaccacuguuagauacuucugccacccauccuaagaguauaguuguucuuggaaaggagucucagcugcu gucagcaggagucccucauucgacuccugugguugcccuuuccaccaugccaaagaauaaaggcaaaggaggcaaaaacagg cgcagagguaaaaaugaaaaugaaucugagaaaagagaguugguguuuaaagaggaugggcaggaguaugcucaggugau caaaaugcugggaaauggacgguuggaagcaaugugcuuugacggugugaggaggcugugccauauaagagggaagcuga gaaagaagguuuggauaaauaccucggacauuauauugauuggucuacgagacuaucaagauaacaaagcugauguaaucu uaaaguauaaugcagaugaagcaagaagucugaaggccuauggagaacuuccagaacaugccaaaaucaaugaaacggacac auuugguccuggggaugaugaugaaauccaauuugaugauauuggagaugaugaugaagacauugaugacaucuagccug accuaagcaugcuaccuuccaaguucucugaagauagcuccacacaguggcaucuugaccuucaucuguuaaguaaaacuu cauggcauguguaugacuuguuaaugcaagcuaaugaauuuuauuuuuugaaguacuauauuucuuugaaaaccaaagau guugaguuaucaucuuaagugacauguuaacacuuugugcuuuugaauauaauugaaccuagcgcacagcagugagcacu guuaagagacugccuuuccauuuguagcuucauuucuggcacgggaguguuuugugucagcaguucugccagguggccau cgaugagcugaaguaaguccuaguccagcacaucugcuucaggccuuuguacucuagucaucuggcugcguucgagacuuc ucagcagaacuuauagauguguacggcugcacuuggagucagacaagauauggcuacuuuuguacuuauggagccaugcca uuuuauacuuucacguuguauacauucguuugacccuuuaaguuguugccacccauaaaaaggcaucuuacagugcaguu uuuaaauuacauggguagcaauuuugaguuuuaaaaauuagucauugcagaaauuaaauacuuagaggagauaauccauua ucuugauuuuaggaauauaauaguugacaauguuuauauauaauuuuacuucucuaaggcauacccaaaaauagaaaauga aaaagagcagugagucuguucugaugcuugcauugcauagagaaguuuuccaacaaagcagcuguuaauaacacauaaaau auguuuuacuuugcaaaguagguuguguuaagucauuuucaaaaaguuaccuacuauaucgaggcucuggauaauuacua uguguugauuaaaguuaguuacagaauuguacaagcuaaguuuuccuuaaacuaagcuuagguuaaagggagaggagcca cagcucaaugaaaacacgguuccuguuuucuaaauggaggcgcccagaaacacaauaaaacauguugguacaaaaaaaaaaa aaaa 57 J04596 caugaucccagccacccgcucgcuucucugugcagcgcugcugcugcuggccaccagccg ccuggccacaggggcgccuaucgccaaugagcugcgcugucagugccugcagaccauggc ugggauucaccucaagaacauccagagcuugaagguguugcccucagggccccacugcac ccaaaccgaagucauagccacacucaagaauggucgcgaggcuugccuugacccugaagc ucccuugguucagaaaauuguccaaaagaugcuaaaagguguccccaaguaacggagaaa gaagacagacugcucugauggcaccgucuggugaacgcuggcuucugacaacacuauaca auuucuuuugaggguccuauuuauuuauguauuuauuuauuccacaaagugugugguuu uuauuuuacauuaauauuuaacaguguggauacauuucaucgaugguaguucaguucug cuuguucaguuuaaagaugguaggcuuaaaauauuucauuaaaacuaauauuuauuggga gaccacuaagugucaaccacugugcuaguagaaggguguugugcgaaaagaagugcagag ag auagaguuuaguauuauguuuuguauguauuagggugaggacaugugugggaggcugu guuuguaugucuugaaaagaaugucaguuauuuauugaaagucgucuuucauauuguau ggucaacacgcacguguugacgcuucccuuggacauuuugugucuaguugguagcccaua augggcuuuuacauucuuuaacccuguuucuccuggucucgucucgcucgggacagagac guucaaaggacuguuacaaaugaaguaaaaauaaaaguuuuauuaag 58 X81580 cgucucccgcauucgucugggccgugcaccugcccgcuagcucgcugcacuaccguugcc cacaagccaacaugcugccgagauugggcggccccgcgcugccgcugcuccugccgucgu ugcucuugcugcugcucuugggcgcgggcggcugcggccccggggugcgcgccgaggug c uguuccgcugcccacccugcacgcccgaggcucuggccgcuugcgggcccccacccgacg cgcccugcgccgagcuggugcgagagcccggcugcggcugcugcuccgugugcgcacggc aggagggcgaagcaugcggcgucuacaucccgcgcugcgcccagacgcuacgcugcuauc ccaacccgggcuccgagcugccccugaaggcgcuugucacaggcgcggguaccugugaaa agagacgcgugggcaccaccccacagcagguugcagacagugaugacgaccacucugagg gaggccugguggagaaccacguggaugggaccaugaacauguugggaggugguagcagu g cuggccggaagccccucaagucaggcaugaaggagcuggcuguguuccgggagaagguca augaacagcaccggcagaugggcaagggugccaaacaccucagucuggaggagcccaaga aguugcgcccgccucccgccaggaccccuugccagcaggaguuggaccagguccuggagc ggaucuccaccaugcgccuuccggaugaucggggcccccuggaacaucucuacucccugc acauccccaacugugacaagcauggccgguacaaccuuaagcagugcaagaugucucuga acggacagcgcggggagugcuggugugugaaccccaauaccgggaagcccauccagggag cucccaccauccggggagaccccgagugccaucucuucuacaacgagcagcaggagacug guggggcccaugcccaaagugugcaguaaaccccagccagucggugccuggcuuccccau cccgaacaccagcagaaauggagggcgucagggugacggguguggaggaguucccaguuu ugacacauguauuuauauuggaaagagaccaacacugagcucagaagccccccucugacc ccccccagcggcuguuaacugaaccucccuugcuucuguuagagaggggaagggugguau ggagggcacuggguacaggccugggaauggggaaagaaauuuuuauuuuugaaucccug u gucucuuuuacuuaagauuaaaggaaggaaaaauaaaaaaaaaaaaaaaa 59 AI314958 gaugugaaaaacguuuuuauuauaaucucuuaaacuuucaguguauauuuucauuacaau cauugguacaauaaauauggaaaugcugagcagacaauuaucacaguggccuaugggcug agggacagggacccaggaauacuguuacccuggauacuuccucagggccaaucaggaggu cuucaaagaguauugagagggagagggauagaaauauuauuaagacugucagugcagcaa cuuuuagaaugucuauuaaagccauggauacaggauuuacgauaacagaagauggauacu aaaaaagaacagagacucaaguucuccuguaagaggcagaagaaacauugcagaagccag ugccuuccucggguccccagugugugcccccauccacccacgcauuguguuggucaucuc caccugcccugugcccagcccugugcccacccagguucuccuaggcacccaccuugcacc ucgcacg 60 AF058798 gaauucugcgcgguuuugcauuuuuugggucagauuggcuuuuuacaugauuacgaagc uccaacgacuagaccacagggaccgucgccuuggcggccgagcagucguauccaacuugg a gacagccaguucgccgugugucugucuguccuucaucgcagucauggagagagccagucu gauccagaaggccaaguuggcugaacaggccgaacgguaugaagacauggcagcuuucau gaagagcgccguggaaaagggcgaggagcucuccugcgaggagcgaaaccugcuuuccgu agccuacaagaacguggugggcggccagagagcggccuggaggguccuguccagcaucga gcagaagagcaacgaggaggggucagaagagaagggccccgaggugaaagaguaccggga gaagguagagaccgagcucagaggugugugcgacaccguacucggccugcuggacucgca ccucaucaaaggggcuggagaugcagagagccgcgucuucuaccugaagaugaaggguga cuacuaccgcuaccuagccgagguggccacuggcgaugacaagaagcgcaucaucgauuc ugcccggucagccuaccaggaggccauggacaucagcaagaaggagaugccgccuaccaa ccccauccgccugggccuggcccugaacuuuucagucuuccacuacgagauagccaacag ccccgaggaggccaucucgcuggccaagaccaccuucgacgaggccauggccgaccugca cacccucagugaggacuccuacaaggacagcacccucaucaugcagcuccugagagacaa ccugacgcuguggacagccgacagugcuggggaagaggguggugaggcuccggaugaccc ccacaucugaagcagcggaaaaacaacccggguuggcuuggccuuccaguccccagccug gcauagaggauuaaaagggagugggauuuugccuuucccaaacccugaauguucagcaac accuugggaaggucuuucgaagggggcgcagccaagcugaagccaccagggcagggaauu uaauuuuucguguagcuguuuggguggguguuucccaaaaccaucccaccccuguuuuu u gaacccccuccccaauucuucccccugagccucccucgggcaccuguugcuuuuggaucc gaauaauccaggagguuccccacccuguggcugagaaauggacuguggcaagggcugugu gugugugagagagagggaaacucugugugugugugugugagagagagagagagagugaa ugagagggaaaaaguuugcugggugugaccaugguaccaaucaauaaaguugcccuguga gacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 61 AW046627 uuuuuuuuuuuuuuuuuaaauaccaaaacauuuaauugaaauaccuguauaaaaaauaug aucuucagacauuucacacuuuugaacuuauacaaccccaccccugaugcuuagucacac cagggucacagaaacacagcugcuaaaauaaauuaagggcuugagacucugucccccaac cccagcuuucagagccagcaagcagacuguacaaggucaauaauuuaaaccccuccccag cgcagagugcucagggugacagggucuc 62 AI848050 uuuuuuuuuuuuuuuuuaauguaacgaccggugugcuucaguuuguuuagcagaaccac ucucuugaaucacauuaacuuuugagauuuaaaaaaaacaaaacaaaaaaaaaaaaaaaca acaaaaaaaaaaccaacccuccauagcacagcugucuuuuaugcaagcaagagcacaccu acuccagcaugauuugucaucuaaagacuugaaaacaaaacaacaacaacaaaaaguuac uuauagucaauggauaagcagaguccgaauuuacacuaaucaagacagaccuucgagggg ucacgauaaguccggaacuuucaaaccuugcuucguaugaauuguacuaucugaacauaa acugcacuuuuauuuuc 63 AF065441 augagacuccacagccucauccugcucuccuuccuucuccuggcuacucaggcguucuca gaaaaggucagaaagagagccaagaacgcaccacacagcacagcggaggaggggguagag gguucagcucccucguuagggaaggcccagaauaagcagagaagcaggacaucuaaaucu cugacgcauggcaaguuugucaccaaagaccaagccacaugcagaugggcugugacugag gaggagcagggcaucagccugaagguccagugcacacaagccgaucaggaguuuucuugu guuuuugcuggugacccaacugacugccuuaaacacgacaaagaccagaucuacuggaaa cagguugcccgcacgcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuug aagaccagagugugcagaaagagauuuccagagucuaaccucaagcuggugaaccccaac gcacguggaaacacgaagcccaggaaggagaaagcagaggucuccgcaagggagcacaac aagguccaagaagcugucuccacggagccaaacagggucaaagaagacaucacacucaau ccagcugcgacccagaccauggccauuagagauccagagugucuagaggauccagaugug cucaaccagaggaagaccgcccuggaguucuguggggaaucuuggagcuccauuugcaca uucuuccucaacauguuacaggcgacaucaugcuaa 64 AF022992 Sequence below cgggucgacccacgcguccgcccacgcguccggcggagcuucuggguugcgggccgaaacggcaagcggauggagggcgcu cgaacggccaggugucgugauuaaauuagucagcccucagagacaggcguccuaccuccuuuauccagaccucaaaagcccc guugugcacccgugguggcuucuucaccuucccuguuucguccuccacuguauggcccagacaugagugguccccuagaa ggggccgaugggggaggagaccccaggcccggagaaccuuuuuguccuggaggagucccauccccuggggccccgcagcac cggccuuguccaggccccagccuggcugaugacacugaugcaaacagcaauggcucaaguggcaaugaguccaacggaccc gaguccaggggcgcaucucagcggaguucucauaguuccucuucuggcaauggcaaggacucagcucugcuggagaccacu gagagcagcaagaguacaaacucacagagcccauccccacccagcagcuccauugccuacagccuccugagugcgagcucag agcaggacaacccaucuaccaguggcugcagcagugaacagucagcucgagccaggacccagaaagaacucaugacugcacu ucgggagcucaaacuucgacugccaccagagcgucggggcaagggccgcucugggaccuuggccacacugcaguacgcucu ggccugugucaagcagguucaggcuaaccaggaauauuaccagcaguggagucuggaggagggugagccuugugccaugg acaugucuacuuacacccuggaggaauuggagcauaucacauccgaauacacacuucgaaaccaggacaccuucucuguggc uguguccuuccugacaggccggauugucuauauuucggagcaggcagguguccugcugcguugcaaacgggauguguuuc ggggugcccgcuucucagagcuccuggcuccccaggaugugggugucuucuauggcucuacuacaccaucucgacugccca ccuggggcacuggcaccucugcagguucaggucucaaggacuucacccaggaaaagucugucuucugccgaaucagaggag guccugaccgggauccagggccucgguaccagccauuccgccuaaccccauaugugaccaagauucgggucucagauggag ccccugcacagccgugcugccuacucauugccgagcgcauccacucugguuaugaagcuccccggaucccuccugacaagag gaucuucaccacccgacacacaccaagcugccucuuccaggauguagaugaaagggcugccccacugcuggguuaccuuccc caggaucuccugggggcuccaguacuucucuuucuacauccugaggaccgaccccucaugcuggccauucauaagaagaua cugcagcuggcaggccagcccuuugaccauuccccuauucgcuucugugcucggaacggggaauaugucaccauggacacc agcugggccgguuuugugcaccccuggagccgcaagguggcuuucguguugggucgccauaaagugcgcacggcaccccu gaaugaggacgucuucacucccccagcccccagcccagcuccgucccuggacucugauauccaggagcucucagagcagauc caucgauugcugcugcagccugugcacagcuccagccccacggggcucuguggaguuggcccucugauguccccugguccu cuacacagcccuggcuccuccagugauagcaaugggggggacgcugaggggccugggccuccugcuccagugacuuuccag cagaucuguaaggaugugcaucugguaaagcaccagggacaacagcucuucauugaaucucgggccaagcccccaccccggc cccgccuccuugcuacagguacauucaaagccaaaguccuucccugccaguccccaaaccccgaacuggagguggccccagu uccugaccaagccucguuagccuuggccccugaggagccagagaggaaagaaaccucuggcuguuccuaccagcagaucaac ugccuggacagcauccucagguauuuggagagcugcaacauucccaguacaaccaagcguaaaugugccuccuccuccucc uacacugccucuucagccucugaugaugacaagcagagggcagguccaguuccugugggggccaagaaagauccgucguca gcaaugcugucuggggagggggcaacuccucggaaggagccaguggugggaggcacccugagcccgcucgcccuggccaau aaggcagagagcgugguguccgucaccagucaguguagcuucagcuccaccaucguccaugugggagacaagaagcccccg gagucggacaucaucaugauggaagaccugccuggccuggccccuggcccagcccccaguccggcccccagccccacaguag ccccugacccaaccccagaugcuuaucgcccagugggucugaccaaggccgugcugucccugcacacacagaaggaagagca agccuuccucaaccgcuucagagaucuuggcaggcuucguggacuugacaccucuucuguggcccccucagccccuggcug ccaccauggccccauucccccuggucgccgacaccacugccgaucuaaagcaaagcguucccgccaccaccaccaccagaccc cccggcccgaaacucccugcuaugucucccauccuucaccugugcccucuucuggacccuggccacccccaccagccacgac ccccuucccagcaaugguccagcccuacccacucccaguauucuccccucgaggaggaccccagccccuucccccugccccua caucuguguccccugcuaccuucccuucucccuuagugaccccaaugguggccuuggugcucccuaacuaucuauucccua ccccaccuaguuauccauauggggugucccaggccccuguugaggggccacccacgccugcuucccacucgcccucuccauc ccugcccccaccaccucucagccccccccaccgcccagacuccccacuguucaacucgagaugcagcuccccacuccagcuca aucugcugcagcuugaggaguccccccgcacggaggggggcgcugcugcaggaggcccaggaagcagugcugggccccugc cucccagugaggagacugcugagccagaggccagauugguggagguuacugagucguccaaucaggaugcacuuucaggc uccagcgaccugcuggagcuacugcuccaagaagacucucgcucgggcacaggcuccgcagccucaggcucccugggcucu ggccugggcucugggucugguucaggaucccacgaagggggaagcaccucagccagcaucacccgcagcagucagagcagc cauacaagcaaguacuuuggcagcaucgacucuuccgaggcugaagcuggggcugcucgggccaggacugagccuggggac caggucauuaagugugugcuccaggaccccaucuggcugcucauggccaaugccgaccagcgugucaugaugacauaccag gugccguccagggaugcagccucugugcugaagcaagaccgggagaggcuccgggccaugcagaaacagcagccacgguuc ucagaggaccagaggcgggaacugggugcugugcacuccuggguccggaagggccagcugccucgggcccuugaugugau ggcguguguggacuguggcagcagcguucaagauccuggccacucugaugacccgcucuucucagaacuggauggauugg ggcuggagcccauggaagaggguggaggcgaggguggugggugugguguuggcgguggugggggugaugguggugagg aggcccagacccaaauuggggcuaaggguucaagcucucaggacucugccauggaggaagaagagcaaggugggggcucau ccagcccagcuuuaccugcagaagaaaacagcaccagcuagauccauuuuggggccgcuuacagcagucuaaugagaggcu uccuuucgaccauguugggguucuuauaacucaagauacagcuggaccaaccaauaggaaacugccccagcuucucccaaca uagggggcuggacccccauuaccagcccaggcacaggagcugccucuagcuucuuagcagaguggaaguucucagccccau uuggaggauuguccacgcccgucccacugaggagacgggcgggucuucgguuaagguugcugacaagcugcugaaguggu cuguccaaaucccagcugagccugagucccagucgcaggguuggggcugcacuuauuuauuugggagagacagcucacucu cccaccucaccccaagaugggaggaggggaaccugggaucuguguaggauccagguccgugaaccccuagcugcuccaggg ugggggagguugguggaccauggagucccuggugcugccccucaggugggacccagguguucucagcucuacccucuacc aaugacauuuguguuuuugauauugugucuguuauuuuuuuuuuaauacaaaaugacaaaaugaaaaaccaaaaa 65 AF064088 Sequence below. gacagcggagcgcgguggcgucgacgucuagugucucagugcucccgucuguggcuaacuaagcagccagcagccaggcag cucgcgaccugcggccaggcagccaaccaugcucaacuucggcgcuucucuccagcaagcuucggaggggaaaauggaacu aauuucugaaaagcccagagaggggaugcaucccugggacaaagcugagcagagugacuuugaagcgguggaagcgcucau guccaugagcugcgacuggaagucucauuucaagaaauaccuugaaaacaggccugucacaccagugucugauaccuccga ggaugacagcuugcuuccagggacgccugaccuucagacagucccagcauuuuguuuaacgccaccuuacagccccucuga cuucgaacccucccaagggucaaaucugacugcaucagcgccaucuacuggccacuucaaaucuuucuccgaugcugccaag ccuccaggcgccacuccuuucaaagaggaggaaaagaauccuuuagcugccccuccucuuccuaaggcucaagccaccagug ucauccgucacacagcugaugcccaacugugcaaccaccaguccugccccgugaaagcagcuagcauccucaacuaucagga caauucuuuccggagaagaacccacggaaauguugaggcuacucgaaagaacauacccugugcugcagugucaccaaacaga uccaagccugagcccagcacaguguccgauggugaugagaaggcgggcgcugcacuauaugacuuugcugugccuuccuca gagacaguaauuuguaggucucagccagcuccuucguccccagugcagaagucaguacuggugucuucaccuacaguaucc acugggggagugccaccccugccugucaucugccagaugguuccccuuccugccaacaacucucuuguuagcacaguuguc cccagcacuccuccuagccagccaccagcugucugcucaccuguguuguucaugggcacucaggugccugagggcaccguc guguuugugguaccccagcccguugugcagagcccaaggccuccaguggugagccccaguggcaccagacugucucccauu gccccugcuccuggauucucuccuucagcagcaagggucacuccucagauugacucguccagaguaagaagucacaucugu agccacccaggguguggcaagacuuacuuuaaaaguucccaucugaaggcccacgugaggacacacacaggggaaaaaccuu ucagcugcagcuggaaaggcugugaaaggagguuugcucgcuccgaugaacuguccagacaccggcggacacacacaggug agaagaaguuugccugucccaugugugaccgucgguuuaugaggagcgaccauuuaaccaagcaugcccgacgccaccuau cagccaagaagcugccaaacuggcaaauggaaguuagcaaguuaaaugacauugcucugccuccgaccccugcuuccgcaca gugacggccagaagauggagacgcagaauaaacuuuggucagagucaggagccagugauggugucaagugcuucugcaag gcuguggcccuccaaaagggccuaaaguagaagcccuggccugggggaggccccgccugggugaaaugacaagaagugcuu cagccacaggcaggucacagaggacagggcucaguucuuaccacagagagagaggagaacccuuuuauuccucccuuauuu uagucuggaaaguuucggcugaggugagcgcagcacagguuuugaaucacauacacauuggggacuuuguuuuugccauu uauacuugagaccagcuuugcagugugauucuuucaaaggauugguuucaagaauauagaggcuggaaauuacgguacag aaauggagcuagaaaaugaguuuguguuacacagagaugucaucuucuccuagaguuaucuuguuucuuauuccuagucu uuccagucaaauccguggauguagcuaaguauaucuaaaacucauuuuuccacuauuguugguauuugaaguugaacagc uguacauugcugugggggagccaaaggauuggaacccucauuaauuuaauugcuuggaaaugcagcuaaaauucuucuuu ggcauuuuguuuugaaaguuuaggcauuuuacucuacuuuagauuuuaguuugcuugcaguuuuuuguguagauuugaa aauuguauaccaauguguuuucuguaggcuuaaaauacacugcacuuuguuuagaaaaaaaucuggagaugaaaauaugua uuauaaagaagagaugucaagaauuugagauaacuccuugagaaaguuggcuuuaugucaucagcaaaggacacuuaacgu caagcauacacugugguuuuuuuguuuuuuuguuuuuuuuuuucaaauuagaaaguuuaaugaccguuacagauggacag ugucuuuuuauuuauaggaguuuuucaggaugucagaguagauagguaggaaaauuguuauuagaacauucgcuucuacc uugaaaaggauguuaauguggucauguucuuagcaccacagugucugggcaucugggaaacuccgagacuuuuuuaaagu gucaugaugugaucacaccugcaguuuggggcaucgaauccagggccuugcaugucuucuguaagagcucucaucgcuga ccuguaucccccgcaagagcaaugacuuuugcuaacaguauuucuuuucuguuguaaaguggacagaugauacacuugguc gcaaagguaaauuauucaaaauccacagugaaaaccucaccacacuuucccauuuaaacuauuuccauaucucagagguuuc ugacaugcaaacuugaacccuugaaagaagaguuuucuuaaaaauuauaaaaaaucacgaguuacaauuugcacaauauuu uuuguugaacuuuauaccuuguuuacaauaaagacuuuucuuug 66 AI787713 uugucanuugcacgacagaaacugcaggaagaugagaugcgccgggcugcggaggagcgc aggaggguaaaggcugaagaguuagcugccagacaaaggguucuagaaaaaauugaaagg gacaaagcagagagagccaagaaguauggugguaguguggguucucggucauccccacca gcaacagacccagguccuguuccuucuucucccagccaggagcccccuacuaagcgggag uaugaccagugucguauacagguuaggcugccugaugggacuucacugacccagacuuuc cgggcccgggaacagcuggcagcugugaggcucuacguggagcuucaccguggggagga g ccuggacaggaccaggacccugugcaguugcucaguggcuuccccagacgggcuuucuca gaggcugauauggaacggccucugcaggaacugggacucgugccuucugcuguccucauu guggccaagaagugucccagcugaggguucuccaucccaccaucuc 67 AI853531 uuuuuuuuuuuuuuuuucacaaauaaguaauauaacuuuauuaaaaugaaaagacaauau ucaaaauaaugcaacaaaaugaauaaauccuuuguccaauacuguacacacagugcggag aucagugcauuuuucuaaagcauguuuuaaccuucauuuaguucauacuaaaguaagcuu uaaauagcucaaauaaugucauucagcaguuuaaacugaacagcuuguugggacauggca gcagugucccugcuagcaagcaccuucucuuuguguuuaucugcacaagauaaacaauca gaggauguaaaaacugaacacaaacugcgugucucacugaaucucagggcagugaagcag ccagcgugaguuuucaaagcaggaagaugcugaagugaccucuggcauuaagacguucug ugcua 68 X14678 Sequence below. uucauuggaaagcacauugcucuucucaguaauuucuuuaguaucuucaugaauuuuuuccuuuugcgucguuauuucag caauucuaucugcagaucauaaagguaguauugacagaugugauucuuuuucuuaaacauuucauuuccaggguaaggaac ucaauggcuauguuuuucucucccucuagugcauccuucuccuuuucuaccauuuucacucuauuuaacuucaucauguu cagucuggccuuuggguuucaucauagcaaucuguucaacuucacccugcaagauuaaaaaucgauuauggucuaagucaa ugccauggcuucuaaggagauuuccaacaucuuuaaacgucuucuucuucccacuuaugugguagacagaagugcuaucuc uguaggcgguucuggauacauagaaguugcuguuaggaaggacuucguaaucaucuccuuccuuaucaauuaucuuuuga aaaugaacuucuacaguacaacucugaauauccuuguguucaucagaauuauguaucaguaccgauagcuuuuuagaccuu auuuuuugugcucgauagccaaacacaaaaagcauggaaucaauaacauuggauuuuccacugccauuugguccaauaaua caggaaaagcgcuuauggaaaggucccacaaguuucucuccagcauaggacuugaaguuuugguuuacaauaugaguuauc augagacgaggagcuccagcuucacuggccauggcuggagguggggguggagggauacuauucaaaaucuccucuaaacu ucuguuauccagcuccucaccuggaggcuuugcgggugcagcgcuccccucaccuacuucgccuacugcaacucccaccacc uccucucgauacaagaccgagcucugucggaccuacucagaaagcgggcguugucgcuacggggccaagugccaguuugcu cacggccugggugaacuucgccaagccaaucgccaccccaaguacaaaacggaacucugccacaaguucuaccuccagggcc gcugccccuauggcucucgaugccacuucauccacaaccccaccgaggaccuagcucucccuggccagccccaugugcugcg acaaagcaucagcuucuccggcuugccucaggccgcagaagcucgccgccaccuccaggcuuuucuggcccuucccugucc ucuuguuccuuuucgccuuccagcuccccaccgcccccuggggaucuuccacuuuccccuucugccuucucugcugccccu gggaccccugugacucgaagagacccuaaccaggccuguugccccuccugccgaaggucuacuacccccagcaccaucuggg ggcccuuggguggccuggcucggagcccaucugcccacucucugggauccgauccugaugacuacgccagcagcggcagca gccugggggggucagacucaccugucuuugaggcagggguguuugggccuccccagaccccugcacccccaaggcgucucc ccaucuucaaucguaucucugucucugagugacaagugccuaccuacccaguauggaucagcuagaucucaaagagagggc agggacugcucauugcuguggggaccuggggcacuccucuaaguuaauaagucccaucuucuggacauuccaagaugcaau aacccauuucccuggugcugggcuggggcaggucccuaguuugcaaauucaguguuuggguggauccguuccuaggguac cuaagauguuugagggagacaguugacaguuggucuuccaggccccaagucuucuguuguuuuugagauaggagcuuauu augguaccccaggcuggcuuugaacucaauauaauccugccuuagccuuuuccaaguucugggguuacagguaugcaccag ccccucugcaacucuggucuccuggaaucuuaagugcugugaagagccggcucccacaauacuauccuaauuuuuacuaga cccugaaguucaguguccgguggucgaagccucuccugagaauccuggugcucaaauuucccuccuaaagcaaauagccaa agccauugccaaaucccuucucccccaaccagugggcccuuuauuuaugacgacuuuauuuauuguauuaagauuuuauag uauuuauauauauugggucgucuacuccguuuuucuuuuuguaauguuaaaacugauacuguauuaaguauaugcuauaa uauauuaauauauugcu 69 AI854358 cggacgcugcagaccugaccgacgugcugugcgaguucgacgcggugcuggccgacuucg cgucgcccuuccacgagcgcacuuccacuaugaggagcaccuagagcgcaugaagcggcg cagcagcgccagcgucagcgacagcagcggcuucagcgacucggagagugcagacucagu guacagggacagcuucaccuucagugaugagaagcugaauucuccaaccaacuccucucc agcucuccugcccuccgcugucacuccucggaaagccaaauuaggugacacuaaagagcu cgaagacuucauugccgaucuggacaggaccuuagcauguaugugaagcaaggaguuugg gguc 70 X67668 ccgggccgaggagaagucugcaaaacaagaggcuggggauugccuuagcgagaaaucagu ucucuuaggagguuagggaaggaagucuuucucuggaggucugagggaagcgcucgugu c agaugccggguugucauggguaagggugaccccaucaagccgcugggcaaaauguccucu uacgccuuuuuugugcagaccugccgggaggagcacaagaagaagcaucccaauucgucg gucaacuucgccgagaucuccaagaaaugcuccaagagauggaagaccaugucugcaaag gaaaacucgaaguuugaagauuuggccaagagcgacaaagcuuguuauuacagggagaug aagaacuauguuucucccaaaggugauaagaaaggaaagaaaaaagauccaaaugcuccg aagagaccaccgucugccuucugccuguuuugcucugaaaaucgcccaaagaucaaaauu gaauacccgggccugucuauuggagauacugcgaagaaacugggugagauguggucuga g cagucugccaaagagaaacaaccguaugagcagaaagcagcuaaacuaaaggagaaguau gaaaaggauuuugcugcauaccgugucaagggcaaaagugaagcaggaaagaaggguccu gguaggccagcaggcucaaagaagaaugacucagaagaugaggaagaagaagaggaggaa gaugaagagggggaagaagaggaugaagaauaaguggcuauccuaaaguguggaguauau gugcucaggcaguuauuuugcuaagaauguaaauucaagcgcagcucaacauuagcucca guaggaa 71 K02236 aucacgcuccuagaacucuucaaaccgaucucucgucgaucuucaa ccgccgccuccacucgccauggaccccaacugcuccugugccuccgguaagggggacugc ugacgggauuucugggagagcuagacaggcuuuuuggccccuccuuuaguaauuacuuu a aggguacgaccggcuaccccuuccgaaugaauucugaagcacuccugcuccuuuaaacua guccuugagauaguggcucgccuacccgggugauuugccucaccuuccuaggagaacagc guucagguacucccgggucccacucaaccgcgcucacugacugccuucuacuuuuagaug gauccugcuccugcgcuggcgccugcaaaugcaaacaaugcaaauguacuuccugcaaga aaaguaaguuggaucuucucugccauuuccccgucacucuccuggggucccuagcccgcc gcgccgcgccuucccucccgggagcguucagguggugugccucugacaagguuucucgcu cacguucaacucuucucuccccacaggcugcugcuccugcugccccgugggcugugcgaa gugcucccagggcugcaucugcaaagaggcuuccgacaagugcagcugcugugccugaag gggggcggagggguccccacaucuguguaaauagaccauguagaagccuagccuuuuuug uacaacccugacucguucuccauaacuuuuucuauaaagcauguaacugacaauaaaagc cguugacuugauu 72 X51829 Sequence below. gcucugaguuuguggaagauuacaugcgauaucccgcgcgaccccgcaucccuuugccggccgggacagccuuugcuacag ccugugaaacauugcguccccgagccccacgccugagggcgacaugaacccgcuggcuucgcgagcaguccggacccacgau cgcuuuuggcaaccagaaccggcgcuucagcccccggggugacgugcagcccgccgcccagacacauggccccgagcccaag accccagcauguccugcacuggagggacgcccacaacuucuaucuccuguccccacugaugggcuugcucagucgggccug gagccgccugaggggcccagaagucccagaggcauggcuggcaaaaacaguaacaggagcagaucagauagaagcugcggc ucugcugacaccuaccccugucucugguaaccuccucccucauggggagacugaagaaaguggaucuccugaacagaguca agcagcccagaggcucugccuuguggaagcugaaaguuccccuccugaaacuuggggacuuucaaauguugaugaguacaa ugcaaagccaggacaagaugaccuuagagagaaggaaauggaacgcacagcuggcaaggccacacuacagcccgcuggccug caaggggcugauaagaggcuuggggaggugguggcuagagaagagggaguggcugagcccgcuuaucccacaucacagcu ggagggugguccagcugagaaugaagaggauggagaaacagugaagacuuaccaagcuucugcugcuuccauagcuccggg auacaaacccagcaccccugugccuuucuugggggaggcagaacaucaagccacggaagaaaaaggaacagaaaacaaggcu gaccccuccaacucuccuucuucaggcucccacuccagagccugggaguacuacucuagagagaagccuaagcaggagggag aagccaagguagaggcacacagggcagggcagggucacccuugucggaaugcugaggcugaggaaggaggaccugagacaa cuuuugucuguacuggaaaugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaagacaacagcg auucggauucagcugaggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguauc gcccaggagaggacacagaggaagaagacagcgauucggauucagcugaggaagacacagcucagaccggugccacccccca uacaagugccuuccugaaggccuggguguaucgcccaggagaggacacagaggaagaaaacagcgauuuggauucagcuga ggaagacacagcucagaccggugccaccccccauacaagugccuuccugaaggccuggguguaucgcccaggagaggacaca gaggaagaaaacagcgauuuggauucagcugaggaagacacagcucagaccggugccaccccacauacaagucccuuccuga aggccuggguguaucgcccaggagaggacacagaagaugacacagaagaggaagaggacagugagaauguggccccaggug acucagaaacagcugacucaagccagagucccugccuucagccccagcguugucuaccaggagagaagaccaagggacgugg ggaagagcccccucucuuccagguggccuucuauuuacccggagagaagccagaaucaccuugggcugcaccuaagcugcc ccuucgacugcagaggcggcucagauuguucaaagcccccacccgggaucaggaccccgagauuccucuaaaagcucggaag guacacuucgcugagaaagucacaguccauuuccuugcugucugggcaggaccagcccaagcugcccgucgaggucccugg gagcaguuugcacgagaucgaagccgcuuugcucgacgcauugcccaggcagaggagaagcugggucccuaccuuaccccu gauuccagggccagagcaugggcacgccuuagaaacccaucucuuccacaguccgagccucgcucuuccucugaggccacuc ccuugacccaagaugugaccacacccucuccccuucccagugaaaccccuucgcccagccuguacuugggagggaggcggg gcuaagccugaguaguuuccuauuauuuauuuauuuauuuauuugaauaagaaauaaagccuuuuaauuuguagugau 73 AW048937 uuuuuuuuuuuuuuuuuaaucaucgagaaguauuuauugagcaccagcuuuggggucgg gugugaggacucgggacaaugcagggugcugucccuucucgugagacgcuuacaaucuga guggagacagggagggagccacaauacauguucuuggggugcgggcuaaggguagacag uccagaccaggauguuacagaaacagggauguuuggggcuggagucagacccacuaagug cu uugacacccacgguauucaacacugagaaaggaucagccauugcucaguguccugugagc ucccuuagcccccaagacaccaucuuggccuggcuccuuguacaacugcuacuaa 74 AV139913 cccaaaacccauucagcaaaguucccaaccucgacgggcuagcaguauuuaaccagugau ggguucacuguuguauuuggugaauacuguauuuuguuucaguucuuucucccagauaa uuugaaaacguuccaggagaaggcagcuuccuauaugcagcgugugcuuucuuauucuu uuuuuuaauauaugacaguuauuugagaacccauuucuacuuugaauucauuuucguug aaagugauguuucuucaccuaccauuuuccuauuaaaguucuguauucaaau 75 M32490 Sequence below. agaccgugagcgagagcgccccagagaagcgccugcaaucucugcgccuccuccgccagcaccucgagagaaggacacccgc cgccucggcccucgccucaccgcacuccgggcgcauuugaucccgcugcucgccggcuuguugguucugugucgccgcgcu cgccccgguuccuccugcgcgccacaaugagcuccagcaccuucaggacgcucgcugucgccgucacccuucuccacuugac cagacuggcgcucuccaccugccccgccgccugccacugcccucuggaggcacccaagugcgccccgggagucggguuggu ccgggacggcugcggcugcuguaaggucugcgcuaaacaacucaacgaggacugcagcaaaacucagcccugcgaccacacc aagggguuggaaugcaauuucggcgccagcuccaccgcucugaaagggaucugcagagcucagucagaaggcagacccugu gaauauaacuccagaaucuaccaaaacggggaaagcuuccagcccaacuguaaacaccagugcacauguauugauggcgccg ugggcugcauuccucuguguccccaagaacugucucuccccaaucugggcugucccaacccccggcuggugaaagucagcg ggcagugcugugaagaguggguuugugaugaagacagcauuaaggacucccuggacgaccaggaugaccuccucggacuc gaugccucggagguggaguuaacgagaaacaaugaguuaaucgcaauuggaaaaggcagcucacugaagaggcuuccuguc uuuggcaccgaaccgcgaguucuuuucaacccucugcacgcccauggccagaaaugcaucguucagaccacgucuuggucc cagugcuccaagagcugcggaacuggcaucuccacacgaguuaccaaugacaacccagagugccgccuggugaaagagaccc ggaucugugaagugcguccuuguggacaaccaguguacagcagccuaaaaaagggcaagaaaugcagcaagaccaagaaauc cccagaaccagucagauuuacuuaugcaggaugcuccagugucaagaaauaccggcccaaauacugcggcuccugcguaga uggccggugcugcacaccucugcagaccagaacugugaagaugcgguuccgaugcgaagauggagagauguuuuccaagaa ugucaugaugauccaguccugcaaauguaacuacaacugcccgcaucccaacgaggcaucguuccgacuguacagccuauuc aaugacauccacaaguucagggacuaagugccuccaggguuccuagugugggcuggacagaggagaagcgcaagcaucaug gagacgugggugggcggaggaugaauggugccuugcucauucuugaguagcauuaggguauuucaaaacugccaaggggc ugauguggacggacagcagcgcagccgcaguuggagaaugccaaggggcugauguggacggacagcagcgcagccgcaguu ggagaagacuucgcuucauaguacuggagcgggcauuauugcuccauauuggagcauguuuacggaugacguucuguuuu cuguuuguaaauuauuugcuaaguguauuuuuuugcuccagacccccccccccuuucuugguucuacaauuguaauagag acaaaauaagauuaguugggccaagugaaagcccugcuuguccuuugacagaaguaaaugaaagcgccucucauuccuucc cgagcggagggggacacucugugaguguccuuggggcagcuaccugcacucuaaaacugcaaacagaaaccagguguuuua agauugaauguuuuuuuauuuaucaaaguguagcuuuuggggagggaggggaaauguaauacuggaauaauuuguaaau gauuuuaauuuuauaucagugaagagaauuuauuuauaaaauuaaucauuuaauaaagaaauauuuaccuaaa 76 AI121305 ccaauaccacagccgugaccacagccaagaccacagccaaaagccuggccauccgcacuc ucggcagcccccuggcagugcccuccauauccugcuuguuuuucucauuaguaaacuccu cuucuaaagaaaacuggggaagcagaucuccaaccuccaggucauccucccgagcucauu ucaggccagugcuuaaacauacccgaaugaagguuuuauguccucaguccgcagcuccac caccuuggaccacagaccugcaacacuagugcacuugagggauacaaaugcuugccugga ucuuucagggcacaaauuccgcuucuuguaaauacuuaguccauccauccugcgugua 77 U35374 auggagaacgaguucacauacgaagauuaugagaccacugccaaguggcuucugcaacac acugaauaucgaccucaaguggcagugaucugugguuccggcuuaggagggcugacugc u cacuuaaaggaggcucagaucuuugacuacaaugagauacccaacuuuccccaaagcaca gugcaaggucacgcaggccgacugguguuuggauugcugaauggcagaugcugugugau g augcaaggccgguuccauauguaugaaggauacucacugucaaaggugacauucccagug agaguuuuccaucuucuggguguggaaacuuugguggucaccaaugcugcuggaggacu c aaccccaauuuugaaguuggagauauuaugcugauccgugaucacaucaaccuaccuggu uucuguggccagaacccucuccggggccccaacgaugaaagguuuggaguucguuuuccu gccaugucugaugcuuaugaccgggauaugaggcagaaggcuuucagugccuggaaacaa augggggagcaacgaaagcuacaagaaggcaccuacgugauguuggcaggccccaacuuu gagacuguggcagagagucgucugcuaaagaugcugggggcagaugcuguuggcaugag c acagucccagaaguuaucgucgcaaggcacugugggcuccgugucuuugguuucucacuc auuacgaacaagguugucauggauuaugagaacuuggagaaggccaaucacauggaaguu cuggaugccgggaaagcagcugcacagacauuggaaagguuugucuccauucuuauggag agcauuccacucccggaucguggcagcuga 78 X15643 Sequence below. uuccaggacagcuggggcuccacgagagaaacccugccucccccccaaaaauggcccaaaguucacugacaaacucacauuu gucugauauuuagcuauguaacagcacuuacgguagcaauagaauuugauucucacucaucacaaugaaaauggcuggcgc ucucucucucccucucuccccauuucaaaucugcaagcacaccccuuagagauggagagaauuugauccauuggagaaucg agcuaaaaauaccaccauggaauugugggaaggauuaaaugcaauaaugcacaaaaggcacauagcagaaugugcccuaaau gucagccauuguuaugguauuauguaaucuacaaaguauguuugcuuacuccgugugaaagacuuucagucuaucaaaca 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cuugucagcuggggcaggagagagaacaggaacugcugugugaggaucccccaggcauggaaggcuuugugaacugucaa gguacugugccuagccuuagcguugacucccaaggaaggaacuguaguacaaaugacucgccacuguaauacaggcuuucu acucucuaagaccccuccuugacaggacacuaaccagacuauuuaacuugaguguaauaacuuuagaauaaaauuguauaga gauuugcagaagggggggcacauccuucucgccuuuuuuuaauuuuuauuuuauuuuuuagcugcaaacaagagagagaa cuguauuugagugcuuauuguucuuguauaguucaguuccucuuguauggaacuuaaagguuucugucugaagaguguu gguucugaggacugagucugucugucugucugucugucugucugucuggaugauguuuucauguaucuaccucacuggu caaguauuaagaaugauauauauugcugcuggaaauccauaucuaaaggagagaguuuucuuccuguacccuuggacuuga aauauccugugucuuggaccuuucugcugugacaaugggcccuuucucucucacuccacuuauuuacucaaauggauucga ggcagggauuugagggacaacacuaguuguuuuguuuuuguuuuuguuuuuuuguuuguuugguucguuuuugguuug uuguuguuuuuugggguuuguuuuuguuuuuguuuuuuuggguuuuuuuuuuuugcugagaaaagucuaaaguuuaca guaaauaaauuguuuaaccaugacuucauugcacccguuucuucaaaaccucuugacucuggaguguccuugucucuccca cuggaaaccacagguaaacuaugugucgugaccgaugaguggcuuaauguguaagaguaccagaauggcaugcuugcaugc accgugccuagcccuuccgugugugucuucagagcuccagaugcaaaccugugccuucccuaacuucacucgugucccaaa gcaguccugccuguucacagcauaacccaguauguccuacaguugcucuucugugcugucacuccagaaacccugacucac ggaaacagaguuauggacauauguuuuuguccccauaugcucugacaccaccuucagccuuacuugcuuaauaacugugua uauuuacaucacugcgucucuuacaguagugccuuuguacugcaucagggcuugguguguucaggaugaggaagauguuc uguguaauagcuguucaagcaucuagaaauucugagggaaaucaaaggccucggucagagagagagagagagagcaaagcu uuaaaaaacauagcuggugaaugcuucacgcccuucagccucuccucgcuccgucugcugucccgugucuucuguucccaa uucucugcacuucuguguaaaccaggcuucccaugucuggcauuccgugcauuauaugauauuuggcggcacgucuguac caguaaauucugguagcacccccuaguuacaauaauugcagacacucagcgcguacgacccccuaguuacauaugcagacac u 79 AI849109 uuuuuuuuuuuuuuuuuaagcguccaggcuguacuuuauuuuacacaagugguggcccc agaaccacagggacaugaccuggagaguaggcacagugccugaggcugcaagagccaaaua cagggauucaugccuucuccuugguccccaugaccaaauuaaaaaaaaaaaaaacaacaa aucacacagcacacaucgccacacccauccccuccuuccuuucagcaacagccaauucag cuuucuagccaaagacaguggcuacaacugaauuuacagagaaccaugcagccaagaaac cagagccacggaggggagaggcuugcguugacuucccacaugugcugucccauagcagcu gagugaccccacca 80 U70132 agaaagauaagggccagcaaggaaagaaugaggaugugggcgccgaggacccguccaaga agaagcggcaacgccggcagaggacucauuucacuagccagcagcugcaggagcuggaag ccacuuuccagagaaaccgcuacccagacauguccacucgcgaagaaaucgccgugugga ccaaccuuacggaagcccgaguccggguuugguucaagaaucgccgggccaaauggagaa agcgggaacgcaaccagcaggccgagcugugcaagaauggcuuugggccgcaguucaacg ggcucaugcagcccuacgaugacauguaccccggcuauucguacaacaauugggcugcca agggccucacgucagcgucucuguccaccaagagcuuccccuucuucaacuccaugaacg ucaauccccuguccucucagaguauguuuuccccgcccaacuccaucucaucuaugagua ugucguccagcauggugcccuccgcggugaccggcgucccgggcuccagccucaauagcc ugaauaacuugaacaaccugagcagcccgucgcugaauuccgcggugcccacgcccgccu guccuuacgcgccgccgacuccuccguacguuuauagggacacauguaacucgagccugg ccagccugagacugaaagcaaagcagcacuccagcuucggcuacgccagcgugcagaacc cggccuccaaccugagugcuugccaguaugcagucgaccggccggugugaaccgcgccca gggcgcggggauccgaggacugucggagugggcaacucugccccagaaagacugagaauu gugcuagaaguucgugcgcacuaugggaaggaagaggggggaaaaaagaucagaggaaaa gaaaccacugaauucaaagagagagcgccuuugauuucaaaggaauguccccaagugucu acgucuuucgcuaagaguauucccaacaguuggaggacgcguacgcccacaaauguuuga cuggauaugacauuuuaacauuacuauaagcuuguuauuuuuuaaguuuagcauuguua a cauuaaaaugacugaaaggauguauauauaucgaaaugucaaauuaauuuuauaaaagca guuguuaguacuaucacuacaguguuuuuaaaggcuaggcuuuaaaauaaagcauguuau acagaaucaguuaggauuuuucgcuugcgagcaaaggaauguauauacuaaaugccacac uguauguuucuaacauauuauuauu 81 M13805 cugagaggccaggugggcggcgaaaucaacguggagauggaugccgcucccgguguggac cugagccgcauccugucagagaugcgugaucaguacgagaagauggcggagaagaaccgc aaggaugccgaagacugguucuucagcaagaccgaggagcugaaccgcgagguggccacc aacagcgagcuggugcagagcggcaagagcgagaucuccgagcucaggcgcaccaugcag gcccuggagauugagcugcagucccagcucagcaugaaagcaucucuggagggcagccug gcagagacagagaaccgcuacugcgugcagcugucucagauccaggggcugaucggcagu guggaggagcagcuggcucagcugcgcugcgagauggagcagcagaaccaggaguacaag auccugcuggaugugaagacaaggcuggagcaggagaucgccaccuaccgccgucugcug gagggagaggaugcccaccugacucaguacaagccaaaagaaccugugaccacccgccag gugcgcaccauuguggaagaaguucaggauggcaaggucaucucaucccgggaacaggug caccagaccacccguuaaggacucagcuccuuccgcccaguuccccgaggcugcagagag gcagcuucccucuccgcuccggcaucacccuccugcuacagccucuccccagcauuccua ugcuugagaccauuaaagcuugcugaccugaagugaacuguggccuuuguucugaacacu gaaauaaaugaccauggugac 82 AV138783 ccccaggggugaaaugaggauucccccacccugcggaacagugaaauguguauaauuaag aggagggcgacgacccuugccgcgggacccgggacucgagcccgggacuucgcagcuaca gcaaaucuauuuuuaauauugugcugagcaagacagaucgcuugcauauuuuuaaaaauu uuuacuacagagacauuccaauaaauucguuaagcc 83 K02927 Sequence below. cugacagucgucucugucccuucuucgccucggagcugcuaacuggucucgaaccucucagcacuucagcuucuagcggcg augcaugugaucaagcgagauggccgccaagagcgaguuauguuugacaaaauuacaucacgaauccagaaacucuguuau ggacucaacauggacuuuguugauccugcucagaucaccaugaaaguaauccaaggccuauauaguggggucaccacagug gaacuggacacccuggcugcugagacagccgcgaccuugaccacgaagcacccugacuaugccauccuggcagcaaggauag ccgucucuaacuugcacaaagaaacaaagaaaguguucagugaugugauggaggaucucuacaacuacauaaauccgcacaa 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gaucuaauagugugaguuucugaugucuacagugagccuguuuucuccucuagguaaccauagagaugaaugagccuguu caccuaacguuugcucugagguaccugaacuuuuucacaaaagccacuccacugucuccuacaguaacacucaguaugucu gcagaugugccccuugguaagaugauaaguuugaacauuguuuuguaaugugguauuuauaguauucggugguuuaauu uuuccugucuuucaguuguagaguauaaaauugcugacaugggacacuuaaaguauuauuuggcucccaagauugaagau gaggaagcaucuuaggcauugcuagaaauugagaaaacuaaaccuuugaagauugcuccugagaugccagcguguccugag gucuuuucugucaccaaguuuguaccugaguauucuuaaauauuaaaauaaaauauguagauaucuucuguaaauaaccua cuuucuuuucucuccauucuccauaauuugcuuaaagaauaagcuccaaaguaaaaacuaguuuuguuaacaugaauguuu cugcuuuacaaauacuggugauuuuccaucaaugaucuugacgcuaaaugcaguuuuaagaaauauuguucaauuuaaaua aaguuaacaauuugaaaaguca 86 M35247 Sequence below. ggugcaggauguaggccugcagaauugucagacccaguggcggcuuuugccacuggaagaauuuccaacauaaaacaga ugaucaguuugggacaaucgauucugcgaccagagguagugucauuugguuacuuuuaaaauucagauugucuggug uuuuccaaucacucgcgacuguaauuugaaguuggguucugagauaauacaaucgcugucgcucuaguuuauaaagcu 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uuugcauaugcaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaaga cucuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuag gccacuccccaggaacuucaguuggcgagucuuuacugucaccuugacuggauuuaggaucaucugggagaugccccu uugaguggcugggcugugaggacagcaggccaguucuugccacccuggacagaaacacaucucaccuuucuggcucaag gaucugaacaccugucucuugccuacucggcuucuagucaggcauuuugucaccuugucaagggucccagggacacaaa gcucccuccucucacccacagcacucuggguccuacccucagugcuucagggacauuuaaucaggucaaauugggauca auggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaauuaaaaaauauaucuuuuuaauuuu 87 AI553024 cuggcacggacauggcugucuucugucugcugugugggaaacgcuuucaggcacaaagcg cacuccagcagcacauggagguccacgcaggcgugcgcagcuauauuugcagugagugca accgcaccuuccccagccacacggcucucaagcgccaccuucgcucacauacagguuuuu uucuccaugugucaccaagugaaguuugugccuucuauagcaaagagaauauuuuuuaca uccuacuaacaguagauuuuuuuguagugaacauuuuuuguauuuuuauuuauaagucuc auaagaaaaauagcgauguucaguuguauaccuugaaucugcaguuagaagagaauaaag uuaacuc 88 X16995 Sequence below. ggagccccagugcaggaggcugcgaaaguugggggagugugcuagaaggacugcggagcggagcgcacgcgggaccaggc ugcgacugggucgcuggucccggccacagggagugggagccggcuggguagguaccccgcagggagcguguuucuguuuc uagggacagugcaugaaagagaugggguguacgcgcgggcgaaaaggaaggguguuuucgggucggcuuacgaggagggg uguguagggugcauuuuugguauuaaaggauagcucuuggaguagggugagccagggcuugaaguuuaggaagcgggcg aagggucugcaaggugcuugguuuugguagguagugggcgcuuguuuaggagguuuccccgcuaggaucuccaguguga ggcacucuguacucuggguuuggguguugauugccggguaggggguugucugagcauggacugggaaaagguacucaga gcuucggcguugcuggggauccauccaaguacaaguaagauuggauuuccacgggucuccuucccggcucucagcccccuu ucccaguguuuacuuaauacuucauaggcuguacuuagauuuucugauucccuuaccgaacuuucuuucugaaccgugcu ggaagaccuggggguugcugaaggaaauggccagcuagguuggcuggguaaugguuguguuagacuaaguugucagagu aucuagaaaccuaggagcuguagccuggugcagcuacugaaagccgcacguggagccuggguggaaguugcucacgauaga gucucgauguaguacugacuaggggggagaccccuucugucaucagacagacuuguauaccccaguggucuuuugaaucu guuagguagggugcagccugcgggcuuggucaccuaacagguguugccaggaccugccccaagccggauucucccacuccc ucuuucaaccccgccucuuccuccuccuugagacacccccacccccucaggaggcuagaugcagaucuguaucuuguguug cugacuaucggccugaagcuggguagauugguggggguugauccggauguaggauguccaaguggagaaacaggauuuga auggagcuggaacaaacgcccaguccugacugcugccacccuucuuccuccacccccaacccaucccuucccaggcuucuug caaacagaggcagaaguggccauauuucuuucuuucucccaggugcuguaugcccuagggacuugacacggggcaggcgg ggugggaacugguuggggggggacgugcuguuuuaugggaagucguaugccuagccagcgguggagcuguccuggcuag gcacccaggggugguguggggaaugggagaaauacugggacuagagggucucaagggccagcagguggugauagucuuuu ucuccaccccacccucugcuccaccaccccucugccucagcaccccucugcccucagcaccccucugccucagcacccucugc cuccagccacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucagcacccucugccucag uguuccugugugaccugucuuuucaacuagaaagucuagaacuguacagaccccagaguuggagguggaaagggacacuag guccuggagccuccucugugggcuuuuuugaccagaugagaacguaagggccuccuccagcuaucccuggucauucaggu gcuucagguuugugaccuuugcugagacccuggaugcugcagcaaacagacaucugcuuuagcagagggacagcuugucu cugugcauccgcugguaggauccuccacucuguccaauuagcuugcgcugcugcuggguucugaguguucucuuacaaaa ugacaagguuagggggcuggagagauggcucaggggcuaagagcacccauguggcaguuugcaacugucuguaacuccug uuccaggggggaucugacacccucacacggacaaacaugcaggcaaaacaccuauuggcauggaaaaugaaaauaaaugacc ggguuagcugagaaauuccuuuugagaguugucuuuucuccaguccaggacugcucucuggaucuuccugcucaguuccu cgccucccuuccauauaugguauuuaagguuuuacuuuuuuuugcguuuucaauuguuuuuaauuguauuuauaugugu cucugugugugcacaugagcauggguguccuacaaggcuagagacaucagauguccuggagcuagaguuacagaugguug ugagccaccugauguaguugcugggaacuggauuuaguuccuguggaagagcagugcaugcucuuaaccacugagcaacu ucuccacgcggcccccccccaguauacgguauuuaaaacucuauagcaaugcuacccaacccauuguggagcuggggaugg ugagguggccuaguuccccccaacuccuggaaacaugucagaaaguacagagugggugccugugggaucagcaugcgggg gguggugguggugagguguggggcugcuuucucccgaggcuaccgugauagacaguuguaccuugcuggcagccucuacc ccauuuccaggaugucagucucugcagacguaugggggacgguggggaagggguauacagagccaugggugugccuggga auguacucccaggaagugacugguugaaaagucagcagaucuccugggggauagaggggugggcugaagcucuguggguu gccucucucagcccugaccugugaacagggaggcuggggguuggaggaacacagcuucccccuguuccuggggggacaug cuggacagccuuuccuagcucccccggcccacugggguguggcuggucgucggacugagcucuuuuggaccuggucucug ccugugagcuuugugacucguugagauagcauuugggcugagggauugggagucuucuguucuuugguccugacacccg cuuccuugucuaggccugccaccuggcuccccccaccccccuccccggccuaccaaguuucuugcuucccuuacugaccccu ccuccucccuccuuugugucuccucccucuccagagaugcccuguauucaagcucaauauggaacaccagcaacgagcccag gaccgcgugaccaccugaccggugauccccuggcccuugaguucggcaagccuaccauggaccuggccagccccgagacagc accugccgcaccugcuacacugcccagcuucagcaccuucauggacggguacaccggagaguuugacaccuuccucuaccag cugccggggacgacccagccgugcuccucagcuuguuccucugccuccuccacgucuucuuccucauccucggccaccucc cccgcuucggcguccuucaaguuugaggacuuccagguguacggcugcuacccgggcacccugagcggcccauuagaugag acccuauccuccagcggcucugaguacuauggcagucccugcucagcccccucgccaucuacacccaacuuccagccguccc agcuuucucccugggacggcucauuuggccacuucuccccgagccagacuuaugaaggccucugggcauggacagagcagu ugccuaaggcuucuucagggccuccgccaccuccaaccuucuucuccuucaguccucccacuggccccagccccagccuggc ccagaguucucugaaauuguucccaccaccagccacccaccagcuuggggagggggagagcuauuccaugccagcagcuuu ccccggcuuggcacccaccucuccgaaccgugacacuuccggcauucuggacgcacccgugaccuccaccaagucccggagc ggggcuucagguggcagcgagggccgcugugcagucuguggugacaaugcuucgugucagcacuaugggguccgcaccug ugagggcugcaagggcuucuucaagguauuuuguugguucugggggacgaugauaucauguuggagguggggguggagu gggucauccguugggaucuguagugaccucuccugagguuucuucccagcugguucuguccugcaggacgagggacaggu gugugccaucuuagaggcugggacuuuuuauucagcagggcacacaucucucuagggcugcagaaagcuggggaaggggg cagaagguguguguguguguggccugcaguggugcucagaaacagaaaaccuagugggcagccucugguucuccacagaa cuuguguuucuggcacuggaugaaaggacacaggcagaggguuugguucuugcuggggguggacuugggaacaggcugu guguuugucccagugcugggugccugcuuggcnnnncccaccuccanccccuuaguccucuccucugcgccaggaaaagg gcagguggacacaugcagacaccuguuagaacaggugucuggacggccgugggaguuccuagacccuggucuuggguucu gggaucuucccugugagguugaaaccuucuccaguaucucccagacuccucucugcgcucuggcccuccguuucucccucc cccuacauccaaauguuaggaaaauagcuaugaacagagggcgcuuuugucugcgucggccacaggaucuggacggucccc uccccugggcucuccaccccccccccaaaccccaugcucugacagccuguuccguguccccccuuccuccagcgcacaguac agaaaagcgccaaguacaucugccuggcaaacaaggauugcccuguggacaagaggcggcggaaccgcugccaguucugcc gcuuccagaagugccuggcugugggcauggugaaggaagguggguggcaagauggugcccucggcauaggcgaccugaug gggugggacagccgggcucaccaggaucugcaccuaauucccacucccacuucuagauuccagccccuaaaugcaggugua gcuuccaccugcuuucuggaaaggguggggugaggagggccuugugggguccccaucauggucugaguucucugucucu gacuucucagaagugggguguauagugugcccugaagacccuccuucuccaggucuccuuucucaauacugcccgucucuc ugcaguuguacggacagacagccuaaaagggcggcggggccggcuaccuucaaaacccaagcagccuccagaugccuccccu accaaucuucucacuucccucauccgggcacacuuggacuccgggccuagcacugccaaauuggacuauuccaaggugagg ucuugcccgcccaucugcccugcccugagaacauaugcaaugccuuugugccuguuaggaaaggcucucccuccagggcaa caucaggaaacaagcauccucuauguacuggcuaguuggagaaaugcauugggauggguguggggucggggagccaguua caaacagcugccguagcccuguuuuccugugggaauugacaagcacaugggcccagaauagggcucuuuugcacgccugga ucuggugucccagugcaugagagcucuguaaugcagcuuguguaggcuuugcuguggacccaaugcaggacacagcugug ugaugcaggccuugcuguggagccagugcgugacacagcuguguggugcaggcccucauguggaacuuaccugcguuccu uucaguuccaggaacuggugcugccccgcuucgggaaggaagaugccggugacgugcaacaauuuuaugacuugcucucu gguucccuggacguuauccgaaagugggcagaaaaaaucccuggcuucauugagcuuugcccaggagaccaagaccuguug cuagagucugccuuccuggaacucuucauccuccgccuggcauaccgguaagcugcccaccauccuccuagcccuggcccca gcccugcggccccggccugccuggacccugaguccugacuguucucugccuucugccagaucuaaacccggugaggggaag cucaucuucugcucaggccugguacuacaccagcugcagugugcccguggcuuuggugauuggauugacaacauccuggc cuucucacggucccugcacagcuuggguguugauguucccgccuuugccugccuguccgcucugguccucaucacuggug aguggcagaaacuagacugggcccaaggguugcaggaccauuggguagguagcaucuaacacuuuggggaccccuagagug ccugcaacauugggauguuaggaccugcaaagggacuuagcucuauucgccccuaaagcuuaaaucagccuccgaaugacc ccggacuccucagguacgacuguaggcgcugggcaucuagcuuagggauucuguuuguuuaaaaaccuagcugucaaccuc acaagacacaggaacgugcacacaugaauuuuucacauucugcgcuuggauagcuaucgccaugguccagaaacaggaccua cuucagcucuguugggcucccuccuuauugucucuguaagagguaaccacucugccagccucaguggcauuccugucaug gauuuuacugugcguaucacaggguauggacucuaguguuaaauguagagguuucugggucccuucucguuccgcuccca uuuccacuuaaauuucuuaggggauccuccugaguagaucaagaccaggagcuggaucuugaaaggguagggagugauau cuacacccagcucaguccuuagucuguccugcgagacuccaggauuuuagaacaguguggagccuggaccuccagaaaacc uggauuaggcuuuugccuuggccagccauucagugguuucaaauauugaccagucuggacagugggcuccugugggacgu gcuagagggcuggggaagcuugucagggagaaggcgucaacugagcggggcugacucuaccuucccugcugcagaucgac acgggcuccaggacccucgucggguggaagagcugcagaaucgcauugcuagcugucugaaggagcacauggcuaccgugg caggagacccacagccggccagcugccugucacgucugcugggcaaacugccugagcuucggacccugugcacucaaggcc ugcagcgcaucuuuugccucaaguuggaggacuugguacccccuccaccuauuguggacaagaucuuuauggacacauugu cuuucugaccccugcccugaacaugugugcgcacacgugcgugcucuucugucacccaugugccuuuaagccuauagccca cggacccccagaccacccuacccccagccugguuuugagcuaagacugacguaccuccucacuccagaagauggacagagaa cucaagaccugggggaggguguguauucacgggggugaccccacuauuugucuuaucccuccagcucaguccuggccuuc guguguuuuuguaagauaaaccauuuuuaacacauaccacucuguuguaaauaagcugacgcuacuguaaauacagaaagg aagagguugagauggggguugggaggaagggguggggcucccaccagcugggcgagccuccaacucgagaucucuuccgc ucuccuuccauguguacauaacugucacucaagaaggugauugacagauucugauuuauauuuguguauuuuccuggauu uauaggaugugacuuuucugauuaauauauuuaauauauugaauaaaaaauagacauguaguugaaa 89 AF038562 ggcacgaggcugugcccgccaugucugcuacccaucacaagaccucccugccucagggcg uccgcgugggcacugucaugagaauucgaggcuuggucccugaccaggcuggcagguucc auguaaaccugcuaugcggugaggagcaaggagcagaugccgccuugcacuuuaacccga ggcuggacacuuccgagguugucuucaacaccaaacaacaaggcaaauggggccgugagg agcgaggcaccggcauccccuuccagcgugggcagcccuuugaagugcuccucaucgcca cagaggaaggcuucaaggcuguggucggggaugacgaauaucuccacuuccaccaccggc ugccgcccgcccgcguucgcuugguggaagugggcggagacgugcagcugcauucauuga auaucuucuaagcaaaggacccaagggccuuugcccgguuacggguuggggguuuuuuga ucccacaagaaagguuuuggaucggccaauaacauuuuucuguuguucugaaaaauuaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 90 Y11666 gccacauuguugcaccaacuccagugcuggagucucaggacaccaca ggcuacccggaguuguucugcuuuggagauccgagggcaggagcaucacgccagugacuc ugauaggugcgaucgccggauuggaacagaacugucauuuuuuuccgaaguugagccuua gugacccagugagugaaguuagcgacgggacgcuaagcagcuagaccggucggcaggagu gagacuuaggguaccuucuaguaguugugauuaaaaaaauugaaaaaaagaaaaaaaaaa acccuguuucuggaaacuugaggcccucagcuggugagccaucgugguuaagcuucuuug uguggcuccuggagucuucgaucccagccggacacccgggccugguuucaaagcggucgg acagcgcugccugcuccaucgguagcgcucgagccucgguuucucuauuuggccccgacu cgccgcaacaagaugaucgccucgcauaugaucgccugcuuauucacggagcucaaccaa aaccaagugcaga 91 U40930 Sequence below. cccagcuguuucguccguaccuagaccgcgguuauggcgucguucacggugaaggccuaucuucugggcaaggaggag g cgacccgcgagauccgccgcuucagcuucugcuucagcccggagccggaggcggaagcccaagccgcggccggcccggg g cccugcgagaggcugcugagccgaguggcugugcuguuccccacgcugaggccuggcggcuuccaggcgcacuaccgc g augaggauggggacuugguugccuuuuccagugaugaggagcugacaauggcuauguccuaugugaaagaugacaucu uccgcaucuacauuaaagagaagaaggagugccggcgggaacaucgcccaccaugugcucaggaggcaccccgaaacau ggugcaccccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccaga cuacgaccugugcagcgugugcgaggggaagggccugcacagggaacacagcaagcucaucuuucccaaccccuuuggc caccucucugauagcuucucucauagccgcuggcuucggaagcugaaacauggacacuuuggcuggccuggcugggag augggcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuu cugcuccaccagaagaucccaaugucaauuuccugaagaaugugggggagaguguggcagcugcccucagcccucuagg cauugagguugacauugauguggaacauggagggaagagaagccgccugacacccacuaccccagaaaguuccagcaca ggcacagaagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcc cugcucagucucugacagagcaaaugaaaaagauagccuuggagucggugggacagccagaggaacagauggagucggg aaacugcucaggaggagacgaugacuggacacauuugucuucaaaagaaguggacccaucuacaggugaacuccagucu cuacagaugccagaaucggaagggccaagcucucuagaccccucacaggaaggacccacagggcugaaggaagcugcccu auacccacaucucccaccagaggcugauccccggcugauugagucccucucccagaugcuguccauggguuucucggau gaaggcggcuggcucaccaggcuccuacagaccaagaauuacgacaucggggcugcucuggacacgauccaguauucga agcacccuccaccauugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagcag ggcuucuauagauaggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucaggcaa uaggaaagugcaugaggagaguuuugaaugugcauaugcugacgccugagaacagacccagguacccguggcugagcu gagcuuccucugcuuccccuaggccuggccucugcagggaacugcagcacacacugcacucccaccugcucuugccgcc agcauugcaccagcaguccagaauuccugccugacaacccguguuuccuuuauuaaaagugauuaguacaacugcuagu uauuuucaacaaauaaagccauuauguuaagaggggacuguccauagugagugaaagguggcaggcaggggccuacag cuccuagggaauggagaauucaugugaagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccacucu uuaguguuugugucuaauguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaaguaacc uguaauaaaaugccauaugcacuuuaacca 92 D26090 Sequence below. gagggaauugcgggaccccgucuggggaagcucccgccgccccggggugcucagcucucugucucccuugacccaggu a cagucaugucgggcuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggcc a ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccgagugggcaccgaucgcacgggcuuc a ccuucaaguacagagaugaacucaagcggcauuacaaccugggugaauacuggaucgagguggagauggaggaccuggc c aguuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaagg a gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaagacauccaggucaugcucaagucagau g ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagc c ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauaucgccaugcc caggccuagagggcuaugccuucccaggaagugcaauauggaucaggcugggcgcccaaagugcccacuggauccauac uucaucaugccugacaagugcaaguguguggacuuccagacucugaaacugcaggagcugccugaugcagucccucaug gugagaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacagggucacca ucaugggcauuuauuccaucaagaaguuuggcuugaaccccagcaagggccgggacaggguaggugugggcauccgga gcucguacauccgagugcugggcauccagguggacacagauggcucuggccgaagcuuugcugggucugucagcccac aggaagaggaggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuucccccuccau cuuugggggcauggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagauggacu cacucgccgaggugauaucaacuugcugauguugggagacccugguacagccaagucucagcuucugaaguuugugga gaagugcucucccauugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauacggga ccccucaucucgaaacuucaucauggaagguggagccaugguucuggccgauggugggguugucuguauugaugaguu ugacaagaugcgggaagaugaccguguugcaauccaugaggcuauggagcagcagaccaucuccauugcuaaagcuggg aucacuaccaccuugaacucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagacaaaag gggaggacaauauugacuucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcacaauga ggagagggacaugaugcuagccaaacaugugaugacucugcaugugagugcacugacacagacacaggcuguggaggg ugagaucgaccuggccaagaugaagaaguucauugccuacugccgagcgagguguggaccucggcuaucagcagaggca gcagagaagcugaagaaccgcuacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcguucca gcauccccaucacugugcggcagcuggaggcuauugugcgcauugcugaggcccucaguaagaugaaacugcagcccuu ugccacugaggcugauguagaggaggcauugagacuguuccagguguccacacuggaugcugcuuugucuggcaaucu gucggggguggagggcuucacuacccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgccguuu ugccauuggcucucaggugucugaacacagcauuguccaggacuucaccaaacagaaauauccagagcacgcuauccga aaggugcugcagcucaugcuacgcaggggugagauccaacaccguaugcagcgcaaggugcucuaucgccucaagugag cccauugcccaucaacccucaagccugaaaugcugccaccacccuaucucccagucagugcuccaaaccuccuuuugccc ugccucuccaccucagacugcugucugcagcacaucugcagccccuggaaauguacuuuggucuguuggcucauacug uguuugagugucugaggacucucugcucugggugucuauccccugucaugccuucucaacaagaugagucuggagcag gaacaggcccuggaauguagaugggucuguauauuggcucccgggccacucacugccaagcuucuuuguauguacaga gguaauaaagcaauugagucccuggcugcuaaggucaguggacccagu 93 AI787627 ggaugcagccggaagugcagcgugcgugcgguuuggugggucgcugugugcgcuccgcgu gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc agccugagggcgaggaagacgccagcgacggcggcagaaagcgaggccaggcgggcuggg aagguggcuaucccgagaucguaaaggagaacaagcucuucgagcacuacuaucaggaac ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc cagccacacugagaaucacuggguacaaaagccaugccaaagagauucuccauugcuuga agaacaaguacuuuaaggaguuggagganccugaaguagauggacagaaaguugaguucc acaaccacuaagcugguacccugaagaacu 94 M33988 gagcucaaauucuggcuuucuauuggguacgauauauuaaccaaugggagaaacacaaac agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu ggcgggcaaugcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcu ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga gucaaaaguguguaagagaugaaaccuuuagaacauacuauaaauuuuuaguagaaauuu ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa gggccauuaaaucccacuuccauaguuuc 95 AI845182 uuuuuuuuuuuuuuuuuggaaaugaagguaauuuauugaaacugguuuugggacaggcga guggacaacuguugaaaggagcuagcgcacagccgggugggagcgggugcuuagccacag auccuaucugaggcccaacuuuuucuuuuccuucugcuucuuacggaccacauccagguu ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu caucucucgcauggcgcgcacauagucacuggggucuuugaagcugacaaagccauagcc cuugguuuugccugugcgcuuguca 96 AA619207 uucggauccuugccaauauauguaucccauuuggaauggugaucuuaaaaugugagugca ugcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccgaagcuggaa cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc uucaugaaaauccaaacacguuaagggaccagggagaugccacugccccccugaauuuuc aucaaaaauagacacguuuauguaaacagaacuauuuuccauauucauagugacuuuuua aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu auuacau 97 AW125783 cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg ccucgcuuuucgugguggcucggauccuagcggaccucaaccagcaggcgccggcgcccg cccccgcggaacgcagagaaggggccgcugcgcgcaaggcgaggacccccugccgccugc cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg cgccggccgcgccccccagccccgcguggagcgagccggaggcggcauuggagcaggagc ccggccccgcggggagcggcgagccuggccucagacaaaggggucggggaggccggagcc gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa 98 J04103 Sequence below. cgucaguccccgccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccggccuugcgcgccgggac cgccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacau ggaccaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucu guuugcugugcucccuucucucagugaagaucagacacuccaagaagugcccacgggccuggauucugucucccaugacuc ggccagcugcgagcugccuuugcucacucccugcagcaaggcagugaugagccaagccuuaaaagccaccuucaguggcuu ccaaaaggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucug ggccaccaacgaguucagccuggugaaugugaaccugcaccaguuuggcaugaacggccagaugcuguguaaccucggcaa ggagcgcuuccuggagcuggcgccugacuuugugggugacauccucugggaacaucuagagcagaugaucaaagagaacca agaaaagacagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuuc agcauggaacaggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucgg ccacgccugcagcucugggcucugagcuccagauguugcccaagucucggcucaacaccgucaaugucaauuacuguucca ucagccaggacuuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaa cgguggggacagcuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggg uaccuuccuucgagagcuuugaggaggacuguagccagucucugugccucaguaagcugaccauguccuucaaggacuaca uccaagagaggagcgacccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggac caauccaguuguggcaguuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggaugga ugggaguucaagcuugcugaccccgaugagguugcccgccggugggggaagaggaaaaauaaaccaaagaugaacuacgag aagcugagccggggcuuacguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuuc guaugugaccugcagaacuugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagac ugagggccuca 99 D90146 Sequence below. auggcucuaacaacgcugcucuuggugguggcggccgcccugacccugaucgagacccgcgcgggugagugcggggucgg gagggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcuc cacucccggcccgcguacccgaccggggucccgggaggaggucggggucucaccgcgcgccgcccccaggcccacacucgcu gcgguauuuccacaccgcugugucccggcccggacucggggagccccgguucaucaucgucggcuacguggacgacacgca guucgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggagu auugggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuaca accagagcaagggcggugagugaccccgggucggaggucacuaccucuccacgucccgaaacagaggccggugaggucccg ggugcaaaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcggugggggg guggggggggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugacau gggguccgacgggcgccuccuccgcggguaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagaccu gaaaacguggacggcggcggacauggaggcacagaucacccgacgcaagugggagcaggcugguauugcagagagagaccg ggccuaccuggaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcaggggcc gcgggcagcuccucccucugcccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguggugccccugg cucagaggggagagagugacccugggucuccugaucccucaucacagugacugcacugacucucccagggcucagccuucu cccuggacagugcccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguucccc uguagccucugucagccauggccucucccaggccaggguucucagccuacacccacugucuguagacacugacuccugucc ugcugagugugucagcccuuacaccucaugaccugaagucuccuuuacccgaugggagacauggacaucuacacuaggcug guucccccaguuucuagaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugacac ccaauucuaucuauuccugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuuguguuu uuccccucucguuuucuuuuuaucuuuacuuuuuuuuuaaggguauuauguugcuuauaaucgguuuuucuucggcacu ggaaugauauugcucucucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucguggaa cucacucuguagaccaggcuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcugggau uaaaggcuugggccaccaccacugggcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccauccag aucacuccugauaucccugugccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagggu cuucugcaauccaggccugagugagagggaagaccacacacccugugagcccacuguguuccagugagugcugcacugggg uccacagcacauuccagggauccugugugacacaucuguaccuugucccccagagucaggggcugggagucauuuucucug gcugagugucagagguucaccacauuucugcuacacacucccugauggcuguuuacuuggacugacaguuaauguugguc agcaagaugaccacagugguuuagucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagauacga acucaaacacauaugaaauuucuuauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacaucaca uaaggaugaccauguugacccacuggcucauguggauucccucuuagcuucugaguccccucaggaaaaugugcaguccug ugcugagggggccagcucugccugcaggucacuagugccaugacaguuaaaguguucauacagacacauaguucauuguaa uuacugauuuagcguugucuuggcaguuuucaguuugcaugcauuuauuuauuuauuuauuuauuuauuuauuuauuua augcauggaaguacacuguugcuguacugaugguuguuugccuuugugugguuguugggaauugaauuuuuuuuuuuag gaccucucuuugcucuggucgacccugcucacuccggucaacuccuaugggucaacucugcucauucagucccugcuuguu cuggcccaaagauuuauuuauuauuuauuauacauaaauacacuguagcugacuucagaugcaccagaagagggcgucaga ucucauuacagaugguugugagccaccaugugguugcuggaguuugaacucaggaccuucaaaagagcagucagugcucu uacccucugagccaucuccccaguccucaguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucccccaa agacacaugugacccaucaccccauaucuuaugaugcugucacccugaggugcugggcccugggcuucuacccuguugaca ucacccugacuuggcaguugaauggggaggagcugacccaggacacggagcuuguggagaccaggccugcaggggaugga accuuccagaagugggcagcugugauggugccuuuuggggaggagcagaauuacacaugccaugugcaccaugaggggcu gccugagccccucacccugagaugggguaaggagggugugggugcagagcuguggucagggaaagcuggagcauucugca gacucugagcuggucagggcugagagcugggaucaugacccucaccuucauuuccuguaccuguccuucccagagccuccu ccauacacugucuccaacauggcgaccauugcuauugugguugaccuuggagcuguggccaucauuggagcugugguggc uuuugugaugaauaggaggugaaacacagguaggaaagggcagggucugaguucucucucagucuccuuuagaagugugc ucuaaucauuaaugggaaacccaucuacaccccacauugcuaccuucuccaacuggguccucugucaguucugggaacuuc caagaucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacugugcuccagcuccagguuagugu ggggacaggauuguccuguggacauugcagugaagcuggagauguuggggagcucugggaacccauaguaacucuuccag agaaaucuuccagggccgcaguuguccaauaugaauacauauauguacauaugcauauacauuuuuuacccuuggcaggga cagcuccuagagcucugauagaucucucccaggugguaaaggugacacucugggaccugauuggggaggggcaaugugga uaugauuggguuucagggacuccacgaauccccucugagugagugguggguuguuggaauguugucuucacagugaugg gucgugucccuc 100 AI563854 uuaaaucuggagggauuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu auuaaacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa acauuuuacaaaagagaacucucuaggaucagcuacaucaaggacaagcagaaaaauaga ugcaguccaacaaagacauugaaaaugacuu 101 AF017128 Sequence below. ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagaggu ucaucuggagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaagugguuca gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacc cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggu cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcaggugagacuggccgaaucgucgggggggggggg accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggccccgagcagcau cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggac gagcgcagcgggaagcgcgaauaucugcgaauuccccuucucgcucgcccguaucucccuagcugacugucuuucugccc cuccgucuccguuacggucuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccugc cuggacaggaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagagacgggguccau cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguccgugucccuu uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccugga gaccacgaaguguugggaugugcgcggggucaccugcccggccacacucgcgcuccacauucucggcacccgacgucucu cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccagggga gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccugggugccccucccuu ccuggccccaaacggccccuaaggaccgacgaccugggagcgagagaugccccuggcagugcuucuagcccagaacgggg gucacugagaugcugggucccccaguauugggcuggggacauagcuguccagacuugccuaagcaugugaggugcuucc uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccaccccca ccgacacucaaucccaacacaugccucagauuucugcaagaaaaggaaggaaaggaugccagaccccuuauaggaggcuuu uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuugaacuuucaaguuuuuaagucgacagcuaggca ugcauuuaaucccagcauucaggaggcagaggcaggcagaucucugggaguuugaagccaauuuggucuacaaagugac uuccaggucagcuagagcuacauaauagagauccugucucaaaacuuaaaaaauaaaaaacaaaaacaaaagccgauuaaa acucugauuucugagcuaugagagcuggcuucucaacagcaauggaacguugaaugauguuaauaacagggaaacugag acuaaauaacaugccccagucucaaagcccaucaauggccaagcuccaagcugaugcuggacucccaagcucuggugcuac augucuauagucuuggugccugggagguagaggcagaggaaucgugaguuuaggucuagccugagcuaugugagaucc ugcccaccccacccccggcccccaaacaacaaauucucauccugauucucagaauugccuugggagcuagaagcugaaagu augcccaucugugaggacugggucucaaaucuuaguuucuacuuacuagcugugggucuaugggcaacugcucuccugu cugaaaacaggauuauggcagcugugugagucacuauuuguuaaauaguuggaacaguguuacgcaguccauacuugau uuaaaacaaaaaaccaaacuaucucugguggggaaacagacagacgaagagagacauuuugugaccugcccaaaaucacac agcuccugaacaaguaaguuucugguugccaaauguugcuccuuguggucucccaaaacugguaucuacacugagguga agggagacagaaguccagccucuguccccgggaagccccucaguccacacagaccuuaucauuucccuucuuaucucuca gaaguuccaccuugugccaagcaucgacagcagcagccaggaacugcacuggauggugcagccucauuuccugggaccca cuggcuauccccgaccucuggccuauccccaguacagucccccucagccccggccaggagucauacgagcccuagggccac cuccgggggugcgucgcaggcccugcgagcagguaagaaacagcgauguuucacuuuccauagcccguagggguccuac uagacagggacaggaucuugcuacgagggaauuucuuauucagcauugaaguuccugagaggccaagaaggagguaaaa ggucaccuuugagucaaggaaggcuuccuggagaaggcuacacguuaaccuaaaccacggauaggauuugcguauggaa gcugaaaagaaucuucugggaggaggguuggaggcacagaauugaggugaaggggacagaguguuaagugagcaugucu ccacugucugacgugcacaggguggaaggaagccugaugcuggcuuuguaccucggggugacucuucuuuucaacaguc acggaaucucagccuauuucuuuuaauuaucacaaaaagugagugggcagugguggcucacaccuuaaauuucagcacug gggaggcagaggcagguggaucucuggguucaaggccagccugguuuacagagugaguuccaggacagccaaggcuaca gagaaacccugucucaagaaagggaaaaaaaaagugaaugggaaauguauuucaauuuuuccaucuuccaucagaggaag ugaagcauagagggguacucacuuguccagauucauacaaaugugaguaaugagacaggacugguccuggccugagguc uacucaacucccaaagucagagcuuaaugagccacugucucaaugggagcucacagaagccugcagagggagugagcuga gaacuuuugccucccugaaugccuuucuaaaauaaagaaggguguguuuugguugguuuguagagguggggucuugag agccuccugccuucccaagugcuaggaguauagguguaugcuagauacccgacagggaugacggaucuuuuaggccaua gcacuuucuuuccucucccugaaguacugagacugagucuagugcagggaggccuccauacuaaaaagcuggguguaccc guaaucccagaacucggaaaaucaagacaggaggagccauucaagucacgcucagaaacauggagaguuuaaggucagcc ugggauauauaaacccuaucuccgauaaccaaacaacaaucaaagcaaaccugacuuaaguguuaaguaggaaagaauaug cuguaagucaucagccuggcugggggacugaccgccucugagggacugaagaaccugcuucaagcccggagcccugcacu caaccccuaguggaugcacacacagauccuugccaugauggcucgaagagggauggcaagacccugggagauaugugaga uuggccagagaagagccagcaacaggcuucccagcaagggaacagcuuaccucugugaucagcuggggcgugagcaagag gcaagcccagggugaauccuuccuuuagcccuguccugaggagacaccuuuugaccacggguacuaguggguuggagcu gugagcuguggguagguggcuuccccucggugugcucuggaacuugaacaaaucacucauccuuccugagcuuccucac augugagugugcagagaucuggaugggugacucagcagcggcucuggcugcuccuuagaggauccggguuccaaucuca gcacccacguggcaacucacuguccacaacgucccccaaagguucugaugcccucuucuggccuccaccagcacugaaugc acaaggugcucauacaaacacacaggcaaaauacucagagguaaauuuguucuuuuuuuucuuuugagacaggguuucu cuguauagcccuggcuguccuagaacucacucuacagaccaggcuggccucaaacucacagaggcaucugccugccuccc aaguguugggaccaaagauguaugccaucacuauaagccuuuuuuuuuuuuguaaauuuuauuuaugaaugagugcuuc cauguauaccuucaugccaggagagggcaucagauccuauuauaggugguugugagccaccguguguggcugggauuug aacucaggaccucugaaagaggagcucuuaacugcuaaaacaucucucuagccccagucuacauauuuuaaaucuuuuuu uaagauugauuuauuuauuauacauaaguacauuguagcugucuucagacacuccagaagagggcgucagaucuuguua uggaugauugugagccaccaugugguugcugggauuugaacucaggaccuuuggaagaguagucaaugcucuuacccgc ugagccaucucaccagccccuuuuuuaaucuuuaaaaaaaaaagggggggggccuggagagauggcucagccguuaagag cacugaaugcuuuuccagagguccugaguucaauucccaacaaccacaugguagcucacaaccaucuguaaugggaucca augcccucuucugguguaucugaagacagcaagggucuacucacauauguuaaauaaauaaauaaaaauuuaaaagccag gugguguugguucagacagcagaucucuguuuaaggccagccuggucugaucuacaaaccaaguuccaggacagccagg gcuacacagagaaacccucuaaaaaaccaaucuauguagggggugcuggugaaauggcuccguggguaaagguacuugcu gcgaaauuaaugaccugaguucaauccuugaaauccacacaguagaaggagagaaccaaccuccaagggugcuaugacaca cacacacacacacacacacacacacacacacacacacacacacacacgacuauauauaugaauauaugacucuagccaggca uaguguggcacaugccuuuaaucacaguacuugggaggcagaggcaggugaaguuugaggccagccuacagagugaauu ccaugacagcuagaacuaugaagaugaacccugucuuuaaaaacaacagcaacauaaagaaucuauguagggaagcuggaa gggaugcugauacagucugcaauccuauuacucuagagguggaagccaaagaaucagggguuucaggccggucuugccu auacacugagcuaaaggccagccugggacacaugagacuuugucucuuuuaaaaagacaaaacaaggggguugguuagau ggcucaguggguaagagcacccaacugcucuucugcagguccgaaguucaaaucccagcaaccacaugguggcucacaac caucuguaacgaaaucugagucccucuucuggagugucugaaaacaacuacaguguacuuacauauaauaaaaauaaaua aaucuuaaaaaaaaaaaaaaaagacaaaacaagccagaugaggucugugaguuccaggccagccuggucuauaaaucaagu ucaaggccaggcagggcuacucagagauucugucuaaaauacaaagaaacaaaacuacaaaaagcagaaaaaggaaucuac gaaagggcuggugaagggguguaacucagugguagagcauuugccgagcuagcauguaccaagccauggguuugauccc uagcacuaagcaaaagaaaaguccuacaaagggcuuuguuggcauaguagauugauucccaguagcuuuuggcacucaag agcaccuucuacaauucacagcuccugggggaagaaaucccaucuuccacagaugaggaggcugagaguccugugaaaag agauaaucaugucucauacacucaggagagaaggcuacuucugccugagaaaugaaaaggcuuccuggggucccaacauc uuaguccaguccuaagaugcggaagggaggaagaucaaaguuuacagagagggaaagcauuucaggaaagaaaccagcag 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cuccgagucugguuuucaccuauccuagcacaccagaaccuugcuccuccgcucaccgaaagaguagcagcagcaguggc gaccccuccuccgacccccugggcucuccuacacuccuggcuuugugaggcacccagccacaucccuugcuggugcuacu ccaagccauccccuuucucccauugauccagcaggccuggaccauacccuugccccaaaccagcagaucuuuuaucucuuc cgacuagaacaaacacauuaugcuuugauguagagccagcuuggaggggauccccaaagcugcucacuguuuuucuagag cuggccuaucauaauuugcacaaaauuagaggaaaauauguucccucugccagagaacgccuggcagcccagacuuugua gauccccagggguccuuugacacccuuaccccuugcagaccacuuucccacaccacgucacuuucuucauguuauccagc cuacucuacaccuagacagaaggugcccuuugacuagccuagaacacuaacucacacagcaucaacagccagcagcaccgg acauccugcaggcuccuccugaauggcacaacgcaggaggcgccaggggcuucugugaggagcggagcugcacucccuag cucugagaagcgcuuagcuucaggguauccgagccuccaccgcaagggcagcugcuauuuauuuuccuaaagagacuauuuuuaua caaaccuuccaaaauggaauaaaaggcuug 102 X67644 Sequence below. ccguggguuccuaauggugcuauugacgacgggcacaaagucucauaauuuuagaaacuucacuuauuuugugacccaccu aguauggggcaaaggcaggagcuucggacuuccugucuucccucuaucccuuugaauagcgucucgggagugucccuaag uaaccauugcaguuuuguguccgugugcucuguugaaaucucugugauguguguaugguuuucacgugaacggaggcag gcagagcccggucuguggguucuaguguguucuuuaucuucuuggaaguuugugcaaugacuucccuccuguuuccugc gcauaccuccaaguaaguacgugaauguguuuucuguggucccuugaucuugcuggacuucacuaaggaggguggcugga ccaucugcuacgugucugagagccccucucuagcuaccucauguccggacgugagcuuacucccaauguuuuuacccacaa gcauucacuacucccaggaaagaacgugcacuggggcaccuagagaauaaccaaucaacgcuccgccuacauuuugcuuccu ccuuggaauuuccagccccuugcagccaacugcuccccagcugcgaagggcggaguuccccccggcccggccccuucuuug gcucuauaaguagcucugcuuugcgggggauuugcacuccucuacacucucugcacaacgucuaaauuaugugccacucgc gcaaccaucuccacaccaugacuggccugagggccccuucuccagcucccuccaccggcccggaacuccggcggggcucugg ucccgaaauuuucaccuucgacccucucccggagcgggccgugguguccaccgcgcguuugaacacuucucgcgggcaccg aaaacgcagccgaagggugcucuacccucgaguggugaguaucgcccgagugggcaucaggaggucgcgucgcccuggaac uuguagguaacaacuaggagcagggaccuucgaucugacguuucccucuuuuaucugcucagguccggcgccagcuaccaa ccgaggaacccaacauugccaagaggguccucuuucuccuguucgccaucaucuucugccagauuuugauggcugaagagg gugugucgcagccccuggcuccggaggaugcuaccagcgccgugacaccugagcccauuucugcgcccauuacugcgcccc cgguccucgagccuuugaaccugaccucggaguccucggacuaugcgcuggaucuuaaagcuuuucucuagcaacauccgg cggccuucuaaacgcgaugggucacaguccgaagaaacaaaggcaccauggauggguaccuggugcgagagaacguauccc aaacugggauuucuaaggcaacgcuaacucagaacacuaccgccaagagacaccgcggguccuggcuaggcccacuggggac ggacagagacuuucuccgugucuaauuaauauuuauguauuuauguauauccuccuaggugaaggagggguguauguaau auuuauucuaacuuaugcaggggugcgagauaugccucccugcuguaacacagauauuuauuacgauuuauagggucggu aagacagaguugugggagggaggacccgggugguaggacucccagcuuggggauuagucugggggggguguaauaagau uagggguaacacuccgucuuccagcacuucaacucuguagucuguuguaaggcuuuggaagacccuugggaauccggccu uugaugucuucugguugcuucucaggggcagcugcaggagucuuggguccauggauugucagagggcggcugucugggg ucgccuaguauguauguucugugaacacgaauaaacuugauuugccugucauuauuaucugcaguucucgaaguguauca uucag 103 AF064088 See above (same Accession Number). 104 AI843085 uuuuuuuuuuuuuuuuuaaauugccgaauuaaguucuuuuaauagauugcauauauagau guuuagccauacucuagaucaacucuuuaagaguagaauuuuauauccaauuuacaugcu ucagauaucaccucuguuuguuacauaaggucuuguauccaaauguccacuuguacacug agagcuuuaggaacaaaaaaggacacagagagaguugccauuuuuagcagcaaugaaaca ucacuaaccccuuuuuacauaccgaauucaagucacuac 105 AW124932 cggccgccgguauuuuuuugcaaguauugagaguucuguauguuuugaaaagaguaauuu uaacguuugggugccaagaaguggguuuucucagaguccauugccggcaaugggcaagcc uggcgguacuccucgugccgaau 106 X58609 augg cgcugggaacgcugcuccugcugcuggcggccgcccuggcccggacccagaaccgagccg gugagugcagggucgggagggaaacagaacuuuccaaacagucugcggggaggggcgggu gcggcaccggggaagccgcgugcccgcgucgcccaccagacccuccgucucuuuacccgc gucccuagccccgcgcccugcuccccuccugucccgcgcauccgcccggggucccgggag aaggucggggucucaccgcgcgccgcccccaggcucacacucgaugcgguauuucgagac cgucgugucccggccgggccucggggagccccgguacgucucugucggcuacguggacga cacggaguucgugcgcuucgacagcgacgcggagaaaccgagguaugagccgcgggcgcg guggauggagcaggaggggccggaguauugggagcggaucacgcagaucgccaagggcca ugagcagugguuccgagugagccugaggaaacugcuaggcuacuacaaccagagcgcggg cggugagugaccccgggucggaggucaggccccuccacuucccgacacagggacgcugac guccugguucccaagucugagguucgggaacagaacggacccgggaccgguuucccuuuc aguuuggaggaguccgcgggugggcggggcugaccgcggggucccgcagguucucacaca cuccaggagauguauggcugugaugugggaucggacgggcgccuccuccgcggguaccgg caguccgccuaugauggcugcgauuacauugcccugaacgaagaccugaaaaccuggacu gcgaaggauguggcagcgcugaucaccagacgcaagugggagcaggauggugcugcagag uauuacaaggcuuacauggagggcgagugcgugcagucgcuccgcagauaccuggagcuc gggaaggagacgcugcugcgcacag 107 M18837 Sequence below. auggcgucaacaaugcugcuucugcugguggcagucgcccagacccugaucgagauccgcgcgggugaguaccggguccg gagggaaauggccucugaggaaaggggagggggcggcacgggggaagccgcgucccggcgucgcccaccugacccuccgcc ccuucuccacccuagccccgcgcccugcuccccucccggcccgcucacccgcgggggucccggaaggaguucggggucucac cgcgcccugccuccaggcccacacuugcugaguuauuucuacaccuccgugucccggccgggccuuggggagccccgguuc aucucugucgguuacguggacaacacggaguucgugcgcuucgacagcgacgcggagaauccgagauaugagccgcgggca ccguggauggagcaggaggggccggaguauugggagcgggaaacacagaaagccaagggcaaugagcagauuuuccgagu gaaccugaggacccugcucagcuacuacaaccagagcgcgggcggugagugaccccggaucggaggucacgaccccuccacg ucccaaaacaggggcccgagacgucccgggccccaaguucgagguucugagcagaacggacgcgggacugguuucccuuuc aguuuggaggagccgcgggugggcggggccggggcgugugggcggggcugaccgcggggucccgcaggcucucacacuau ucaggugaucucuggcugugaagugggguccgacgggcgccuccuccgcggguaccagcaguucgccuacgacggccgcg auuacaucgcccugaacgaagaccugaaaacguggacggcggcggacauggcggcacagaucacccgacgcaagugggagca ggcuggugcuacagagaaaagcaaggccuaccuggagggcgcgugcgugcagucccuccgcagauaccuggagcucgggaa ggagacgcugcugcgcacaggugcaggggccgcgggcagcuccucccucugcccucgggcuggggcucaguccuggggaa gaagaaacccucagcuggggugaugccccugucucagagggagagagugacccuggucuccugaucccucaucacagugac ugcacugacucucccagggcucagccuucucccuggacagugcccaggcugucucaggagggaaggagagaauuucccuga gguaacaacagcugcucccuucaguuccccuguagccucugucagccauggccucucccaggccggguucucagcccacug ucuguagacacugacuccuguccugcugagugugucagcccuuacaccucaggaccagaagucgccuuuaacugaucggag acauggacuacccuacacuaggcugauugccucaguuuccugaauuuucaaaagaauacauucucccagaucccucccuguc ugugggguuuccaccccuucgacaaccuaauucucucuauuccuauagugguggucacaucagcccuuaugggguacccug gaggaauaucaauaguggaauuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuucuu cuucuucuucuucuucuucuucuucuucuucuuccuucucucucucucucucucucucucucucucucucucucucucuc ucucucucucucucucucucuucuucaguuuuugagauaggguuucucuguaugcccuggcuguccuggaacucacuugu agaccaggauggccucgaccucagaaauccgccugccucugccucccagugcugggauuaaaggcguguggccaccuugcc cagccuuucuuauuuucuuuacuuuuuuuuuuuuuuuuggaggggguaauuuuguuucuagucaucuuuugucuuuug ucugcacuggagugauccuguuucucccugcccuuauauuaucauguguaucagucuccacaggugccagggaaguuaag acaaguuaaaucaggguucucuuuaaaggagagauuccugugaacuuagacuguuuccugucagaacuaaacauccagaag ccuccugcucuuccucugucccacaaguuacagugcuccccccccccccccagugaaucuggacuuggacucugagagacag ggucuucugcaauccagggcuggagugagagggaagaccacacacccugugagcccacuguguugcagugagugcugcacu gggguccacagcauacuccagggauccugugugacacaccuguaccuugucccccagagucaggggcuggaagucauuuuc ucuggcugagugucagagguugacaccauuucugcuacacacucugugauggcugcucacuuggacuggcgguuaugcua guuagcaagaugaacacagugguuuacgucucaguugucacacccuuccaguggcauauggcucuaauuucuacuuuuga uacgaacucaaacacuuauuaaauuaguuaguuuccauuccaucuuccauucuaguccauucaugcuaaagaacaucacaua aggacugccaggaugacccacuggcucauguggauucccucuuagcuucugagucccccagaaaaaugugcagcugaggaa accagcucugccugcaggucaccagugccaugacaguugaagugucaaacagacacauuguucagugucaucagugauuua acugugccuuguguagauuucagagggucuuguuaauugugguacuuuuuuuuguuuuuuguuuuuuuuuuuuuuugu uuuguuuucaagacaggauuuuucuguauagcccuggcuguccuggaacucacauuguggaccaggcugaccacgaacuca gaaaucugccugccucugccucccgagugcugggauuaaaggcgugugccaccaccaaccagcuaaucgugagauuucuuu cuuuuuucuuuucuuuucuucuuuuuuuuuuuuuuuuuguuguuguuguuuuguuuuuugagacaggguucucugugu aucccuggcuguccuugaacucacuuuguagaccaggcuggccuugaacuuagaaauuugccugccucugcuccggagugc ugggauuaaaggcaugugccacuaccaaccagcuaauugugggauuucuuaaaucuuccacacagauccuccaaaggcaca ugugacaugucaccacagaucugacggugaugucacccugaggugcugggcccugggcuucuacccugcuaacaucauccu gaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccuucaggggauggaaccuucc agaagugggcaucugugguggugccucuugggaaggagcagaauuacacaugccaugugcaccaugaggggcugccugag ccccucacccugagaugggguaaggagggugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccug agcugcucagggcugagagcuggggucaugaccucaccuucauuuccuguaccuguccuucccagagccuccuccauccac ugucuccaacauggcgaacguagcuguucugguuguccuuggagcuuggccaucauugcagcugugguggcuuuuguga ugaagagaaggagacacacagguaggaaagggcagagucugaguuuucucucagccuccuuuagagugugcucugcucauc aauggggaacacaggcacaccccacauugcuacugucuguaacugugucugcucucaguucugggaacuuccuagugucaa gcucuuccuugaacucucacagcuuuccuucucacagguggacaaggaggggacuaugcucuggcuccagguuagugugg gggacagaguuguccugaggucauuggagugaagcuggaguuguugggugcucugggaacccauaauagcuucucuguu guaauccucugguggccugugucagaucuugcuauagauauaucuuuguauauauuuuucccuaggcagggacagcuccc agagcucugauauguuucucucaagauuguaaaggugacauucuauggccugauugcagaggggcacuguggacaugguu guguuucagggacucccacaauccccugugagugguggguuguugggauauugucuucauuguggugguuccugacccu cauucucuaucaugaagacagcugccuggaguggacuuagugacagccagugugaccuugggucuucauuuuucuuuaga gaacagcgccugauguucccugugagccuaugggcucaaugugaagaauuguggagcccagccuucgccuacacaccagga ccugucucuugcauugcccuguguucccuuccaccgccaaccuuccgggucugcag 108 AW124268 uuuuuuuuuuuuuuuuucagaauaauugcagacaaauuccauuuauuuuucuaaaaaccu cauuaucuaaaauuuauacagccucacauuccuaaaccaccucuggcacuuuucuugaau uaagucaaggcguacacagcuccgaaagaaaaauagagauccgguuccaggaagauggcc augaggacucgcagauaugucuccucggaccuggaagcgugucagccaugggauccacua auccaccauccgguacacagggucacccacucucaggcucccaagcuucuccaccgagaa auacaucccaaaaaguggagaugacugguauauacucuucacagaaggaucacacaggcg auagcucuucagggucuccaguggc 109 AF090738 Sequence below. cucuagaugaauacacucucaugagggccaccuucucugguaguucaggucgccucugcccauccuucccugcguccucuc ccaaaguggccuacaacccuuacccagaggacuauggagacauugagauugguucucacaagaguuccagcaguaaccugg gggcagaugauggcuacaugcccaugaccccuggggcagcccuuaggagugguggucccaauagcugcaagagcgaugacu acaugcccaugagccccacaagcgugucugcucccaagcagauccugcagccacgcuuggcagcggccuugcccccuuccgg agcagccgugccagcacccccuucaggggugggcaggaccuucccaguaaacggagguggcuacaaagccagcuccccagcg gagagcuccccagaagacaguggguacaugcgaaugugguguggcuccaagcugucuauggagaacccagacccuaagcua cuccccaacggggacuaccucaacaugucccccagcgaggcaggcacugcagggaccccaccugacuucucagcagcuuugc guggaggcagugaaggccucaaaggcaucccgggccacugcuacagcucuuugccccgcucuuauaaggcucccuguuccu gcagcggagacaaugaccaguaugugcucaugagcuccccugugggccggaucuuggaagaggagagacuggagccccagg ccaccccaggggcuggcaccuuuggggcagcuggugguagucauacccagccucaucacucagcagugccuuccuccauga ggccgagugccaucgguggccgcccugagggcuuccugggccagcgaugucgggcagugcggccuacacgccuaucgcua gagggacugcagacccuucccagcaugcaagaguacccucuacccacagagcccaagagcccuggcgaguacaucaacauug acuuuggugaggcagguacccgucugucuccgccugcccccccacuacuggcauccgcggccucaucuucuucacugcucu cagcuaguaguccugcuucaucccuggguucaggaaccccaggcaccagcagcgacagccggcagcgcucuccacucucuga cuauaugaaccuggacuucaguucucccaagucccccaagccuagcacccgcaguggggacacaguaggcuccauggaugg ccuucucucuccagaggcuucauccccauacccaccacugcccccacguccuuccacuuccccuuccuccuuacagcagccu cugccaccugccccgggagaccuauaccgccugccuccagcaucagcugccacuucccagggucccacugcuggcuccucaa uguccuccgagccuggggauaauggugacuauaccgagauggccuuugguguggcugcaaccccgccacaaccuaucgugg caccuccaaagccagaaggugcccgaguggccagucccacaucgggcuugaagcggcuaagucucauggaucagguaucug ggguggaggcuuuccuucaagucagccagcccccugacccccaccggggugcuaaggucauccgugcagacccacaggggg gacgucgucgccacaguucagagaccuuuuccucuaccaccaccgucaccccaguguccccauccuuugcccacaauuccaa gcgccacaauucggccucuguggaaaaugucucacucaggaaaagcagugaaggcagcaguacccugggaggaggugauga gccgcccacauccccaggacaggcacagcccuugguggcugugcccccagugccacaggcuaggccguggaaccccggucag cccggagcuuugauuggcuguccuggaggcagcaguucucccaugcgcagagagaccuccguggguuuccagaacggccuc aacuauaucgccaucgaugugagaggcgagcagggguccuuggcgcagucucagccgcagccaggagacaagaacuccugg agccggacccguagccuuggggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccaggcac uggagcuuugcccucugccagcaccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucgugaaagg ugaggcccuuugaccuugaggaugggggagggagaguggaguauuggguggcu 110 AI834950 uuuuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg acgggccagaggaggguggagagagcacgagugguuuaaauaggggaggaugggagcaug gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu ggaauauuuuauaacaauauauauaagauucugguuugcuuuuccuuuucgucucguaaa ggagagagaauugcauaguucgauucuguccaagggggcagcugcauauggucggccggg cgggucacuggucgu 111 AI851365 uuuuuuuuuuuuuuuuuaagugucaccacuugugacagucagcauguuacuaucagcucc agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac agugcucuuguugacauucagacaguucugagggccacucugagaggcgccuuccuguuc ucaccugacaaggauauuguuugguuugguuugguuugguuuugccuuacuauggcuuuu cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua gagacgccacaagagccacugccgugacauaccucacaagcuacaucccuguccucaaaa u 112 AW047339 cggccgcggccaccggccugcgccaagcugcugcugcggcagccaguaccucggugaagc ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa ggacgggauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug guugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag cagcggacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc uuauccaaguucuauaugg 113 U06834 Sequence below. gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauu cagccaaagugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuagaagagacccug uugaacacaaaacuggaaacggcggaucugaaaugggugacuuacccucaggcagagggccagugggaggagcuaagcggc cuggaugaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca gggggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacguguaugccacgauacgcuucacc augauggaaugccugucccugccgagggccagucgcuccugcaaggagacauucacugucuucuauuacgagagcgaacgu gauacggccacggcccauacgcccgccuggauggagaaccccuacaucaagguggacacaguggccgcagaacaucugacuc ggaagcgcccuggagcugaagccacagggaaaguuaauaucaagacgcugcgccug gguccucucagcaaagcuggcuucuaccuggcuuuccaggaccaaggagccugcauggcucugcucucccugcaucucuuu uacaagaagugcuccuggcugaucacgaacuugaccuacuuccccgagacggugccucgggagcucguggugccgguggca gguagcugcguggccaacgcggucccuaccgccaaccccagccccagccucuacugccgggaagauggucaaugggcugag cagcaggucacgggcugcagcugcgcgccaggguacgaggcugcggaaagcaacaaa guaugcagagccuguggccagggaaccuucaagccccaaauaggagacgaguccugccugccgugcccagccaacagccacu cgaauaacauugggucuccugucugccugugucgaauuggguauuaccgggcccgcucagacccccggaguucaccuugca cuaccccacccucugcuccaagaagcgugguucaccauuugaaugguuccacccugcgccuggaguggagugcuccccuug aguccggaaggccgagagaccucacuuaugcuguucgcugccgagagugccguccuggggguuccugcuugcccuguggg ggcgacaugaccuucgaccccgguccucgagaccugguugagcgcuggguggcaauccgagggcugcguccugaugucacc uauaccuuugagguugcugcuuugaauggugugucuaccuuagccacuggaccaccuccuuuugagccugucaaugucac cacugaccgugaggugccuccugcagugucugacauccgagugacucggucgucacccagcagcuugauccugucaugggc uauccccagagcacccaguggggccgugcuggacuacgaggucaaguaucaugagaagggcgcagagggccccagcagugu ucguuuccugaagacaucagaaaaccgagcugagcuccgggggcugaagcggggagccagcuaucugguccagguacgcgc acgguccgaggcuggcuacggucccuucggccaggagcaucacagucagacucaacuggaugagagcgagagcuggcggga gcagcuggcccugauugcaggcacugcgguugugggugugguccugguccugguggucgucaucauugcaguucucugc cucaggaagcagagcaaugggagggaaguugaguacucggauaagcaugggcaguaucucaucgggcacgguaccaagguc uacauugauccuuuuacuuacgaagacccuaaugaggcagugagggaauuugccaaagagaucgaugucuccuaugucaag auugaagagguaauuggugcaggugaguucggcgaggugugccggggucggcugaaggcaccagggaaaaaggagagcug uguggccaucaagacucugaaggguggcuacaccgagcgccagagggcugaguuccugagcgaggccuccaucaugggcca guucgagcaucccaacaucauccgccucgagggcguggucaccaacagugugccgguuaugauccucacggaauucaugga gaacggagcccuggacuccuuccugcggcugaacgacgggcaguucacagucauccagcuggugggcaugcugaggggcau cgccucgggcaugcgguaccuggcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacaguaa ccuggucugcaagguguccgacuuuggccucuccagauucuuggaggagaacuccucugaucccaccuacacaaguucccu gggaggcaagauucccauccgauggaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggcg cuaugggaucgucaugugggaggucaugucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaaug ccauugaacaggacuaccggcugccuccuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcagaa ggaccggaaugcccggccccgcuuuccccagguggucagcgcucuggacaagaugauccggaaucccgcuagccucaaaau cguggccagggagaauggcggggccucacauccacucuuggaccaacggcagccucacuacucugcuuucgguucuguggu cgaguggcuucgagccaucaagaugggaagauacgaggaaaguuuugcagcggcuggauucggcuccuuugagaugguca gucagaucucugccgaggaccuucuccgaauuggagucacucuggcaggacaccagaagaaaaucuuggccagugugcagc auaugaagugggaagcuaagccaggagccccuggugggacagggggaccagcccagcaguucugaccuccaaggacucacc accguggcagauucuucuuuccgggaggcagaguuggguggggacucacaagaugagccccucccccucgucacagccuuc ccauuggauugcacuuugaacagagggggucggagacacagauuuggggaaccgugccauaugggaucauacaugugccc uccaggcggggaaccccaaacucagagugagucuuucccucaagacugggcaaagaaacaucccuacgucucuaaccuccca ucuucccagaggcucucuccccaagcgccuuccaccucaacgggcaugucccugcagaccaaagagaaagggugaccagccu gccaacuugggaguggaaaaugccgucccaggaggcaggaaggggcugucaggacccggugauguaaucauuggguuuug auguccugacuugcugucaccaccaaaggcaaucauuuuucccuuguaaaugccccuccccucaucugccuucauauugaa gguucugaaguuuuacuguuuuuuauuuuguuaauuuuuuccuccuuccccccucccuccccuucuuguccagauuuugu guguuaaagggcaccugguuccacuaucuccuguugggaacaaggacccaucgauauguucuagaacagugccuuggaaau gcca 114 AA980204 ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug gagaagagagcagcacaucu 115 AI843232 ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug gagaagagagcagcacaucu 116 U59807 Sequence below. augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggccca ggucaggccagucugagccaggccugcggagacccggcggccucagggaccggccugcccagacuggucagguccugcagc ggguuuccggggcggccacaagugugacugggagcugggggcucuggaucugguuggaagauucagggccgggaacugg ggcgagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccggu ggucccagagaauucaggaaggcaguguuagaaccuagacggcaccuuuuugacuuacacccaggccuaaacaagagaaagc cagacugggcuacugugcuugucuccucaaaagaaagagcuaggacuguuuagcucaguggcaggaauucaacugauacca ccaccaccaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacuugcuugugccuaguc ugaaacgaggggguggaccuugggccugggcugcccuuccugugacuguuagcagagcagagauucaguacaagguaggg ggagguucaggguauuagcaagagaagaaaaguuaaacaaauccucucuucagcucuccugccacgccccaagcccaggacc cuguccacuaagccuagcugaucuugggagguguuugcucugaacugaaguggccaagaaggaagugagucagcuccaug agacccuagaaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucaggag gcagagacaggcgagucucucugaauuugaagccagcccaguuugcuuaguuccaugccagccauagcuacauagugagac ccugucccccccccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaau gaggaguauugaaggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccauc caggugaagucccagcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauagug gcuggcaccaaccucuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcaga guguccugcaacuuccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuaggguu cccggccuuaaaggaggagacaaggguuaucacuggcuaaguuaguggcugguggccuguucuggcucaguuucuaaggc uggguuaagccuggaacuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguuggugga gauaaaugcgugcacuugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaaca aagaaaggcacgaugagcucuccuacuucuga 117 AI152659 gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu auacugugcacccugugaugcaugaagugauuuuauguauggucugcuaugugggcagag gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac cacuguguggaauuauaaauacaucccaugugca 118 AI850090 uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu uguaauuuaccuguguaauuuauccaagaacacagcacagcaauugcuuuaugugguacu cugaccuuaaguaacaaguuguuaacagaaaacacaucaaacaaaaggauaauucucuaa uuaucaagucagccaucagcuuuucuuaggagagagagagagagugugugugugugugug ugugugugugugugugugucugucugucugucugucuggguaucccacuuagggccaugu gcauguuagguaaaugcuccaccacugagcuguuucuuagccgcacuuuucucagauuuc agguuuguuuguuuguuuguuuguuuuuuaacuaggcaugaaaauaaacuucacuucaaa u 119 AF064635 See above sequence (A1850090). 120 AI843106 uuuuuuuuuuuuuuuuuguggaaauuacucuuuauugaaaaauaccaguaauacugacag acuucaaaaucaauuuacgguuccagaauacaaaguacuuaauacauuuuuuuccaaacc uguuuguaucucaaaguuagcauuuuuguaaaucaagauacaaauaugauaacuucacua aaauauuuuccagcuuuauucuuuaaggagcuguauaaccuucaaagucagggucccgag gucagcagggcauggggcagaaugcaccuggcacucccugugcagcagacugcaaccaca uu 121 AF033186 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc gguuag 122 Z50159 auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc gguuag 123 X78683 Sequence below. gaauuccgugugcaaggcgaggucuguaagcuggagcggggcagaggcuggcgggcaccccuuccugaccgcuggugccg ccgccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggc augggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaagg cggucauagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggauccc cugguuccaguaccccaucaucuaugacauucgggccagaccucggaaaaucuccucccccacaggcuccaaagaccugcag auggugaacaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcuggac uaugaggagcgagugcugccguccauuguuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcugau cacccagcgggcucaggugucccuguugauccgaagagagcugacagagcgcgccaaggacuucagccucauccuggauga uguagcuaucacagagcugagcuucagccgagaguacacagcugcuguagaagccaagcaaguggcccagcaggaagccca gcgggcccaguuuuugguggagaaagcgaagcaggaacagcgacagaagauugugcaggcugagggggaggcggaggcug ccaagaugcuuggagaagcacugagcaagaauccuggcuauaucaagcuccgaaagauccgggccgcccagaacaucucuaa aacgaucgccacaucacagaaccgaaucuaucucacagcugacaaccuugugcugaaucuacaggaugaaaguuuuacucgg ggaagugacagccucauuaaggguaagaaaugaguguggacaucaagaaccccaccaccagagaaguuggcacacuugucca gcuuggaggagccagcucggggucaagcacagcccacccugccccaggcaucaugugauggacuuuucuguaucugcccuc uuggauuaaggaagacugagaccagcccuuucagaggcuuuccuccuuccuguguuggcugggaagcgggguggacaaug ugauuucuccgugauuuccuacagccuugagccucucccagagugggggagauaaccaccaugccaggaauuc 124 X68193 acccaccggcuuucggaccauggccaaccucgagcguaccuucauugccaucaagccaga uggcgugcagcgcggccuggugggcgagaucaucaaacgguucgagcagaagggguuccg ccugguggccaugaaguuccuucgggccucugaagaacaccugaagcagcauuacaucga ccugaaagaccguccuuucuucccggggcuggugaaguacaugaacucggggcccguggu ggccauggucugggaggggcucaauguggugaaaacgggccgagugaugcugggggagac caauccagcugauucaaaaccaggcaccauccguggggauuucugcauucaaguuggcag gaacaucauucauggcagugauucaguggagagugcugagaaagagauccaucugugguu uaagcccgaagaacugaucgacuacaagucuugugcccaugacuggguguacgaguagac augaagaaaccagaauccuuuucagcacuacugauggguuucuggacagagcucuucauc ccacugacaggauggaucaucuuuucuaaaacaauaaagacuuuggaacugaaaaaaaaa aaaaaaaaaaaa 125 AA062013 uuuugcuuucaacaugacagaugccgcuguguccuucgccaaggacuucuuggccggugg aguggccgcagcaucuccaagacagcggucacaccaucgagagggucaagcugcugcugc aggugcacaugccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacug cgugguucguauccccaaggaacagggagugcucugguccuuugggcgugggaaccgggc caaugucaucagauacuuccccaccaaggcucucaacuuggccuucaaaguuaauuccaa gcagaucuuucugggugguguugacaagaggacccaguucuggcgcuacuuuugcaggga accuggcaucaggugguugccgcuggggcuacauccuugggcuuuguguacccucuugau uuuugccgguaccgucuagcagcugaugugggcaagcuggagcuaaagggaauucaaggg ccuugggacugccugguaagacuucaaucugaugggauaagggcuguac 126 AI465965 auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac uuccgccaauguguguaugacaugugugcccauaagggugacaaagccuaucucugccgu agccuggcugcuuauacugcagccugucaggcagcuggggcagcagugaagcccuggagg acagacagcgucugcccucuccaguguccugcccacagccacuacuccaucugcacccgc uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac 127 U50413 Sequence below. ggcacgagccgaguuggaggaagcagcggcagcggcagcggcagcgguagcggugaggacggcugugcagccaaggaaccg ggacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcugaagcccaggc ugggcagaggaaggaagcgagccgacccggaggugaagcugagaguggagcguggcaguaaaaucagacgacagauggaca gugugacaggaacgucagagaggauugggccucgcugcgagagucagccuggagucaagguguugacaaguugcugagaa ggacacgugggaggacgguggcgcgcggagggagagcccugucuucagucaccccguugauggaggacagauggacagca gccggacggccagucaccucucuuaaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuuagc ccauucucugaacucacuuucucuuaaaacguaaacucggacggcagugugcgagccagcuccucuguggcagggcacuag agcugcagacaugagugcagagggcuaccaguacagagcacuguacgacuacaagaaggagcgagaggaagacauugaccu acaccugggggacauacugacugugaauaaaggcuccuuaguggcacuuggauucagugauggccaggaagcccggccuga agauauuggcugguuaaauggcuacaaugaaaccacuggggagaggggagacuuuccaggaacuuacguugaauacauug gaaggaaaagaauuucacccccuacucccaagccucggcccccucgaccgcuuccuguugcuccggguucuucaaaaacuga agcugacacggagcagcaagcguugccccuuccugaccuggccgagcaguuugccccuccugauguugccccgccucuccu uauaaagcuccuggaagccauugagaagaaaggacuggaauguucgacucuauacagaacacaaagcuccagcaacccugca gaauuacgacagcuucuugauugugaugccgcgucaguggacuuggagaugaucgacguacacgucuuagcagaugcuuu caaacgcuaucucgccgacuuaccaaauccugucauuccuguagcuguuuacaaugagaugaugucuuuagcccaagaacu acagagcccugaagacugcauccagcuguugaagaagcucauuagauugccuaauauaccucaucaguguuggcuuacgcu ucaguauuugcucaagcauuuuuucaagcucucucaagccuccagcaaaaaccuuuugaaugcaagaguccucucugagau uuucagccccgugcuuuucagauuuccagccgccagcucugauaauacugaacaccucauaaaagcgauagagauuuuaau cucaacggaauggaaugagagacagccagcaccagcacugccccccaaaccacccaagcccacuacuguagccaacaacagca ugaacaacaauauguccuugcaggaugcugaaugguacuggggagacaucucaagggaagaagugaaugaaaaacuccgag acacugcugaugggaccuuuuugguacgagacgcaucuacuaaaaugcacggcgauuacacucuuacaccuaggaaaggag gaaauaacaaauuaaucaaaaucuuucaccgugauggaaaauauggcuucucugauccauuaaccuucaacucugugguug aguuaauaaaccacuaccggaaugagucuuuagcucaguacaaccccaagcuggaugugaaguugcucuacccagugucca aauaccagcaggaucaaguugucaaagaagauaauauugaagcuguagggaaaaaauuacaugaauauaauacucaauuuca agaaaaaagucgggaauaugauagauuauaugaggaguacacccguacuucccaggaaauccaaaugaaaagaacggcuauc gaagcauuuaaugaaaccauaaaaauauuugaagaacaaugccaaacccaggagcgguacagcaaagaauacauagagaagu uuaaacgcgaaggcaacgagaaagaaauucaaaggauuaugcauaaccaugauaagcugaagucgcguaucagugagauca uugacaguaggaggagguuggaagaagacuugaagaagcaggcagcugaguaccgagagaucgacaaacgcaugaacagua uuaagccggaccucauccaguugagaaagacaagagaccaauacuugauguggcugacgcagaaaggugugcggcagaaga agcugaacgaguggcuggggaaugaaaauaccgaagaucaauacucccugguagaagaugaugaggauuugccccaccaug acgagaagacguggaaugucgggagcagcaaccgaaacaaagcggagaaccuauugcgagggaagcgagacggcacuuucc uuguccgggagagcaguaagcagggcugcuaugccugcuccguagugguagacggcgaagucaagcauugcgucauuaac aagacugccaccggcuauggcuuugccgagcccuacaaccuguacagcucccugaaggagcuggugcuacauuaucaacaca ccucccucgugcagcacaaugacucccucaaugucacacuagcauacccaguauaugcacaacagaggcgaugaagcgcugc ccucggauccaguuccucaccuucaagccacccaaggccucugagaagcaaagggcuccucuccagcccgaccugugaacug agcugcagaaaugaagccggcugucugcacaugggacuagagcuuucuuggacaaaaagaagucggggaagacacgcagcc ucggacuguuggaugaccagacguuucuaaccuuauccucuuucuuucuuucuuucuuucuuucuuucuuucuuucuuuc uuucuuucuuucuuucuuucuuucuaauuuaaagccacaacacacaaccaacacacagagagaaagaaaugcaaaaaucucu ccgugcagggacaaagaggccuuuaaccauggugcuuguuaacgcuuucugaagcuuuaccagcuacaaguugggacuuu ggagaccagaagguagacagggccgaagagccugcgccuggggccgcuugguccagccugguguagccugggugucgcug gguguggugaacccagacacaucacacuguggauuauuuccuuuuuaaaagagcgaaugauauguaucagagagccgcguc ugcucacgcaggacacuuugagagaacauugaugcagucuguucggaggaaaaaugaaacaccagaaaacguuuuuguuua aacuuaucaagucagcaaccaacaacccaccaacagaaaaaaaaaaaaaa 128 AW120502 uuuuuuuuuuuuguuuuaauuuggcuccaaugaucgcauucucaaacuccuuugggaggg cauuagaugacccaguauccgacgacuuagauucacacguguuuuucuccucugagcucu uuucuccaggcucacngucuuuguuuuucaagcuuucuugggccuuugaacaauuuucuu ccuuugaagauucuccugg 129 X62940 Sequence below. agccgaguaggaccgagcugcugcagacgcgccgggucacucgagccagcaccaccguucucacgcccugagcugcagacag cuaggcgguuuuaucuaguuugaaccaggcugcuggagcuugcucccucccgcccucucucuuuuuuuuccacggggcug uuuuuuuaauuuggcugcaauugcaugaaaucccaaugguguagaccaguggcgauggaucuaggaguuuaccaacugag acauuuuuccauuucuuucuugucgucuuugcugggaaccgaaaacgcuuccgugagacuugacaauagcucuggugcaa gugugguagcuaucgacaacaaaauagagcaagcuauggaucuggugaaaagccauuugauguaugcggugagggaggaa guggaaguucugaaggagcagaucaaagaacuaauagagaaaaacucccagcuggagcaggagaacaaucugcugaagacgc uggccaguccggagcagcucgcccaguuucaggcccagcugcagacuggcuccccuccggccaccacgcagccacaggggac cacacagcccccugcacagccagcaucccagggcucaggaucaaccgcauagccuccuaggccccaacagaacuggcugcug cugcugcugucugaacugaacagaccgaagagaugugcuagagagaagccgccuccacagucacccauuucauugcugucu acgaaagagacgugagacucacacgcuguucucgcuuucuccccaguauuaagcacucauaagcuuuuggcuugaagaaau guacuaguugagugaauuaaagguuaaucagagagugagcagggaugugcccugugcaacguggcagaugucugaggaau gguuuaauugaccccgaggagcucugugccuuuucaacccuccccagccgcccacccugcuucugagagcucgggcggcuc gccuucguggggcucgccugcgugggguucgaaagugggcugcuccuggauucugcgcucucuucuccuucccuucaaag aacucggagaggccagaaacaagacugcaauggggggcggggggagggaugaugcaguccuuauacaaaaccgacaacugu caccaaagcuuauaaaacacgauaguacugucccucuuuucugaaccaucagaagacacaaaacuguuagugacacaacggu gacagguagcugggaccuaggcuaucuuauuaugaagguuguuuugcuuguuguauauuuguguauguaguguaacgaa uuuguaccauagaggacuguccguaacuacuguuuagcuucuacacauugaaauguagauguuucauuggcugucugaaa agguguggcuuguccuuccuagagagaucuacuuaaaaacugcuuuguggcaaaaaccacaccugaagaaauuuuaagaau uuggcccaguuagucacucuguguaaucccggaaucuagcugcugaagucuugcgaaguaaacuccccgugaccgauguca guuaagcuggugauaccuggagaaguggucaguugcuaaggaaguggauuucccaguagggguuucugcaccucaccugu auagucguucugcgcaugucccccacacaguccccaccuguauuuaccuguucuacuugucaccuuucaauaaagcauauc aaauguugau 130 U60020 Sequence below. auggcugcgcacgucuggcuggcggccgcccugcuccuucugguggacuggcugcugcugcggcccaugcucccgggaau cuucucccuguugguucccgaggugccgcugcuccgggucuggguggugggccugagucgcugggccauccuaggacuag ggguccgcgggguccucggggucaccgcaggagcccauggcuggcuggcugcuuugcagccgcugguggccgcacugagu uuggcccugccuggacuugccuuguuccgagagcuggccgccuggggaacacuccgggagggugacagcgcuggauuacu guacuggaacagucguccagaugccuucgcuaucaguuauguggcagcauugcccgcagccgcccuguggcacaaguuggg gagccucugggcgcccagcggcaacagggacgcuggagacaugcugugucggaugcugggcuuccugggcccuaagaaga gacgucucuaccugguucugguucucuugauucucucuuggcuuggggaaauggccauucccuucuucacgggccgcauc acugacuggauucuucaggauaagacaguuccuagcuucacccgcaacauauggcucauguccauucucaccauagccagca cagcgcuggaguuugcaagugauggaaucuacaacaucaccaugggacacaugcacggccgugugcacagagagguguuuc gggccguccuucgccaggagacaggguuuuuccugaagaacccagcagguuccaucacaucucgggugacugaggacacag ccaacgugugcgaguccauuagugacacgcugagccugcugcugugguaccuggggcgagcccugugucucuugguguuc auguuuugggggucaccguaccucacucuggucacccugaucaaucugccccugcuuuuucuuuugccuaagaagcuggg aaaagugcaccagucacuggcagugaaggugcaggagucucuagcaaaguccacgcagguggcccuugaggccuuaucggc gaugccuaccgugcggagcuuugccaacgaggagggugaggcccagaaguucaggcagaaguuggaagaaaugaagacgcu aaacaagaaggaggccuuggcuuacgucgcugaagucuggaccacgagugucucgggaaugcugcugaaggugggaauuc uguaccugggcgggcagcuggugaucagagggacugucagcagcggcaaccuugucucauucguucucuaccagcuucag uucacccaggcuguucagguccugcucucccucuaccccuccaugcagaaggcugugggcuccucagagaaaauauucgaa uacuuggaccggacuccuugcucuccacucaguggcucguuggcacccucaaacaugaaaggccuuguggaguuccaagau gucucuuuugccuacccaaaccagcccaaaguccaggugcuucaggggcugacguucacccugcauccuggaacggugaca gcguuggugggacccaauggaucagggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggccag cugcugcuggauggccagcgccugguccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagccg cugcuauuuggaagaaguuuucgagaaaauauugcguauggccugaaccggacuccaaccauggaggaaaucacagcugug gccguggagucuggagcccacgauuucaucucuggguucccucagggcuaugacacagagguaggugagacugggaacca gcugucaggaggucagcgacaggcaguggccuuggcccgagccuugauccggaagccacuccugcuuaucuuggaugaug ccaccagugcccuggaugcuggcaaccagcuacggguccagcggcuccuguaugagagccccaagcgggcuucucggacgg uucuucuuaucacccagcagcucagccuggcagagcaggcccaccacauccucuuucucagagaaggcucugucggcgagc agggcacccaccugcagcucaugaagagaggagggugcuaccgggccaugguagaggcucuugcggcuccugcagacuga 131 L32752 gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauucaugaa gcgccacuugaccggagaguuugagaaggaguauguagccacccugggcguggaggugca cacauuagucuuccauaccaacagaggaccuaucaaguucaaugugugggacacagccgg ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau aauguuugacguaacaucaagaguuacuuacaagaaugugccuagcuggcauaaagaucu agugcgugugugugaaaacauccccauuguauuguguggcaacaaaguggauguuaaaga caugaaagugaaggcaaaaccuauucucuuccaccgaaagaagaaucuucaguacuauga cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu cauuggagauccuaacuuggaguucguugccaugccugcucuugccccaccugagguagu cauggacccagcuuuggcagcacaguacgagcaugauuuagagguugcucagacgacugc ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc uauuuuaggcaacuguccugugaugccagccagcggugcagugugugugccaccuuauuu agcuaaaggagaucgugcaauucauugggaugcugaaggagaugaaugggcuucggagug aauguggcaguuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac agaguuguucuggauuucaaagauaagacugcuaccguagcaucacaauagucaguggug accggaauuc 132 AI840013 uuuuuuuuuuuuuuuuugauuuaugaaaaguuuuauuuaucaguacugugaagaauucuc aucauaauugcuacguuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu cgauacuggaccucccagcccaugcucccuaugaggagucuagcugcugugguggucuuc acagcuuugguuuucuggagacgaagcucaugauugcguucaugcacuccucugacagcc accuugcuugcagaguagugcacucuucagcguugacugcguagagcuuuucuuucucau uuuuucugauuaacucuuuggaaauucucauuggguuuggcgggagcuucgcauau 133 AB020424 ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguguuucggga augauuugcgguggaugaacgaaaccccgguacguccugugccaaggagcauaugucagg acggacgcucguuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu gugaauugcagaauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu ucgguugagggcacgccugccugggcgucacgccuuguuuugcucugugcccgugcucuu ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu uguggucccccgucaccuuaaggggcucaagagacccggacuaggcgagccgcgcuucgu aagaggagggcgagcugucucgcaau 134 AI848453 uuuuuuuuuuuuuuuuugaaguugcugccccuuuauuggugacccgggcaaguuuaagga gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac uuuccaaguuaacgaaccgauaagaaaagauucucccuuaaacugacaaguacaauguac auguacaugauuuuggaauaauuuaauacuuuaaccucaagauacaacuauauucuaaga ccauuauuuuaaaggaacggauccuuacaaaaccaaaauaacccauauagcacgagguug guuuagccuuucuucuucuuucaacaaacgugcaccacauguuucaguagcaaggccgau gccauggauaugagagcugugauuugcagggaccaaccacaucuagaaccggggaggcca aucanacgguggguu 135 AU040563 cccuuggaggauaguuuuauugacaagucgaguuagguuuuagaguaaacuuuuaucacc ccagucaggccccuucccaggggaggcucgcugguagcucagauggccuugguggugggc agauuguuguaguugucuuccuggcccuccagcaggcuucgggagguggcuaucuccugc uccagccuggacuugauguccaguagcugcuuauacuccggguucuggcgcucuaugugc ggcacgcaggugcngcg 136 X89749 Sequence below. ggacugacuccuugggcagauugccucuccuccuucucaugccagaggcugcugaugaggaaagguccaggggacugucca ugcugucuucauccucagagucacugccugaugcugcaacaagacccuucuuguuuagcaauagugguuggaacacucucu uguaaguuaccggagcacuaguauaggaggaggaucaucgacuacccucccgccacuccacggcugcuggcuccuagaaac cccagcuucaccucucacugggacucgaguuccagaaugaaaagcaagaagggucuuguugcagcaucaggcagugacucu gaggaugaagacagcauggacaguccccuggaccuuuccucaucagcagccucuggcaugagaaggaggagaggcaaucug cccaaggagucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagcac ugcugucccagcagacacaccuguccacacuacaggucuguaacugguucaucaacgcccgccgcaggcuccuuccugacau gcugagaaaggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauuga agcugcaauggguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaacc cuagggagaccagugucucccaaaccucccuccccaggauccauuuuggcucgcccgucagugaucugccauaccacugug acugcauugaaggaugggccuuucucucucugucagccgauuggugugggacagaguacagauguaccgcaaauagcaccc agcaacuuuacagacaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucuuu ucaacacuccucccccuacuccaccagaccucaaccaggauuuuaguggauuccagcuucuaguggauguugcacucaaacg agcggcagagauggagcuucaggccaaacucacagcuuaaccguuuuuucaaacaaaacaguucuccaaaauacgguccuga uugccgggggugauggcaagagaugcauuauuuuauauauuuuuuc 137 AW125390 uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauugaauccacuguggauagau aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga acaaugaugaugacacuaacaauggugauaacaaccaucaggaugcugaggaccaaggug cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug ggcauguugaucacaguaguucugacagaagccga 138 X05862 Sequence below. aagcuucaggauacagugcacacucguaaauaaaaacuacaggcugcugcgaauuauauuucaacugaccggagaggcaaag ccugacuguccauuaacccuuaacuuccaaacgcaaacugcuuacugcaucuuuuggcauuuuaccuuaugccuuguuagg uccaaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaag agccuuugaguuaggagugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgaca ccgcgugcuuggccagcuccccgggcagcagcaggcgcacggccgucuggaucucccgggacgugauggucgagcgcuug uuguaaugcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucguucacgaacgaguucaugaugcccauggcc uuggaggagaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcugcg cuugcgcuucuugccguccuucuucugggccuuggugacggccuucuuggagcccuucuucggggcgggagcggacuug gcgggcucaggcauacugagaggaugaagugaacuaaguugaaaaaggauaacuaaaaguuaaugacuguucuggcugcaa uuuuaaacaaacuuacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuucaa accagggcgccauugguaaccaauguguaaccaaugaaaucucuccguuuucgcguccagccuugacuauauauacuaugc guauacguuuuugcuucuuacugcggugguuaucuacagcugaguuaugucuggacguggcaagcaaggacguggcaagc aaggaggcaaggcccgcgccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcaccggc ugcuccgcaagggcaacuacucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccugacg gccgagauccuggagcuggcgggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcuggcca uccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggccg ugcugcugcccaagaagaccgagagccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuuuu cagagccacucacuuucucaaagagaccuaacacuacugggauagugcauugugggaaauacguguauuaaccuuccuccu auuuucccugcuugugguuaguucaaccccuaagccuuaggcuaagaguauauugguuuuuggaaggcaggcacccaacc ucggaccuaguacauaaaacagacacaucuugaacuccaggccagccuacucugcaggacgaguuccaggacagaccggacu gcacaaagaauugucuugaaauguuccuuuaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucacuu gaauccuguuuauguggcaugauugacaaguccugccauuuggcaaagucaaaaucagcaaaggauguuaaagcauuuggu gguaucacagcuaaaac 139 AW046181 uuuuuuuuuuuuuuuaugcaaauaguuuucaagauuuuauugcaaaccaaaauugguuua ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu uaauuacaguacauuaaaaugaugguuuacaaauaagccuguaaguuuaaauaucuagug uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuuaaac aauugaaaacaccaaccggcuuugacugacaacuggggcauugguccauaaaaacccuuu cuaaaaauagaaauau 140 U10118 Sequence below. gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugc uguucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcucuucuua aggagaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauaga agagcuaaagcaagagcugauucuggcagaaauucauaacggaguggagcaagugcguguucgauugaguacuccacugca gacgaacuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagau caaagcgggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagca aguacugacuccaagccuaucgacgcaucgcgucuggaucuucgaauugguuguauuguuacugccaagaagcacccugau gcagauucacuguauguggaggaaguagaugugggagaagcagccccgcgcacggucgucagcgggcuggugaaucaugu uccucuagaacagaugcaaaaucguauggugguuuuacucuguaaucugaagccugcaaagaugcggggaguucugucuc aagccauggugaugugugccaguucaccagagaaaguggagauucuggccccucccaacggguccguuccuggggacagaa uuacuuuugaugcuuuuccuggagagccugacaaggagcuaaacccuaagaagaagaucugggagcagauccagccugacc ugcacaccaaugcugaguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuugcagagcccaaa ccauggccaauaguggaauuaaauaagugcucuguaacugaaagacauuggcgaaaacuuaauaacaauaaagagaagugu guuuaucacuuacauau 141 AW212775 ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca aagcagcccuuagccuccccgacccccuuucccucccucccagca 142 AI846302 uuuuuuuuuuuuuuuuuaaacaaugacgccguuuauuuaaaauguuuacucccagaaaua uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuguccuaga gcuucccgugggaaagcuugggugagaauuuuagccuaaagggagggggcuguggccggg cacuuugcgcucauccacugcagg 143 M22998 Sequence below. acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuacagcgcguccguucuccgucucgcag ccggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaaggugacgggccgccucauguuggcugu gggaggagcagugcucggaucacugcaguucggcuauaacacuggugucaucaacgccccccagaagguuauugaggaguu cuacaaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggcc aucuucucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugcu gaugaugaaccuguuggccuuuguggcugcugugcuuaugggcuucuccaaacugggcaaguccuuugagaugcugaucc ugggccgcuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagaggugucaccuaca gcucuacguggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuaga cuccaucaugggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccuguu gcccuucugccccgagagcccccgcuuccugcucaucaaucguaacgaggagaaccgggccaagagugugcugaagaagcu ucgagggacagccgaugugacccgagaccugcaggagaugaaagaagagggucggcagaugaugcgggagaagaaggucac caucuuggagcuguuccgcucacccgccuaccgccagcccauccucaucgcuguggugcugcagcugucccagcagcuguc ggguaucaaugcuguguucuacuacucaacgagcaucuucgagaaggcaggugugcagcagccuguguacgccaccaucgg cuccgguaucgucaacacggccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccuca uuggccuggcuggcauggcaggcugugcugugcucaugaccaucgcccuggccuugcuggaacggcugccuuggaugucc uaucugagcaucguggccaucuuuggcuuuguggccuucuuugaaguaggcccugguccuauuccaugguucauuguggc cgagcuguucagccaggggccccguccugcugcuauugcuguggcuggcuucuccaacuggaccucaaacuucauugugg gcaugugcuuccaguauguggagcaacugugcggccccuacgucuucaucaucuucacggugcuccucgugcucuucuuc aucuucaccuacuucaaagucccugagaccaaaggccgaaccuucgaugagaucgcuuccggcuuccggcaggggggugcc agccaaagugacaagacacccgaggagcucuuccacccucugggggcggacucccaagugugaggagccccacacccagccc ggccugcucccugcagcccaaggaucucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgggc aagccgggccugggcgccuuuccucagccagcagugaaguccaggaggauauucaggacuuugauggcuccagaauuuuua augaaagcaagacugcugcucagaucuauucagauaagcagcagguuuuauaauuuuuuuauuacugauuuuguuauuuu uuuuuuuuaucagccacucuccuaucuccacacuguagucuucaccuugauuggcccagugccugaggguggggaccacgc ccuguccagacacuugccuucuuugccaagcuaaucuguagggcuggaccuauggccaaggacacacuaauaccgaacucu gagcuaggaggcuuuacgcuggaggcgguagcugccacccacuuccgcaggccuggaccucggcaccauagggguccggac uccauuuuaggauucgcccauuccugucucuuccuacccaaccacucaauuaaucuuuccuugccugagaccaguuggaag cacuggagugcagggaggagagggaagggccaggcugggcugccagguucuagucuccugugcacugagggccacacaaac accaugagaaggaccucggaggcugagaacuuaacugcugaagacacggacacuccugcccugcuguguauagauggaaga uauuuauauauuuuuugguugucaauauuaaauacagacacuaaguuauaguauaucuggacaaacccacuuguaaauaca ccaacaaacuccuguaacuuuaccuaagcagauauaaau ggcugguuuuuag 144 X64837 Sequence below. gcuuucuaaacuagcaagcaucguguggguccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacac ugacuguacuuccacuccugaaggacccacacgaugcuuucuaaacuagcaagucugcagaccauugcugcucugcgccga ggaguccacaccucagucgccucugccacgucuguugccacaaagaagacagagcaaggcccaccauccuccgaguacauuu uugaacgggaaucuaaauauggugcacacaauuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauaugu gggauguggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagauca uagaugccaugaagagucagguggacaagcugacauuaacaucucgggcuuucuauaacaauguccuuggugaauacgagg aguacaucaccaagcuuuucaacuacaacaaaguucucccuaugaauacaggaguggaggcuggagagacugcauguaagc ucgcucgucguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuugg ggucgaacacuaucugcaaucuccaguuccacagauccgaccaguuaugauggcuuuggacccuucaugccaggcuuugaa accaucccauauaacgaucugcccgcacuggagcgugcucuucaggauccaaauguugcugccuucaugguggagcccauc cagggugaagcaggcguuaucguuccggauccaggauaccugacaggaguucgggaacucugcaccaggcaccagguccug uuuauugcugaugaaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugagaaugucagaccuga uaugguucuucuugggaaggcccuuucuggcgguuuauacccugugucugcagugcugugugacgaugagauaaugcug accauuaaaccaggcgagcacggcuccacauacggcggaaacccacuaggcugccgaauugccauugcggcucuugagguu uuagaagaggagaaucuugcugagaaugcagacaagaugggcgcuauccugaggaaggagcucaugaagcugcccucugac guugugaccucagugagagggaaaggguugcuaaaugccauugucaucagagaaaccaaagacugugaugcuuggaaggu gugccugcgacuucgagauaacgggcuucuggccaagccaacccacggugauaucaucaggcuugccccuccccuugugau caaggaggaugagauccgggaguccguggagaucaucaacaagacuaucuuguccuucugagaguaggaacucuggggagc caucuucagacagggcucuugugaaacucugcuugcaguggccagagccugucuccugaaaggcauauauuucaguugau gcauaauagagugacaccuaggaaccugcagguggcugcgugacagaaaagugagagcgagaggcgaggcgucucuuugu ugagguuugacugugugggaacuuucuaaggagaaacggacccaucugcguacagccugcagauggaggccugcagucau uuacgugcgucuuuacaguuuccuugcugaugugaaugguuuguauuuagaaguuauuucugagauacuacagaacaguu aaaucauuauaaucaaugaauguuaaguugauugaagguuaagcauauguaaaauacuaguuuaaaguaaacuuuucauug gccaacaccagaauguauuauauagauucugagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacauu uauuuucaguauuucuuugaauaaagcuuaauguuucuuuuuacgccaacagaguauuuuguauuuccauuuugguaaua aucaguguauuauuucauccugaugacuggcauuucaucaccuauugagaucacuggguguguuucaggccuuuuauucu aaauaaagcuaugaccaguuucugucugu 145 AI843119 uuuuuuuuuuuucuuuuccgacgcccacaagaggaauaagagauuuaaugauggaaagua uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu uaggaccauuagaucagau 146 A1837786 uuuuuuuuuuuuuuuuuacaguuuuaaaacaauacacagcuuucucgggcugaagcaauu gcaagaacguauugguauugguauauuacagcuacauacaagguuuaugaauagcaaugg agaaaaauaaguuauuuaaauauugacuucauaaagagaaagugcaauguuguuaguugu cauaucacuugcuugacaguuugugggguuucuucccuaucaauuuuaacaaucaagaua acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau uucucagagaagaaucaauucgaguuccauccacaccuggggucgggacaca 147 U41465 Sequence below. ccgggcucgaauucucuagacucgaguuuagagaauucgagcucucccaguuuuaaagcaaaauuuuggacugugaagcaa ggcacugggcaaacacaacauggccuccccggcugacagcuguauccaguuuacccggcacgcuagugauguucuucucaa ccuuaaucgccuccggagucgggacaucuugacggacguugucaucguggugagccgugagcaguuuagagcccauaagac agugcucauggccugcagcggccuguucuacaguaucuucacugaccaguugaaaugcaaccuuaguguaaucaaucuaga uccugaaaucagcccugagggguuuugcauccuccuggacuucauguacacaucuaggcucaaccugagggaaggcaauau cauggcggugaugaccacagccauguaccugcagauggagcauguugucgacacaugcaggaaguucaucaaggccaguga agcagaaauggccccugcacuuaaaccuccccgugaagaguuccugaacagccggaugcugaugccccaugacaucauggcc uaccgaggucgugaggucguggagaacaauaugccacugagaaauacucccgggugugagagcagagcuuuugcuccuccu cuguacaguggccugucaacaccaccagccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugaug aggagcuccgagaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccaggca agucccuaaugaguauagcaggccagccauggaggugucccccaguuugugucacagcaacaucuacucgcccaaggaggc agucccagaggaggcucggagugacauacacuacagugugccugagggccccaagccugcugucccuucugcucggaaugc uccauacuuccccugugacaaagccagcaaagaagaagagagaccuucuucggaggaugagauugcccugcauuucgagcc ccccaaugcacccuugaaccggaagggucugguuaguccccagaguccccagaaauccgacugccagcccaacucacccaca gaguccugcagcagcaagaacgccugcauccuucaggccucuggcucuccgccagccaagagccccacugacccgaaagccu gcaacuggaagaaguauaaguucaucguucucaacagccucaaucagaaugccaaacccgagggcucugagcaggcagagcu gggucgccucuccccucgagccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucuccagucc ccgaccaagcucagugccaguggggaggacucuaccaucccccaagccagccggcucaauaaucucgugaacaggucccugg gaggcuccccccgaagcagcagugagagucacucaccacucuacaugcaccccccaaagugcacauccugcggcucucaguc cccacagcauacagagaugugccuccauacugcugggcccacguucccggaggagaugggggaaacccagucagaguauuc ggauucuagcugugagaaugggaccuucuucugcaacgaaugugacugccguuucucugaggaggccucgcucaagaggc acacgcugcagacgcacagugacaaaccauacaaaugugaucgcugccaggccuccuuccgcuacaagggcaaccucgccag ccacaagacuguccacacgggugagaaacccuaucgcuguaacauuuguggagcgcaguucaaucggccagccaaccugaag acccacacucgaauucacucuggagaaaagcccuacaaaugugaaaccuguggggccagguuuguucagguggcccaccuc cgugcccacgugcucauccacacuggagagaagccguaccccugugaaaucuguggcacucgcuuccggcaccuucagacu cugaagagccaucugcgcauccacacaggagagaaaccuuaccauugugagaaguguaaccugcacuuucgucacaaaagcc aacugcgacuucauuugcgccagaagcacggcgccaucaccaacaccaaggugcaauaccgcgugucggccgcugaccugcc uccggagcuccccaaagccugcugaaugaagcauggaguguuccucgcccuuuccucuccagccccuucucagaaucuaccc aaaggaugcuguaacacuuuauacaaaggucaucccaugauguagugccucucucauccacuagugcaaaucauaguuggg guggggguggg 148 U70494 ucgcgguccgacggaggagugggcgcugggaucucgcugagcguccgccuggccucgucu cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg acuccggaaaggccaagacaaaggcgguuucccgcucgcagcgagccggcuugcaguucc cugugggccguauucaucgacaccugaaaucuaggacaaccagccacggacgugugggcg cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu uggcaggaaaugcgucaaaagacuuaaagguaaagcguaucaccccucgucacuugcagc uugcuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugguggug gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguua uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaa 149 D17666 Sequence below. caccaccgugcacgcagcuccgggcccgugggguguugguucuugcccucguaacccccucuguccagccaccaugauaag cgccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaag cugccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaau ccggagcgaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugagu cacaauccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugugc cuggacuuaggcaguggacguaguuuacuggaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuacauacuaaggacuaaag cuugcauguguuccucagaauaugaaaagcccaaguucuuguguaguugauggcugaugcaacuuuuuuccccccaggau ggcuggaauggccuuagccaugaggcuuuuagauuuguuucaagaagagauuaugcguaaguacaaccucaguuucucug agaaaaaaaaaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauucaa uaugccacugguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuucu uacagaucagaagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggaggg caaacaagcaaaggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaaguacauaggaaugcuga gucggagcccagguuaguggugggcacuuuaauccuaguaaaggcagagggaucucugaguucaggaccagccuagagua caaagugagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuuuaaucagugucuuugggaauuuuagguccuggagaaugcuga aggugccagaacuaccccuucugugguugccuuuacagcagauggagaacgacuuguugguaugccagcaaaacggcaagc ugucaccaauccaaacaauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaagac acgugaguaauaggaaaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggaucac cuuggaucacuuuuucauuauuucugcuugggaagaaaucacaccaccaucagaggcauauagguuuuuuuuuuguuauu ucuuuguuguuguuguuuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaacuca uucuguagaccaggcuggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnucaugugauauaugaugaacuuagagugguuaaguuu cacagggauaguuuacuuacauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaauggu gaugcuuggguugaggcucauggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaagagac ugcagguaaguggauuuauuucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaacuuc auauucuguagauaauggagucugaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaauucaugcuccuccugcugccucc ugggugcuaaguugcaaggugauagcucagguacucacucuagugucuuucuuggggugcucuuuuccaaggccucucua cauauuaagccacaaaggagucuguugccccucaagaggaugagauguggaauauuaggcuacaguuuuguugccuuuuu uuuauuuuccuaacaugguaccacaauugaauuuuauucuuuguuucccagaaaauuacuugggccacacagcaaaaaaug cugugaucacagucccugcuuauuucaaugauucacagcgacagguaaaauuagaucucuuguuugcugggaguggaggu gggguaccugaguuaaaggauggaaagauagauuuauuucuacuuucucuaggccacuaaggaugcuggccagauaucug ggcuaaaugugcuucgagugaucaaugagccuacagcugcugcucuagcuuacggucuggacaaaucugaagauaaagugu aaguuggucagaugacguagcauuaccugcauuuacagggguuguguguguguguguguguguguaauuuuacuacaau uuguguggguccguguguugugguacauuuguacauuuguacauggcauggauauggaugucaaagauunnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnaaaccaguaguugguguguuacuaauuuuacuuguuucuguaugacaugcuuauaugauacguua acaggcaugccacuuagguugauaacuacauucaguuauuaaguauuucaggaaauaucauaguuaauaauuaaacuuuug gucuuuuaauucguuccuuuguuuuguuccuuggaacuuaacuuacuuauuuauuuuuuagcauugcuguguaugauuu aggugguggaaccuuugacauuucuauccuggaaauucagaaaggaguguuugaggugaaaucuaccaauggggacacuu ucuuaggaggggaagacuuugaccaagcuuuguugcggcacauugucaaggaguucaagagagagguuaguuaccacugc uuagucaccacugguuaagguguaggcguuggguuguugagaauuuuuguuuguuugcauugcuuuuagcuuuguuaau agcuuuuuuauacuaagguaacuaacuauacuucagauucauggguaaacuaaaccaguuuaguuauauaaucuuagauug ggaacaaaagaccaagugacaguguuauaguagggagaagnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnacuacucucucgcagu cuauauaugucuccuaauccuauuuauagacagggguugauuugaccaaagacaacauggcgcuucagaggguucgggaag cugcugagaaggcuaaaugugaacuuuccucaucugugcaggugagggauggaaaaaucccaguacugagcauauuugaau aguguauucuaauuuaccuaaugucaguguagcucuuuacaguuuucuguuggcugaaaacuuggggcaugagcaaagga acaacuugaugaucaguucuuuucauuugaaugaaugaaguagauuuauggauguguguaucuuuugccugcaugugug ucuguacuacauuugugcuugguuucuguggcggccagaagaggguaucagaacugacaugucaguguuggggannnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnncacacugagucuaaauucugaucaugucuuucagucguguuauguuacuuugagugagua ucaaagaucacgucucccaucugacgugugguccugugcagacugacaucaacuugccauaccuuaccauggaugcuucug gaccaaagcauuugaauaugaagcugacucgagcucaguuugaaggcauugucacagaucuaaucaagagaacuauugcuc cgugucagaaagcuaugcaggaugcagaagucagcaagagugacauaggagaagugauucugguugguggcaugacaagg augcccaagguauggacucaugguauuucuccuagaggaaaaaaauaacaaugcauucuugaggcaaauggcuuguguugu guguggaaacaaaugugauccauucuucuaguguucuuuaaagaguggugagaccagacucaccaaaaagugcuuuuaguc gccugugauggcucauguaggaggauggccuugaguucuggguaagaugcagcuacagaauucuaccuugcacacacacu uaaacccagucugguaaagagaaguuguuaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncagauguaaaauugauaauac uucuuccuaagauugggcgauuguguagaauaugagaacuguauuuuauaaccccuugucaugugccuucuauuucaaau gauauccucugggaagcuagauaauuaaauucuucucucauuuaaguggacaguggaugagaugcucugaaguugucaaa uacaaacaagucugcagucuuggauaugaaucucucugacuugcugucuggcaggcguauucuguuuggcuccaucaguc gcccuggguguuggcuaacagguucuuucucccugaugcuuagguucagcagacuguacaagaucuuuuuggcagagccc cgaguaaagcuguuaauccugaugaggcuguagccaucggagcugccauccagggagguguguuggcuggugacguuaca gacgugcugcuccuggaugucacuccccucucucuggguauugagacucugggaggcgucuuuaccaaacuuauuaauag gaacaccacuauuccaaccaaaaagagccagguaagagccauucuuuuuuccugccuauuaacagucccaaguuguacaagu gcuguuuacaaucacuuuaugaacucuuuaaaacuuuguuucuaagacuauacuaacuggacugggugnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnccuagguguuuucuacugcugcugauggacaaacucaaguagagauuaaagugugucagggggaacga gagauggcuggagacaacaaacuucuaggacaguucacuuugguaaguguuuuugagucugaguaucaugcuuuuggggu cuauagcuugcaaagcuccaaacugcugacauuacaggcauauuguguuauuuuuuaaaaagaacguuauguacaugaguu augaaacccaugauuuuaguuuuuuaccuaaagugcuuuguguuuucagaauuugaaauuuucaaagccugggaaauguu cagacucagaagcaaugcuaacucagaaguuaguuuuauccugauuacucauuuuaaaaaacuuaauagcuacugguucug gucagcauugcuacaguagagaaguuuauuugcuguaaauucugggcacauauaaccaucaugguuauuaacuucuugaa gcccagugauuucagaaagcacuaaaacuaccaccaucacuuaaaaucucaagguuuugaacauucagugaagauacuuguu uuaggaaacaagugguuaguuggccugauuuggaaaugagaauacaugggccuuucaaaggagcucacucuggauauuua uuuuagauuggaauucccccagccccucguggagugccccagauugaaguuacauuugacauugaugccaaugggauugu gcacguuucugccaaagauaaaggcacuggucgugagcaacaga 150 X14897 Sequence below. auaaauucuuauuuugacacucaccaaaauagucaccuggaaaacccgcuuuuugugacaaaguacagaaggcuuggucac auuuaaaucacugagaacuagagagaaauacuaucgcaaacuguaauagacauuacauccauaaaaguuuccccaguccuua uuguaauauugcacagugcaauugcuacauggcaaacuaguguagcauagaagucaaagcaaaaacaaaccaaagaaaggag ccacaagaguaaaacuguucaacaguuaauaguucaaacuaagccauugaaucuaucauugggaucguuaaaaugaaucuu ccuacaccuugcaguguaugauuuaacuuuuacagaacacaagccaaguuuaaaaucagcaguagagauauuaaaaugaaaa gguuugcuaauagaguaacauuaaauacccugaaggaaaaaaaaccuaaauaucaaaauaacugauuaaaauucacuugcaa auuagcacacgaauaugcaacuuggaaaucaugcaguguuuuauuuaagaaaacauaaaacaaaacuauuaaaauaguuuua gaggggguaaaauccagguccucugccaggaugcuaaaauuagacuucaggggaauuuugaagucuucaauuuugaaaccu auuaaaaagcccaugauuacaguuaauuaagagcagugcacgcaacagugacacgccuuuagagagcauuacuguguauga acauguuggcugcuaccagccacagucaauuuaacaaggcugcucagucaugaacuuaauacagagagagcacgccuaggca gcaagcacagcuugcugggccacuuuccucccugucgugacacaaucaauccguguacuugguguaucugaagcgcacgcu gcaccgcggcacugcccggcggguuucugggcggggagcgauccccgcgucgccccccgugaaaccgacagagccuggacu uucaggagguacagcggcggucugaaggggaucugggaucuugcagagggaacuugcaucgaaacuugggcaguucuccg aaccggagacuaagcuuccccgagcagcgcacuuuggagacguguccggucuacuccggacucgcaucucauuccacucgg ccauagccuuggcuucccggcgaccucagcguggucacaggggccccccugugcccagggaaauguuucaagcuuuucccg gagacuacgacuccggcucccgguguagcucaucacccuccgccgagucucaguaccugucuucgguggacuccuucggca guccacccaccgccgccgccucccaggagugcgccggucucggggaaaugcccggcuccuucgugccaacggucaccgcaau cacaaccagccaggaucuucaguggcucgugcaacccacccucaucucuuccauggcccagucccaggggcagccacuggcc ucccagccuccagcuguugacccuuaugacaugccaggaaccagcuacucaaccccaggccugagugccuacagcacuggcg gggcaagcggaaguggugggccuucaaccagcacaaccaccaguggaccugugucugcccguccagccagagccaggccua gaagaccccgagaagagacacuuaccccagaagaagaagaaaagcgaaggguucgcagagagcggaacaagcuggcugcagc uaagugcaggaaccgucggagggagcugacagaucgacuucaggcggaaacugaucagcuugaagaggaaaaggcagagcu ggagucggagaucgccgagcugcaaaaagagaaggaacgccuggaguuuguccugguggcccacaaaccgggcugcaagau ccccuacgaagaggggccggggccaggcccgcuggccgaggugagagauuugccagggucaacauccgcuaaggaagacgg cuucggcuggcugcugccgcccccuccaccacccccccugcccuuccagagcagccgagacgcaccccccaaccugacggcu ucucucuuuacacacagugaaguucaaguccucggcgaccccuuccccguuguuagcccuucguacacuuccucguuuguc cucaccugcccggaggucuccgcguucgccggcgcccaacgcaccagcggcagcgagcagccguccgacccgcugaacucgc ccucccuucuugcucuguaaacucuuuagacaaacaaaacaaacaaacccgcaaggaacaaggaggaggaagaugaggagga gaggggaggaagcaguccggggguguguguguggacccuuugacucuucugucugaccaccugccgccucugccaucgga caugacggaaggaccuccuuuguguuuugugcuccgucucugguuuucugugccccggcgagaccggagagcuggugacu uuggggacaggggguggggcggggauggacaccccuccugcauaucuuuguccuguuacuucaacccaacuucuggggau agauggcuggcuggguggguaggguggggugcaacgcccaccuuuggcgucuugcgugaggcuggaggggaaagggugc ugaguguggggugcaggguggguugaggucgagcuggcaugcaccuccagagagacccaacgaggaaaugacagcaccgu ccuguccuucuuuucccccacccacccauccacccucaagggugcagggugaccaagauagcucuguuuugcucccucggg ccuuagcugauuaacuuaacauuuccaagagguuacaaccuccuccuggacgaauugagcccccgacugagggaagucgau gcccccuuugggagucugcuaaccccacuucccgcugauuccaaaaugugaaccccuaucugacugcucagucuuucccuc cugggaaaacuggcucagguuggauuuuuuuccucgucugcuacagagcccccucccaacucaggcccgcucccaccccug ugcaguauuaugcuaugucccucucacccucacccccaccccaggcgcccuuggccguccucguugggccuuacugguuuu gggcagcagggggcgcugcgacgcccaucuugcuggagcgcuuuauacugugaaugaguggucggauugcugggugcgcc ggaugggauugacccccagcccuccaaaacuuucccugggccuccccuucuuccacuugcuuccucccuccccuugacagg gaguuagacucgaaaggaugaccacgacgcaucccgguggccuucuugcucaggccccagacuuuuucucuuuaaguccuu cgccuuccccagccuaggacgccaacuucuccccacccugggagccccgcauccucucacagaggucgaggcaauuuucaga gaaguuuucagggcugaggcuuuggcuccccuauccucgauauuugaauccccaaauauuuuuggacuagcauacuuaaga gggggcugaguucccacuaucccacuccauccaauuccuucagucccaaagacgaguucugucccuucccuccagcuuucac cucgugagaaucccacgagucagauuucuauuuuuuaauauuggggagaugggcccuaccgcccgucccccgugcugcaug gaacauuccauacccuguccugggcccuagguuccaaaccuaaucccaaaccccacccccagcuauuuaucccuuuccuggu ucccaaaaagcacuuauaucuauuauguauaaauaaauauauuauauaugagugugcgugugugugcgugugcgugcgug cgugcgugcgugcgagcuuccuuguuuucaagugugcuguggaguucaaaaucgcuucuggggauuugagucagacuuu cuggcugucccuuuuugucaccuuuuuguuguugucucggcuccucuggcuguuggagacagucccggccucucccuuua uccuuucucaagucugucucgcucagaccacuuccaacaugucuccacucucaaugacucugaucuccggunugucuguua auucuggauuugucggggacaugcaauuuuacuucuguaaguaagugugacugggugguagauuuuuuacaaucuauauc guugagaauuc 151 AJ006289 Sequence below. caccugauucccggaggcccgagcccuuagucugggcgggguggcgcgggccggaaggacgccaucccggccugggccaug gaggcucccgcaccgucccucacggaggaggauuugacugaagugaagaaggacgcuuuagagaauuuacguguuuaccug ugugagaaaaucauagcugagagacauuuugaucaucuacgugcaaaaaaaauacuaaguagagaagacacugaagaaauu ucuugccgaacuucaaguagaaaacgggcugggaaguuguuagacuacuuacaggagaaccccaggggccuggacacccug guggaauccauccgcagggagaaaacacagagcuuccugauucagaagauaacggaugaggugcuaaagcuucggaauaua aaacuggagcaccucaaaggccugaagugcagcagcugugagcccuuugcagccggagccaccaacaaccucucuaggugca auuccgaugagagcaaucucucugagaaacagagagcauccacugucauguaccacccggagggagaguccagcacggcucc cuucuucucuauggcgucgucccugaacuugccaguccuggaaguuggcaggacugaaaacagcagcuucucuucagccac ucuuccucgaccuggggacccuggggcucccccuuugcccccagaccuucgguuggaagaggggggaaguuguggaaacu caagugagauguuucuccccuuacggucacgggcucuuucacgccaaugauacaucaccgccuaguuguuuuacuagugau gcaaaaugcugugaaggaggccaucuuucuauacaaaccacggugacaggucacucacauucgaugcgugccuuuaaaauc aguguacacauucucuguaaauaggauuuguuaggguaaagaagcgcucuggggcggcgugguguaaucaugguggucgu gacuuuuccauaauguccuuucuuuuuuauuauuuuuagguguuugcguauuuugaacuuuucauaagauuaauuuuau cggaauauuucucaauuugagaaaacaacuuguggauugggaauaauguuuuuagcacauuuaugcuacaaauuuucagu cugauuguuuuucccacugaucuggcaguauauuuuagcaguaagcuguugugugucaggaaagcuggacacgggaaagc ugccgacacacucagcagugucccacuccuuaguucugagaagccgucggguucugaggagacaccugguggcacugagcc uggugaccucagugggccaaaauuuguuuuauacucacccugccagcgugagugucuuacuuucacaggccuuguguccu cagucuuaucuuaaaggauguuaucuuggcagggcaucacuuguaauuaauggaugauacuuguaauugacuaaaguccu cgcucugagccguuuguucuggcuccgagagcgcugacaugugaagcauggugagcagcgagggaacugacaggaugugg ccguggccaguguggcuuuaguguuugcaucaggcagccaccagcuccauccguguucuuacugcuuuacaaaguuugac uaacuuuacacauuuuaaaaaugcugauugucuucguuuaaauuauaauuuuaccuauuucuugacaucuaacuccuauuu auuucuauuauuuaaaaauuaagaaaugaaaauuugcuauuaacaauaaaguuuuuuuaaugu 152 X12944 Sequence below. ggggggggggggucagcgccgacguccccugccgccaccaugcccaaaagaaaggcugaaggggaugcuaaaggagacaaa accaaggugaaggacgagccacagagaagaucugcaagguugucugcuaaaccugcuccuccaaagccagagcccaaaccua aaaaggccccugcgaagaagggagagaagguacccaaggggaagaaggggaaagcugacgccgggaaggaugcgaauaauc cugcagaaaauggagaugccaaaacagaccaggcacagaaagcugaaggugcuggagaugccaagugaugugugugcauuu uugauaacuguguacuucuggugacuguacaguuugaaauacuauuuuuuaucaaguuuuauaaaaaugcagaauuucgu uuuacuuuuuuuuuuuuuuuaagcuauauuguuagcacacagaacacuucauuacugggugggggaaggaucauguguca guaacaaaaucucucccaagcuggauugaggacagaaaaccucuuucccugauaauuuuggaaggcuccuguuggcuccca ggagagagauccuggucuugaccuagguggccaccaaggcacaacaaugccuuguggucugggaaaacuauaaauucacuu uuauauccucuucccccuguacuaucaacauagacuuaauucccuuaaaaaccagagaccuguuggaaccuggcccccaaaa uugguuucccaguccauugagugauggggacuuugcagugacuucauugaguguucucaaaagagcacugguuccuuuua uaaaagauuguggaucuucagauugauaauucugccuaaaagucagggucggcuugugaaaaguuguuaaaacaacauccu uaaugugaaaugucaacccucacucuaagcuacuucccccuuuucaaagcauugaaugaagacuucauuggguuuuauagu ggcuuucugauuuugguagucauaucagaagggaauuuggaaguucuuguauauuguugcauugucugcccauguccug ccugaauaccaugauuguuuaugaaagaaucuuaauaaagcugguuacaguuaggcuggaaaa 153 AW061302 uuuuuuuuuuuuuuuuuggaaguccauaaguaguuuauugucuucaagacuacagugugg auuccucucccagagaagggucuuucagaggcaggggacugucacccaggugcaggccgu cuacuugucauuuucauacauggcuggauucuuccuuuucgacugcucaaacuccugguu gccccauguguagaucagguagaccacuacaaacggcggcgccacgcgcaggaugcgcuc gcgagugcggcgcaacacguuggggaugccuuugcugaaauagcuugggaaggcgcgcug cucaaagggcgacaagcugua 154 U67328 Sequence below. caugaagccagagauguggaagaugugucuagacugcaucaaugaacugauggauacguuggaugcacauuccaacaucuc ugucggagagaacauuuuggcagagagugagaacuuacacaacuuugaucaguucacuccguguacgacgcugcauccuaa cuuugguggagcgaauggaugaagaauuuaccaaaauaaugcaaaauacugauccucacucccaagaguauguggagcacc ugaaggaugaggcacaagugugugcaucauugagcgagugcagcgcuaccuggaggagaaagguaccacugaggagaucu gccagaucuacuuaaggcgcauccugcacacguacuacaaguuugacuacaaggcccaucagcggcacguuacuccuccuga aggauccucaaagucugagcaagaccaggcagaaaaugagggugaggacucagcugugcuaauggaaagacugugcaagua caucuaugccaaggaccguacagaccggauccguaccugugccauccucugccauaucuaccaucaugcgcuccacucccgc ugguaucaggcccgugaccucaugcucaugagccaccuacaggacaacauucagcacgcagacccgccggugcagauccugu auaaccguacuauggugcaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucuggau auucagucaagugguggugccaaggagcuucuaggucaggguuugcugcugcgcgcuugcaggagcgaaaucaggaacag gaaaagguagagcgacgccggcaggugcccuuucaccugcacaucaaccuggagcugcuggagugugucuaucugguguca gcuaugcuccuggagauccccuacauggcugcccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccaccacc aacugcgggugggcgagcggcacgcccugcuagguccucccgagucaaugagggagcauguggucgcugccuccaaggcca ugaagaugggcgacuggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuucccug aggcugacaaaguucgcaccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcagug ucuaugacucaaucaguauggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaaga ugaucauuaacgaagaauugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugccc agcaagaaacuuggcucugcaagcuggcugagaaaacuuggcacccuaguggagaauaauggacggguguuugaccaaaaa cagggaaccuaugguggcuauuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcuac ccccagcaacagucucagacaaccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccuaa cucaccccaaucauuaaagaucuuuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaa 155 AI604314 uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa cuagguaaguucugauguaagauuucuaugggauuauuuuagaauauauagauuugugua guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa aacaucuuugcaugauuacuuuacacacacaaauauaguaaaacuuacauaguacaaauu cacauaagacuccauucugucuauaacuucauccaugugguuuuaccaugaauuauaauu cuuaaccucuccuauaacugucagcuuccauuuaauuuugaaaguaucacuucacaaaga gcacuucauuugcuuuuagaguauacauagacu 156 AI845121 cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca ugggguauggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu aucagugggaccacucagaacucaggaugaacuggggugaaccgauacacugggaccuag acauguacaucaggaaucguguggacacgucaccuaccccuguguccugngaugucaugu guaaacaucucuucggcuuuguggcuuucaugguuuucauguucuggguagggcacgugu ucccuuccuaccagccuguggguccgaagcaguacccuuacaaaaaucuguaccuggagc g 157 AW047756 uuuuuuuuuuuuuuuuugaugcaaaugucuuuauuuuccacuuaaacaaguuucccuuuu gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc caugcagcccaguuacaccuuuaggucagaaaggcugaugcgugaccagccucuauugcc ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu uuuacaacuccauaagcccuuuggccaaagucccugcaguguuuggggaggaccuuccca cccuucaccagucagugucugaucugguggag 158 AI838021 uuuuuuuuuuuuuuuuuaauaucuguaauaguuuauuucaaagauuugacauuuacaagu agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcuuugu ucccaacucaggacaguacuuuagugcuugcuucauuuacuggaaaaguucacuggacau aguuuccacuucuucccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc uuucagugucggugucagaaguccguuuucaa 159 AW122893 uuuuuuuuuuuuuuuuucugagguauuaaaauaucuagacugaauuuugccaaauguaag agggagaaaguuccugaagacucugacuacuugcuuauuuuugauugaccuucuaugcuu augucauuacugccucacaacguguuugauguccuuuaaugauacaaagugagccugugc cuucauuuucuugcccauuuugguaccccucgugccg 160 M59821 Sequence below. gcgcccgaacgucuagcagaguaccugcugcuguaagcuugucgucugggcugcaccgcccgucuuaacccauucucgacu uaacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguacca cucucgcaugcagcgagguggcuugcgacuccaccggagucugcagcuaucccucguuaugcgcagcgcucgagagcucua ccucucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcgg gaagccgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcug cgaguccaggagaccccugcgcucugugacccgccccccgcuagagucagccgcaagcgccggagcagcagcgauuugagc gacaguagugaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucc cgaucgccugcagcuuccuccggcacaaagcgaaggugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccagu cuccugaacuguggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaaua ugcucaacgugcuggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggag aacgcacacccgaggcgaaggccggcgggggccgugaagaagagccgcggcccgagcugccgagaggccagggcaaggacu gaggagcgaggggcgcgggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuugg agaagggacaccuagaucuugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccau ucgcguuucggccccuacaagugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccug uugccuugcguggguguggggccugggaggaggccaggguguggacccgcccuagggacugggaagugacuugagucacc ucgcccccacaggcugcugugggugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccggg acuggucaaccuagaugaucgccuggcguggaccaccgcgggacgggugggccgcuggucguaguugcugccguagacac agcuucuucgggcaggaaagaaaauuuuuuuuuuaccagcguguuuaagaaagucuguuuacuuuucccacgguggguug uuuaauuagcaacuaccuggaguuuuacaaugucagcuaggaaaauaaagaccaucggugu 161 M13805 See above (same Accession Number). 162 AI845886 uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagca auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc acacuggugacugcccagagugcccuggccccaguguguuggcacucagucugacuuuac aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag uuccaauauuucacauauauuucuucuugugcagucuaagccgagaaugccauguaaaug ggucacugcgaaaugcagcaauuuagu 163 X53157 gucucgggcgagauggcuucaagguuacuucgcggagugggcgcuuuggcggcgcaggcc cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc 164 U19118 See above (same Accession Number). 165 AF062071 Sequence below. gcgcaccgccygyguygcgcgscagcgucgucuaggugcaucgcgggcccccgcagrwagaaaaauauggcucaggagacu aaccagaccccagggcccaugcuguguaguacaggauguggcuuuuaugggaauccuaggacaaauggaauguguucugu uugcuacaaagaacaucuucagagacagcagaauaguggcagaaugagcccaauggggacagcuagugguuccaacagucc uaccucagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaa aucaagaaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaacu accccgaaaacagaggugucagagccaguugucacucagcccaguccaucaguuucucagcccaguucuucucaaagugaag aaaaagcuccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuugacu gccgauguggaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagcug cagcaaaaaucagaaaagaaaauccaguuguuguggcugaaaaaauccagagaauauaaaauuacuacaugugaagagacug aaacuuuguuuuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucuccag aguuuugcuuuauacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggauaga uacagcccuacaaauguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauugaaauacacauauacua ggaacaaaauuuaguuccacgugccaaacuaaaggaaugaaaucucugcauguuugcagcauaucugccuuuugggaaugu aaucaagguauaaucuuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggcagu cuacuaccauagucaaacuucaccuuaauuucgacaugacuuuuggaagcaggaagaaagcuacaaaacugguauuuggua ccaugugugagccugguuaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacaacugguuc uaagucaaaccaucaagucaacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagauauc ugcauucucauuacuaaaauuguagcacagaacugcacuaggauuuguuuacaaggagaaauuaaacucuguuugguuuuc acauauagcagcucuguuaaauaacaugcaucugaauuuuaaguugcaaagguaucugaacaguuaauuuuucaugugcau cuuuuguugaauguuuugguucaagaaagaauguuuaaagcuuuuuaaagacuucaguucuuaauguaacuguacccuuc ugcauggaaaaucauaaccaacauggcugcaguagacuucuuuagugguauccagcaccacuugcagagggcugcuuuauc auauuguacuuggguguaggacucuaguguucuuggguguauugcaugggcugcauuaucuacagcauuguacaauaaca acuagaaaaggcgguauacuucacugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugugaugu augaaacuuguguuuuuuauauauaaaugaguauaguuagauuaguguugugguaaugccuguuuucaucuguaaauag uuaaguauguacacaacaaggcacuacuucugauuuuugcaguguucaguccuaguuuuucuuuauuaaaacauugaguu uugcuucaauuuuauguaccuuaguucuaaguuagauuugcagauguguacagauaguucauauuuauguauugcacaua aucaugcuauucagcauugaugcuauauuguauuauguaaauaauaaaagcaguguacagagggaaaa 166 U10404 augacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagcc aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau gccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucgu auccccaaggaacagggaguccuguccuucuggcgugggaaccuggccaaugucaucaga uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu ggugccgcuggggcuacauccuugugcuuuguguacccucuugauuuugcccguacccgu cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc cugguuaagaucuacaaaucugaugggauuaagggccuguaccaaggcuuuaauguguca guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc acugcugucgcuggccugacuuccuauccuuuugacacgguucgccgucguaugaugaug cagucuggacgcaaaggaacugauaucauguacacaggcacgcuugacugcuggcggaag aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccaacguucucaga ggcauggguggcgccuuugugcuugucuuguaugaugagaucaagaaauacacauaa 167 U07634 Sequence below. cguagaaguugucucugucggcgggcgggcgggcaggauuggggcaccgagaccggcgugcggacagcagggaucgcggg gagcgaggggugcggcauggagcuccgggcagucgguuucugccuggcgcugcugugggguugcgcgcuggcggccgcg gcggcacagggaaaggaaguuguuuuguuggacuucgcagcaaugaagggagagcucggcuggcucacgcaccccuaugg caaagggugggaccugaugcagaacaucauggacgacaugccuaucuacauguacucggugugcaacgugguauccggcga ccaggacaacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcg agacuguaacagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacua uggcaccaacuuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgag gcucgcaacgucaagcugaacguagaggagcgcaugguggggccccuuacccggaagggcuucuaccuggccuuccaggac aucggcgccugcgugcggcugcucuccguucgcgucuacuacaagaagugucccgagaugcugcagagcuuggccugcuu ccccgagaccauugcugucgcuguuuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggu gccuuaugggggcgagggggcucucaugcacugcacgguggauggcgaguggcuggugccauccgagugccugugccagg aaggcuacgagaaggucgaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuuccc uggaguguccagagcauacccugccauccacagagggugccaccuccugccagugugaagaaggcuauuucagggcaccug aggacccacuguccaugucuugcacacguccacccucugccccuaacuaccucacggcaugcaugggugccaaaguagaacu gcguuggacagcucccaaggacacugguggccgccaggacauugucuacagugucacuugugaacagugcugcgcagaguc uggcgagugugggcccugugaggccacggugcgcuauucagaaccuccucacgcccugacccgcacgagugugacagucag ugaccuggagccccacaugaacuauaccuucgcugucgaagcacgcaauggcgucucaggccuggugacuagccgaagcuu ccggacugccagcgucaguauuaaccaaacagagccccccaaagugaggcuggaggaccgaagcaccaccucccugaguguc accaggagcaucccggugucacagcagagccguguguggaaguacgaagucaccuaccgcaagaagggggaugccaacagc uauaauggccgccgcacggaaggcuucuccgugacccuggaugaccuugcuccggauaccacguaccuggugcaggugcag gcauggacgcaggagggccaaggagccggcagcaaagugcacgaguuccagacgcuguccacggaaggaucucgcaacaug gcggugaucggcgguguggcuguagguguuguuuugcuucugguacuggcaggaguuggccucuucauccaucgaagga ggaggaaccugcgggcucgccaguccucugaggauguccguuuuuccaagucagaacaacuaaagccccugaagaccuaug uggauccucacacuuacgaagaccccaaccaggcuguacucaaguuuaccaccgagauccacccauccuguguggcaaggca gaaggucauuggagcaggagaguuuggagaggucuauaaagggacgcugaaggcauccucggggaagaaggagauaccgg uggccaucaagacacugaaagcgggcuacacugagaagcagcggguggacuuccugagcgaggccagcaucaugggccagu uuagccaccacaauaucauccgccuggaggcgguggucucuaaauacaaacccaugaugauuaucacagaguacauggagaa uggagcgcuagacaaguuccuuagggagaaggauggugaguucagcguacuucaguuggugggcaugcugagggguaucg cauccggcaugaaguaccuggccaacaugaacuacgugcacagagaccuggcugcccgcaacauccucgucaacagcaaccu ggugugcaagguguccgauuuuggccugucgcgugugcuggaggaugaccccgaggccaccuacaccacaaguggcggca agaucccuauucgauggacagccccagaggccauuuccuaccgcaaguucaccucagccagcgauguguggagcuacggca uugucaugugggaagugaugacuuauggcgaacggcccuuacuggaacugucaaaccacgaggucaugaaagccaucaacg acggcuuccggcuccccacgcccauggacugcccuucagccauuuaccagcucaugaugcagugcuggcagcaagagcgcu cccgccggcccaaguuugccgacaucguuagcauccuggacaagcucauccgacgccccgacucccucaagacgcuggcuga cuucgauccccgaguguccauccggcugcccagcaccagcggcucggagggaguccccuuccguacgguguccgaguggcu ggagagcaucaagaucgaacaguacacggaacacuucaugguggcuggcuacacggccaucgagaaggugguacagauguc caacgaagacaucaaaaggaucggagugcgucuuccuggccaccagaagcgcauugccuacagccugcugggacucaaggac caggucaacacaguggggauuccuaucugaguccauuggggcugucacacaauacuugaagagccacaguggucucccugc cgaucuggugcuggcccacuggaacuuuauuuauuucuguuuccucgucuaugccucccuaggacucugcaggggcuuuu ugaaugacaccugccugagccugggaaacuuggauugcuggucagggcucucuuuccccugaaaaggacccagcuaagaac uuagcaguuugccauggccuucccagcauccccugaggcuaaaguuccaccaagagucgauaucgacgagggacauuucca aacggaccuccccaucuucauuuggccuccugagaagccacucuggagcugaggcuaagcacuaagcccaggaccauaugac uagcacuguaccgcccgccccuaguuagaggguagguuuuggacuuggcuggguuguggucacaagcaaucucccagugc cuuuuacagaccccagucugcccucccgucgagggccagcuucuugcuuuccuagggcccucucaggaugcuuggcugugc ugagguuuuuauuaaauauauauuuuauacuugcggaaagaaugaguguguggcagggacuugccagggcuggagacaga ggauccccugcaacaagacauucccgggcugggggcuggcggaccugcaggagacuuuccgccaccaccccgucuccagccc cuuuggacaaaugucgcugucaguguuacagauuucuuuuauuggguuguuuuuuuguuguauuuuuuugaaccuuaac uuauuauuuuuuuuauauuuauuguuagaaaaugacuuauuucugcucuggaauaaaguugcagaugguuca 168 X04663 Sequence below. ccaaaaaccuuaauuuucuuucuuguucgguaccuacauuggaaccaccaaaaacaauuauuucaguaaaccguagccauga gggaaaucgugcacauccaggccggacaguguggcaaccagaucggugcuaaguucugggaggucauaagcgaugaacaug gcaucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugaagccacagg uggcaaguaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcucagguccuuuuggcc agaucuucagaccagacaacuucguuuucggucagucuggggcaggcaacaacugggcuaaaggccacuacacagagggag cugaguugguugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugac ccacucacuggguggaggcacuggcucuggcaugggcacccugcucaucagcaagauccgggaagaauauccugaccguau caugaauaccuucaguguggugcccucgcccaaagucucugauaccguggucgagcccuacaaugccacccugucugucca ucaguugguugagaacacggaugagaccuacugcaucgacaacgaggcccucuacgacaucugcuuccguacccucaagcu caccacgccaaccuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggc cagcuuaaugcugaccuucgaaagcuggcugucaacauggugccauucccacgucuccacuucuucaugccuggcuuugcc ccucucaccagccguggaagccagcaguaccgggcccucacugugccugaacuuacccagcaggucuucgaugccaagaaca ugauggccgccugcgacccgcgccacggccgguaccucacaguugccgccgucuuccguggacggauguccaugaaggagg uggaugagcagaugcucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcug ucugugacaucccaccgcguggccucaagauggcagucaccuucauuggaaacagcacagccauccaggagcuguucaagc gcaucucugagcaguuuacggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagaug gaguucaccgaggcugagagcaacaugaacgaccuggugucugaguaccagcaguaccaggaugccaccgcggaagaggaa gaggauuucggagaggaggcagaagaggaggccuaacggcagagagcccugcaucagcucaggcugcuuagaucccucagc cuuucuccaacugcccuuuguccuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauu ggggguaaauggugccuggcacauggcaggcacucaauaaauauuuguuugugg 169 X61232 Sequence below. ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugc cgcgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgcc ggcggcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcugcgcgaggcgcuggugucgguauggc ugcagugcaccgccaucagcagaaucuacacagugggcgccagcuucgagggccgggagcuccuggucaucgagcugucug acaaccccgggguccaugagccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacggg aauugcucauuuucuuggcccaguaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagca cccgaauucauaucaugcccuccuugaaccccgacggcuuugagaaagccgcauggcagcccgggcagcugaaggacuggu uugugggccgcagcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaggaucguauauguuaaugaga aagaaggcggucccaacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaa ggcugucauucacuggaucauggacauuccauuugugcuuucugccaaucugcacggaggagaccuuguggcuaauuacc cauaugaugagacacggagcgguacugcucacgaauacaguuccugcccugaugacgcaauuuuccaaagcuuggcucgcg cguacucuucuuucaacccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaug auggaacgaccaaugguggugcaugguacagcguccccgguggaaugcaagacuucaauuaccugagcagcagcaacugcu uugagaucacuguggagcuuacgugugagaaguucccaccugaagagacucucaaaagcuacugggaagauaacaaaaacu cccucaucaacuaccuggagcagauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacg caaccaucucuguggaugggauagaccaugaugucaccucggcuaaggauggggauuacuggcgauugcuugcuccugga aacuauaaacuuacagccuccgauccuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguuggg guggacuuugagcuugagucuuucucugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugauguc agaaacuuugaauuuuuaagaaaggcuucuaacuaauugcuuucaucuaucuauagacuguaguaagaugcaauguggcuc uuuucuuuuagguugugugcaguugauauuuaacauugauuuauuuuugaucauuaaguaauaguuacuaaucacguaaa uacacccggacagaaauauaaugcuggacaucuucauucuacaucaacauucgcuuaaaucauucgaagccucuuuuaacgu aaugggugacaaugucacuugacagaugcaugagagucacgauauagcugacugugacccugcacugcaaucacauaguuc cauauaaguuguccuuagucucuugugcugauucacuguauaagcaugauccugguaaugcacuuuggaugggaagaaaa uguacgugcuuuucagaggggcucugaacagaaugaaaaccuaguucuugcguguacuuugaagaauggaauuguauuag ucagcuguuaaugccacuucagaaguuugggguuuugucuugauuguagauugg 170 X14309 Sequence below. gccacggacgccucucugaacggggauccaggcaggauuagagcugccucacugacuacaggccgugucgugucaccguuu cugcaggcaccaugagccaggacaccgaaguggacaugaaagauguggagcugaacgagcuagaaccggagaagcagcccau gaaugcagcggacggggcggcggccggggagaagaacggucuggugaagaucaagguggcggaggacgagacggaggccg gggucaaguucaccggcuuauccaaggaggagcuacugaagguagcgggcagcccuggcugggugcgcacccgcugggcg cugcugcugcucuucuggcucgguuggcugggcaugcuggcgggcgccgugguuaucaucguucgggcgccgcgcugcc gugagcugccuguacagaggugguggcacaagggcgcccucuaccgcaucggcgaccuucaggccuuuguaggccgggau gcgggaggcauagcuggucugaagagccaucuggaguacuugagcacccugaaggugaagggccugguguuaggcccaau ucacaagaaccagaaggaugaaaucaaugaaaccgaccugaaacagauuaaucccacuuugggcucccaggaagauuuuaaa gaccuucuacaaagugccaagaaaaagagcauucacaucauuuuggaccucacucccaacuaccagggccagaaugcguggu uccucccugcucaggcugacauuguagccaccaaaaugaaggaagcucugaguucuuggcugcaggacgguguggauggu uuccaauuccgggaugugggaaagcugaugaaugcacccuuguacuuggcugaguggcagaauaucaccaagaacuuaagu gaggacaggcuuuugauugcagggacugaguccucugaccugcagcaaauugucaacauacuugaauccaccagcgaccug cuguugaccagcuccuaccugucaaauuccacuuucacuggggagcguacugaaucccuagucacuagguuuuugaaugcc acuggcagccaauggugcagcuggagugugucgcaagcaggacuccucgcagacuuuauaccggaccaucuucuccgacuc uaccagcugcugcucuucacucugccagggacuccuguuuuuagcuacggggaugagcuuggccuucagggugcccuucc uggacagccugcgaaggccccacucaugccguggaaugaguccagcaucuuucacaucccaagaccuguaagccucaacaug acagugaagggccagaaugaagacccuggcucccuccuuacccaguuccggcggcugagugaccuucgggguaaggagcgc ucucuguugcacggugacuuccaugcacugucuuccucaccugaccucuucuccuacauacgacacugggaccagaaugag cguuaccugguggugcucaacuuccgagauucgggccggucagccaggcuaggggccuccaaccucccugcuggcauaagc cugccagccagcgcuaaacuuuugcuuaguaccgacagugcccggcaaagccgugaggaggacaccucccugaagcuggaa aaccugagccugaauccuuaugagggcuugcuguuacaguuccccuuuguggccugauccuuccuaugcagaaccuaccac ccuccuuuguucuccccaggccuuuuggauucuagucuuccucuccuuguuuuuaaacuuuugcagauuacauacgaauu cuuauacuggguguuuuugucuucaaauaaaaacaucaccccugccucaug 171 U42386 Sequence below. gncuuaagccncguuuauuuugaugnccuguuggcucagunaugnccaagaugccnauuguuuuugcccnaaauaaauuu acugaacuugggcuaaaaccaaaccuuggcacacaggugugauacaacuuaacaggaaucaucgauucauccauaaauaaua uaaggaaaaacucaagugguagccugucuuaaggcuuuugauacuugcagauuggggaaaaacaaacaacaaacgucuuga agcauauuaauggaauuaguuucuaauguggcaaacuguauuaaguuaaaaguucugauuugcucacucuauccuggaua gguauuuagaaccugauaauagucuuuaaacaagccauuccagucaugaugaggugauguauggauacaugcauacauuca aagcacuguucucaaaguuaaugcaaguaaauacagcaauuccucuuucaauguuuaggcagaucguuaacuaugagcuag ccaaaugugggcauguuauuacagggaaaguuuaaaggucugauaacuugaaauagguuuaggagaauucaucuacuuag acuuuuuaaaugccugccauaaaaaauugaaaugguagaauggcugaccacagcaaugaccagcccucaccuagggcucug gaugauuuuuggucuaauaacgcaugcuaguguugauguuuuuuggucaagaugggaaugaacaggaagaauuaugcagc aggcuuuauuuuaaaugccgauucacauuacucuguucaagcugcguugagauguuaaacuggcuuacuauagacuuugu aaaaaaaaaaaaaaccaaacaaauggcuccagaagaguaacaaacugaaaucugagaucacacagguuggaaauauguacaua acugaacaaggugucaauucugcucuacagugcaguuuagucaguuuuaguugcauagguuuccauuguuuuuauagucu guuuaugcuaaaucuggccaaagaugagcauuguccaccacuaaaaugccuaugccacugggaauucuggguuaauuuugu gaccagaaugcagugaucaaaauguucaaucuuuuuacaguggcauaggaagauggcaaaaauuuccuaaagugcaauaga uuuucaaguguauugugccuuguucuaaaacuuuuauuaaguaggugcacuugacaguauugaggucauuuguuauggu gcuauuucaauuagucuagguuuaggcccuuguacauuuggcccauaacuuuuuacaaaguacuucuuuuauugcacauu cagagaauuuuauauauaugucuugugugcguguccuuaaacuuccaaucuuauuuugucucuuggagauuguugaacgc agcuugucuaggaaagggaugggacuagauucuaaaauuuauuugggaccaugggaaugauaguugggaagaaacuuugc acacgacagauuucuagauacuuuuugcugcuaguuuuauguaauauuuauugaacauuuugacaaauauuuauuuuugu aagccuaaaagugauucuuugaaaguuuaaagaaacuugaccaaaagacaguacaaaaacacuggcacuugaauguugaaug ucaccguaugcgugaaauuauauauuucgggguagugugagcuuuuaauguuaagucauaauaaacucuuaagucaaauu aagcagacccggcauuggcguguagccauaacuuucugauguuaguaaaaacaaaauuggcgacuugaaacuaaaucaugc caagguuugauacacuugucuugagauauuaacgaaacacuuccaaacacugauacaaaguguccagauucucagauguuu guugugugaguuuuguuuaguuguauuuuuuuuucagugaaugucuggcacauugcaauccucaaacaugugguuaucu uuguuguauuggcauauucagugacuuguacauucagcaauagcauuugagcaaguuuuaucagcaagcaauauuuucag uuauguuuccaaauuaagaauggguuuaaacuugcugaauguaaagauugacccucaagucacuguagcuuuaguaguug cuuauuguauuaguuuagaugcuagcacugcaugugcugugcauauucugguuuuauuaaaauaaaaaguugaacugcac agucuccuuuguuguugucaauugugguuuacuuuuagaggugaaaauaaaguugugcucuugccucgugccaauaugua cauaacugnacaaggugucaauncugcucuacagngnaguuuagncaguuuuagungnauagguucccaunguuuuuaun gncuguuuaugcuaaaucuggccaaagaugagcauugcccaccacuaaaaugccuaugccacugggaauccuggguuanuu uggngaccagaaugaagugancaaaauguccanucuuuuuacaguggnauaggaagauggnaaaaauunccuaaagugnaa uagauuuccaaguguuungugccugguncuaaaacuuuunuuaaguagggugcacunganaguauugaggncauugguu auggugcuauuuccanuuagucuagguuuaggcccu 172 U51126 Sequence below. cucggucuccaagaugguggcuaacaaaacgugaggccuagagguugauccuaggucacuggaagcauguccuugaagagg acuaugggcaucuggguucuuccucuucuacuuggccacgagguaaccggcuucuuguaccacgugugcucaccucuacaa ucugugcggauucagacuccaagcaacuaggcuacccagugacaggcuaaaaacuacagcucuaacgucuuggaaggcgau uccauggaccaggauguggaaagcccaguggccauucaccagccaaaguugccuaagcaggccagggacgaccugccgagac acaucagccgagacaggaccaaaaggaaaauccagagguacgugaggaaggaugggaagugcaacguucaccacggcaaugu gcgggagacguaccgauaccugacggacaucuucaccacccugguggaccugaaguggagauucaaccuguugaucuuugu cauggucuacacagugacguggcuuuucuuugggaugaucugguggcugauugcguacauccggggagauauggaccaca uagaggaccccucguggacuccuugugucaccaaccucaacggguuugucucugcuuuuuuauucuccauagagacagaaa ccaccaucgguuauggcuaccgggucaucacggacaagugcccugaggggauuauucuccucuuaauccaguccguguugg 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ugugcacacuccggccacgcagcucaacagccaggagugcuucuccacuuagcccugcccuggcauccauuuaugaucucg ucuguuguguuaauuacccagcuagcuuuuuucucaaaaauaauaucucccagccauagaccuacucaucuguguccucuu uaauuucaacccacaguuacaucauucacuggcuugcucaguuucuucaacucugaaaugggaaugaugaugaugaugccu cuucccccaagccaccauccucccccgugaccuuccuagguacagacucaaaccagggaagauuauuuccuucucauaggcc acagggugaaaugcaauaaagaacaaagccuuguagggaggcagagggaaagaccaguccucacaagaggcuccauuguuu ccagggacuuugaagcuuggacagaaugucagaugauccccuuugaaggugcuccaaagagucaaugugaaaaauauugac ugaugugugcccguccacaagccaaggugccucugcccuggucaccuaccaugaauuauaaacugaugauauuugaaauaa uaaggaacacuggagccggccagaaaggauucugcagucccauaaauagcaacauucaucacuacaaugccugccaacggug gccgugaauguagauuacccccggcucuucugaggccacugaggacagggcaaacuaccucugagaauggaggcucacugu ucugcaucccacuucuaaauguuccaugaauuuuuugagacaucucccauaucccuguuagaaagauucaaccuugugcua uuaaccaaaucauuuugaauuccauaaaccucuacucuaaaguauacacuuaauucuacaauacagacaacaaauaugacuu uuuccuaugaaagagugauaaagauacuguaucagucugcuuugacucaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aa 173 AF093853 Sequence below. uggaaugggugcuaggugaaggcuuuguugaaucaggaugcugagcugguguuuuuacagguccagauaugaugagcug gaguuuugguaggcccagguaccuccuccaaaauugaccacauaauuggucacaaaucaggccuccacagauacaaaaauau ugaaauuaucccaugcauccugucugaucaccacagacuaaggcugaucuucaauaacaacauaaaaauagaaagccagguu cacugcugcggcugcgccuccuuguucucagcgucaccacugccgccaugcccggaggguugcuucucggggacgaagccc ccaacuuugaggccaauaccaccaucggccgcauccgcuuccacgauuuccugggagauucauggggcauucucuuuuccc acccacgggacuuuaccccagugugcaccacagaacuuggcagagcugcaaagcuggcgccagaguucgccaagaggaaug uuaaguugauugcucuuucaauagacaguguugaggaucaucuugccuggagcaaggacaucaaugcuuacaauggugaa acacccacggaaaaguugccauuucccaucauugaugauaagggcagggaccuugccauccuuuugggcauguuggaucca gucgagaaggacgauaacaacaugccugugacggcccgugugguguucauuuuuggcccugacaagaaacugaagcugucu auccucuacccugccaccacgagcaggaacuuugaugagauucucagagugguugacucucuccagcugacaggcacaaag ccgguugccaccccaguugacuggaagaagggagagagcgugaugguaguccccacccucuccgaagaggaagccaaacaa uguuucccuaaaggagucuucaccaaagagcucccgucuggcaaaaaauaccuccguuauacaccccagccuuaagucuuug cggaaauuggggcugcaucugcacguccagcacuggggccugaggacgucagccggcagccguggguccuugcagcaggu ccguagaaagaucguggcaugaucacagccgguccuguagaucgcucgcuauacuacugggucauuaaauggaaauggcac caaaaccuucucgggauucuuuacucugugccuucgccagcauucugccccucugccugucacagugcccuacugacuggc ucucuuugaaacgaauuauguauugaagauuccuuaggucucugcagggucuuugaucagcaagcaagguagugucagug ugggcucugugcuagaaugaugaaacaccuuuuguagcuuuccgaacggaaucuucuguuacccauuuuggagagcacug acauggggagaagcuuucaauucuguauuuuuaguaaauaaaguggggacagccgggagaauucuuacagggaaucuauu guaaguuucuaucgaagugggcucagaaagccuuucgccucccaagagugcgcauguaccuccuagaguuuccacaucugc ucucuggugaugucugccugugaacgcaccuuauaaaagacgggcggugacaguguuuuaccacucaguguccuaguagu ggguggccauuucugaauucugcuuuuugagguucaacaaauaaaauccugaucagaaaaaaaaaaaaauagaaagccaaca uucauguggaaacugaacaacacuacucaaugauuccuuggucagagaugaaauaaagaaagaaauuaaagacuuuuuaga guuuaaugaaaaugaagccacaacauacccaaacuuaugggacacaaugaaggcauuucuaagaggaaaacucauagcccug agugcauccaaaggaaaaaaaaaaaaaccuagagagaguguacacuagcagccugacugcacacuuagaagcucugcaaaaa aaggaaucaaauucacccaagaggaauagacagcaggaaauaaucaaacuuagggcugaaaucaaccaaauggaaacaaaaag aacuauucaaagagugggccaaaccaggagcuaguucuuugagaaaaucaacaagauagauaaacccuuagccagacucacu agagggcacagggacagcauccuaauuaacaaaaucagaacugaaaagggagacauaacaacagauccugaagaaauccaaaa caccaccagauccucuacaaaaggcuauacucaacaaaacuggaaaaccuggaugaaaggaaaagcuucuagacaga 174 Z19521 Sequence below. augagcaccgcggaucugaugcgucgcugggucaucgcccugcuccuugcugcugccggaguugcaguagaagacucagg cagcaggaacgaguuccaguguagagacggaaaaugcaucgcuagcaagugggugugcgauggcagccccgagugcccgga uggcuccgaugaguccccaaagacaugcaugucugucaccugucaguccaaucaauucagcuguggaggccgugucagccg augcauuccugacuccuggagaugugauggacagguagacugugaaaaugacucagacgaacaaggcuguccccccaagac gugcucccaggaugacuuccgaugccaggauggcaagugcaucuccccgcaguuugugugugauggagaccgagauugcc uagauggcucugaugaggcccacugcccagccaccacuuguggccccgcccacuuccgcugcaaaucauccauaugcauccc cagucuuugggccugcgacggggaugucgacuguguugacggcucccaugaguggccacagaacugccaggccgaagacac ggccuccaaaggcguuagcagccccugcuccucccuggaguuccacugugguagcagugaguguauccaucgcagcugggu cugugacggcgaggcagacugcaaggacaagucagaugaggagcacugcgcgguggccaccugccgaccugaugaauucca gugugcagauggcuccugcauucacgguagccgccagugugaccgugaacaugacugcaaggacaugagcgacgagcucgg cugcgucaaugugacacagugugauggccccaacaaguucaagugucacaguggggagugcaucagcuuggacaaggugu gcgacuccgcccgcgacugccaggacuggucggaugagcccaucaaggagugcaagaccaacgaguguuuggacaacaaug guggcuguucccacaucugcaaggaccucaagauuggcucugagugccugugucccagcggcuuccgguugguggaccuc cacaggugugaagauauugacgagugucaggagccagacaccugcagccagcucugugugaaccuggaaggcagcuacaag ugugagugccaggccggcuuccacauggacccacacaccagggucugcaaggcugugggcuccauaggcuaucugcucuuc accaaccgccacgagguccggaagaugacccuggaccgcagcgaguacaccagucugcuccccaaccugaagaauguggugg cucucgacacggaggugaccaacaauagaaucuacugguccgaccugucccaaaaaaagaucuacagcgcccugauggacca ggccccuaacuuguccuacgacaccaucaucagugaggaccugcaugccccugacgggcuggcgguagacuggauccaccg caacaucuacuggacagauucagucccaggcagcguaucuguggcugacaccaagggcguaaagaggaggacacuguucca agaggcaggguccagacccagagccaucguaguggacccugugcauggcuucauguacuggacagauuggggaacacccgc caagaucaagaaaggggguuugaaugguguggacauccacucacuggugaccgaaaacauccaguggccaaauggcaucac acuagaucuuuccaguggccgucucuauuggguugauuccaaacuccacucuaucuccagcaucgaugucaaugggggcaa ucggaaaaccauuuuggaggaugagaaccggcuggcccaccccuucuccuuggccaucuaugaggacaaaguguauuggac agaugucauaaacgaagccauuuucagugccaaucgacucacggguucagaugugaauuugguggcugaaaaccucuuguc cccggaggacauuguccuguuccacaaggucacacagccuagaggggugaacuggugugagacaacagcccuccuccccaa uggugguugccaguaccugugccugcccgccccacagaucgguccccacucgcccaaauucaccugcgccugcccugaugg caugcugcuggccaaggacaugcggagcugccucacagaagucgacacuguacugaccacccaggggacauccgccguccg gccuguggucaccgcaucagcuaccaggccaccgaagcacagugaggaucucucagcucccaguacuccuaggcagccugu ggacaccccagggcucagcacaguggcgucagugacagugucccaccaaguccagggugacauggcuggcagagggaauga ggagcagccacaugguaugagguuccuguccaucuucuucccuauugcacugguugcccuccuuguccuuggggccgucc ugcuguggaggaacuggcggcugaagaacaucacaaucaacagcauaaacuuugacaacccagucuaccagaagaccacaga ggacgagcuccacauuugccgaagccaggauggcuauaccuaccccucaagacagauggucagccuggaggacgauguggc augagcagccgggagagccgucucuuuccgggauccauugccaagcuuaggcagaaaagacacucucuccagaccuccccau ccagcacugguccugccaccucccugggucuguguugcucaaagcaagauagagcaaagcugggcuggggggccaagcuca gcuuccugucugccccagguucuguuuuauauauuuauugucugggacagaaaaggcuacuggcugugcuugaaauucga 175 U04354 Sequence below. accggucaucgggcucuuccuugggcucagggcacggaucaaguccucggcucgcucggccagcaccgcggcaccauggcg caggagcugcagcaccccgaguucgcgcgcgcaggccagcaggcugggcugcagguguggagggucgagaagcuggaacu gguaccggugccccagggugccuauggugacuuuuacgucggagagcccuaccuggugcugcacaccaccaaguccagcag gggcuucuccuaccgccugcauuucuggcugggaaaggaguguucccaggaugagagcacagcggcugccaucuuuacgg uccagauggacgacuauuuggguggcaagccaguccagagcagagagcuucaaggcuaugagucgacugauuuugugggc uauuucaaaggcggucugaaguacaaggcuggagguguggcuucuggacuaaaccauguccucaccaaugaucugacugcg 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cuaucuaucuaucuaucuaucuaucuaucuauaugcuccucuuuuccuucucuuucaaagggaauugcuguauguuacua uacugaaauaaccuaaagcaaccauuuguuuucgagcaauuuugcaaucuggggaccucugaggaaguaauuuugucauuc agccacugcuagccaaacuugucuuuucccauagagaggaaggagagccacagugcuucuaagcauuuccccgucugcuac ucuguuugcagugagcuuuacuuuauguauggcuuuaacaaugccuugcuguuucccaucucaagucaaugccacuugga ugccauucacucccaaguguccuuacauaggaugaacuucuuuagcuuuuuuagaaaacuaaaaucaugucuuuuaugaua aaacacauuuuauuucuauaaguuuaacuuuauauauuugauagcacaugcucaauagcauaaagaauaugcauugaauga uguuuuucauaauuaaaauauauccuuuugg 176 M35244 Sequence below. caggguugagagcaagaaggugcaggauguaggccagcagaauuaucagacccaguggcggcuucugccacuggaagaauu uccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauuca gauugucugguguuuuccaaucacucgcgacuguaauuugaaguuggauucugagauaauacaaucgcugucgcucuagu uuauaaagcuguccaagaucugcccagucccagauguccuggguccucagggcggcuguggucugcgcccuucuccugcag cuggaugccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggccu ggccuuggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagac uccgaggauggcacccuggcuggagcaggaggaagcagaugacugggaacagcagacucauauagucacaauucaaggaca gcugucugaaaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugca ggacugcgauguggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccu gagcgaaaacccaaguuccuguacagugggaaacagcacuguaccucagaucucucagcaccuggagggccacugcucagau gugcugcagaaauaccuggaaaaagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucacccca gaccugaaggugaugucacccugaggugcugggcccuggguuucuacccugcugacaucacccugaccuggcagaaggaug gggaggagcugacccaagauguggaguuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugug guggugccucuuggaaaggugcagaguuacacgugccauguggaccaugaggggcugccugagccccucacccugagaug ggagccugcaugguaccaaaagccuuggauuuggauuguugccacgguuuuuuccauuuugcucauuugucucugugug gcucgcagacccaugaagaagaaugcaggugggagaggaaggcgugacacccaagaagcaggcagagacaguccccaagacu cuagcaagacuguuguggaugaugaggagauggggguuugcuuuuggaagauuaaguccuguaaaacuugucuaggccac uccccaggaacuucaggaucaucugggagaugccccuuugaguggcugggcugugaggacagcaggccaguucuugccacc cuggacagaaacacaucucaccuuucuggcucgaggaucugaacaccugucucuugccuacucggcuucuagucaggcauu uugucaccuugucaagggucccagggacacaaagcucccuccucucacccacagcacucuggguccuacccccaaugcuuca gggacauuuaaucaggucaaauugggaucaauggcuuugaugcagaaaagaacuguggacuaauagagauaggguuuaau aaaaaaaauaucuuuuu 177 AW121930 uuuuuuuuuuuuuuuuucaacuuuaaagacuggauuugagguucagucugggucucuggg ggggaccucugucaucacgccuauaaucaucccgagaguagucaucccuggagcuccacg accgaucaucccgucugucauagcggucuucauagcgguccccaccuccucuguagucau caucucuccgguacccacuuccaaaugcccuucugccacugccuauccuggagucauagc cucggucauagucucugcugccucggucaucauagcgaucccggcccccauagcggucca ugucucugcgugggccgucccgauauccgucccuauacccaucccgauaccggucugaau cguaacgaucucgauacuugucuccaaagcuaucaucgccucuucuagguggguagucau cacaacugucuguggugggacgggcccuccagucugugucuguuuug 178 AI852632 uuuuuuuuuuuuuuuuuggcccccaggcucugucucaaggaugggaauagaucaagccaa acagugaaaaauaaggcaaaucguggcuucgggguuugagacuggcaccaauggcaaauc agcagaggagaugcaaaugggguaacaaucacaguuagugggguaacaugagcaggcagg aaacccuugagacaacacccaagguccacgucuucgcaugugcagggcacaacuccagca gcaguuucugggcuuggaggcuuguuacucuuccuaccuuucccacccccuaaaagacac caagauggagcccacgaagagauuacaucaagcucuucuggcuggg 179 U70475 Sequence below. ucuaggacagccagggcuacacagagaaacccugucucaacuaaaacaaagcaaaccccccgaauauuguuuuuuauuugcg gaugucuguuuauugagacgggguucauggcagacaugagugucucagugcauuugcuauccucucuucuaaaggggcgg gggggggggugcgcuggagagguggcucagcaguuaagagcacugacuucucuuccagagguccugaguucaauucccag caaccacaugguggcuuauaaccaucuauagugagaucugaugccuucuucuugccuguaggcagaccacuguauacauaa uaaauaaaucuuaaaaggggggggaagguguggagcuaaaaguauggcaauaugcauaaguuuagcuauuucuguuguuu ugcagucaucagugagccaaacuaauucgaauggguagcuagaucuuguugcuuuuagcgaauauauauugagugaaugg aauugacagucuucuguauucucauucaguuuguuuguguucuuccccaucagugauaacauguagugaacuaacccgug uggaccaucuuaaccauggcuucuccuuccuuuucuguuuuaaacauaggacauggauuugauugacauccuuuggaggc aagacauagaucuuggaguaagucgagaaguguuugacuuuagucagcgacagaaggacuaugagcuggaaaaacagaaaa 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gaaaauacagaggcauuuuauagccauguguggcaguccaugauuuuuuauucccgacauucaggaggcagaagcaggcag aucccugggcuccaggacggccaaggcuacaugagagccugucucaagaaagacaaacccuuucuauacuaaacguuagcua ggauugucaaggagaugguauauauccacaaugguaugccugcuguacaguacuguggcacagagaacaaaaccuguaacc uccuguguucuuagaaguggcauucuaagaagggcuaggaaga 180 U09659 ggccagcaggacucuccuugcagcagcggcccgaguucagaguccggagcugcgguggug gcggcgaaggcgagagucauggcuggacaagcuuuuaggaaguuucuuccgcucuuugac agaguauugguugaaaggagugccgccgaaacuguaaccaaagguggcauuaugcuucca gaaaagucucaaggaaaaguguugcaagcaacggucguggcuguggggucaggagggaaa ggaaagaguggagagauugaaccugucagugugaaaguuggagauaaaguucuucuccca gaauauggaggcaccaaaguaguucuagaugacaaggauuauuucuuauuuagagauagu gacauucuuggaaaguaugucgacugaaaucacuguugaaauggugucacgugaagcugc cauuccacugaugucugaacuauuucaucauguaaauaauuu 181 AW124785 uuuuuuuuuuuuuuuuucaggucucauuuucguuuauuugaaauucggugcucguguaag uuuuuucucuuccccucaaauuuuauuucaguaaaaggagacuugggcgagguggauacc ccacagccggauucuucccccccugccccccaggguggcuaaugcuaucuggggaagucg ucauagggaagagaacuaugggugggcuccugccugaggccuccaaucucagcccagugg acauaucacaggcagcuuaaaaaaaaaacccuaaaaaaaacaccccaaaacacacauuua aauagguauucaagacagcuuuaaaaaaugcacccacucacaccccccucccuuuucuuu uuggaaaaaaaaauaggaaaaaaaaaaaaaccaaaccgaauucucgcuuggccucua 182 AF071315 Sequence below. auuuggcuccgaggccaagaauucggauccaaggcgggcgcggggaaaauggcggcggcagcugcggcgggggcgaaugg gagcggaggcagcagcggcauggaaguggaugcagcaguccccagcgugauggccuccggagugacugggaguguuuccg ucgcucuucauccccuugucauccuuaacaucucagaccauuggauccgcaugcgcucccaggaggggcggccuaugcagg ugauuggggcucugaucgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccgug gaagagaagauuaucauugacaaagaauauuauuacaccaaggaggagcaguuuaaacagguuuucaaggagcuggaguuu cuggguugguauaccacaggggggccaccugaccccucagacauccacguccauaagcaggugugugagauaauugagagu ccgcucuuucugaaguugaacccuaugaccaagcacacagaucuuccugucagcguuuuugagucugucaucgauauaauc aauggagaggccacaaugcuguuugcugagcucacuuacacucuggccacugaggaagcugaacggaucgguguagaccac guggcccggaugacagcaacaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaag augcugcacagccgugugaagcucauuuuagaauaugucaaggccucugaagcaggagagguucccuucaaccaugagauc cugcgggaggccuaugcccuaugucacugucucccaguucucagcacugacaaguucaagacagacuuuuaugaucaaugc aaugacguggggcucauggccuaccucggcaccaucaccaaaacgugcaacacaaugaaccaguuugugaacaaguucaacg uccucuacgaccgacaaggcauuggccggcgaaugcggggacuguuuuucugaugaugguucuggaagggauggugugug gggcucagacagcuguuccauggaccugaguaccacauucccuuuagagaaacucauuaauaaaagagcagccccuuaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaa 183 D49733 Sequence below. aaaacccaauguuugguuuuaaagccaaaaauauaagggaagugcauagguuuggguuuuguuuuuuguuuuuucccgag guccuugaucuuugcccccaaauuugagggcauaaaguaaucccucaguuaccuaaaaacacagccauuccuuugccauucc acucuccuggauuggccgcuucugugcgcgggggagaggugacucacuauuacuacugaggaaaggggagccaguggugg aaguggggugagucacugaugggcagcagcuucagcccuccccccaacuuccuuggcucucuggggaugccugauccucuc ccucacuuugcaccuacuuccccuggucccucaccacuacccuuugcccacccacucaaauucuuuggcucugcucuuuacu ccagaaggccaaaggcaagcuuagaguugaguaggcaggaaccaacauugugaagccccaggccagaaagggguguucugc agagugaggguuggcaugcuggcuccuccucaccauaccugcccccgccccuuuggguacaggauggcuccuuuaagagca guggauccacccccuguagaggagggccuauuagagccucugccuggcugucagugacucaguguucgcgggaacgcugc cucagccucaacaccagccaacccagaucccgaggugcgccagcgcccagcccagaucuccacgccugccaggagcgagcuu cgccggcucgcugucccccugagcagccucuguccuucuguccaagucccgcgcccuucucgggaccccugcccagcgggc agcacugucacccugccggccauggagaccccgucacagcggcgcgccacccgcaguggggcgcaggccagcucuaccccac ugucgcccacucggaucacccggcugcaggagaaggaggaccugcaggagcucaaugaccgccuggccguguacaucgauc gcgugcguucccuggagaccgagaacgcggggcugcgccuucgcaucacugagucugaagagguggucagccgagaggug uccggcaucaaggcggccuacgaggccgagcugggggaugcccgcaagacccuugauucuguggccaaggagcgcgcccgc cuccagcuagagcugagcaaagugcgugaggaguucaaggagcugaaggcucggugagugaggcccggccggccggcacca gggaggcagcagucgccuguaacuggccaucuaguccccucccuccccggaacugccucccgcgggugacuggcagugcca annnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnngcuaggccagauauagaaagcuuucuguauuuaauacacaguacaugcaucauuc augucuacauaauuaagauaaaggaagcugcauuguuaaugggaaaaaaaauagggucugggaauguagugugccuagcau uuacgaacuucgggguuuggguuugaucccagcaucucacaaaccacguguaaucccagcacuuggaagguagaggccgga ggauccgaaguuuaaggucauucuugacuacuuagcaaauucggggcacccuaggauaccugagacccugucaugaauaaa aauaaauaauaaauaaaccaauaugggucuagguugagcagcagcuugggcaggguagggccggaaguuagccagguagag gguugcagucccaggaggacccuggcugggagcagcaccucaguccccugcccaaccacagggggccaccgggucuuuccg gaacuccugagggcgcaaggccuugcucucucuggcccagccauggggaacgcggagggccggugaggcaggcggcaggc gggcgggcggggcgcgggccgucauccccuccugcuccuuauuuuuagcccaguguagagucugggccgccugucccucc cccaggacagggggaggaaauunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaugccaacaauccuaauguaaugaugcccucuuc ugacagcugcggggaccgcagagaggucccaucccagaugcacuccugaaaccugcuuuucuuuuucuagcaacaccaaga aggagggggacuuguuggcugcgcaggcccggcucaaggaccucgaggcucuucucaacuccaaggaagcugcccugagca 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agcauauguggggugagcgagggguguccuuccuaucccucauccauccagcaccuuuuaaaaggggccagcaauccacau gugcaucagacacaggagcacagagagacggaggguagaguagggcagaguagcagagcuuccuugcugcccuguagucgc aggcucuugaucgugugaucgcu 184 X80899 Sequence below. gcggugcgaagcgggccuccgccaacauguacuacaaguuuagcaguuucacgcagaaguuggcuggagcuugggcuucg gaagccuacaccccgcagggguuaaagccaguuuccacagaagcaccaccuaucauauuugccacaccaaccaaacugaccuc cagugugacagcauaugauuauucugggaagaacaaaguuccagagcugcagaaguuuuuccagaaggcugaugguuucca ccugaaacgaggccuuccagaccaaaugcuuuaccggaccaccauggcucugacacugggagggaccaucuacugccugauc gcccucuacauggccucgcagcccagaaacaaaugagcuugccuguggaggacugguucacuuuguggcacaaacccuuug aauccucacguuucauguuuuccacuuggauagucuacuuaacauuuugcaaacaaaggaaaagauaagaauacauuguuu ugauuuguuuauggugugcagauggccugucagaugucagagcugguuugacaguuaaaacuauuguuuaaggaaauguc acugagccaucacugagcugugcuucugcuccugauuucccuggaguucugcaggaaaguugcucuccagcucauucgug gccagccgugcucagggccucgggacucaggcggugucugagcgggaagcgaacgcggaagccuuuuggaguguaggugu 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AI839906 uuuuuuuuuuuuuuuuucauauuaaacuuguaguuuuauucagguuugauuuuuaac aaaugugucagggagagagcccacaggaaaggguaaagcccgugggggcaaggccuucc cagaugccugaggagggaucguguccccucccccccuccucuucucaccaccccuacagg gguuugggaagagacacaggcagggaaggggcugguccccagucuguacaguggugcu ugggggugaaggacuauggagaacaggggaccagaucggggaugaguaggauaaaggg cacaagaccauuuaccagaauccagcuuucugauuccaaauugaauuaaaaagaaaaaaa ggagaggggaaccuaaaccacaagcaguacccaacucccuuucccccaucagggcugc 188 AI843448 uuuuuuuuuuuuuuuuuagggaagaggcugaugccagauaaguuuuuauuauauuaa aaaaaaaaaaaaaaccagugcaacuggaaaucagggugagucgcuggaggugagugaga gucggaaggcccuccacaccucagugguggcaggaucuggacccguagccuaagccugg ucugauccagccgagaugcuggaaagcagagcacacgguggugcccaucagggcaaaga gggcaagagagcccacggcuccuccauaccgcuugcuagggucuccuguguaguagcca uaugcguaaaggacucgcccaauaauccaggccaggcccaggccagaagcuaugcgcgg gugguaaacaccucccaccguuaggaaaaa 189 AW125336 cggccgcgugaguuuugacugagcuucugcangaaguucanaugcaacuccauacauca guucauuuucuagcauuaccacuggguuauuaucacgaauggccgauuuaauaagucc 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cuuuuagccgaugcuguagcuguuacaauggggccaaagggaagaacagugauuauugaacagaguuggggaagucccaaa guaacaaaagauggggucacuguugcaaagucaauugauuuaaaggauaaauacaaaaauaucggagcuaagcuuguucag gauguugccaauaacacaaaugaagaggcuggggauggcaccaccacugccacuguucuggcacggucuauugccaaggag ggcuuugagaagaucagcaaaggggcuaauccaguggaaauccggagaggugugauguuggcuguggaugcuguaauugc ugaacuuaagaaacagucuaaaccugugacaaccccugaagaaauugcucagguugcuacaauuucugcaaacggagacaaa gacauugggaacaucauuucugaugcaaugaagaagguuggaagaaagggugucaucacagugaaggauggaaaaacccug aaugaugagcuagaaauuauugaaggcaugaaguuugauagaggauauauuuccccauauuuuauuaacacaucaaaaggu caaaaaugugaauuccaagaugccuauguuuuguugagugaaaagaaauuuuccaguguucaguccauugucccugcucu ugaaauugcuaaugcucaucggaagccauuggucauaaucgccgaagauguugacggagaagcucuaagcacgcugguuuu gaacaggcuaaaaguuggucuucagguuguagcagucaaagcuccaggguuuggggacaacaggaagaaccagcuuaaaga uauggcuaucgcuacugguggugcgguguuuggagaagaggguuugaaucuaaaucuugaagauguucaagcucaugauu uagggaaaguuggagaggucaucgucaccaaagaugaugccaugcuuuugaaaggaaaaggugacaaagcucacauugaaa 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gagaguucagaagacagccuuucuguggaagggugggaaugauuguguacaaaguagagaaguauccaauuaugugacaa ccuuuguguaa 193 M32599 acagccgcaucuucuugugcagugccagccucgucccguagacaaaauggugaaggucggugugaacggauuuggccgua uugggcgccuggucaccagggcugccauuugcaguggcaaaguggagauuguugccaucaacgaccccuucauugaccuca acuacauggucuacauguuccaguaugacuccacucacggcaaauucaacggcacagucaaggccgagaaugggaagcuug ucaucaacgggaagcccaucaccaucuuccaggagcgagaccccacuaacaucaaauggggugaggccggugcugaguaug ucguggagucuacuggugucuucaccaccauggagaaggccggggcccacuugaaggguggagccaaacgggucaucaucu ccgccccuucugccgaugcccccauguuugugaugggugugaaccacgagaaauaugacaacucacucaagauugucagca augcauccugcaccaccaacugcuuagccccccuggccaaggucauccaugacaacuuuggcauuguggaagggcucauga ccacaguccaugccaucacugccacccagaagacuguggauggccccucuggaaagcuguggcgugauggccguggggcug cccagaacaucaucccugcauccacuggugcugccaaggcugugggcaaggucaucccagagcugaacgggaagcucacug gcauggccuuccguguuccuacccccaauguguccgucguggaucugacgugccgccuggagaaaccugccaaguaugaug acaucaagaagguggugaagcaggcaucugagggcccacugaagggcaucuugggcuacacugaggaccagguugucuccu gcgacuucaacagcaacucccacucuuccaccuucgaugccggggcuggcauugcucucaaugacaacuuugucaagcuca uuuccugguaugacaaugaauacggcuacagcaacagggugguggaccucauggccuacauggccuccaaggaguaagaaa cccuggaccacccaccccagcaaggacacugagcaagagaggcccuaucccaacucggcccccaacacugagcaucucccuca caauuuccaucccagacccccauaauaacaggaggggccuagggagcccucccuacucucuugaauaccaucaauaaaguuc gcugcacccac 194 AF035644 agaagcuuccuaaggaacaagcaaguugaauagagaaaauagugaucaauaauaggcauu uuaguggucuuuuuaauguuuucugcugcggaacauuucaagauuuauugauuuccucc uccccccauuuuuuucccaccacacucacacacgcacgcucacacuuuuuauuugccauaa ugaaccguccagccccuguggagaucucuuaugagaacaugcguuuucugauaacucaca accccaccaaugcgacucucaacaaguucacagaggaacuuaagaaguacggagugacaa cuuugguucgaguuugugaugcuacauaugauaaagcuccaguugaaaaagaaggaaucc acguucuagauuggccguuugaugauggagcuccacccccuaaucagauaguagaugauu ggcuaaaccuguuaaaaaccaaauuucgugaagagccaggcuguuguguugcagugcauu guguugcaggauugggaagggcuccugugcuaguugcgcuugcauugauugaaugcgga a ugaaguaugaagaugcuguucaauuuauaagacaaaaaagaagaggagcauucaauucca aacagcugcuuuacuuggagaaguaccgaccuaagaugcgguuacgcuucagagauacca augggcacugcuguguucaguagaaguagaagcaggcuggcuggaucguggcauuagag g gaa 195 Y00629 Sequence below. auucagguuccucacagacccagggggugaggauguugcuuuuugcccacuugcuucagcugcuggucagcgccacaguc ccgacccagaguaguaagugaggggaggggugaggggagggguugggagcgaaaaagacucugugaggaaaagcgggagg guggugguggcggaggugcagcaccccaaguuccgccgcccuguccuagucccucccccgccuuuaccugggaccuugagc cugggggaggucggggucucaccgcgcgccgcccccaggcccacacucgcugcgguauuucaccaccgccgugucccggcc cggccucggggagccccgguucaucauugucggcuacguggacgacacgcaguucgugcgcuucgacagcgacgcggaaaa uccgaggauggagccucgggcgcgguggauugagcaggaggggccggaguauugggagcgggagacuuggaaagccaggg acauggggaggaacuucagaguaaaccugaggacccugcucggcuacuacaaucagaguaacgacggugagugcggcuggg aucacagcuaugaucacuccauguccccugagacgggccugggucaucuugacccgcugagacaaaguuucauccaaacgcc uacccagaaccucagacaaaaaagcccccgcagaguucugcuuagguuugggguuguacuuuuguuucucuuuuguuuug agauaucuacuaacauugggcaaaguggccacagguggcgcucaucagcguaucccuuccagaaucucacacgcugcagug gauguacggcugcgacguggggcccgaugggcgccugcuccgcggguauugucaggaggccuacgauggccaggauuaca ucucccugaacgaggaccugcguuccuggaccgcgaaugacauagccucacagaucucuaagcacaagucagaggcagucga ugaggcccaccaacagagggcauaccugcaagguccuugcguggaguggcuccauagauaccuacggcugggaaaugagac acugcagcgcucaggugcccuggagagcucuccucacuuuuccucugcgguuugggggaaauccuugagguauaaccuca ggggcagaacgcuguucagcgggcacagcgcggaggaggagggagagggacucccaaaacugcuuuuccccuguagggau ucuaauccuuaacaaaagcagaucaggcucgacaauggcccuggacccauggggggagggggcucuuucucaggccucccu ccuugcccuacucagugucucuauagucagacuccagcuuuucucaaucucuuggcccucauccagcucaggaccagaagc ccuucccaugagucugcagagaccuggagccuccuguccauguuguccugcucacauccuaaggcaucccuaagagcagau ccucccaggugcaggugcucuagcuggugucuagaugauggacaccauaaucccaccgcaguccuccuguccaccccagga cggucacaugaacacugcugaguccccagaagaaagcaagaugccucauccuuucaacucucucccucagacccuccaaagg cacaugugacccaucacccuagaucugaagaugaagucacccugaggugcugggcccugggcuucuacccugcugacauca cccugaccuggcaguugaauggggaggagcugacccaggacauggagcuuguggagaccaggccugcaggggauggaacc uuccagaagugggcagcugucguggugccucuugggaaggagcaguauuacacaugccauguguaccaugaggggcugcc ugagccccucacccugagaugggguaaggagggugugggugcugaacuggggucagggaaagcuggagccuucugcagac ccugaguuggucauggcucagagcugggaucauaacccucaccuucauuuccuguaccuguccuucccagagccuccucca uccacugucuccaacaugguaaucauagcuguucugguuguccuuggagcugugaucauccuuggagcugugguggcuuu ugugaugaagaggaggagacacauagguaggaaagggcagggucugaguuuucucucagccuccuuuugcagugugcucu gcuccuuaaugggaaacauagccacacccacauugcugcagucuccaacugggucagcugucaguuccgggaacucccuag ggcugguguuucucuggucucucauggcuuuucuucucacagguguaaaaggaugcuaugcucauguucuagguaagugc gagagaggggcaggggacacccuugucccugaggcucucaggauggagcugggauuuguuccagcccauaaucuccucuu gccacauccucucugucuccucugugugccuuguuaucucuucuacugcaggcagcaagagcuuccagaccucugacuggc cucagaaggcaugaaaaucccugggggggcuggugagauggcucaguggguaagagcacugacugcucuucugaaggucc agaguucaaaucccagcaaccacaugguggcucacaaccauccguaacgagaucugacucccucuucuggagugucugaaga cagcuacaauguacuuacauauaauaaa 196 AW125380 uuuuuuuuuuuguucccuugaaagccagauguuccaaaaaguagccugcuccauuguucu ucucagucucauagcgacugccagcgucaauccacacucccaccgugcagguagcaugcg aggacugcuccgaggccacacgcagcccguuguccaagaugcugaccugggucuccggca cgcucuggagggccugggcgaagguugcgguaccccgcaaggcagguaaccucagcaggg ccggcgagcggcgggugcgccucgugccg 197 U68564 Sequence below. ggugcuuaauguuuugaccuguagagguccucacuuuucgucauggcgcugaagguggcgauagcugcuggcggugcug caaaggcaaugcucaagccaacucuccucugccguccuugggagguucuggcugcccauguggccccccgaaggagcauuu ccucacaacaaacaauuccuccaucugcuaaguauggugggcggcauacagugacuaugaucccaggggauggcaucggcc cagagcucauguugcauguuaagucuguauucaggcaugcaugugugccgguggacuuugaagaggugcauguaagcucc aacgcugaugaggaggacauccgcaaugccaucauggccauccgccggaaccguguggcccugaagggcaacauugaaacaa aucauaaccugccaccaucccacaaaucucgaaacaacauccuucgcaccagccuagaccucuaugccaacgucauccacugu aagagccugccaggaguggugacccggcacaaggacauagacauccucauuguacgggaaaacacagaaggcgaguacagca gccuggagcaugagagcguagcaggagugguggagagcuugaagauuaucaccaaagccaagucccugcgcauugcugaau augcuuucaagcuggcccaggagagugggcguaagaaagugacggcugugcacaaggccaacaucaugaaacugggugaug gacucuuccuccagugcugcagggaaguagcagcccacuacccucagaucaccuuugacagcaugauuguagacaacacaac aaugcagcugguaucccggccucagcaguuugaugucauggugaugccuaaucucuaugguaacauugucaacaacgucug ugcagggcuaguuggaggcccaggccuuguggcuggggccaacuauggccauguguaugcaguauucgagacagcuacaa ggaacacaggcaaaaguauugccaauaagaacauugcuaacccgacugccacacugcuagcaagcugcaugaugcuagacca ccucaagcuccacuccuaugccacuuccauccgcaaagcugucuuagcauccauggacaaugaaaauaugcauaccccagau auuggaggccagggcaccacaucccaagccauccaggacaucauucgucauauccgcaucauuaauggacgggcuguggag gcuuagcuaucccuacaguuuugcucagcuugucuguaggacucucuucucacuuuagcacuccagcuagcuugggggac aggacccagaauaaagccacuucuguuccagaaaaaa 198 AW125346 uuuuuuuuuuuuuuuuuguucuuaauagaaaacuuuauuuucacugauaaugucacugua acauaauuucauagcagaccugugcaaaagaucccacaucaccaaugucuccaagagauu ucacacacuucugggcaggacgcacagcucugcccccacccccguguugacagucaacau uuuacccccgcuaugaguacagaaaggcgaggcaucauaacgaagccgccugaaggcagc gugagcugaagucggacgcuugccaccucugaaugaauggucaccacagcaacagcacau gguugccucagugugcucagggugggucuuugaaaaaacgucccacuauguaaauaugcu gcacuuaucccuucaacauugu 199 X61232 See above (same Accession Number). 200 D20333 gauccuguauauguguguuuugggggagcuaugauaaguuuuauggcaaacgguugguau uguuaacuuuuuauugucaucaaaaguucauaaaaguccuauuaauccccauauucunnn ncugcccuuaacucugguauacaccaaaaagaaaucuuuacuuuccuuguuuuaucauua uaaaaauaaaguauuuugcuaguauggaaa 201 AB025218 aguccgcgucccggcgucggcccgucccgcaccauggugacgcucgccgagcugcuggcg cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc gaggagugcuucuucgagcgggucaccuccggcaccaagaugggccucaucuucgaggug gcggagggcggcuuccuggacaucgacguggagaucacaggaccagauaauaaaggaauc uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca uacaaguucugcuuuagcaauaggauguccacuaugacuccaaagauaguaauguucacc auugacauuggggaggcucccaaaggacaagacauggagacagaagcucaucagaacaag cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug guccuuugguccuucuucgaagcucuuguucuaguugccaugacauugggacagaucuac uaccugaagagauuuuuugaaguccggaggguuguuuaaaaggccuuuuccuguugaucc caaauucaugauuuacu 202 U84411 Sequence below. gcauuggcucugggcugcggccggcucggcgacgcuccucgggcagcucacugcauggucgucuggugcccccgccgccu gcauccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguauga uuaggccacaaucuucaaugaguagacauauuccucaguucugugguguucucggucacacauuuauggaguuucugaag ggcaguggagauuacugccaggcacagcacgaccucuaugcagacaagugaacuguagaaauucauuacuacuccaccaaga aacccccauaagaguggauaaccuggacacaggcguguugaauugaaaucugcacagcauuugagaagagcucagaccugg augggguaaaccucagugccacuuccuuuguauugccucuaguauuacugggauugaagagucacugcuucuuguuuagg agguucauuucauuggcccguuucucccaauuucauacucaagcacugagaauuucaaguggaguauaucgaauaucgaag uagacuucagguuguuuuuugguuuuguuuuguuuuuuuuuuguuuugguuuuuuuuuuuuuuuucuguuuugguuu aaaucauuucuguauucaauuuuuuaauucuuucauaacccuauuggguguuuuuuuaaacuaaauuaacauggcucgaa ugaaccgcccugcuccuguggaagucacauacaagaacaugcgauuucuuauuacacacaauccaaccaaugcgaccuuaaa caaauuuauagaggaacuuaagaaguauggaguuaccacaauaguaagaguaugugaagcaacuuacgacacuacucuugu ggagaaagaaggcauucauguucuugacuggccuuuugaugauggugcaccaccauccaaccagauugucgaugacuggcu aagucuugugaagauuaaguuucgugaagaaccugguugcuguauugcuguccauugugucgcaggccuuggcagagcuc cggugcuuguugcccuagcauuaauugaagguggaaugaaauaugaagaugcaguacaauucauaagacaaaagcggcgug gagcuuuuaacagcaagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaaugguc auagaaacaacuguuguauucaauaaaacuggggugccugaugccauugccuuggaaguggaacuucagaugggaccugau uugucaugcauauuacccaaugugucggcuuacugaauaagucuacugcagcuccacaggaauacugaaaaaccagucuua ccaggccacaaguuugacagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuuu gcuguucagcauuuaaaaugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaaa uguacuccugugccagaauauuauuagucuauaaggaauuuagaaggauuaggugccaaaauacccagcacaauacuugua uauuuuuagcaucauacagaaccaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuuc aaacacugcagggcuccucucguuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguuu gcuuagccauccuuuauuuuuuuuauuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucugucucauuuu guuuuguuuugggaaaccucugucugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaaa gccuuauaguuaauuuaauguuugcacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuauu aaauauuuuuaguaauauguugccuuugucaugugcagaacauguagaguaugcucuuaauuuaguaaauauuuuuaaga cauagagauacauguguagcuaacccauucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguuuc cagcuuguuugaauuauggcuuuccucuucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacugag cagaaauguuuuauaacgccuuuugagcuauguaacuuaauaauuggauacuugaucauuuguuuuauuauguaaucgga uaaaauggugauguguauuaaaguuaguucaaccauauauuuauacugucugggaaugugugguuauaguucuguggga gaaauaguuugucaguguucaccagcuuguaaaaacuuaguaugagagcuucaacauuuaaauaaaugaugaaccgcauuc gucacugaggacacuuuugccuaaaauuaacuuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuaugga aaaaauuguuaggguugccaagugcuuuuuauuaaaaguuucucuuuaaaggucuagauaauugugaaucaguugaaugu ugggcaccgaggggaaacaguuuguaauagaugaucuagauuuuucaguucaguuccaucagucacuuguagcucugcaa uuuccagaccaguuuucucauuuuuaaguucauuacaugccuguauauauuuugaaauuaacuugaaccugaguauuugg cacaugauggcuuaauaaauuuuaacuuuc 203 M62362 Sequence below. acgcuccccaaccuccaccuccccucgcucggccucuauaugcucccgggcucccuaguguuggcuggaagugggugacuu agaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcu gcaagccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccc cacucaccgccuuggaaagucacaggagaaggcgggcucuaagacccagcaggcaccauccuacuggcgccuucgauccgag acccguuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagc ugcgcgggcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggc ucgccaugccgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcggcccccgaugagcagu caccuccagagccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagcc ccaccugccgccccggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgc cuucaacgacgaguuccuggccgaccucuuccagcacagccgacagcaggagaaggccaaggcggcggcgggccccgcggg uggcggcggugacuuugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccc cucccggcuacggcugugcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcgc uacggccgcuggugaucaaacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuacc agccaccgccgccaccgccaccgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgcg cacugcggccagaccaccaugcaccuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgcc cgccuugggugcugcgggccugccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacggg aggcggcggcgguggcagcggugccggugcgggcaaagccaagaagucgguggacaagaacagcaacgaguaccggguacg gcgggaacgcaacaacaucgcggugcgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcug gaguugaccagugacaaugaccgccugcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuuc cgccagcugccugagagcuccuuggucaaggccauggcaacugcgcgugaggcgcgcggcugcgggaccgccuugggccg gcccccuggcuggagacccagaggaugguuucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuagga gauuccgguguggccugaaagccuggccugcuccgcguguccccucccuuccucugagccggacucggugcgucuaagau gagggagucaggccguggugguuucuccuugagaccgagagacuuuuccgcggagcugagcugggggcccggcaguacua guauuaaggaaguaaccuugugccuuggauacucaaaacucgcuccuuuuccuaccgaguagggggagcaaaaaugugccu ugauauuuuauuuggaggauuccugcuuccucucgggccucagcuggcccccgugagaaaaaugaagggugcaggcccag ggcaggaggaagauacaggaagcugagaucccggcagugcccugagcugccccucagucccugucuuuagaggggagggac uuagguguuggggauuugagucuguguccucacccccagcuacagggagguggagggcuccuaaucccuugcuuuuugca ccuccaccuacauccccccccccccacucagcuuacaacaggccagguuuccugggugaguucauggagaaugggggcacca cccccagucagacagaaagcugaguugugaguuagccaugugguaggagacagagaccuagguuucugggcuuugugggg ugggggauaggaggacacggggaccauuagccuuguguguacuguaugucgccagccgcuguugcugaaggaacuugaag cacaaucgauccaucccagagggacuggaguuaugacaagcuucccaaauauuuugcuuuaucauccgauaucaacacuug uaucuggucucugugucccagcggugccuugugcaauggcagugugcacgucuaugcuaaaccaccauuuuauuuggucu uuuguuuuguuuugguuuugcucugauucuugccaaacugagacucuucacuaacggcugggggaaggagcugagugag gcucucauucuuuuugguuuagggauguuuggguuuuuucgucugccucccagaggaccaaugaaaugaagugggcuucc cccucuccccuaguuguccaaggguguauguaguagugggucuuagcuuccuccggcuaagacuuaggcuuccccacccac ccaaccccauccccaacggcccuggcucugggucuggaaagaaggccaccuccagccaguucauacacacaccccuguggcu gggagcagggcuggaccgcuuccuucucuucuuuuuuuggggggggggacacaaaguuucaugcuagaugucguaugua uuauaucuauaauauaaacauaucaaacucaa 204 AA032310 gaagcucagugucgugaaauggaaaccaaaccuuggagccaucgcugaguauaaaaaaaa ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua auuuuagacaagcauaugaagaucuucgaaaacaaaggcugaaugaauuuauggcugguu uuuacguaauaacaaauaaacuaaaagaaaacuaccagaugcucacauugggaggagaug cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguuc ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua guuccuggccuuaguguuug 205 M94087 Sequence below. gccgguuugaguugugcgcucgggugucccuuuccucuuccccucccgcagggcuugcggccaccauggcguauuagagg cagcagugccugcggcagcguuggccuuugcagcggcggcagcagcaccaggcucugcagcggcaacccccaccggccuaa gccauggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaa uccagcaaagccccacaacaugaccgagaugagcuuccugaacagcgaaguguuggcgggggacuugaugucccccuucga ccagucggguuugggggcugaagaaagccuaggucucuuagaugacuaucuggagguggccaagcacuugaaaccucaug gguucuccagcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaagg aggaugccuuuuccgggacagauuggauguuggagaaaauggaucugaaagaguuugacuucgaugcucuguuucgaaug gaugaccuggaaaccaugccagaugagcucuugaccacguuggaugacacaugugaucuuuuugccccucuaguccaagag acuaauaaggagcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugcccccu uuacauucuugcagccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuaggca gugaaguugauaucucugaaggagacaggaagccugacucugcugcuuacauuacucuaaucccuccauguguaaaggagg aagacacucccucugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuccac cuccagggccccaccagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccugga guuaguuugacagcuaaagugaagacugagaaauuggauaagaagcugaaaaagauggagcaaaacaagacagcagccacua gguaccgccagaagaagcgggcugagcaggaggcccucacuggcgaguguaaggagcuagaaaaaaagaaugaggcucuga aagagaaggcagauucucuggccaaggagauccaguaucugaaagaccugauagaagagguccguaaggcaagggggaaga agagaguuccguaauaggguagucaggugcuuugugcuuguacauagucuuguguugcuguguuugcuguaauaaauua uuuuguagugaaagu 206 AI847609 uuuuuuuuuuuuuuuauguagggaaguucauauuuuauuuguccagugacauuuuuua caguugaauacaaguuaaaggccugcuugcacaccaaagccagguccuuugggugguuca gucaaagaaguaaggccuccagcuggcucacaacagaagcggccacuccuuggcccuggu uu gggaacuuuuccagcuuugaguucaucaauaaucucuucaauauccuugggugucagauc cucauaguaguugucauuuauuugaaccaucggugcauuuacacaggccccuaaacauuc cacuucuauaagagugaaaaguuugucagguguagucucuccaaccuuuauuccaa 207 AI853294 uuuuuuuuuuuuuuuuuggggugaauauagccaaguauuccauuuauuaacaaaauagu cuuagcaagggagagcucuguucaccccacaagaggccccgcagccgaggccggcccgaag ccccagcgcugcugcguaagaccgggagggagggaagguguuggggagaagacuuguau u aagucuuuaauccuagccaccgcaggaacccacggaaaccuaaugccagcuuuggcgauu gcuggcucaggucugggacauggcgaagggagugcucugauccuagggcucccugaguc c ccagccugcccccaacagagcuccuaaaguugucuggucugcugacuugaggacugguaa gcuuuggagggauccaucaaggauuccccgaccccaccccuaucgccagggga 208 M33934 Sequence below. ccucugcggcgcgguccucggagcggcgcgguucucggagccacgcgucugucuuccuccguggucauggcggacuaccu gauuagcggaggcaccucuuacgugccggacgacgggcucacagcgcagcagcucuucaacugcggggacggccucaccua caaugauuuucucauucuuccuggguauaucgacuucacugcagaucagguggacuugacgucugcucuaacuaagaagau uacacuaaagaccccauugguuuccucacccauggacacugucacagaggcuggaauggccaucgcgauggcgcuuacagg agguauugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacaggga uucaucacugaccccgugguccuuagccccaaggaucguguacgcgauguuuuugaggccaaagccaggcauggcuucugu gguauccccaucacagauacaggccggauggggagucgauuggugggcaucaucuccucaagggacauugauuuccucaag gaggaagagcaugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucacucu gaaagaggcaaaugagauucugcagcgaaguaaaaagggaaaguugcccauugugaaugaaaaugaugagcugguagccau cauugcccggacagaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcaacugcuguguggggca gccauuggcacucaugaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuuggacuc uucccagggaaacuccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauuggaggc aauguagucacugcugcgcaagccaagaaccucauagaugcagguguagaugcuuugcgagucggcaugggaagugguuc caucugcaucacccaggaaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcccgucg cuuugguguuccuguuauugcugauggaggaauccaaaaugugggucauauugccaaagcuuuggcucuuggggcuucca cagucaugaugggcucccuccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggcugaaga aauaccgagguauggguucucuugaugccauggacaaacaucucagcagccagaaccgauacuucagugaagcugacaaaa ucaaaguggcccaaggaguuucaggggcagugcaggacaaggggucuauccacaaguucguuccuuaccugauugcuggca uccagcauuccugucaagacauuggugccaagaguuuaacccaagucagagccaugacguacucgggggagcuuaaauuug agaagaggacauccucugcucagguggaagguggcguccacagccuccauucguacgagaaacggcuuuucugaaaacaga uccaguauaugccuugaauuuuucaauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaa 209 X16202 gugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcuc acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag ccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcu uggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguagga aagggcagagucugaguuuuu 210 AI661431 acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu cggggucacccucaggaacaugcagucucugcacgugaggaaagaaacacgcagagaugg acgagcacuuuuacacccuaauaaaauuagaugcacuaaccacagaccccccu 211 AI839109 uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu uacauuuuauugucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu acuaaaagguagaagucagcuucaaaaacacacucuugcaauggacacugcucaugaugu cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga gcauucgguuugac 212 AI849135 uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg aaguacgcaccuccauuccaccgggaaggggcagauucccaaaucaaacugguuuugauc cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu uuaaacauggccacgcgccacacgaaauucuaguuugugugggguagaagcaagaaaaaa aaaaaaccauggcgccucgugccg 213 M32459 gguccggauaguaaacugcucccuuacaucuccuuaaauauaaaguaaggaaaaagaaaa aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua augguaacaauguggcugaggaagcaauaguuaacaaagaggagcuaagcuaugcaacaa accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc ggcaccguggcgcugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug uuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggac auccagcuggcccgccguauccgcggcgagcgggcuuaauaggcacgcuuucuacacugg cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaaugugagca ccacccgacgaagcagucugag 214 AI841389 uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacugggggg agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugauugcaaaacu gggucuccagcagggauucugguggucagguguggaugccuaaggaagcagugacauggg aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu acuu 215 X03039 Sequence below. auucuaaggaucaugucugcgagucaggauucucgauccagagacaauggccccgacgggauggagccggaaggcgucauc gagaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccua ugguuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagccc agucugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuu ugguucuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucu ugucaugccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggg uaccccuggccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagc agaugaaauguuaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguaguuuu guugucugcuacaaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaaga aggaagaauugacccuggaggguauccgccaauucuacaucaauguggaacgagaggaguggaagcuugacacauugugug acuuguaugagacgcugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaaga ugcaugcccgagauuucacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagggaguucc ggucuggcucuagcagaguauuaauuaccacugaccuguuggccagaggcauugaugugcagcaggucuccuuagucauc aacuaugaccuucccaccaacagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggcu auuaacauggugaccgaagaagacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagagaugcccc ucaacguugcugaccucauuugaggggcuguccugcgaccuggcccuagcccaggguucaguccugggguggggcuaagg aagagcuggaggggggaggggagggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuguuuca guuuuuuuucucuaugaauaaaugucacuuuuugaggc 216 AW049795 uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu ccacagagugaguuuucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu uuccuguucaaucugaagacugaauugggcuacacugggauggagauuucaggugcugca ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau caucaaacgucugugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga cacaguuuugagcuucgggacaacucuuaaucagguuguggaugguuggaugagaaaacc caaagaagucggcaccgcauga 217 D87691 Sequence below. auuguaacagaagaaggaaaggaaaagaaaguuaacauugacuuugaaccuuucaaaccaauuaauacaucauuguauuug ugcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuauuguaauagacgg aaguggugcucuuuuuggcacgcuccaaggaaacaccagagaaguccugcacaaauucacuguggaucucccaaagaaacac ggcagaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgag acugcugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaac ugaacuaagucaaucugacauguuugaccagagguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguggug aaaauggauucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauag gacgauauuuugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaug ggagcuguacaaauucuaauagucuaugaaaaucuggauauaaugagauacguucuucauugccaaggcacagaagaggag aaaauucucuauuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacuga uagaaagcaugccucucuuggaaugguuugcuaacaacuauaaaaaauuuggagcuacacuagaaauugucacagauaagu cacaagaaggaucacaguuugugaaaggauuugguggaauuggagguaucuugcgguaccgaguagauuuccagggaaug gaguaccaaggaggagaugaugaauuuuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccucac ccuccagcauucaacccaaggagcauacccgugguggaguccaacagaucccugccuuacaauuggagcauuuccagaacuu aauccgugagcauuggauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucguggugucag cgcagcagccgacaacuaagucucu 218 AI117211 cagaggagucauuguugcugugguggcuuuugugaugaagaggaggagaaacacagcgua agccagcugccuggaguggacuaagugacagacaaugucuucacacaucuccugugacau ccagagcccucaguuuucuuuagucaaguaucugauguucccugugagccuaugggucaa agugaagaacugugcagcccagccugcccugcacacagaacccugucccugcacugcccu ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc ugccagcuccaugcugcccugagcugcagcuccucacuuccacacugagaguaagaaucu gaaugggaccuugauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag 219 Y00520 ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa aaagccauucagcuucguuaucgauuagguaucagugggaacaucaagaugaaugaguua acuaaguaucagaucgaccaaauugaacaaaugauagcucaagaucauguuguucauugg gaauugaagaggggagaacgagcagacaucgaacgauuaauuucuauuucucguuaucgu ggaauucgucaucaagauggaucgcccuuacgcggucaacgaacucauacuaaugcaagg acugcucgcaagcaaauucggaaaugaaagaaggcuaccgaaagaacaagcaacggauuu cgcgcucaucccuugcuaaagcgcauacguuuucuugcuccuugguacuugucugaucaa ucacacuguucauuaguucacuugauuuuucguucgaugucuugaaccgcuuacuaauca cguauacguauaguaggcccccuucgccacuccacgucuggcccgucuuggucucgcuca cuucgcccgccuaucguaucggcucggcuucguccgucaagcgacagcuucugccucuga cggcuucacuaucgcucaugacugguaguacucuauguaguagucggccuuuguuaagcu u 220 AA638002 uauaaccauguuagaagcggaaguuggccugaaaaccugaggcuuaggcuucauagcugg gcuguagauuggauuuaaacccaguuggagugcaaagucauggugugcucaaggugauga cagugaacagaguaug 221 Z22661 caugggccuccugagaga uccuuagauccagguuagugcauaggaaaguguccccccacuaccuacagcuaagggauu gggguggugggaucaugguggagggccguggugaauacuagcgaugucccccgcuacccg ugcgucugccuccagggugccccuccaaccaggaugaggcucuucaucgcucuuccuguc cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag augcuuggaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau cccaccugccaggugccuuauuuuugugucaaagugggugcugaaggaggcaacucuguc cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuggaauuggcuaaucuucc uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc caggcggccccggauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu uugaccaagacccg 222 X99644 Sequence below. cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcggcugccuggcc guuggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcgg cgugugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcggccucugguagcccagg gucgggcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucguccc cugcggggggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcgggau ccucggcugcugcccugucuacauucggccugcagugccugccugggccccgcuacacccgccgcagcgaauaauucgggg gauggcggcucggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucgugga gaauuauuuuaugcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaag auaaugccccagccacuagcuauuguguggagugcucugaaccacuuugugagaccuguguggaggcucaccagcgggug aaauacaccaaggaccacacugugcgcuccacaggaccugcuaagacucgagauggagagcgaacagucuacuguaaugugc acaagcaugagccccucgugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaagga ccaucaguaccaguuuuuggaagaugcagugaggaaccaacguaaacucuuggcuucacuggugaaacgucuuggggacaa acaugccacacuucagaaaaacaccaaggagguucgaagcucgauccgccaggugucugaugugcagaagcgagugcaggu ugaugucaagauggccauucugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccagaagg ugaccgagggucagcaggaacgucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuuugcg uuuugccucuugggcucuggagagugauaacaauacagcucucuugcucucuaagaagcugaucuauuuccagcugcauc gggcccucaaaaugauuguggauccuguggagccucauggugagaugaaguuucagugggaucucaaugccuggaccaag agugcugaagccuuuggcaagauuguggcugagcguccugguacgaacuccacagguccugggcccauggcuccuccaaga gccccaggcccucuaagcaagcaagguucuggcaguagccagcccauggaaguacaagagggauauggcuuugggucagau gaucccuauucaagugcagagccgcauguaucaggcaugaagcggucccgcucuggugagggagagguaaguggccucuu aaggaaggugccacgugugagccuugaacgccuggaucuggaccucaccucugacagccagccaccagucuucaaggucuu uccuggaagcacuacugaggacuacaaucugauuguuauugagcguggugcugcugcagcagcugcuggucaggcuggga cugugccaccaggagccccuggugccccaccccuuccuggcauggccauugucaaggaagaagagacagaagcugcuauug gagcucccccggcugcccccgaggguccugaaaccaagccuguguugaugccucugacugaagguccuggugccgagggac cucgucuagcuucaccuaguggcaguaccagcucaggcuuggaggugguggcuccugagguuacuucagccccaguaagu gggccagguauccuggaugacagugccacuaucugccgagucugccagaaaccaggugaccuggucauguguaaccagugc gaauuuugcuuccaccuggauugccaccucccugcccugcaggauguuccaggggaggaauggaguugcucacucugccac gugcucccugaccuaaaggaggaagauggaagccucagccuggauggagcagauagcacuggugugguagcuaaacucuca ccagccaaccagcggaaaugugagcguguucuccuggcccuguucugccaugaaccaugccgucccuugcaucagcuggcu accgacucuacauucuccauggagcagccuggugguacccuagaccugaccuugauucgugcucgccuccaagagaagcug ucaccuccuuauagcuccccccaggaguuugcucaagaugugggccgcauguucaaacaguucaacaagcugacugaggac aaggcagauguucaguccaucaucggcuugcagcgcuucuuugagacacgcaugaaugaugccuuuggugacaccaaguuu ucugcugugcugguagaaccaccaccauugaaccuucccagugcuggccuaaguucucaggagcucucuggcccuggugau ggccccugaagcuggggcucuuguggucagcccaguccagcucuggucucuguauuuucaccccauacccuguccuuugg uggccugacuccuguucuugcuggccccaucguccccucagucccucuucacaaaaugguuuuuacuucuguggauuuaa uaaaaacuucacugagucaguuaaaaaaaaaaaa 223 AI843895 uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa ccuaugaaaauaaaguuugcaaaagucaaaguaguacaugggccugcccuggagccaggc ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca cuaaggugccuacagagcaagagggugccaucgggccagugcagccucugcaauuuccag aucugccacuagaggucggcaugguccugauugcuugucaggcucacccucuggaagacc acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg guccgccgcccaggcgcaggagcaucugcuggcaguccagcaguaaccggugaucgccaa 224 M38724 uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugcucaugcag gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc cuccagggaauuguguuuugccacucccggcgaguucuucacagagacuugaaaccucaa aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca gaaguguugcugggcucggcucguuacuccacuccgguugacaucuggaguauagggacc auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac gucaagaaccuggacgagaacggcuuggauuugcucucaaaaaugcuagucuaugauccu gccaaacgaaucucuggcaaaauggcccugaagcacccguacuuugaugacuuggacaau cagauuaagaagauguagcccucuggauggaugucccugucugcuggucguaggggaaga ucg 225 AW122989 uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaaacugaaaaga gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca uaauaaacaaaaaaauuuuaaaaagcagucaugauauaaaauagcagcuccuguaauuuc ugcaaguaucaccuucuucagaaguugcuucaauucaguuugccucauucuuagaagccu caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg gugcuuuuccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca ggcugucugcaccaagcugguugaggaugcugggaagcauuucugucagcugcuuuguc 226 AI844810 uuuuuuuuuuuuuuuuuauucaugcuugccuagggauggggaauagaucauucaauaaaa acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa cguacauggacagccucaggacgagcugacgucucggaucagcucggcaggcaacaaacc auagugccaaauggaaagaagggcaguugcaaauaaacuuaaaacuaaguuaacuuuuau aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca cuucacuauaaagaaugaacaccaugacauccucgugccg 227 AA940430 agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca ugaaagaguaugaaggaggaagaggggacucaucuaaaagggacaagucuaagaagaaaa agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga gcuagccaguaccccuccaagcucagaggacucugccucgggaucugaugaauaaaggag ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccaucu gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag 228 M38381 Sequence below. aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguug gaaagaugagacauucaaagagaacuuacuguccugacugggaugaaagagacugggauuauggaacauggagaagcagca gcagucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacaga cagcuauuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacua caugggcuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggag uggaagaagcaguuacaaaaguaaacacaggagucgccaccacacaucgcagcaccauucacacgggaagagucaccgaagg aaaagaucgaggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauauga aauuguugauacuuuaggugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguag caguaaaaauaguuaaaaauguggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaa cagacccccauaguacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaa cuucuggggcuuaguacuuaugauuucauuaaggaaaacaguuuucugccguuucgaauggaucauaucaggaagauggc auaucaaauaugcaaaucuguaaacuuuuugcauaguaauaaauugacucauacagacuugaagccugaaaacaucuuauu ugugaagucugacuacacagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagu gguggacuuuggaagugcaacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaagu uauuuuagcccucggguggucacagccaugugaugucuggagcauaggauguauucuuaucgaguauuaucuuggauuua caguuuuuucgacucaugauagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauac agaaaaccaggaaacgcagauauuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucuc ggcgcuguaaaccucugaaggaguuuaugcuaucucaggaugccgaacaugagcuucucuuugaccucauugggaaaaug uuggaguaugaucccgccaaaagaauuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgu gauuuauaaacacagugcucugaaaggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuu aauuuguaaaacauuuuauguuuuuuagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauaga augauuuauuuggaauaaaauuugugcuuaugaauguaaaaaaa 229 AF014371 ggacucgcgacaagcguccucagcgcgaagaggcggacucggaguccucgccuugagccu ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguguguuuucag caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc ccacgguguuugaaaacuauguggcggauaucgagguggaugggaagcagguagaguugg cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu acauggaguguucagcaaagaccaaagauggagugagagagguuuuugagauggccacga gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc uugugaacgcagccucaugcgguuaauuugaagugcuguuuauuaaucuuaguguaugau uacuggccuuucauuuaucuauaauuuaccuaaga 230 Z30939 uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc accaucaugcccaaggacauccagcuggcccgucgcauucguggggagagggcguaaauu aggguagugagugaauuuggaccccaaaggcucuuuucagagccacccacauuuucuaua aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc 231 U28208 uuaugugauaaaaaaauucaacuugguauuaacuuaacuaagggccuuggugcuggugcu uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua aaagauagccauaugcucuuuaucacagcagggauggguggugguacuggaacaggugcu gcaccgguaauugcaaaagcagccagagaagcaagagcgguaguuaaagauaaaggagca aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu auugucauucccaaucaaaauuuauuuagaauugcuaacgagaaaacuacauuugcugac gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug gguaaggcaaugauugguacuggagaagcagaaggagaagauagggcaauuagugcugca gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau agagugcgugaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag gcgauggagggaagaguuagaguuucuguucuugcaacuggcauugauagcuguaacgac aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag 232 AV218217 ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu

Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways.

Example 9 Molecular Pathways Activated During Induction of Epidermal Cells to Differentiate into HF Stem Cells

The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5.

TABLE 4 Genes up-regulated in HF stem cells. Numbers in parentheses are the fold increase as determined by quantitative real time PCR. Gene Name/ Protein name/ SEQ GenBk Fold ID Acces #. Incr. Sequence No. Cell surface proteins Cd34/Cd 34 43 uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauaca 233 antigen (189) cccaauccucucaucucuggaaaguuuuguuccuagccaucauuaagau AI847784, caggaccccuguucuccccuuaaccccaggagaggaagcuuauagucuu AI173145 uguagauauucugaaccucugaucacaaaggguuauaaaauagugaagg gguuuggacuaggaaaggcacagacugaaaggaaucugccaggggacug aggccacagcucccccaggagucagaggaagggggaagucacguauuuu auagaaggccaagggccucagagcaagaguauuccuuugaagagcuca Calcium-related S100a4/ 35 ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggcc 234 S100A4 (144) uguggucuggucgccagcaaccugaaucucaaaccuggggaaugucuca (mts) aaguucggggagagguggccucggacgccaagagcuuugugcugaacc X15986 ugggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaau gcccauggagacgccaacaccauuguguguaacaccaaggaagauggga ccuggggaaccgaacaccgggaaccugccuuccccuuccagcccgggag caucacagaggugugcaucaccuuugaccaggcugaccugaccaucaag cugccagacggacaugaauucaaguuccccaaccgccucaacauggaggc caucaacuacauggcggcggauggagacuucaagauuaagugcguggcc uuugagugaagccagccagccuguagcccucaauaaaggcagcugccuc ugcu Transcription Factors and related genes Id2 helix- 11 (25) gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauu 235 loop-helix cucuaaacugcguuucucucccaaucuuuugcaggcauuuggggacuu protein uuucuuuucuuuuuacuuucucuuuuucuuuugcacaagaagaagucu AF077861 acaagaucuuuuaagacuuuuguuaucagccauuucaccaggagaacac guugaauggaccuuuuuaaaaagaaagcggaaggaaaacuaaggaugau cgucuugcccaggugucuuguucuccggccuggacugugauaccguua uuuaugagagacuuucagugcccuuucuacaguuggaagguuuucuuu auauacuauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaa ucacaaggaauugcccaauguaagcagacuuugccuuuucacaaaggug gagcgugaauuccaggaggacccaguauucgguuacuuaaaugaagucu ucggucagaaauggccuuuuugacacgagccuacugaaugcuguguaua uauuuauauauaaauauauauauauugagugaaccuuguggacucuuu aauuagaguuuucuuguauaguggcagaaauaaccuauuucugcauuaa aauguaaugacguacuuaugcuaaacuuuuuauaaaaguuuaguuguaa acuuaacccuuuuauacaaaauaaaucaaguguguuuauugaauguuga uugcuugcuuuauuucagacaaccagugcuuugauuuuuuuuuaugcu auguuauaacugaacccaaauaaauaccaguucaaauuuauguagacug uauuaagauuauaauaaaaugugucugacaucaa Id4 4 (12) cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccguc 236 AJ001972 gggcugcggcggcggggagcuggcgcuacgcugccuggcggagcacgg ccacagccuggguggcucggcagccgccgccgccgcugcggcggccgcg cgcugcaaggcggccgaggcggcggccgaugagccggcgcugugccugc agugcgauaugaacgacugcuacagucgccugcggaggcucgugccuac caucccgcccaacaagaaagucagcaaaguggagauccugcagcacguua ucgacuacauccuggaccugcagcuggcgcuggagacucacccugcuuu gcugagacagccgccaccgcccgcgccaccucuccacccggccggggcuu guccggucgcgccgccgcggaccccacucaccgcgcucaacacugacccg gugagaagccuuggcgggcacccugggcaucgcgggaaagguggcggg gcggcgagauacggguggucuugcuccucucagggaaugacagccgcu ucucccgucuccaccgagagccgccugcugggcuuggugauccacuggu cccugagccgagggcgguugggcuuggagcccugcgucuccggagugu cccuugcaucacaggaggcuuccccagcuucgggcucggguggggacuc ugcucaccugccuaguuuuccaggacgucuccugggugguggcgacac ugugauaugcgcacucuaaccgcuuuuccccuugguguuggguugcug uuccaggccggcgccgugaacaagcagggugacagcauucucugccgcu Peg3/ 12 Sequence below. 237 Paternally expressed gene 3 zinc finger protein AF038939 acuagucucgaccauguaccaucacggagacgacaccaacagugacaugaacagugacgacgacaugagccgaagugggaga gaaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggagcgcaggggcagaagcagagauguggag ccucgagaccgcuggccauacaccaggaaucccagaagcaggcugccucaacgggaucuuucucuuccugugaugucaaga ccacauuuuggacuggacagagaugaugacagacguuccauggauuaugagucucgaucccaggaugccgagucauaccag aauguuguggaacucaaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgc ugggaguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaagagagcugccuaccc aagcaccagccgaggucucaaacccaugccugaggccaaaaagccaucccacaggcgugggaucugugaggacgagucuucu cauggagugauaauggaaaaauucaucaaggauguggcucgcaaccccaaauccggaagagcaagggagcugaacgagcgu ccuccuccaagguuccccaggccuaaugauaacuggaaggacaguuccuccagcagaagagagucagugauccaggagagg gguuaugaagggagcgcauuuaggggcggcuuccgguucaacgcagaccuggcuuccagaagcagagcucuagaaaggaag aggcguuaccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugaggaagaagccuuuugagug uggugcugagaugagacaggcuaugagcaugggcaaccugaacagcccuuccuucucugagucgcagucaaucgauuuug gggccaacccauacgugugugaugagugcgggaggcaguucagugucaucucugaguuuguugagcaccagaucaugcac acuagggagaaccucuaugaauauggagaguccuuuauucauagcguggcugucaaugaggugcaaagaagucagggugg ggggaaacgcuuugaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgccaaauccaugc uagagaauaucuugcagaauguagagaucaggaggaugaggagaccaucaugccuagcccgaccuuuagugagcugcagaa gauguauggcaaagauaaguucuaugagugcaaggugugcaaggagaccuuucugcacaguuccgcccugauugagcacca gaaaauccaugguagaggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcacgugcacg agagcagcgugagcgcgaacgugaacgggagcgugagcgugagcuuggggaacccuuucugaccuguccaaacuucaauga guuucggaagauguacaggaaagacaaaaucuaugagugcaaaguguguggggagagcuuucuucaucucucaucccuga gggagcaucagaaaauccauacuagaggaaacccauuugaaaauaagagcaggaugugcgaggagaccuuugucccuaguc agucucuccgacggcgccagaaaacuuacagagagaagcuguucgacuuuaacaaugccagggaugcacugaugggaaacu cagacuccagcgagcaucagaaaaaccguucccgaaggaacuucuuugagggcagaggauuugagaaacccuucguugaau cucagaagagucauacuauaacaagaccaccugaaaacaaagacgaugacaagccguucacaaucagugucaacccuaaugac aagcugaaacuccccaucauggaaaauggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgca gaagcucagaagagucaugguggacugggguucaguaaaccaagaccaguggcagagucuagcacccagagcucaagcagc auuuacuaccccagagcacacucuggaggcaacaccuaugaaggaaaagaauacaaggacucuaucauccauagcuugccag cuccucgaccucugaaacgucauagagcaaaugaccauauucaaugugaugaggggggagaauccuccauuuauaucccag auauuauuaauaagggaaggaagauuccugccagagaagaugcuuaugaaggaaguagcagcagcaacuaccacacaccaaa uguaucccgugcugagccuccaagucuuucuggagagucccaugacucuaagcaggaugucacguuuucaguucccagcuc aaguguucgugaacaccagaaagcucgugccaaaaagaaguacauugagcccaggaacaacgagaccucuguuauccacucc cuaccuuuuggugaguugcuugcaggucaccguagggcaaaguucuuugagugucaggaaugcggggaggccuuugcucg uaggucugagcucauugagcaccagaagauucaugauagagaaagaccuucuggaagccgacauuaugagcgcucugucau ccgcagccuugcgcccagugacccucagaccaguuaugcccaagaacguuucauccaagaacaagugcguaaauucagagcg uuuggacaacgcucaacuaccagcaacaaccucaguguacagaaaaucuaugcccaagagacauuuaaugccgaggagcccc augauaaagaaacucauggucaaaaaauucaugacaaagagccauaugguaaggagcccaguggcaaggagccccaugguga ugagccccaggacaaagaaccccuuguucaggagaugcgcagugaagagccccaugaugauaagccccauggccaggagccc caugaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccacggugaugagccccauggcc aggagccccacggugaugagccccaugacaaggaacccauugaucaggagaugcgcagugaagagccccacagugaagaguc ucauggugaugagccccauggugaagagucccauggccaggagaaaguugaagaugcuaccauucaggccucaguuucuga agagcaucagaaagaugacgcuggugaugcaaucuaugaaugccaggacugugggcugggcuuuacugaucucaaugaccu cacaagccaccaggacacccauagcagaaaggcucugguugacagucgugaauaugcacauucugaaguucaugcccacucc gucagcgaauuugagaaaaaaugcucuggagagaaacuauaugaauguccaaaauguggggagucuuucauucacagcucg uuacuuuucgagcaccagagaguucacgaacaagaccagcuguauuccguaaaggccuguuaugacgcuuucaucgcucug uugcccguuagaccaaggagaaauugcacuguugaaaggaauccugccguuucugggucagccauucgaugccgucagug uggacaaggcuucauucacaguucugcccuaaaugagcacaugagacagcacagagauaaugaaauaauggaacagaguga gcuuucagaugagauuuucauucaaggccuagcccucacugaguaucaggggagugaaacagaagagaagcuuuucgagug cacaaucuguggggaaugcuucuucacugccaaacagcucggggaccaccacaccaaaguucacaaggaugagcccuaugag uaugggcccuccuacacccaugccuccuuucucaccgagccccucaggaagcacaucccacuguacgaaugcaaagauugcg gccaguccuuccuagacgacacugucaucgcugagcgcaugguguuucauccugagcgagaaggugggucagaaauaguag cugccacugcccaagaggucgaagccaauguccucaucccacaagaaguacugcgaauccaggggucaaaugcagaagcugc ugagcccgaaguggaggcugcagagcccgagguggaggcugcagagccugagguggaggcugcagagccuauuggagagg cugaagggccagauggagaagcugcugagccugauggcgaggcugagcagcccaauggagaggcugaacagccaaacggug augcugacgagccagacggagccgggaucgaagacccagaagagagagcugacgagccugaggaagacgucgaagagccag agggagaugcagaugagcccgauggugcagacauugaagacccagaagaggaaggagaagaucaagagauugagguugaag aaccauacuacaacugucaugaaugcgcagaaacguucgcuuccagcucagccuuuggcgagcaucugaaaagucacgccag ugugaucaucuucgagccggccaaugcuccuggagagugcucuggcuacauugaacgggccagcaccagugcagguggug cggagcaggcagacgacaaguacuucaaaugugaugugugcgggcaacucuucaacgaccgccucucccuugccagacacca gaauucucacacugguugaguaaccaggcugaagaaaagaagagcaaagccaaaccuucuucccagaaccagacccuuaaua aaucacaaagagagccuaaaccaacccauaaugucuauaagaaauucaccuuccuguauacauaccggacuucacaucaaaga cuuucacucucaucacagacugaaaaaagaaaagacauugaacgcagggacucuuucaguuuuagcuguucccuauggaac aucaguguauauuugggaaagcuagagugaacaucuacaucuuccauuucaucuaaguaacuagauugagggaaaccuagu gacaauuccagaccacagagguugccccagucgacuguaaaugauaccccuuucauacccuauacauaaugauuccugccau guauauaaaugagcaaaucagugauacauauauuuggauuuagugugcuauagaauuuacaguuuacucuacagagcuacc uagccugguacucugauuuuuucccugaggaggaagagagcaacaauuuagcauauauuuguaaguauuguccaugcaga agcuuuucugugcaucauuugaaccccauuaguauccuuuccaguaauggaguguucuguccccuaccucuuagauagucc ugugaaggugugggugugaaagaucgugugucuuugaauccuggcuguguggaaacaggcauuuuagcuucuacagccau uuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauauggauuugucucugugacccaaaucaacc caucccuacauuuauauaccuuacagugguuuucuugc Growth Factors, Receptors and Related genes Fz2/ 9 (17) uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauagga 238 Frizzled 2 guccguagggugcacccuccccccuccugagugaaggagggcacggugc AW123618 aguccggaccugggagaggggaaagcccggcaggcaggcgagaccgcuu cacacaguggucucgccaugccggcuguuggugagacgaguguagaacu uccuccacgagugcagugucuugccggaccagauccagaagcccgacgu gaugcccacgaugagcgucaugagguauuugaucauguagacugugaa gucgggcgacaugcggggcguguagugggccgggcaggggauggcuag gcucuugcagugcuggcuuacccaggagcgcucccagugcucgcggaag gccugcucauagaaguagcaggcgaug Dkk3/ 6 (22) Sequence below. 239 Dickkopf 3 AJ243964 ggccgcgucgacgccucuccagcugcucuguggcagcccagcuaccggucgugaccagauccagcuugcagcucagcuuug uucauucgaauugggcggcggccagcgcggaacaaacaugcagcggcucggggguauuuugcuguguacacugcuggcgg cggcgguccccacugcuccugcuccuuccccgacggucacuuggacuccggcggagccgggcccagcucucaacuacccuca ggaggaagcuacgcucaaugagauguuucgagagguggaggagcugauggaagacacucagcacaaacugcgcagugccgu ggaggagauggaggcggaagaagcagcugcuaaaacguccucugaggugaaccuggcaagcuuaccucccaacuaucacaa ugagaccagcacggagaccagggugggaaauaacacaguccaugugcaccaggaaguucacaagauaaccaacaaccagagu ggacagguggucuuuucugagacagucauuacaucuguaggggaugaagaaggcaagaggagccaugaauguaucauuga ugaagacugugggcccaccagguacugccaguucuccagcuucaaguacaccugccagccaugccgggaccagcagaugcu augcacccgagacagugagugcuguggagaccagcugugugccuggggucacugcacccaaaaggccaccaaagguggcaa ugggaccaucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggccugcuguuccccgugu gcacaccccugcccguggagggagagcucugccaugaccccaccagccagcugcuggaucucaucaccugggaacuggagcc ugaaggagcuuuggaccgaugccccugcgccaguggccuccuaugccagccacacagccacagucugguguacaugugcaa gccagccuucgugggcagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaagauguugg cuucauaggggaagugcgccaggagcuggaagaccuggagcggagccuagcccaggagauggcauuugaggggccugcccc uguggagucacuaggcggagaggaggagauuuaggcccagacccagcugagucacugguagaugugcaauagaaauggcu aauuuauuuucccaggaguguccccaaguguggaauggccgcagcuccuucccaguagcuuuuccucuggcuugacaagg uacagugcaguacauuucuuccagccgcccugcuucucuggcuugggaaagacaggcauggcggguaagggcagcgguga gucgucccucgcuguugcuagaaacgcugucuuguucuucauggauggaagauuuguuugaagggagaggaugggaagg ggugaagucugcucaugauggauuugggggauacagggaggaggaugccugccuugcagacguggacuuggcaaaaugua accuuugcuuuugucuugcgccgcucccaugggcugaggcaguggcuacacaagagcuaugcugcucuguggccucccaca uauucaucccuguguuucagcuccuaccucacugucagcacagcccuucauagccacgcccccucuugcucaccacagccua ggaggggaccagaggggacuucucucagagccccaugcucucucucucaaccccauaccagccucugugccagcgacagccc uuccaaauggagggagugaaauccuuugguuuuauuauuuucuccuucaaggcacgccugccacuaaggucaggcugacu ugcaugucccucuaacguucguagcagugugguggacacugucuuccaccgacugcuucaauaccucugaaagccagugcu cggagugcaguucguguaaauuaauuugcaggaaguauacuuggcuaauuguagggcuaggauugugaaugaaauuugca aagucgcuuagcaacaauggaaagccuuucucagucacaccgagaagucacaaccaagccagguuguguagaguacagcug ugacauacagacagaagaaggcugggcuggaugucaggccucagaugacgguuucaggugccaggaacuauuaccauucug uaucuauccagaguuauuaaaauugaaaguugcacacauuuguauaagcaugccuuucuccugaguuuuaaauuauaugua uacacaaacauguggcccucaaagaucaugcacaaaccacuacucuuugcuaauucuuggacuuuucucuuugauuuucaa uaaauacaaauccccuucaugcaaaaaaaaaaaaaaa Sfrp 1/ 6 Sequence below. 240 Secreted frizzled- related protein 1 U88566 gcacgagcagcccgcagcccgccgcgccugugcgagccgggacagcacucggccccgcgcgcuccccgccccgcgccagccc cgccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgcgagccgacgggcc ccgacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgugggcagccccgac gucgccgagcaacaugggcgucgggcgcagcgcgcggggucgcggcggggccgccucgggagugcugcuggcguuggccg ccgcucugcuggccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucagagcgggc gcuucuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugccacaacgugggcuacaagaagaugg ugcugcccaaccugcuggagcacgagaccauggcagaggugaagcagcaggccagcagcugggugccgcugcucaacaaga acugccacaugggcacccaggucuuccucuguucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcu ggcucugcgaggccgugcgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugu gacaaguuccccgagggcgacgucugcaucgccaugaccccgcccaauaccacggaagccucuaagccccaagguacaaccg uguguccuccaugcgacaacgaguugaagucagaggccaucauugaacaucucugugcaagcgaguuugcacugaggauga aaaucaaagaagugaagaaggaaaacggugacaagaagauuguccccaagaagaagaaacccuugaagcuggggcccaucaa gaagaaggagcugaaggcgcuugugcuguuccugaagaacggugccgacugucccugccaccagcuggacaaccucagcca caacuuucucaucaugggccgcaaggugaagagccaguaccugcugacagccauucacaagugggacaagaaaaacaaggag uucaaaaacuucaugaagagaaugaaaaaccacgagugucccaccuuccagucuguuuuuaagugauacuggggcggacug gggaaggggaguguggcuuggggugagggugggggcgcguggaugacccuggcucuunggggcucacauauugcucuca cccauacaguuguggcuuuugcauugcaccuggcucuguuccuacagcgaacccucucccuunccuccauagccacaucca gcuaaggccacggccuuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugcaaaagg agaggcagaauccuuucacugagccuggggcacaaaaaacagaaaauguunnccgguuuggaaaaacaaaacaaaacggauu guaaagaacugcagacggacagcugcucagcucaacguuguucgggacaucauuaccaauugcuuguggagucuaagccuc uacagguagaagagucugaucauugccaagccaggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauaga ccaucgccaccuucaaaacacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaaguag ccaggguaucccaguauagaacgggauagcuaaggguuugggugggaggccacugcuacucuaccuucagcuuuugaacu ggccaccuuugauaggaaacugaggucucagauggacacuucuaccaguccaucgggauacaaggaugccaggcaaggguc ugcuuuugucugaaggagguacgugggcaugaagagacaugaggcauuucaggcugagaagcaacagcuacuaguuuuca acaauagaguggaagaaaugagcaaagguagaaaugucaagcaggucacaagucagggugauugggggaauccugugccaa cagccucacuuuguaauuccaucugucacuuucaaaagaacagcagcauaagacagggauaaaagcccacauacccuccaag gcuugaguaaaaguccacacucagcauuucaaagacuaacgucguugacugcccaaggcugcccucuuaauacaccgccuau gcaugugcuguggaaggcaacucugugcaugugcuguggaggagaugggccucauggcugugcuggcugcccggaaucag uauagcguggaaggagacaguauccauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaa uucagacaaauuuaaaaucgcugccugccugagcccuccaccuuuacuuuugcauucuccggucauauucuuuugaggcua aagugcccuauccgaggagaugguuucaaaggcuaacuaaucugcagcuuucccaagugcccagagguauuucucaaaguu gguaugcuuaauaagugauguaaauauuccaguucucuuaggcagccuuacuccuguugucccug Dab2/ 15 Sequence below. 241 Disabled homolog 2 U18869 aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcugcagccuugaggcuucgggcgcggg ggaagucaugcuggcuccacagaagcacuagcuaguccguguacuuuguggguucuguccuuuugagaccugcccgccgg ggauuggcugguaucagugacugucuacugcuggauuuucugcuugccuucccgucaugucuaacgaaguagaaacaagc acaaccaauggccagccugaccaacaggcugccccgaaagcgccaucaaagaaggagaagaagaaagguucugaaaagacag acgaguacuuguuggccagguucaaaggugaugguguuaaauacaaggccaagcuaaucgguauugaugaugugccugau gcucgaggagacaaaaugagucaggauucuaugaugaaacucaagggaauggcagcagcuggucgcucucagggacaacac aagcaaagaaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaacau ccaguaaauaagauuuccuucauugcucgugaugugacagacaacagagcauuugguuauguguguggaggugaaggcca gcaucaauuuuuugcuauaaaaacagggcaacaggcugagccauuagucgucgaucuuaaagaccuuuuucaaguuaucua uaauguaaagaaaaaggaagaagauaagaaaaagguugaagaagccaacaaagcagaagagaauggaagugaggcccuaaug acccuugaugaucaagcuaacaaauugaagcuggguguugaccagauggauuuguuuggggacaugucuacaccuccugac cuaaauaguccaacagaaagcaaagauauccuguuaguggaucuaaacucugaaaucgacaccaaucagaacucuuuaagag aaaauccauucuuaacaaauggagucaccuccuguucucucccucgaccaaagccucaggcauccuucuugccugagaacgc cuuuucugccaaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcacagccagaccaaucg gcacccucuucguucgauucucucacaucuccagaucagaagaaagcgagucugaguagcucgucuacuccacagaguaaa gggccccugaacgucgauacugauuacuuuggucagcaauuugaccagcucucuaaccggacuggcaaaccggaagcucag ggaggcccguggcccuacccaaguucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagagaacagaacg gcuuccauaucaaaucuuccccgaacccuuuugugggaagcccucccaaaggacuaucgguaccgaauggcguaaagcagg acuuggaaaguucuguccaguccucagcacaugacuccauagccauuaucccaccuccacaaaguaccaaaccaggaagagg cagaaggacugcuaagucuucagcaaacgacuugccugcuucagacaucuuugccucagaaccuccaggccagauguccccc acaggacaaccugcagucccgcagucgaacuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccuugua ggucuagguacggucccaguaacacccccccaagcaggacccuggacgccuguugucuacaguccuucgacaacugugguc ccaggagccauaauaaguggccagccucccaguuuucgccagccacucguuuuugguacaaccccagcaguacaagucugg aaucagucuccaucauuugcaaccccagcuuccccuccaccccccacaguuugguguccuaccacaucuguggcgcccaacg cuuggucauccacaagcccucuggggaauccuuuucagaguaauaauaucuuuccaccucccaccauguccacucaguccuc uccucagccuaugauguccucuguucuggccacaccgccucaaccaccuccccgaaauggcccacuaaaggacauucccagu gacgcuuucacuggcuuagacccccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcgg cagccaccucuuguucccucaaggaagggggagacgccucccucugggacuucaagcgccuucuccaguuacuucaacaau aaaguuggcauuccucaggagcauguagaccaugaugauuuugaugccaaucaacuguugaacaagauuaaugaaccacca aagccagccccgagacaagguguccucuuggguaccaagucugcugacaauucacucgagaacccuuucuccaaaggguuc agcucaucaaaccccucugugguuucucagccugcaucuucugauccccacaggagcccuuucggaaauccuuuugccuag cuucugaaguuguaaugaugacuauccagaugagcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacaug uugaccucuguccucgcuccagcuuugacguauuaucuguuacccuauuuguuuuggccucuuguacuuguaaaaugccu uucauuuuccugucuaggcuaaagcuaaacuuaaacuauggcuuuacguaaauuaagcuccuaaacucucuagcuccaaua uaaaugaaguagcuucccuaucaaaucccugucuguugugcccccuugaaacuuccagaauauucuccauucuacccucca uuugggaggagcggcuaccuuuacccuuaauaucacacugccuugagucaauguccaaauacucauagcucucaaagucau uugggguuccuggugugcggccuaaaccuaaagcauccuauuaauagggaaguaagacaccuugcuuccuauguccacuca gggagaauuuuauuuaauaaaaugaaagcaagacuaacuucucaaauccacccaaggaccauuuugagauggucguuucuc agcuaacugcaccauuuaccaauccugccccaaguggugcuuacauuugacuugaagaagagaaagagcuaacucaaaacac aaggcauuauucaaagcuaauaaaacaauuucucccuggggccccacauuguuuucauuccagauacguugcagcuguuug acccugaugacauuaugcccuacauuuuccuugaagauccugauuuuauuucaugugauuuuuguuucucaauaaagaug auuauugugugcacggaauuc Cktsf1b1/ 12 (12) Augaaucgcaccgcauacacugugggagcguugcuucuccuccugggg 242 Gremlin, acccuacugccaacagcugaggggaaaaagaaagguucccaaggagccau Cysteine uccgccuccugacaaggcucagcacaaugacucugagcagacccaguccc knot caccacaaccuggcuccaggacccgggggcggggccaggggcggggcac superfamily cgccaugccuggagaggaggugcuugaguccagccaagaggcccugcac 1, BMP gugacagagcgcaaguaucugaagcgagauuggugcaaaacucagcccc antagonist 1 ugaagcagaccauccacgaggagggcugcaacagccgcacuaucaucaac AF045801 cgcuucuguuauggccagugcaacuccuucuacauccccaggcacaucc gaaaggaggaaggguccuuucagucuugcuccuucugcaagcccaagaa guucaccaccaugauggucacacucaacuguccugagcuacagccaccca ccaagaagaaaagggucacacgcgugaagcagugccguugcauauccau cgacuuggauuaa Fgfr1/ 10 Sequence below. 243 Fibroblast growth factor receptor 1 U22324 guggaauauccauggagguacggagccuuguuaccaaccuuuaaccgcagaacugggauguggggcuggaagugccuccu cuucugggcugugcuggucacagccacucucugcacugccaggccagccccaaccuugcccgaacaagcucagcccugggg agucccuguggaaguggagucucuccugguccacccuggcgaccugcuacagcuucgcugucggcuucgcgaugaugugc agagcaucaacuggcugcgggauggggugcagcugguggagagcaaccguacccgcaucacaggggaggagguggaggug cgggacuccauccccgcugacucuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccg ucaaugucucagaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggacaa caccaaaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugcaugcggugcccgcu gccaagacggugaaguucaagugcccgucgagugggacacccaaccccacucugcgcugguugaaaaauggcaaagaguuu aagccugaccaccgaauuggaggcuacaagguucgcuaugccaccuggagcaucauaauggauucuguggugccuucugac aagggcaacuacaccugcaucguggagaaugaguaugggagcaucaaccacaccuaccagcuugacgucguggaacgaucu ccgcaccgacccauccuucaggcagggcugccugccaacgagacaguggcccugggcagcaauguggaguucauguguaag guguacagcgauccgcagccucacauucaguggcugaagcacaucgaggugaacgggaguaagaucgggccagacaacuug ccguauguccagauccugaagacugcuggaguuaauaccaccgacaaggaaauggaggugcuucaucuacggaaugucucc uuugaggaugcgggggaguauacgugcuuggcggguaacucuaucggacucucccaucacucugcaugguugaccguucu ggaagcccuggaagagagaccagcugugaugaccucaccgcucuaccuggagaucauuaucuacugcaccggggccuuccu gaucuccugcauguugggcucugucaucaucuauaagaugaagagcggcaccaagaagagcgacuuccauagccagauggc ugugcacaagcuggccaagagcaucccucugcgcagacagguaacagugucagcugacuccagugcauccaugaacucugg gguucuccugguucggcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauaugagcucccuga ggauccccgcugggagcugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgggcagguggugu uggcugaggccaucgggcuggauaaggacaaacccaaccgugugaccaaaguggccgugaagauguugaaguccgacgcaa cggagaaggaccugucggaucugaucucggagauggagaugaugaaaaugauugggaagcacaagaauaucaucaaccuuc ugggagcgugcacacaggaugguccucuuuaugucauuguggaguacgccuccaaaggcaaccuccgggaguaucuacagg cccggaggccuccugggcuggaguacugcuauaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauc cugugccuaucagguggcucggggcauggaguaucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacg uccuggugaccgaggauaacguaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacuacaaga aaaccaccaacggccggcugccugugaaguggauggccccugaggcguuguuugaccggaucuacacacaccagagcgaug uguggucuuuuggagugcucuugugggagaucuucacucuggguggcuccccauaccccggugugccuguggaggaacu uuucaagcugcugaaggagggucaucgaauggacaagcccaguaacuguaccaaugagcuguacaugaugaugcgggacug cuggcaugcagugcccucucagagaccuacguucaagcaguugguggaagaccuggaccgcauuguggccuugaccuccag ccaggaguaucuggaccuguccauaccgcuggaccaguacucacccagcuuucccgacacacggagcuccaccugcuccuca ggggaggacucugucuucucucaugagccguuaccugaggagcccugucugccucgacaccccacccagcuugccaacagu ggacucaaacggcgcuga Fgf1/ 10 auggcugaaggggagaucacaaccuucgcagcccugaccgagagguuca 244 Fibroblast accugccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaac growth gggggccacuucuugaggauccuuccugauggcaccguggaugggaca factor 1 agggacaggagcgaccagcacauucagcugcagcucagugcggaaagug M30641 cgggcgaaguguauauaaaggguacggagaccggccaguacuuggccau ggacaccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugu cuguuccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaa gaagcaugcggagaagaacugguuugugggccucaagaagaacgggagc uguaagcgcgguccucggacucacuauggccagaaagccaucuuguuuc ugccccucccggugucuucugacuag Gpr49/ 64 Sequence below. 245 G protein- (377) coupled receptor 49 FEX AF110818 auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcucaccgggacca gaugcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcucaggguggacugcucgga ccuggggcucucggagcugcccuccaaccucagcgucuucaccuccuaccuggaccucaguaugaacaacaucagucagcua cccgccagucuccuacaucgccucugcuuccuagaagaguuacgucuugcuggaaaugcuuugacacacauucccaaggga gcguucacgggccuucacagccucaaagugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacag aauuugagaagccuucaaucccugcgccuagaugccaaccacaucagcuacgugccacccagcuguuucagcggccugcacu cccugaggcaccuguggcuagaugacaaugcucucacagacgucccuguccaggcuuucagaaguuuaucagcccugcaag ccaugaccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagccucgugguucugcaucu ccauaauaauagaauccacucccugggaaagaaaugcuuugauggacuccacagccuggagacuuuagauuuaaauuauaa uaaccuugaugaauuccccacugcaaucaagacacucuccaaccuuaaggaacuaggauuccacagcaacaacaucagguca auaccggagcgagcguucguaggcaacccuucucuuaucacaauacacuucuaugacaaccccauccaauuuguuggagua ucugcuuuucagcauuugccugaacuaagaacacugacuuugaauggugccucgcacauuacugaauuuccucacuugaca ggaacugccacccuggagagucugacuuuaacuggagcaaagaucucaucucuuccccaggccgucugugaucaguuaccu aaucuccaagugcuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugccaaaaacuucagaaaauu gaccugaggcauaacgagaucuaugaaauuaagggcagcacuuuucagcaguuguuuaaccuccgaucucugaacuuagca uggaauaaaauugcuaucauucaccccaaugcguuuucuacguugccgucucuaauaaaguuggaccuaucauccaaucuc cugucguccuucccugugacuggguuacaugguuuaacucacuuaaaauuaacagggaaccgagccuuacagagccugaua ccaucugcaaacuucccagagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggugugagaau gucuauaaaauuucuaaccaauggaauaaagacgacggcaacaguguggacgaccuucauaagaaagacgcuggguuauuu caaguucaagaugagcgggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcccuucacucggugcagugc ucgccuuccccaggucccuucaagcccugugagcaccuauuugguagcuggcugauccgaaucgggguguggaccacggca guacugacgcuuuccugcaaugccuugguggcuuugaccguguucagaacuccccuguacaucucuuccauaaagcugcua auugggguaaucgcgguaguggacauucucaugggggucuccagugcugugcuggcugccguggaugcauucacuuuug gccguuuugcucagcacggugcguggugggaagacggaaucggcugccaaaucguuggcuuccuguccauuuuugcuucc gaaucgucgaucuuccugcucacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagugaa agcuccccuuuuuagccugagagcgaucguuuugcuauguguccuguuggcccugaccauugccacaauccccuugcuag gaggcaguaaguacaaugccucuccccucugccugcccuugcccuuuggggagcccagcaccacgggcuacaugguggcuc ucguguugcucaacucucucuguuuccucauaaugaccauugccuacacaaagcucuacugcaguuuggagaaaggagagc uggagaaucuuugggauuguucgauggugaagcacauugcucuguugcucuucgccaacugcauccuuuacugccccgug gcuuucuuauccuucuccucuuugcuaaaccucaccuuuaucaguccugacgucauuaaauuuauacuucucgugaucguc ccacuuccuuccugucucaacccacuucucuacauugucuucaauccccauuuuaaggaggauaugggcagccugggaaag cauacccguuucuggaugagaucaaaacacgcgagucugcuguccauuaacucggacgauguugagaaacgguccugugag ucaacccaagccuuaguauccuuuacccacgccagcauagccuaugacuugccuuccacuuccggggcaucaccagcuuacc ccaugacugaaagcugucaucucucuucaguugcauuugucccaugucucuagugacuaugagagaggaacguuuuuaag aguuggaaaccugaaaagugauuucuaucagagcaguagcuaagaaaagcugagcuaaaaaccuaccuuaaaacccaagcaa acaucucuaaauugguguggaaacaguggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuuguucagc uaagaaggaaagccaucaagucacuuaggugaacccagaugagaaaagcagccugaaaugcucuucgcauuguagucucuu cugacucaccagcauagucucccauagugagaagacucguuggaugacucaauggguguauuuaaauccacaaauuccuug uuuaaaagguuagaguuuuaagaaaaaaaaaaaaaaaaa Igfbp5/ 37 Sequence below. 246 insulin-like growth factor binding protein 5 L12447 uuuuuuuucuucaccuccucccuuuucaaggccuccaagcuaauuauuucuguugcuuuggagugagcaauucugugguu cucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuccgcucacucugcgugcaccuggcgc gccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgcaauugggacuugcgugcaggcaccugaauccuccu ugccucauauuuugcaaguguuugggggagagcaccugcucuaccugcaagagauuuaaaaggaaaaaaaucuccaggcuc ccucuuucuccacacacucucgcucuccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcguggucc uccugcugcuggccgccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcuc uguccauguguccccccagcccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugcgcccug gcggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccucccccggcaggaugaggagaa gccgcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuacggcgagcaaaccaagauagagagagac ucucgggaacacgaggaacccaccaccuccgagauggcugaagagaccuacucccccaaggucuuccggcccaagcacacuc gcauuuccgagcugaaggcugaggcugugaagaaggaccgcagaaagaagcugacccaguccaaguuuguggggggugca gagaacacugcccaccccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcagacacaugg aagcuucccuccaggaguucaaagccagcccacgcauggugccccgugcuguguaccugcccaacugugaccgcaaaggau ucuacaagagaaagcaguguaagcccucccguggccgcaaacguggcaucugcugguguguggacaaguacggaaugaagc ugccgggcauggaguacguggauggggacuuucagugccacgccuucgacagcaguaacguugagugacgcguccccuccc uuccucccccuauccuacccccccagccccaacuccagccagcgccucccuccaccccaggacgucacucauuucaucucauu uaggggaaauauauauacauauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaggagacacucccca ccaugaccccggaaauguauuccuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaagagggagcg agagauggaaagaaagcaaagcguuggaauagaggaaaagagggaaggacagauaggauuagagagagaagagagaaacag caaggcagaaaggacuccacaaccaaggcugaaucugcccuuuugcuuucagcucuagccuggggucagaaaaaguguggc auucagugacacccaguuuagauuggucaaggggagaaaagaaacaaggugugucagugccucucgggucuguccccuccu gcagccagcaguguggauggcuagaccccucacccuccucuccucuuacccaagugcagggugauuucauccccaaauuua caaagacuaaaaugcauuccaucccucugaaaauaaacaaaagugagugauugaagauagguuuucccccagcagacaagug aacucagaaugugugcaaauuuuacucuuguuaaagauuuuuuuaagaagucaguacgcacccccaacacuggaaagacuu gauucuccagggugacaagcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccggcagcc ucuguggaggaggaugagagguggagaaaaccaaggggcuuguacucacccacaagacuccauguagacuuuauaggcaua uaaaucuauuuucuuuaccuuuuuuucccuuucccuuucuuucgaaguuuugcauuaccucuuuaaaguaguuuuuuuua ggacacugaagaucuuccucauucugggaaaaauccauauuucacaaauacaacccagaacgccagcuuggccugcguccag gcagccuuucucgugagcuacaaguguggcucuuuuguggggcaccgauuuggaucuucucaugauuccaaacguguguu gaagugaauccaccaagccagguaacugccagcacccaagggugcaucaagugcauagcccaggucaccccauuucagccuu ccaacccgcagaaaguaacugucucacaccacaccacauaaaccugccagauccaucuguaacccacuggccugcccagaccu uuuuuucccaucugcauuuuuuuuuuugaacugcauuuugaaagccucccucagaugccaggcugacagaucagagagaaa cuaacaugagagaugacagaggaggaggaaguggagggugggggcagagacuuccacagagagacauagaagauggagcag aggucuggggguggggaggacaagaaagagacagagagaggaaaauaccaauagaauuuuccuuggugucucccaucuaau caacucucugagauuugagaggaaaaagaaggcaggggaagaacuugagguagaaaugaggucaguucaagucacagggcc cagaugguggguaacugaggcaggauccagacuugagacacacgguuggaaacaaggcugguuagccugacuggguauug aagggugaagaggaugccuuggaaagacagcacaacuucaguucaacuucaggcccccaaggaggaacugaggccaaagaau ccuucaagugcuucaugagucuccucugcccgacucaaacauccuucccugugauggaggaugguagaaagcccaggacaa cucaggcccggaucuucacgacuguugucauuugccagccugauuuugauccaagagaagcaucucauugcccacuggcuu cuucaacaaagaggugcuuaacaaaaggcucaggacuaucuuugaagacugaagauaaccuuccaggagaggagacucgga cauugguacaggaggccccuuuuggcgggggacacagcucuuugcgcucucuugauggcauggcauaguagaggcccccu ccaacccggaacauggagcaacacaaagggagagcaaagaaacugacgugcgucgacucauaggacauggguggcugcggg cacagaaagggaugccuccuguugccuggacaggacaguuggcugggaaggaaagagaaaauugaucuucauaagacaaag ggccugaugggauggcaauagaaggacuuaccagaccugcagggucaguauacccaucaccccgcacaacauccccagcccc caacucaaacuucaauauaucuuaggccaguauccuagaccuaagucucuccuuucugccauuauuucuccgcaucuugag cagucaucugacugagauuugccaaguggauacugggguaccacugccccccaagaaaagacugagccaggaacugccuac ucgcucccccucccgagccuggagcuaacuccugugaggggugcucucuucaccccacaacuuacuagaccuugagugagc cucugucccuuaugugggcucuucgcugugagccacagauggaggucauuguauagacaguuagccuuccccaggucagc cuaccucccccaaacuugugagucuccccgcugcucauauggagaggcaugucuaagacagcaagucuucuagaggaagcu ugccuuuaacagacagauggaacuaaaccuuccaaaugggagaucuggcugaacccaggauacagagaccauggacaugga uggggucaucaagagaagagggauguccuucuccagguuagggagagagaaggcaaguuugcaacgaucccaucaugcccu gagcaagaagcuuuuggcccaggcuagccuuuaacuccauuagaggccucucuguuggguuuauccacagcaguaggccca aguauggccuguccccaccucuacuaucccguggaagguuucuucccaccccuuuuugacaaaugccucacucgagcagug gaaagauagcucucuucccccucuucugccagguaacaaagagaccuaaccaggaccuauucuccaccccagccagucuuga ccagccagaacaaagcagggaaccuggagaauaaaagacucuacguuccucugacaaagacucuacguuucucugacggcca ggccuaaacagacaaggcuugggaacaucugccccacaggauacggaggaggucagcugugcucacuccucuucuccuucc aagacccucuuccgaccaugacuuaucuccaugguaacauccucaccaucauucucccacuaccaaggguugccauggcaac cucccaaccaccugcccaucccaggcaggcagcuguccuucugcucagaacccuagaggacucuaggugaaauuuuacagcu uaagagaggagugagccaaggagaagagacccuguaguccucuggcuuucaagagaaagaaggcuaugauuuaaaacacag uagaagggaaagaggucucgucgaggucgaccucucccggggagcuuagggguuguacugucuuuauuuuuuaaaccacu aaagugcaaunuuuccugcacucuuguuaccccgccucucuucccuguuagguuuucauuuccuugagcagacuuucuug guuuuuuaauggaguauagacuuucaccacuucacagacucuggccuccucuccaagucucucuggauggggaaaaggaag guagagggucagaggggaaggggucccucgucaccccgcauccauucacccccacuucucuggucccuagucaccggcuuc accccnaucuccgacaccaucacugucacacaguagccugucacacggauaguacaguucagacaagacuccuucagauucc gagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuuguuuguuuguuuguuuuuuacaacagcaau aaccacaucacauauuacuguagcucucuauaguguuacguucagacaccguagcucuguccucucuuauuuuguugguu uugacuuaaaaaaaaauacuuaugcuuuuuacuggugaaacagauugaaaaaaaaauugaacaacaaaccaguuugugaaaa aaaaaaaaaaugugaaaaaaaaucaccccgauguggaagagcucggcuccucuuuagcauuuuguacuuaaggaaauaaaaa agaaaaaccuggaagaucucacauuuuauuacaaagugaaaaaaaaa Myoc/ 111 Sequence below. 247 trabecular meshwork induced gluco- corticoid protein AF041335 guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuuaauucauca ggauguggagcgcuagucuggguaggagagccagucacccugaggacagcugaaacaaucgcuggcaaguauggagugug gaugagagaccccaagcccacccaccccuacacccaggaaagcacauggaggauugacacgguuggcacagagauccgccag guguuugaguacagucagauaagccaguucgagcagggcuauccuuccaagguccaugugcucccucgggcacuggagagc acgggugcugugguguaugcggggagccucuauuuccagggggcugaguccagaacuguggucagguaugagcuagacac ggagaccgugaaggcagagaaggaaauuccuggagcuggcuaccacggacacuucccguacgcgugggguggcuacacaga cauugacuuagcuguggaugagagcggccucugggucaucuacagcacggaggaagccaagggggccauaguccucuccaa auugaacccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccuuuguuau cuguggcaucuuguacacggugagcagcuacucuucagcccaugcaaccgucaacuucgccuacgacacuaaaacggggacc aguaagacccugaccaucccauucacgaaucgcuacaaguacagcaguaugauugacuacaacccccuggagaggaagcugu uugccugggacaacuucaacauggucaccuaugauaucaagcucuuggagaugugaggagccucuaugccuaccagcaaag gccagaaaaggugaaguuccgggcucccgggugaagcagcugucagcagaggcagccagaugcauggaguuucuccuccug cuaaagauuuuguuuauccgggucaauguacagcuagcuccccucugacugacacguccuccaggcuuguauagucgcaua gacucuguucucuucugucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug Itm2a/E25 30 Sequence below. 248 putative Integral membrane protein 2A L38971 gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcugcucaagcaagcgcgauccucucc ucuuucaaccugcagcccaagauacugauucgagccgcgccuuaccgcgcagcccgaagauucaccauggugaagaucgccu ucaacaccccuacggcggugcaaaaggaggaggcgcggcaagauauagaggcgcucgucagucgcacuguccgagcucaaa uccugacuggcaaggagcucagaguugucccgcaggagaaagauggcucaucugggagaugcaugcuuacucuccuaggcc ucucauucaucuuggcaggacugauuguugguggagccugcauuuacaaguacuucaugcccaagagcaccauuuaccaug gugagaugugcuucuuugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugag gaggcugauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgauccggcggc aauuauucacgacuuugagaagggaaugacugcuuaccuggacuugcuuuugggaaacuguuaucugaugccccucaauac uuccauuguuaugacuccaaagaaucugguggaacuuuuuggaaaacuggcaaguggcaaguauuugccucauacuuaug ugguucgugaagaccugguugcuguggaagaaauucgugauguuaguaaccuugguauuuuuauuuaccaacuuugcaac aaccgaaaauccuuccgccuuagacgcagagaccuucugcuggguuucaacaagcgugccauugacaaaugcuggaagauu agacacuuccccaaugaauuuaucguugaaaccaagaucugucaggagugaaaugugacagauaaagaguauccuugauaa uaagaagucaggaacuuaccgucugacuuggaaaauugaaauugaugggauacucaugcuauuuacucauacauuuacucu auugcuuauacuggaaaaggaaagggaaaggggggagaaaacuacuaaccacugcaagcgauuguccaauucuacuuuaau ugacauugcuugcuguuuucaacaagucaaaugauuaucuuuucucuugaauuuauaggguuuagauuucugaaagcagc augaaugugucaucuuaccauccugacaauaaagcccauccucugguuuuauuuaaagcaagcucuuuccaacaucacuug gcuagagcaugcuuuaaauuuaaaauauuugaaauuuguuuuugacauuuuuuugugugaaacaugucaaaucucuuacc auucuuugguuuucuucuuuauuauguucaacucuccugauuucagaaguuacauuuuugcauuucuaucaggugcugu guaacgaaucugacugauaugugaacaaucuucaugaggaagcaauuuuuuacucauguaaugauucuuucucacugauau cuguauugugaaauccacagaacuguacaggugcugaaugcuguaaggaguucugguuguaugaauucuacaacccuauaa uaaaguuuaccguauucaauca Eps8/ 15 Sequence below. 249 epidermal growth factor receptor pathway substrate 8 L21671 ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggcgcagggcgc ggggcaagccccagcagcgugucugcaacggggcgcggcgggcgcuccagcuccgggaucuuucucccucggucaccuccc ucgcgucuagggaggucguggcacucccugaggagcgcggcugcucggagggcggauccuagaacagaggcgugagagcc ggcaugaauggucauaugucuaaccgcuccaguggguauggagucuacccuucucaacugaaugguuacggaucuucacca cccuauucccagauggacagagaacacagcucaagaacaagugcaaaggcccuuuaugaacaaaggaagaacuaugcccgag acagugucagcagugugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaa ugaucacugucgaggacggaauaagaaagcugaaguugcuggaugccaagggcaaaguguggacucaagauaugauucucc aaguggaugaccgagcugugagccugauugacuuagagucaaagaaugaauuggagaauuuuccucuaaacacaaucucgc auugucaagcaguggugcaugcaugcagcuaugacuccauucucgccuugguaugcaaagagccaacgcagagcaagccag accuucaccuuuuccagugugaugagguuaaggcaaaccuaauuagugaagauaucgaaagugcaaucagugacaguaaag gugggaaacagaagaggcggccggaggcccugaggaugauugccaaagcagauccuggcaucccuccuccucccagagcuc cugccccugugccaccggggacugucacacagguggacguuaggagucgcguagcagccuggucugccugggcagcugacc agggugacuucgagaagccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucgacagggaug ugcaaaucuuaaaccauauuuuggaugacauugaauuuuuuaucaccaaacuccaaaaagccgccgaagcguuuucugagc uuucuaaaaggaagaaaaguaagaaaaguaaaaggaaaggaccuggagagggcguuuuaacacugagggcaaaaccgccacc uccugacgaguuuguugacuguuuccagaaguuuaaacauggauucaaccuucuggccaaguugaagucccauauccagaa cccgagugcuucagaucugguucauuuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccugaacugg ccaguucgguacucagcccacuguugacaaaagacacaguugauuucuuaaacuacacagccacugcggaggaacggaagcu guggaugucacugggagauaguugggugaaagugagagcagaguggccgaaagaacaguucaucccaccuuacgucccgag guuccgcaacggcugggagcccccgaugcugaacuucaugggcgcgcccacagagcaagacauguaucaacuggccgaguc cguggccaacgcagaacaccagcgcaaacaggacagcaagaggcuguccacagagcauuccaauguguccgacuauccucca gccgacggauaugcguacaguagcagcauguaccacagaggaccacaugcagaccacggggaggcugccaugccuuucaag ucaacuccuaaucaccaaguagauaggaauuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuu uguggcgaggaacagcagcgagcucucgguuaugaaagaugaugucuuagagauacucgacgaucgaaggcaguggugga aaguccggaaugccaguggagacucuggguuugugccaaauaacauucuggauaucaugagaacuccagaaucuggagugg ggcgcgcugaccccccauacacacauaccauacagaaacaaaggacggaauacggccugagaucagcugacacuccuucugc cccaucacccccuccaacgccagcacccguuccggucccccuuccaccuucuguaccagcacccguuucugugcccaagguu ccagcagaugucacccgccagaacagcagcuccagugacagugggggcagcauugugcgggacagccagagauacaaacaac ucccaguggaccgaaggaagucccagauggaagagguucaggaugagcucuuccagaggcugaccaucgggcgcagugcug cgcagaggaaguuccacgugccacggcagaacguuccagugaucaauaucacuuaugacuccucaccggaagaaguaaagac uuggcugcagucaaagggauucaaucccgugacugucaauagccucgggguguugaacggagcacaacucuuuucucucaa caaagacgaacugaggucugucugcccggaaggugccagagucuuuaaccaaaucacuguucagaaagcugcuuuggagga caguaauggaagcuccgaguuacaagagaucaugcggagacggcaggagaagaucagcgccgcugcgagcgacucgggagu ggagucuuuugaugaagggagcagccacugaguccaugaacuuccuuauucuugguguggucguugaacagugauggaca ugcuuuguuuuaagaagccuugaagggaaugucaaagcugucgucuugguauauguaauuuaucgccauauaaggaaaca guauaugccugaguaagcagaggacccgcugcuucugugcacauuaguuugauuaaaacugagaagcggguaggugagau ggcucagcaaguaaaggugcuugcugccaagcccaaugacccaaguucgagucccugggucuacaugguaggagagagcug gcuucugcaaguuguccucugaccaccacacauaaauaaauaacaaauguaauuuacaaacuuuuaaaagaaaauguaauuu aaaaaaccagacguucuagacuguucugggcuugggaaauauuuuuuucacuuuccuaagguguacuuuccuuugcuaca uuaauuauugcagccuuguucgaugaucuaaguggggauauuugacaauggcagauuuauucauugcaacaaggaaagac acagccauugaugaaaaaaaaaagaaagucucagcuuucagugacugggauaccugcuguccagggaggaggcucaguuag acuacccucugcuuacuugaggucugacaugcccaaugagaguguauuuagcuuuauuuaaaguucuuaaugccaacaguu uuaaaaaucacauuuaaaugaacuguacaagguagccagaccuugaauguaugaauagacuauauaauaugucccgagaaac uuuguuacucucagcucuguugauugcgaaaucuugcauagauuaugcuuugauuuaguuucu Fyn/Fyn 10 Sequence below. 250 proto- oncogene M27266 ccugggccccgccgcggacgcgcggagccgccugggccgcgccggaggagggcggggagaggaccaugugaaugugcucc ggagcugagcgccaagccaagcaguguuugaaaggaacaggaugcugaucuaaucguggcaaaaagucaguccgaccgcug guuucgaagacaugugguguauauaaaguuugugauaguugguggaaauuugggagcuuggauaaugggcugugugcaa uguaaggauaaagaagcagcgaaacugacagaggagagggacggcagccugaaccagagcucuggguaccgcuauggcaca gaccccaccccucagcacuaccccagcuucggcgugaccuccaucccgaacuacaacaacuuccacgcagcugggggccagg gacucaccgucuuugggggugugaacuccuccucucacacugggacccuacgcacgagaggagggacaggagugacacugu uuguggcgcuuuaugacuaugaagcacggacggaagaugaccugaguuuucacaaaggagaaaaauuucaaauauugaaca gcucggaaggagauuggugggaagcccgcuccuugacaaccggggaaacugguuacauucccagcaauuacguggcuccag uugacuccauccaggcagaagagugguacuuuggaaaacuuggccgcaaagaugcugagagacagcuccuguccuuuggaa acccaagagguaccuuucuuauccgcgagagccaaaccaccaaaggugccuacucacuuuccauccgugauugggaugaua ugaaaggggaccacgucaaacauuauaaaauccgcaagcuugacaaugguggauacuauaucacaacgcgggcccaguuug aaacacuucagcaacugguacagcauuacucagagaaagcugaugguuuguguuuuaacuuaacugugguuucaucaaguu guaccccacaaacuucuggauuggcuaaagaugcuugggaaguugcacgugacucguuguuucuggagaagaagcugggg cagggguguuucgcugaaguguggcuugguaccuggaauggaaauacaaaaguagccauaaagacccuuaagccaggcacc augucuccggaguccuuccuggaggaggcgcagaucaugaagaagcugaagcaugacaagcuggugcagcucuacgcgguc gugucugaggagcccauuuacaucgucacggaguacaugagcaaaggaaguuugcuugacuucuuaaaagauggugaagg aagagcucugaaguugccaaaccuuguggacauggcggcacagguugcugcaggaauggcuuacaucgagcgcaugaauua uauccacagagaucugcgaucagcaaacauucuaguggggaauggacuaauuugcaagauugcugacuuuggauuggcuc gguugauugaagacaaugaauacacagcaagacaaggugcgaaguuucccauuaaguggacagcccccgaagcggcccugu auggaagguucacaaucaagucugacguauggucuuuuggaaucuuacucacagagcuggucaccaaaggaagagugccau acccaggcaugaacaaccgggaggugcuggagcagguggagagaggcuauaggaugcccugcccacaggacugcccgaucu cccugcacgagcucaugauccacugcuggaaaaaggauccggaagagcgcccgaccuucgaguacuugcagggcuuccugg aggacuacuuuacggccacagagccccaguaucagcccggugaaaaccugugagagccugcgcuucagacgccucuucccga ggccucccuaccccuccccauuagcuuccaauucuguagccagcugccccagagcaggagaaccguccaggaucagauugca ugugacucuugaagcugaacuuccacggcccucauuaaugacacuugucccccaguccgaaccuccucugugaaccaucug agacagaagcguguuauuucucagacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuguucaguguaa auagcugcuccugugccaacaaucccagugcuuuccuuuuuuaaaaaagaaaaagcaaauccuaugugauuuuaacucuga uuucaccugauucaacuaaaaaaaaaaaaguauuauuuuccaaaaguggccucuuugucuaaaacaauaaaauuuuuuuuc auguuuuaacaaaaaaaaaaaaaaaaaaaaaaaa Structurally-related Col6a1/ 36 Sequence below. 251 Procol- lagen, type VI, alpha 1 X66405 cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucugccuuucccagcgccca cccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggcccacgcucugcugccccugcu gcuacaagccugcuggguggccacacaggacauccagggcuccaaagcgauugccuuccaagacugcccuguggaucuauu cuucgugcucgacaccucggagaguguggccuugaggcugaaaccuuauggggccuugguggacaaggugaaguccuuca cuaagcgcuucauugacaaccugagagacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacu acagugacgagguggagaucauccgagggcucacgcgcaugcccaguggccgcgaugagcucaaggccagcguggaugcgg ucaaguacuucgggaaaggcaccuacaccgacugcgccauuaagaaggggcuggaggagcugcucauagggggcucccacc ugaaggagaacaaguacuugaucguggugaccgacgggcauccucuagagggcuacaaggaaccaugcgggggucuggaag augcaguaaaugaggccaaacaccugggcaucaaggucuuuucuguggccaucacaccugaccaccuggagccacgucuaa guaucauugccacagaccacacauaccggcgcaauuucacggcagcugacugggggcauagccgcgaugcagaagagguca ucagccagaccauugacaccauuguggacaugauuaaaaauaacguggaacaaguguguuguucuuuugagugccaggcug ccagaggaccuccagggccccgaggcgacccuggguaugagggggagcgaggaaagccaggucuuccgggagagaagggag aagcuggagacccuggacgaccuggggaucuuggaccagucggguaccaggguaugaagggagaaaaggggagccgugga gagaaggguuccagaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucgacggcaugaaggga gagacgggguacccaggacuaccgggcugcaagggcuccccaggauuugauggcauucaaggacccccgggucccaagggu gaugcuggugccuuugggaugaagggagaaaagggugaagcuggagcagacggugaggcugggagaccagggaacucagg gucaccuggagaugagggugauccuggagagccugguccccccggagaaaaaggagaggccggugaugaaggaaaugcug gcccagacggugccccuggagagagggguggcccuggugaaagaggaccucgggggaccccuggugugagaggaccaagg ggagacccgggugaagcuggaccacagggugaccaaggaagagaggggcccgucggcaucccuggagacucgggugaggcu ggccccauuggaccuaaaggauaccgaggugaugaggguccuccagguccugagggccucagaggagccccaggaccuguu gguccuccuggagaccccggacugaugggugagagaggugaggauggaccaccaggaaacggcacggaagguuuccccggc uucccuggguauccaggcaacagaggcccuccugggcuaaauggcacaaaaggcuacccuggccucaagggggaugagggu gaagugggagacccaggagaggauaacaacgacauuucaccccguggggucaaaggggcaaagggauaccgaggcccagaa ggaccccagggaccuccaggacaugugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugc uccugcugugagugcacauguggacccauugacauccucuucgugcuggacagcucggagagcauuggccuacagaacuuu gagauugccaaggacuucaucaucaaggucauugaccgguugagcaaggaugagcuggucaaauuugagccagggcagucu cacgcgggcgugguacaguacagccacaaccagaugcaagagcacguggacaugcggagccccaacguccgcaacgcccagg acuucaaagaagcugucaagaagcuacaauggauggcugguggcacauucaccggagaagcgcugcaguacacccgggacc ggcuacucccacccacacagaacaaccgaauugcccuggucauuacggauggacguucugacacucaacgggacacgacacc ucucagugugcucuguggugcagacauucagguaguuucugugggaaucaaggauguguuuggcuuuguggcgggcucc gaccagcucaaugucauuuccugccaaggcuuaucgcaaggucguccagguaucucccuggugaaggagaacuaugcagag cuucucgaugacggcuuucugaagaacauaacagcccagaucuguauagauaagaaguguccggauuauaccuguccaauc acauucuccuccccggcugacaucaccauccugcuagacagcucagccagugucggcagccacaacuucgaaaccaccaagg ucuucgccaagcgccuagcugagcgauuccugucagcaggcagggcggauccuucccaggaugugcggguggccguggua caguauaguggccaggggcagcaacagccaggucgggcggcucuucaguucuuacagaauuacacagugcuggccagcucu guggacagcauggauuucaucaacgacgccacagacgucaacgaugcucugagcuacgugacucguuucuaccgggaagcc ucgucaggugccaccaagaagagagugcuguuguuuucagacggcaacucucagggggccacagcagaggccauugagaag gcugugcaggaggcccagcgugcaggcauugagaucuuuguggugguggugggaccccaggugaacgagccccacauccg ugugcuugucacuggcaagacugcagaguacgacguggccuuuggcgagcgccaccuauuccguguaccaaacuaccaggc ccugcuacguggcguacucuaccagacagucuccaggaagguggcacugggcuagagggccacacacguggcuggacacac auggcauggagacacauuucaacaggccuucccgcccuucccacugacaaaacaggaauaggaaaugugacccaacugguca acucaacugucuuaaagggaacgcugagaugcacacucuuugcuuuguguaauguccccuguggcucaccugagcuccuau cuagaucccgcccuugguuuguacaucaugguggccaucuugcugaccccucccccaucugggacuggauccagccaucuc gucuuccuccucacugccccuaaccuauccguggugucuucacaccaucacugcaguuuccgucuguguucugucuuccau gcucaacaugaagcagaccuucucaugaguucagcuugcuggauuauggcuuuuaggaaauugaacacaggaggaguucca aacacaaacuuggaggagaccccuccucuucaucaggugcuugucagugaccuacaugcaucuuggucugguccuuagugg cuaguccuuccacucugaaagcaaaggugcuaucuaucuguaagggcucucucuacacacccagaggcuuagcuuggacag uucacacucaaguguccugucagaaucaauccagagcuuucucccucaaaauagugacuugucucccccugguccccaaagg cuccccuuuaguuaguuucuucauggcucccccacauuccccguaaucugauccaagccagcuaucucugcuaauaaaggu uuccauuuuucaaaaaaaaaaaaaa Tnc/ 17 accccaugccccacccccaccuucgauguuuugaacauuucuaacaacug 252 Tenascin C aagccaguaaagucauauucuuuaaauuuccaggacauucauauuauuc AV230686 acauaaucauggucauggugaugauggaaacugaggacuuuaaaagaga X56304 uuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuu guuuuguuuuguuuuuuaauaaaagcacaguacuuuucc Krt2-6a/ 10 Sequence below. 253 Keratin complex 2, basic, gene 6a (keratin 6a) K02108 gucugcccugccguuucucuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaaagucaaacc agccaccguggcuacagugccagcucagccagagugcuuggacucaaccgcucgggcuucagcaguguguccgugugccgc ucccggggcagcgguggcuccagugcaauguguggaggagcuggcuuuggcagcaggagccucuaugguguggggagcuc caagaggaucuccaucggagggggcagcuguggcauuggaggaggcuauggcagccgauucggaggaagcuucggcauug gugguggagcugguaguggcuuuggcuucggugguggagcuggcuuuggugguggcuaugggggagcuggcuucccgg ugugcccacuuggaggcauccaagaggucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccau ccagcgggucaggacugaggagagggagcagaucaagacccucaauaacaaguuugccuccuucaucgacaaggugcgguu cauggagcagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacaccaagaccgugaggcagaacaug gagcccauguuugagcaguacaucagcaaccuccgcagacagcuggacagcaucauuggagagaggggucgcaugaacuca gagcugaggaacaugcaggaacucguagaagaacuacggaacaaauaugaagaugaaaucaacaagcgcacagacgcagaga augaauucgugacccugaagaaggauguagaugcugccuacaugaacaaaguugaacugcaagccaaggcagacagucuaa cagaugauaucaacuucuugagagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacacaucugugg uccucuccauggucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugaggucauagcuc agagaagucgggcugaagcugagucauuguaccagacuaaauaugaggagcugcaggucacagcuggcagacauggggacg accugcgcaacaccaagcaggagauugcugagaucaaccgcaugauccagaggcugagaucugagaucgaccacguuaagaa gcagugugccaaccugcaagcugcuauugcugaugcugagcaacguggggagauggcccugaaggaugcaaggggcaagc uggaagggcuggaggaugcccugcagaaggccaaacaggacauggccaugcugcugaaggaguaccaugaacucaugaaug ucaagcuggcccuugauguggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggugaaggu guuggaccagucaacaucucuguggugcaguccaccguguccagcggcuauggcagugccgggggugccagcagcagcuu aggcauggguggaggcagcagcuacuccuauagcagcagccauggccuuggagguggcuucagugcuggcaguggcagag ccaucggagguggccucagcucuucugguggccucagcucuucuaccaucaaauacaccaccaccuccuccagcaagaagag cuacaggcagugaauucugucaccaagagcuugucucuggucccagaugucauggcugcagcugaaccacaugcuuugguu cccggaagggaacgaaucccaaccucuggccuccccauggcucaguucuacauuuguguugcacgucagcaccuauacaug uucuuuggugacccagaccccaaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccu aaauucugucaugguucugacuuccuccagagucuguaaaauaaaaugcccccacaacaaac Channel-related Potassium 14 uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuc 254 channel, caguucacaguuuauacgugguacaucccaccaugucagcuuccaga subfamily acggcuauucaggagauggguggagcuuucuuuguaaaggaacccga K, member cauuuuaaaauuuugguuagaaucuucauagguuuauaaaaguacuc 2 ucugcaagcgaacuggauauauuuacauuuauagcuuaaauucaaau AI849601 uuuggaaaauaggaaucuuuuuguguuuuuaaacauccuggguuua ugucuuaagacuuuacucugaaugccacaugaucacguaagcccaag ccucccccagaagggaaaaaucaguuuugc Skd3/ 4 uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuua 255 Suppressor uuagauguucagggcacagacagguggaugcuagaugguguagcaca of K+ ccuucucaggguggaguggugccuggauguccaguuugcgggucuu transport gcuguccuuaucaaugaucuccagucgcaauguagguggacgcuucu defect 3 cagccuggggugagggcagcucacggcucuugaggaggugcuuguc AI837887 cgaauccuccacagugauacccagggugcaacccccugg Clic4/ 3 uuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuu 256 Chloride acacaauauuacaacucccccaguacauaaauguuccuauaccaugca intracellular cacagcaacaugggguccacugaugucgcaggcgacuuuucuaaugg channel 4 uggaacauagcaccucaaguucugccaucuacacagugaagggacgu (mito- gauggucggggcuccagagugacagcaaacugccucuugggugacac chondrial) gcuuguggcgaagugccucc AI845237 Col18a1/ 5 Sequence below. 257 Endostatin (alpha 1(XVIII) collagen) L22545 gagaauguugcugaggagguggggcugcugcagcuccuuggagacccccuaccugagaagaucucacaaaucgaugacccu cacgucgggccggccuacaucuuuggaccagacuccaacaguggccagguggcccaguaucauuucccaaaacucuucuuc cgggacuuuucgcugcuguuucauguccggccagccacagaggcagcaggggugcuauuugccaucacagaugcugcccag gugguagucucacugggcgugaagcucucagagguccgagauggacagcaaaacaucucauugcucuacacggagccuggg gccagccagacccagacgggagccagcuuccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgac ggaggcucuguggcucucuacguagacugugaagaauuccagagggugccauuugcucgggccucgcagggacuggagcu agagcguggcgcuggccucuuugugggucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagcuga agguacgcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgggcaucuggagauu uuggaaguggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuaccugggcucccucagccaccuccug ucacuuccccaccccuggcuggaggcagcaccacagaagauccuagaacagaagaaacggaggaagacgccgcgguagauuc uauaggagcugagacccuuccuggcacagguucaagcggugcaugggaugaggcuauccagaaccccggaaggggcuugau aaagggagguaugaaaggacaaaagggagaaccaggugcccagggcccaccuggcccagcuggcccccaggguccugccgg uccagugguccagagccccaacucacaaccugucccuggagcacaaggacccccgggaccucaggggccaccagggaaggau ggcacuccaggaagggauggugaaccgggugacccuggugaagaugggagaccgggugacacuggaccucaaggcuuucca gggaccccaggagaugugggcccuaagggcgagaagggagauccugguauugggccccgaggaccuccagggccuccaggg ccaccaggacccuccuucagacaagacaagcugaccuucauugacauggagggauccgguuucagcggagacauagagagcc uuagaggcccacgaggcuucccuggccccccggggcccccuggugucccaggacuuccuggugagccaggacgcuuuggga ucaaugguuccuaugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuuccaggucccc cgggaccuccagguccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguuggugaugugggcaucc caggacccaaggggagcaaaggagaccuugggcccaucgguaugccuggcaagucuggcuuggcuggauccccugggccag uuggacccccaggaccuccagggccuccagggccaccaggaccaggauuugcugcuggauucgaugauauggaaggcucug gaauaccccucuggacaacagcccgaagcucugaugggcugcagggaccucccgggucgccgggacucaagggggauccug gaguggcaggccuaccuggagccaagggagaaguuggagcagauggagcccagggcaucccuggucccccaggaagagaag gugcagcuggaucuccggggccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggcc ggccgggccucccugggccuccaggaccuccagggcuggugaucuaugugucaagugaggauaaagcaauagugagcacgc caggaccugagggcaagccaggguacgcaggcuuuccuggaccugcuggaccgaagggugaccuggguuccaaaggcgagc agggucuuccgggguuuaagggugagaagggagagccaggcacuaucuuuaguccugauggcagacgucugggccauccc cagaagggagccaagggagagccaggcuuucgaggacccccggguccuuauggacgaccugggcacaagggugaaauuggc uucccuggacggccgggucgaccuggaacgaauggcuuaaagggagagaagggagagccuggagaugccagccuuggguu cagcaugaggggauugccuggccccccugggccuccaggacccccagguccuccugggaugcccaucuaugacagcaaugc auuuguggagucuggccgaccuggacuaccaggacagcagggugugcaggggccuucaggaccaaagggugacaaaggaga gguggggccaccugggccaccagggcaauuccccauugaccucuuccaccuggaagcggaaaugaagggggacaagggaga ccgaggggaugcuggacagaaaggagagaggggagaaccuggggcuccuggugguggauucuucagcucaaguguaccug gcccacccggcccaccuggauacccuggaauuccggguccaaagggagagagcauccgggggccaccuggcccuccuggccc gcagggaccuccuggcauuggcuaugagggucgccagggucccccaggaccuccaggaccuccaggaccucccuccuuccc uggcccucacagacagacugucaguguuccugguccuccgggcccaccugguccuccaggucccccaggagccaugggugc cucugcugggcaggugaggaucugggccacauaccagaccaugcuggacaagauccgggaggugccggagggcuggcuca ucuuuguggccgagagggaagagcucuauguacgcguuagaaauggcuuccggaaggugcugcuggaggcccggacagcc cuccugagaggcacgggcaaugagguggcugcuuuccagcccccauugguccagcuucaugagggcaguccauacacccgg agggaguacuccuauuccacggcacgacccuggcgagcagaugacauccuggccaacccaccgcgccugccagaccgccagc cuuacccuggaguuccacaucaccacaguuccuaugugcaccugccgccagcccgccccacccucucacuugcucauacuca ucaggacuuucagccagugcuccaccugguggcacugaacaccccccugucuggaggcaugcgugguauccguggagcaga uuuccagugcuuccagcaagcccgagccguggggcugucgggcaccuuccgggcuuuccuguccucuaggcugcaggauc ucuauagcaucgugcgccgugcugaccgggggucugugcccaucgucaaccugaaggacgaggugcuaucucccagcugg gacucccuguuuucuggcucccagggucaagugcaacccggggcccgcaucuuuucuuuugacggcagagauguccugag acacccagccuggccgcagaagagcguauggcacggcucggaccccagugggcggaggcugauggagaguuacugugagac auggcgaacugaaacuacuggggcuacaggucaggccuccucccugcugucaggcaggcuccuggaacagaaagcugcgag cugccacaacagcuacaucguccugugcauugagaauagcuucaugaccucuuucuccaaauaggccucugccagcuaggg uggcagacagaggccaugcagaacuuugacacagcgcagggagcauucagucagcacccagggcucuggcugggauacaac uccuguauaguucccauuuuuauguaauccucaagaaauaaaaggaagccaaagaguaaaaaaaaa

TABLE 5 Genes down-regulated in HF stem cells. Gene Fold SEQ Name/protein Decr Sequence ID No. Growth Factors, Receptors and Downstream genes GNA- 14 32 Sequence below. 258 Mouse G protein alpha subunit (GNA- 14) M80631 aacugccuucgagaagcguuagccuagagauccgagccucuucuccauaccauaguugguucaggugguuuccucuucaaa ccuugcgucugcggauaauccgcgcggccgggcguuaagcuccaggucccugucgcuccgucgagguggcaagccauggcc ggcugcugcuguuugucugcggaggagaaagagucucagcgcaucagcgcggagaucgagcggcacguucgccgcgacaa gaaggacgcgcgccgggagcucaagcugcuguugcugggaaccggugagagugggaaaagcaccuuuaucaagcagaugag gauaauccaugggucuggcuacagugaugaagauagaaagggcuucacgaagcugguuuaccaaaacauauucacggccau gcaagccaugaucagagcaauggauacccugaggauacaauacaugugugagcagaauaaggaaaaugcccagaucaucagg gaaguggaaguagacaaggucacugcacucucuagagaccagguggcagccaucaagcagcuguggcuggaucccggaauc caggaguguuacgacaggaggagggaguaccagcugucagacucugccaaauauuaccugacggacauugagcguaucgcc augcccucuuucgugccaacacaacaggaugugcuucguguuagagugcccaccacuggcaucauagaauauccauucgac cuggaaaacaucaucuuccgaaugguggauguugguggccagcgaucugaacgacggaaauggauucacugcuuugagag ugucaccuccaucauuuucuugguugcucugagugaauaugaccagguucuggcugagugugacaaugagaaccgcaugg aggagagcaaagcccuguuuagaaccaucaucaccuaccccugguuucugaacuccuccgugauucuguucuuaaacaaga aggaucuucuagaggagaaaaucauguacucucaucuaauuagcuacuucccagaguacacaggaccaaagcaagaugucaa agcggccagggacuuuauccugaagcuguaucaagaccagaauccugacaaagagaagguuaucuauucucacuucacuug ugcuacagacaccgagaauauccgcuuuguguuugcugcugucaaagacacaauccuacagcuaaaccuacgggaguucaa cuugguguaaauggagggccuacuccuccgagacagagggugaucugagcccuuccugccugaucuacaagugcuucugg accaggaccuaaggacauuauguagcccacaggacagagauggguagugcaaugugaaaaauacuucaccaacccuuuuaag ugucuuuaauucuucacugucuaacucuuuucucgccuuuugguugaacgauuagguaucauuuuugagugguucccccu cuccuauuuuuuuaaacuaguguucaacaguuauuaaaaaaucaugc Ly6/Lympho- 12 gaauucccugcaaccuugucugagaggaagcaaggacuggugugag 259 cyte antigen 6 gagggagcugugagguuuuaucugugcagcccuucucugaggaug complex gacacuucucacacuacaaaguccuguuugcugauucuucuugugg X04653 cccuacugugugcagaaagagcucagggacuggaguguuaccagug cuauggagucccauuugagacuucuugcccaucaauuaccugccccu acccugauggagucuguguuacucaggaggcagcaguuauuguggg uucucaaacaaggaaaguaaagaacaaucuuugcuuacccaucugcc cuccuaauauugaaaguauggagauccuggguacuaaggucaaugu gaagacuuccuguugccaggaagaccucugcaaugcagcaguuccca auggaggcagcaccuggaccauggcaggggugcuucuguucagccu gagcucaguccuccugcagaccuugcucugaugguccucccaaugac cuccacccuuguccuuuuauccucaugugcaacaauucuuccugga gcccucuagugaugaauuaugaguuauagaagcuccaaggugggag uagugugugaaauaccauguuuugccuuuauagcccugcuggguag guaggugcucuaauccucucuagggcuuucaagucuguacuuccua gaaugucauuuuguuguggauugcugcucaugacccuggaggcaca cagccagcacagugaagaggcagaauuccaagguauuaugcuaucac cauccacacauaaguaucugggguccugcaauguucccacauguauc cugaaugucccccuguugaguccaauaaacccuuuguucuccc Bmp4/Bone 11 Sequence below. 260 morphogenetic protein 4 L47480 ggaagaaagagagggagggaaaagagaaggaaggaguagaugugagaggguggugcugagggugggaaggcaagagcgcg aggccuggcccggaagcuaggugaguucggcauccgagcugagagaccccagccuaagacgccugcgcugcaacccagccu gaguaucuggucuccgucccugaugggauucucgucuaaaccgucuuggagccugcagcgauccagucucuggcccucgac cagguucauugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaauggugagcaggg caaccuggagaggggcgcuauucugaggauucgaggugcacccguaguagaagcuggggauggggcucaggcuguaaccg aggcaaaaguuggccuauuccuccuuccuucuccaacaguguuggaggugggaugauggaggcuaaaaggcaccuccauau auguuacugcgucuaucaaccuacuuuagggaggugcgggccaggagaggcgggaaggagagaaggccuuggaagagagg ucauugggaagaacugugggguuugguggguuugcuuccacuuagacuauaagagugggagaggagggagucaacucuaa guuucaacaccagugggggacugaggacugcuucauuaggagagagaaccuagccagagcuagcuuugcaaaagaggcugu aguccugcuuugcucuaaagcgcgacccgggauagagaggcuuccuugagcggggugucaccuaaucuuguccccaacgca cccccucccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuauuuucuuagacauggg cacccaugauucugccuucugguacucuccccucccugggaaagggguguaagguuccgacggaaccguggccaggaugcc gaaaggcuaccugugcgggucuucugccaugcugugucugugcggacaugccagcagggcuaaugaggagcuugcgauac uccaaaggguucgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgccacggcu uugguugauaguuuuuuuaguauccugguuuaugaacugaagguuuugugagauguugaaucacuagcagggucauauu uggcaaaccgaggcuacuauuaaauuuugguuuuagaagaagauucuggggagaaagugaaggguaacugccuccaggag cuguaucaaccccauuaagaaaaaaaaaaauaccaggagaugaaaauuuacuuugaucuguauuuuuuaauuaaaaaaaauc agggaagaaaggagugauuagaaagggauccugagcgucggcgguuccacggugcccucgcuccgcgugcgccagucgcua gcauaucgccaucucuuucccccuuaaaagcaaauaaacaaaucaacaauaagcccuuugcccuuuccagcgcuuucccagu uauucccagcggcgacgcgugucggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcggacuguc gcucaggggcgcccgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgccaggaaggacgu gacucuccauccuuuacacuucuuucucaaagguuucccgaaagugccccccgccucgaaaacuggggccggugcgggggg ggggagagguuagguugaaaaccagcuggacacgucgaguuccuaagugaggcaaagaggcgggguggagcgggcucugg agcgggggaguccugggacucgguccucggauggaccccgugcaaagaccuguuggaacaagaguugcgcuuccgagguu agaacaggccaggcaucuuaggauagucaggucacccccccccccaaccccacccgaguuguguuggugaauuucuuggag gaaucuuagccgcgauucuguagcuggugcaaaaggaggaaaggggugggggaaggaaguggcngngcggggguggcgg uggggguggaggugguuuaaaaaguaagccaagccagagggagaggucgagugcaggccgaaagcuguucucggguuugu agacgcuugggaucgcgcuuggggucuccuuucgugccggguaggaguuguaaagccuuugcaacucugagaucguaaaa aaaaugugaugcgcucuuucuuuggcgacgccuguuuuggaaucuguccggaguuagaagcucagacguccaccccccacc ccccgcccacccccucugccuugaauggcaccgccgaccgguuucugaaggaucugcuuggcuggagcggacgcugagguu ggcagacacgguguggggacucuggcggggcuacuagacaguacuucagaagccgcuccuucuaacuuucccacaccgcuc aaaccccgacacccccgcggcggacugaguuggcgacggggucagagucuucuggcugaaaguuagauccgcuaggggucg gcugccugucgcuagaagcauuauuuggccucucggagacccguguggaggaagugcuggagugugcgaguguguuugc gugugugugugugugugugugugugugugugugugugugugugugcgcgcgcccuuggagggucccuaugcgcuuucc uuuucauggaacgcugucgugaggcuuugguaaacugucuuuucgguuccucucucggcugcacuuaagcuuugucggcg cuguaaagagacgcgucuucaagugcacccugauccucaggcuucagauaacccguccccgaaccuggccagaugcauugca cugcgcgccgcagguagagacgugccccacguccccugcgugcagcgacuacgaccgagagccgcgccagugugguguccc gccgagaguuccucagagcaggcggggacaacucccagacggcuggggcuccagcugcgggcgcggagguuggccucgcuc gcaggggcuggacccagccggggugggaggauggaggaggggcgggcgggcucuucggugaguggggcggggccucugg guccacgugacuccuaggggcuggaagaaaaacagagccugucugcuccagagucucauuauaucaaauaucauuuuagga gccauuccguagugccauucggagcgacgcacugccgcagcuucucugagccuuuccagcaaguuuguucaagauuggcuc ccaagaaucauggacuguuauuaugccuuguuuucugucagugaguagacaccucuucuuucccuucuugggauuucacu cuguccucccaucccugaccacugucugucccucccgucggacuuccauuucagugccccgcgcccuacucucaggcagcgc uaugguucucuuucuggucccugcaaggccagacacucgaaauguacgggcuccuuuuaaagcgcucccacuguuuucucu gauccgcugcguugcaagaaagagggagcgcgagggaccaaauagaugaaagguccucagguuggggcugucccuugaag ggcuaaccacucccuuaccagucccgauauauccacuagccugggaaggccaguuccuugccucauaaaaaaaaaaaaaaaa acaaaaaacaaacagucguuugggaacaagacucuuuagugagcauuuucaacgcagcgaccacaaugaaauaaaucacaaa gucacuggggcagccccuugacuccuuuucccagucacuggaccuugcugcccgguccaagcccugccggcacagcucugu ucuccccuccuccuguucuuaaccagcuggaaguuguggaaauugggcuggagggcggaggaagggcgggggugggggg guggagaaggugggggggggggaggcugaagguccgaagugaagagcgauggcauuuuaauucucccuccnccucccccc uuuaccuccucaauguuaacuguuuauccuugaagaagccacgcugagaucauggcucagauagccguugggacaggaugg aggcuaucunauuugggguuauuugaguguaaacaaguuagaccaaguaauuacagggcgauucuuacuuucgggccgug cauggcugcagcugguguguguguguguagggugugagggagaaaacacaaacuugaucuuucggaccuguuuuacaucu ugaccgucgguugcuaccccuauaugcauaugcagagacaucucuauuucucgcuauugaucgguguuuauuuauucuuu aaccuuccaccccaacccccuccccagagacaccaugauuccugguaaccgaaugcugauggucguuuuauuaugccaaguc cugcuaggaggcgcgagccaugcuaguuugauaccugagaccgggaagaaaaaagucgccgagauucagggccacgcggga ggacgccgcucagggcagagccaugagcuccugcgggacuucgaggcgacacuucuacagauguuugggcugcgccgccgu ccgcagccuagcaagagcgccgucauuccggauuacaugagggaucuuuaccggcuccagucuggggaggaggaggaggaa gagcagagccagggaaccgggcuugaguacccggagcgucccgccagccgagccaacacugugaggaguuuccaucacgaa ggucaguuucugcucuuaguccuggcgguguagggugggguagagcrccggggcagaggguggggggugggcagcuggc agggcaagcugaagggguuguggaagcccccggggaagaagaguucauguuacaucaaagcuccgaguccuggagacugu ggaacagggccucuuaccuucaacuuuccagagcugccucugaggguacuuucuggagaccaaguagugguggugauggg ggaggggguuacuuugggagaagcggacugacaccacucagacuncugcuaccncccagnggguguucuuuagcuauacc aaagncagggauucugcccguuuuguuccaaagcaccuacugaauuuaauauuacancuguguguuugucagguuuauca auaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuccaaaguaaaucugaguuauuaauccucca gcaucauuacuguguuggaauuuauuuucccuucuguaacaugaucaacaaggcgugcucuguguuucuaggaucgcugg ggaaauguuugguaacauacucaaaaguggagagggagagaggguggccccucuuuuucuuuacaaccacuuguaaagaaa acuguacacaaagccaagagggggcuuuaaaaggggaguccaagggugguggaguaaaagaguugacacauggaaauuauu aggcauauaaaggagguugggagauacuuucugucuuugguguuugacaaaugugagcuaaguuuugcugguuugcuag cugcuccacaacucugcuccuucaaauuaaaaggcacaguaauuuccuccccuuagguuucuacuauauaagcagaauucaa ccaauucugcuauuuuuuguuuuuguuucuuguuuuuguuuuguuugguuuuuuuuuuuuuuuuuuuuuuuuugucu cagaaaagcucaugggccuuuucuuuuccccuuucaacugugccuagaacaucuggagaacaucccagggaccagugagag cucugcuuuucguuuccucuucaaccucagcagcaucccagaaaaugaggugaucuccucggcagagcuccggcucuuucg ggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuaugagguuaugaagcccccagcaga aaugguuccuggacaccucaucacacgacuacuggacaccagacuaguccaucacaaugugacacggugggaaacuuucgau gugagcccugcaguccuucgcuggacccgggaaaagcaacccaauuaugggcuggccauugaggugacucaccuccaccag acacggacccaccagggccagcaugucagaaucagccgaucguuaccucaagggaguggagauugggcccaacuccgccccc uccuggucacuuuuggccaugauggccggggccauaccuugacccgcaggagggccaaacguagucccaagcaucacccac agcgguccaggaagaagaauaagaacugccgucgccauucacuauacguggacuucagugacgugggcuggaaugauugga uuguggccccacccggcuaccaggccuucuacugccauggggacugucccuuuccacuggcugaucaccucaacucaaccaa ccaugccauugugcagacccuagucaacucuguuaauucuaguaucccuaaggccuguuguguccccacugaacugagugc cauuuccauguuguaccuggaugaguaugacaaggugguguugaaaaauuaucaggagauggugguagaggggugugga ugccgcugagaucagacaguccggagggcggacacacacacacacacacacacacacacacacacacacacacacacguuccc auucaaccaccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuaaaaaaaaaaaaaagaaagaaagaaa gaaagaaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacucaccuugaccuuauuuaugacuuuacgug caaauguuuugaccauauugaucauauuuugacaaauauauuuauaacuacauauuaaaagaaaauaaaaugag IL1r2/Inter- 11 gaaucccacuuacaugcgagcaucucuauauacauccucaaucuauc 261 leukin 1 cccucgaauccacggacuuaucagucaaucaauacuacagucaaaga receptor, type auuuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuu II cuaaucaucuugguuguggggccaauauggaugcgcagacggugua AV223216 aacgcagggcuggaaagacauauggacugaccaagcuacggacugac X59769 aaccaggacuucccuuccagcccaaacuaaauaaaggaaaugaa Wnt3a/wing- 4 Sequence below. 262 less-related MMTV integration site 3A X56842 gaauucaugucuuacggucaaggcagagggcccagcgccacugcagccgcgccaccucccagggccgggccagcccaggcg uccgcgcucucgggguggacuccccccgcugcgcgcucaagccggcgauggcuccucucggauaccucuuagugcucugca gccugaagcaggcucugggcagcuacccgaucuggugguccuuggcugugggaccccaguacuccucucugagcacucagc ccauucucugugccagcaucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugcccagcg uggcugagggugucaaagcgggcauccaggagugccagcaccaguuccgaggccggcguuggaacugcaccaccgucagca acagccuggccaucuuuggcccuguucuggacaaagccacccgggagucagccuuuguccaugccaucgccuccgcuggag uagcuuucgcagugacacgcuccugugcagagggaucagcugcuaucugugggugcagcagccgccuccagggcuccccag gcgagggcuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggaguuugccgaugccag ggagaaccggccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgccagucacaugcac cucaagugcaaaugccacgggcuaucuggcagcugugaagugaagaccugcugguggucgcagccggacuuccgcaccauc ggggauuuccucaaggacaaguaugacagugccucggagauggugguagagaaacaccgagagucucguggcugggugga gacccugaggccacguuacacguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucacccaacuucugc gaaccuaaccccgaaaccggcuccuucgggacgcgugaccgcaccugcaaugugagcucgcauggcauagaugggugcgac cuguugugcugcgggcgcgggcauaacgcgcgcacugagcgacggagggagaaaugccacuguguuuuccauuggugcug cuacgucagcugccaggagugcacacgugucuaugacgugcacaccugcaaguaggagagcuccuaacacgggagcagggu ucauuccgaggggcaagguuccuaccugggggcgggguuccuacuuggaggggucucuuacuuggggacucgguucuuac uugagggcggagauccuaccugugagggucucauaccuaaggacccgguuucugccuucagccugggcuccuauuuggga ucuggguuccuuuuuaggggagaagcuccugucugggauacggguuucugcccgaggguggggcuccacuuggggaugg aauuccaauuugggccggaaguccuaccucaauggcuuggacuccucucuugacccgacagggcucaaauggagacaggua agcuacucccucaacuaggugggguucgugcggaugggugggaggggagagauuagggucccuccucccagaggcacugc ucuaucuagauacaugagagggugcuucagggugggcccuauuugggcuugaggaucccgugggggcggggcuucacccc gacuggguggaacuuuuggagacccccuuccacuggggcaaggcuucacugaagacucaugggauggagcuccacggaagg aggaguuccugagcgagccugggcucugagcaggccauccagcucccaucuggccccuuuccaguccugguguaagguuca accugcaagccucaucugcgcagagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauaccaagacc uaacaaaccccgugccuggguaccucuuuuaaagcucugcaccccuucuucaagggcuuuccuagucuccuuggcagagcu uuccugaggaagauuugcagucccccagaguucaagugaacacccauagaacagaacagacucuauccugaguagagaggg uucucuaggaaucucuauggggacugcuaggaaggauccugggcaugacagccucguaugauagccugcauccgcucugac acuuaauacucagaucucccgggaaacccagcucauccgguccgugauguccaugccccaaaugccucagagauguugccuc acuuugaguuguaugaacuucggagacauggggacacagucaagccgcagagccaggguuguuucaggacccaucugauuc cccagagccugcuguugaggcaauggucaccagauccguuggccaccacccugucccgagcuucucuagugucugucuggc cuggaagugaggugcuacauacagcccaucugccacaagagcuuccugauugguaccacugugaaccgucccucccccucca gacaggggaggggauguggccauacaggagugugcccggagagcgcggaaagaggaagagaggcugcacacgcgugguga cugacugucuucugccuggaacuuugcguucgcgcuuguaacuuuauuuucaaugcugcuauauccacccaccacuggau uuagacaaaagugauuuucuuuuuuuuuuuuucuuuucuuucuaugaaagaaauuauuuuaguuuauaguauguuuguu ucaaauaauggggaaaguaaaaagagagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa Il12rb2/ 3 Sequence below. 263 Interleukin 12 receptor, beta 2 U64199 cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugccaggaucccucucugcg uccugugcgcgggaagagcucuggagaaccagaguugcauucuggaguugaagacucauggcacagacuguuagagaaug cucauuggcacuucuuuuuuuguucauguggcugcugauuaaagcaaauauagaugugugcaagcuuggcacugugaccg uccagccugccccugugauuccucuugggucagcugccaauauuuccugcuccuugaaucccaagcaaggcuguucacauu aucccaguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccauggcaagaaaguccaug accacacuggucacuccuccacuuuucaagucaccaaccugucccuugguaugaccuuguuugucugcaagcuaaacugua gcaacucucaaaagaagccaccagucccaguaugugggguggagaucucaguugguguugcuccagagccaccucaaaaca uaucauguguccaggaaggagaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaaccaauu acacuuuacaguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaaucgucagaauugcaaucgcc uggaucuugggaucaaucuaagcccugauuuagcugaauccagguucauaguccguguuacugccaucaacgaucuuggaa auucuucuucacuuccgcauacguucacguucuuggacauagugaucccucuuccuccgugggacaucagaaucaacuuuc uaaaugcuucugggagcagagguacacugcagugggaagaugaggggcaagugguacucaaucaacucagauaucagccuc uuaacagcacguccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccugcgagaucugagaccguuuacaga auaugaauuucaaaucuccucuaagcuacaucucucuggaggaaguuggaguaauuggagugagucacugagaacacgaac accagaggaagagccuguugggauauuagacaucugguacaugaaacaagacaucgacuaugacagacagcagaucucucu uuucuggaagagucugaauccaucagaggcaagggggaagauccuccacuaucaggugacguuacaagaggugacaaagaa aacaacacugcagaauacuacaagacacaccuccuggaccagggucaucccccgaacuggggcuuggacggcaucagugucu gcagccaacucaaaaggcgcuucugcacccacucacauuaacauaguggaccuauguggcacuggguugcuggcuccucac caggucucugcaaagucggagaacauggacaacauucuagugaccuggcagccuccuaagaaagcugauucugcuguucgg gaguacauaguggaauggagagcucuccaaccagggagcaucacgaaguuucccccacacuggcugcggauccccccggaca acaugucugcucugauuucagagaacauaaagcccuauaucuguuaugaaaucagggugcaugcacugucagagagccaag gagggugcagcuccauccggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucacagagaaaaa ggaacgccuuuucauuuccuggacccacauuccauucccggagcaaaggggcugcauccuccauuacagaauauacuggaa agaacgagacucgacagcacaaccugagcucugcgaaauucaguaccgacgcucucaaaacucacauccaauaagcagccuac agcccagggugacauauguccuauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagggaauuuu guccacagggcaaagccaacuggaaagcauucgugauaucaagcauuugcaucgcuaucaucacggugggcacguucucaa uucguuacuuccggcaaaaggcauuuacucuccugucuacucucaaaccucaaugguauagcagaaccauuccagauccagc aaacagcacuuggguaaagaaguaucccauucuggaggagaagauccagcuaccuacggauaaucuccugauggcauggcc cacuccugaagagccugagccccugaucauccaugaaguccucuaccacaugaucccaguugucagacaaccauauuacuuc aaaagaggccaaggauuccaaggcuacucuaccuccaagcaagaugcaauguauauugccaauccacaagcuacaggaacuc ucacagcugagaccagacaacuagugaaccuauacaaggugcuagaaagcagagacccugacucaaaacuggccaaccugac cagccccuugacagucaccccagugaacuaccuuccuagccaugaaggcuauuuacccuccaacauagaagaucugucacca caugaggcugacccaacugauucuuuugaccuggagcaucaacauauuucucuuuccauuuuugcaucaaguucucuccgc ccacucaucuucgguggugagcggcugacucuagaucgguuaaagaugggcuaugacucccucaugaguaaugaggcuug auacuagaaagccaacguaccucauuuuaucugcccaguuccuacuccaaaggucugugacagugaagacaagccagcuguc ucuggauaaaguuagcuucaccauagguacuuaagucuuauggauaagguggcaauacaccaacacugauaucauauagaa aggaccccaagauagucaugcuc Wnt10a/Wing- 3 Sequence below. 264 less-related MMTV integration site 10a U61969 ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccaguccaaagcggacucaguggc cucggggacgggagcaugccaccuccuguggugacgucacuugggguagaacccuuagacacuacauggggggggggggu acagaacucccgagccaggacagucacucacucuucaggcgguggggcugggccagacaguaccgcccccaccgcgcccgcc ucgcacacccucggaagcgcaggcucgcagcgcggcgcuggggugggggguugcgccccagaacuucggccuccagucccc agcccgcugcaccuccuuacccucuagaggcccccucccccuuacccucuagaggcaccaggaguugucgcaaggggcccuu gggaaauucccuggaccccugugccaggaggugcccgguucgcccgcuccccauccacccccccgagggcggugcccgggg gcgcugccccauggagcggggaggcgggcgccgucugcugcgggagcugugaccugaguaggagcugugugucgcagccg ccccaccccugccgaucaugcgccggcgacccugguucgccagucccacugggcugugagccccccacuccuggccugucac ggcccgcgcgccaugggcagcgcccacccucgccccuggcugcggcucccacaagggccccagccgcggccugaguucugg gcgcuccuguucuuccuacugcugcuggcugccgcugugcccaggucagcacccaacgacauccugggccuccgccuaccc ccagagcccgugcucaacgccaacacagugugccugacauugcccggccugagccggcggcagauggaggugugugugcgu cacccugacguggccgccucugcuauccagggcauccagaucgccauccaugagugccagcaucaguuccgggaccagcgc uggaacugcuccagccuggagacucggaacaaaguccccuacgagagccccaucuucagccgagguuuucgagagagugcu uucgccuacgccauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucuggguaaacugaaggcuugcgg uugcgacgccuccagacguggggacgaagaagcuuuccgucggaagcugcaccgcuugcagcuggacgcgcugcagcgcgg aaagggcuugagccacggggucccugaacacccggccauacuuccugccagcccaggucugcaggacuccugggagugggg uggcugcaguccggaugugggcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagagacaucca ugcucgaaugagacuccacaacaaccgugugggccggcaggcggugauggagaacaugcggcguaagugcaaaugccacgg caccucaggcagcugccagcucaagaccugcuggcaggugacgccugaguuccgcacaguaggggcgcugcugcgcaaccg cuuccaccgcgccacgcucauccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcacccucgcca gcaccgggcacuccagggcugcgccgcagggccagccacuccgaccuggucuacuuugagaaaucucccgacuucugugag cgcgagccgcgccuggacucggcaggcacugugggccgccugugcaauaagagcagcacgggucccgauggcugcggcagc augugcuguggccgcggccacaacauucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggugcugcuuc guggucugcgaagaaugccgcaucaccgagugggucagcgucugcaagugagcagacccaagcuccucugggucucaagaa ugguuguccucuuggugccuggcuucugccgcuagcggaucugagccaggcagcaagcagcagccuuggcuccugagaga ggugguuggcucuuacagccccgagggucuacaaucaccagacaguccagaucugauugacauuccuccgcucaccucugu agguuccccucuuucuguuccuagcucagacagcugggggugauaguggagacuguuccacacccuaggacaggucaccaa agcagcccagccuggcaugccuaccuccugucaucucuucuucccuuccccaggagugauaggcaaugcacugaagcugau gggcaccggggaagaaaacuaaaaggcagaaauggccgucaucgggcugaagugacucuaagggcuccagaccucugcucc ugucuuucacuuaacagauauuuauuuuugcgcucucuuugagacacucucuggggaaaaagaagcuccggagucuacag gcugauuaagggacauggacaauaaaccaguaaacacacaaaaaaaaaaaaaaaaaa Ifngr2/Inter- 3 Sequence below. 265 feron-gamma receptor precursor M28233 gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacgggcagcgcggguccccuguca gaggugucccucgcgcaggaaugggcccgcaggcggcagcuggcaggaugauucugcuggugguccugaugcugucugcg aaggucgggaguggagcuuugacgagcaccgaggauccugagccucccucggugccuguaccgacgaauguucuaauuaag ucuuauaacuugaacccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuacuguacagguaaaggug uauucggguuccuggacugauuccugcaccaacauuucugaucauuguuguaauaucuaugaacaaauuauguauccuga uguaucugccugggccagaguuaaagcuaagguuggacaaaaagaaucugacuaugcacggucaaaagaguuccuuaugug ccuaaagggaaaggucgggcccccuggccuggagaucaggaggaagaaggaagaacagcucuccguccucguauuucaccc ugaagucguugugaauggagagagccagggaaccauguuuggugacgggagcaccuguuacacauucgacuauacugugu auguggagcauaaccggaguggggagauccuacauacgaaacauacggucgaaaaagaagaguguaaugagacucugugug aguuaaacaucucaguauccacacuggauuccagauauuguauuucaguagacggaaucucaucuuucuggcaaguuagaa cagaaaaaucgaaagacgucuguaucccuccuuuccaugaugacagaaaggauucaauuuggauucuggugguugcuccuc uuaccgucuuuacaguaguuauccugguauuugcguauugguauacuaagaagaauucauucaagagaaaaagcauaaugu uaccuaaguccuugcucucugugguaaaaagugccacguuagagacaaaaccugaaucgaaguauucacuugucacaccgc accagccagcuguccuagagagugagacggugaucugugaagagccccuguccacagugacagcuccagacagccccgaagc agcagaacaggaagaacuuucaaaagaaacaaaggcucuggaggcuggaggaagcacgucugccaugaccccagacagcccu ccaacuccgacacaaagacgcagcuuuucccuguuaaguaguaaccagucaggcccuuguagccucaccgccuaucacuccc gaaacggcucugacaguggccucgugggaucgggcagcuccauaucggacuuggaaucucucccaaacaacaacucagaaac aaagauggcagagcacgacccuccacccgugagaaaggcccccauggccuccgguuaugacaaaccgcacauguugguggac gugcuuguggauguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguccuaaggucu cccgaggccugcuggugguaaagaaacugaccuuuuaggcaguuuuucugcauugauuucaugaaagaagcuauacauua gcuaauacuaaccacauagaauaucagacuuagauacgugaauaaggauccugugggcacugcuggguccacucugcaaau gccaagacuaucaaaggaacguauugucgcuucuggcuccuucccaggugggcuagcaucugugaguuugccucggcuag ccuugcuuccuacagccgccacugcuccuccacccugaucaucucacaggacaggguggaccggguuuuuuuuuuuuuuuc acacaccuuuguauauguaaguucauguauauaauauguuuacauguuucacuuugaacugaaagcuacucaaagccagcc guaagucuaugguagaaugugauggaacauguugguggaagcuuguacaauagaacacauuggugggagcuuguacauac uuuuuuauggagcauuacuuacgauuuuuuaaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc Fgfbp1/ 3 augagacuccacagccucauccugcucuccuuccuucuccuggcuac 266 Fibroblast ucaggcguucucagaaaaggucagaaagagagccaagaacgcaccac growth factor acagcacagcggaggaggggguagaggguucagcucccucguuagg binding protein gaaggcccagaauaagcagagaagcaggacaucuaaaucucugacgc 1 auggcaaguuugucaccaaagaccaagccacaugcagaugggcugug AF065441 acugaggaggagcagggcaucagccugaagguccagugcacacaagc cgaucaggaguuuucuuguguuuuugcuggugacccaacugacugc cuuaaacacgacaaagaccagaucuacuggaaacagguugcccgcac gcugcgcaaacagaaaaauaucugcaggaacgccaagagugucuuga agaccagagugugcagaaagagauuuccagagucuaaccucaagcug gugaaccccaacgcacguggaaacacgaagcccaggaaggagaaagc agaggucuccgcaagggagcacaacaagguccaagaagcugucucca cggagccaaacagggucaaagaagacaucacacucaauccagcugcg acccagaccauggccauuagagauccagagugucuagaggauccaga ugugcucaaccagaggaagaccgcccuggaguucuguggggaaucu uggagcuccauuugcacauucuuccucaacauguuacaggcgacauc augcuaa Transcription Factors and Related Genes Klf5/Kruppel- 5 aauucgucgacaugcgccguuccagugcauggugugccaacgcagc 267 like factor 5 uucucccgcuccgaccaccucgcgcugcacaugaagcgccaccagaa AA611766 cugagcgagcgagcgcugccccacccgccugacgccuugcaguccgc ucugccauccuuuaaaccgcagaccuaacuucauaaaaaga Gata3/GATA 4 Sequence below. 268 binding protein 3 X55123 gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuugcucuccuuuucuauacccuuaacugcaaaca aaccauuaaacgaccccucuccugggccuccgacggcaggaguccgcggaccucccaggccgacagcccucccucuacccgc gagguuccgggccgggcgagagggcgcgagcacagccgaggacauggaggugacugcggaccagccgcgcugggugagcc accaucaccccgcgguccucaacggucagcacccagacacgcaccacccgggccucggccauucguacauggaagcucagua uccgcugacggaagagguggacguacuuuuuaacaucgauggucaaggcaaccacgucccguccuacuacggaaacuccgu cagggcuacggugcagagguauccuccgacccaccacgggagccagguaugccgcccgccucugcugcacggaucucugcc cuggcuggauggcggcaaagcccugagcagccaccacaccgccucgcccuggaaccucagccccuucuccaagacguccauc caccacggcucuccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacuccaguccucau cucuucaccuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguccaccccgggauccgccgggucggcca ggcaagaugagaaagagugccucaaguaucaggugcagcugccagauagcaugaagcuggagacgucucacucucgaggca gcaugaccacccuggguggggccucauccucagcccaccaccccauuaccaccuauccgcccuaugugcccgaguacagcuc uggacucuucccacccagcagccugcugggaggauccccuaccggguucggauguaagucgaggcccaaggcacgauccag cacagaaggcagggagugugugaacugcggggcaaccucuaccccacuguggcggcgagaugguaccgggcacuaccuuug caaugccugcggacucuaccauaaaaugaaugggcagaaccggccccuuaucaagcccaagcgaaggcugucggcagcaagg agagcagggacauccugcgcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggacccggucugca augccugugggcuguacuacaagcuucauaauauuaacagaccccugacuaugaagaaagaaggcauccagacccgaaaccg gaagaugucuagcaaaucgaaaaagugcaaaaaggugcaugacgcgcuggaggacuuccccaagagcagcuccuucaacccg gccgcucucuccagacacaugucaucccugagccacaucucucccuucagccacuccagccacaugcugaccacaccgacgcc caugcauccgcccuccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagagaggcagagcc cugcuccacaugcgugaggagucuccaagugugcgaagaguuccuccgaccccuucuacuugcguuuuucgcaggagcagu aucaugaagcccgaaagcgacagaucuguguuuuugaaggcagaaagcaaaauguuugcuucuuuuuucaaaggagcucga gguggugucugcauuccaaccacugaauccggaucccauuugugaauaagccauucagacucauauucccuauuuaacagg gucucuagugcugugaaaaaaauauugcugaacauugcauauaacuuauauuguaagaaauacuguacauuugaggaagac uuuauuguaccuggauagcuguaagaaaggcaugaaggacgccaagaguuuuaaggaauauaggggnnuuaaaguaugga gauacagaagaaaccacuaagucugauguccaaaugggcacacugucaguuuuguuucccuucaguuguuugaugcauuua aaaaaaaaaaaaagaaagaa Stimulated by 3 Sequence below. 269 retinoic acid 14, basic-helix- loop-helix protein Y07836 caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugcccacauguacc aaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcugauugagaa aaagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacuuuggg ucacuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagcagcagca gaaaaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaauguucu gcucagguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuuccc agcucgucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacucggcuccca aagccgucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugccagucaucca gcggacuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggaga aaggggacuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacgugucagcacaa uuaagcaagaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacuucgcgggcaguga ucugauggguuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggc cacugccuaccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaacaccucagcu gcagcccucuccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagacucccuucuccuuuggcac auucgucccuugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacuc uggagggaucuccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagagagauca gcccacccugcagacccacagagaagauucagagugugugugagagugagugagugugcgugcgugcgugcuuguaugua uguuuguauauguaggacaauaaguuccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacug gaggacuguagcacaucucugggcguuucccuacccagagaagagcc Cell Cycle Related Mki67/antigen 4 Sequence below. 270 identified by monoclonal antibody Ki67 X82786 agucaccgacguuguauaacgacggccagugaauuguaauacgacucacuauagggcgaauuggguaccggccccccccuc gaggucgacgguaucgauaagcuugauaucgaauucucgnccgcgugcgggucuggucggggcggagcgaaggccgcggg uggccguggucgguccuccgcggcuaaggagccgagggcuccgacgcgggcugcgcccggugagcggcggccagagcuaa cuugcgcugacuggaccagcugaggagcggcccggcggggcgacugcgagcuucaccgagaggcuucuccgcccugguccg cagucccgacggccgggcggaccauggcguccucggcucaccuggucaccaucaagcggagcggcgaugacggcgcacacu ucccgcugagccucagcuccugccuguuuggaaggaguauugaaugugacauucguauccagcugccuguagugucucaa agacauugcccaauuguaguccaagagcaagaggcgauauuauauaauuucaguucuaccaauccaacucaaguaaacggg guuacuauagaugagccugugaggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaagaugga aaucaugaggauggaagcaaaccaacagaauuuccaggaaagucccuuggaaaggaaccaucaaggcgagccucaagagaua gcuucugugcugacccugauggggaaggucaagauaccaaagcuucaaaaaugacugcuucaagaagaucuuuuguguaug ccaagggccuuucugcagauagcccugccucagauggcucaaagaacaguguuagccaagacucaucagggcauguagaac agcacacuggcagaaacauaguagagcccacuucugggggaucucuuuuaagaaguccaggucuacagggagcaguuacag ggaaccgaagucuucuuccuacacagagccuuagcaauagcaacgaaaaggaaucucccuuugagaaacuuuaucaaucaau gaaggaagaguuggauguaaaaucccagaaaucuuguaggaaaucagaaccccaaccugaccgugcagcagaggaaucgcg ggagacacagcuauuggugucaggcagggcaagagcaaagucuaguggaagcaccccuguuacugcagccucuucacccaa aguaggaaagaucuggacugagagauggcgcgguggaauggugccuguccagacuuccacagagacagcuaaaaugaagac cccugugcggcauucacagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucuggaugaagg uggaagugcccaggcaguccauaaaacagucacuccugggaaacuggcgacuagaaaccaaacuccgguggaggcugggga uguuggcagccccgcugauacaccagaacauuccucuuccccccagagaaguauuccugcaaagguagaggcuccaucugca gagacacaaaaucggcucucuuuaacucagcgccuuguuccaggugaaaagaaaacucccaaggguuccuucagcaagccug agaaacuggccacagccgccgaacagacuugcucuggccuaccuggucuuaguuccguugauaucagcaacuuuggugauu ccauuaacaagagugagggaaugccuaugaagagaagacguguauccuuugguggacaucuaagaccugaauuauuugaug aaaacuugccuccuaauacaccacugaaaagaggagaaacgccaaccaagaggaagucucuuggcacucacagcccagcugu ccucaagacaaucaucaaggaacggccccagucuccagggaaacaagagucuccugggauaacgccaccgaggacaaaugau caaagacgcagaucaggcaggacuuccaguggaagcaauuucuuaugugagacagacauucccaagaaagcaggcaggaaga gcgguaaccugccugcgaagagagcauccaucagccggagucagcauggcauucuacagaugauuugcuccaaaaggcgaa guggagcuucugaagccaacuugauuguugcaaaaucaugggcugauguuguaaaacuuggcgugaaacaaacacaaacga aaguugcgaaacaugucccuccaaagcagacgagcaagagacaaagaagacccagcacuccaaagaaacccacaagcaaucuu cacaaucaauuuacuacaggccaugcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaaguaagugug ccugcccgacccuacaaaaugcugaauaacuugaugcuaaaccgaaaaguggacuucagugaagaucugucaggacuaacug aaauguucaagacuccagugaaggagaagcagcagcagaugagugauacaggcuccguacuuuccaauucagcgaauuugu cugaaagacaauugcaaguaacuaauucaggagacauaccugagcccaucaccacagagauuuugggagaaaaagugcuauc caguacucggaaugcagcaaagcagcagucugauagauauucugcaaguccuaccuuaagacggcggagcaucaaacaugaa aacacagugcaaacuccuaagaauguccauaacauuacugaccuugagaagaagacuccggucucugagacagagccccuga agacugcaucgagugugagcaaguuaagaagaucuagagagcucagacauacccuuguggaaacuaugaaugaaaaaacag aagcaguccuugcugagaacaccacagcaagacauuuaagggggacauuucgagaacaaaaaguagaucaacaggugcagga caaugaaaacgcuccucaaagaugcaaggaaaguggugaauuaagugaagguucagaaaagacaucagcuaggagaucaag ugccaggaagcagaagccgacaaaagacuuacuaggaagucagauggucacccaaacagcagacuaugcugaggaacuacuu agucaaggacaaggaaccauacaaaaccuagaggaauccaugcacaugcaaaacacaucaauaagugaggaucaaggaauua cagaaaagaaagugaacauaauaguauaugcaaccaaagagaagcacucgccaaagaccccuggcaaaaaggcacaaccucua gaagggccagcuggucucaaggaacacuuugaaacaccaaaccccaaagauaaaccuauaacggaagacagaacuagagucc uuugcaaaucaccacaagucacaacagagaauaucacaacaaacacaaagccacagacuagcacaucugggaagaaaguagac augaaggaagaaagcucugccuugacaaaacguauacauaugccaggggaauccaggcauaaucccaaaauuuuaaaacuug agugugaggauaucaaagcuuugaagcaaucugaaaaugaaaugcugaccucaacaguaaauggaagcaagaggacuuuag gaaaaucuaaaaaaaaggcucagccccuggaagaccugacuuguuuccaggaacucuuuauaucaccaguuccuacuaacau aaucaaaaaaauucccagcaaaucuccacacacacaaccagucagaaccccagcgagcacaaagagacucuccaagacagguc ucaguaaaguggaugugagacaagaaccuucaacacuugggaaaagaacgaagucaccaggcagagccccaggcacaccagc accagugcaggaagaaaaugacugcacagccuacauggaaacuccaaagcagaaacuggagucuauagaaaauuuaacaggg cuuaggaaacaguccagaacaccuaaagacaucacugguuuccaggauaguuuccaaauaccagaucaugcuaauggcccau uagugguugucaaaaccaaaaaaauguucuuuaauucuccacaaccagaaagugccauaacccgaaagagcagagagagaca gucuagggcaaguauaaguaaaauagauguuaaagaagaacuuuuagaaucagaggaacaccuacaauuaggagaaggugu agacacauuucagguauccaccaacaaagucauuagaucaucuaggaaaccugcaaagcguaaacuggauucaacagcuggu augccuaacagcaagaggaugcgcuguucuucaaaggauaacacaccaugccuagaagaccugaauggcuuccaagagcucu uccaaaugccaggcuaugcuaaugacucuuugaccacuggaaucucaacaaugcuugcuagaucaccacaauuaggaccagu uagaacccaaaucaacaaaaagagucugcccaagaucaucuugagaaaaauggaugugacagaagaaauuucaggucucugg aagcagucacugggcagaguccacaccacacaagagcaggaggauaaugcaaucaaagcaauuauggagauuccaaaggaaa cacugcagacugcagcagauggaacuaggcuuaccagacagccacaaacaccuaaggaaaaaguucaaccgcuggaagauca cagugucuuccaagaacucuuccaaacaucacgcuacuguucugauccauuaauugguaacaaacaaacaagaauguccuug agaucuccacaaccaggauuuguuagaacuccacgaaccucaaagagacuggcuaagacaaguguugggaauauugcugug agagaaaagaucucuccagugagucugccacagugugcuacaggggagguuguacacauacccauagggccagaagaugac acagagaacaaaggugugaaggaauccacaccucagacacuggacucaucagcaagucgaacugucagcaagaggcagcaag gggcacaugaggaaaggccucaguucucaggagacuuauuucauccccaagagcucuuucaaacaccagccaguggcaaaga cccaguaacuguugaugaaacuacaaaaauagcucugcagucuccacaaccaggacauaucauaaacccagcaagcaugaag agacaguccaacaugagucucaggaaagacaugagagaauuuuccauacuugaaaaacaaacacagucacgaggcagagacg caggcacaccagcaccaaugcaggaagaaaauggcaccacagccauuauggaaacaccaaagcagaaacuggauuucauagg aaauucaacaggacauaagaggaggccucggacacccaaaaacagggcucagccccuagaagaccuggauggcuuccaagaa cucuuucaaacaccagcuggugccagugacccugugaguguugaagaaagugcaaagauaucuuuggcaucuucacaagca gaaccagucagaaccccagcaaguacaaagagacgcuccaagacaggucucaguaaaguggaugugagacaagaaccuucaa cacuugggaaaagaaugaagucacuaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacagcacagccuu cauggaaacuccaaagcagaaacuggauuucacaggaaauucaucaggacauaagaggaggccacagacaccuaagaucagg gcucagccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggugccaaugacucagugacuguugag gaaaguguaaagaugucuuuggaaucuucacaagcagaaccagucaaaaccccggcaagcacaaagagacucuccaagacag gucucaguaagguggaugugagagaagacccuucaauacuugagaaaaaaacaaagucaccaggcacaccagcaccagugca ggaagaaaaugacugcacagccuucauggaaacuccaaagcagaaacuggauuucacaggaaauucaucaggacauaagagg aggccacggacaccuaagaucagagcucagccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggug cuagugacucagugacuguugaggaaagugcaaagaugucuuuggaaucuucacaagcaaaaccagucaaaaccccggcaa gcacaaagagacucuccaagacaggucucaguaagguggaugugagagaagacccuucaacacuugggaaaaaaacaaaguc accaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacagcacagccuucauggaaacuccaaagcagaaac 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uaaggaaggaagcuuugagcuuuccuggucauacucucuucagacgccaauggaggucaugaggaagaucaccagggaucu cagcgcaauuacaguuuaggggugagcaggcagaaauguggcccucuguccuauccaauaaagcucugaaauucgcugcca aaa Cks2/CDC28 4 gacguagagccccuugcgcccgguuuccugaucccgcuuacuc 271 protein kinase cucugcgcgccggcaggauggcccacaagcagaucuacuacuc regulatory agacaaguacuucgaugagcacuacgaguaccggcaugucaug subunit 2, sim uuacccagagaacucucuaaacaaguacccaaaacucaucugau to cdk guccgaagaggaguggaggagacuugguguccaacagagucu regulatory aggauggguucauuacaugauucaugagccagaaccgcauauu subunit 2 cuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaa AA681998 gugcagcugggaucaucuaaucuuuuucaaauuuaauguaua uguguauauaagguaguauucagugaauacuugaaaagugua caaaccuuucauccauaccugugcaugcgcuguauucuucaca gcaacagagcucagucaaaugcaacugcaaguagg Ccng2/ 3 Sequence below. 272 Cyclin G2 U95826 cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcuguccugagcucgaacggucc gacgcccccgccgcgccgguccgugacgccggggccgacacgaugaaggauuugggggccaagcacuuggcagguggcgaa 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Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN.

Example 10 Expression of Wnt-1 Inhibitors During the First Nine Days after Wounding Causes Pigmentation of New HF Materials and Experimental Methods

In this Example, doubly transgenic mice expressing both tetO-Dkk1 and K5-rtTA were utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, Md.), they express Dkk1, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkk1.

Results

A 1 cm²wound was induced on the lower back of the doubly transgenic mice at 21 days or 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkk1 expression, and then doxycycline was discontinued after completion of the re-epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (FIG. 23A-B). Control mice lacked pigmented HF (FIG. 24).

In other experiments, continued expression of Dkk1 after the 9-day period inhibited formation of new HF.

The findings of this Example show that pigmented HF can be produced by suppressing expression of Wnt or by inducing expression of Dkk1 during the period of re-epithelialization, then inducing expression of Wnt1. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkk1) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles.

Example 11 Inhibition of EDIHN by Epidermal Growth Factor Injection

21 day-old mice were wounded as described in previous Examples. Starting from day 11 after wounding, a time point corresponding to the point at which the wound had recently reepithelialized, 10 μL of 1 μg/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (FIGS. 25 A-B), while control mice (n=2) had many new HF, as expected. (FIGS. 25 C-D).

In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and stained for K17 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN.

The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation.

Example 12 Enhancement of EDIHN by Inhibition of EGF Receptor

To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 μM in 10 μL volume) was administered as a single injection 11 days after incisional wounding (1 cm²) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (FIG. 26A). As shown in FIG. 26B, large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas.

The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists.

Example 13 Enhancement of EDIHN by Expression of a β-Catenin Activator

To determine the effect of administration of β-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the β-catenin pathway activator, Wnt7, in the epidermis, were subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (FIG. 27 A-C).

Thus, administration of β-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell.

Example 14 Enhancement of EDIHN by Administration of FGF

To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF.

Example 15 Enhancement of EDIHN by Administration of Edar

To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-A1 transgenic mice, which overexpress (ectodysplasin-A1) Eda-A1 in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a factor that enhances signaling by ectodysplasin.

Example 16 Enhancement of EDIHN by Administration of Minoxidil

To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as described in Example 11. Minoxidil administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil.

Example 17 Removal of HF by Abrasion and Administration of EGF

Hair-bearing regions of the epidermis of mice is abraded, as described in Example 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF.

Claims

1-37. (canceled)

38. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) wounding an area of the balding scalp of said human subject by disrupting an epidermis or dermis of the area of the balding scalp, thereby creating a wounded area; and (b) contacting the wounded area with a compound or factor that activates a beta-catenin protein or an inhibitor of a protein that suppresses an activity of the beta-catenin protein and minoxidil.

39. The method of claim 38, wherein said wounding is performed with a tool that comprises sandpaper, a laser, a Fraxel laser, a CO2 laser, an excimer laser, a felt wheel, a dermabrasion device, a light-based method, irradiation with visible light, irradiation with infrared light, irradiation with ultraviolet radiation, orthovoltage radiation, xray radiation, a surgical tool, a dermal biopsy punch, or is performed with a burn treatment or chemical treatment.

40. The method of claim 39, wherein said dermabrasion device is a micro-dermabrasion device.

41. The method of claim 38, wherein said wounding is dermabrasion.

42. The method of claim 38, wherein the wounding-step comprises disrupting the epidermis and dermis of the area of the balding scalp.

43. The method of claim 38, in which only part of the epidermis is removed.

44. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with a precursor cell, an inductive cell, or a hair follicle or a portion thereof.

45. The method of claim 38, wherein the method further comprises contacting said area of the balding scalp with one or more of the following compounds: finasteride, dutasteride, fluridil, spironolactone, cyproterone acetate, bicalutamide, flutamide, nilutamide, an inhibitor of an androgen receptor, an androgen antagonist, or an anti-androgen.

46. The method of claim 45, wherein said wounding-step is performed between 3-12 days, 4-12 days, 5-12 days, 4-11 days, 6-11 days, 6-10 days, 6-9 days, 6-8 days, 7-8 days, 5-11 days, 5-10 days, 7-10 days, or about 1 week prior to said contacting step.

47. The method of claim 38, wherein said area of the balding scalp is subjected to depilation or administration of a retinoid prior to said wounding.

48. The method of claim 47, wherein said depilation is performed by plucking, waxing, abrasion, laser, electrolysis, or administration of thioglycolic acid on said area of the balding scalp.

49. The method of claim 38, wherein said wounded area of the balding scalp is not surgically closed, or not contacted with a bandage, dressing, or ointment that facilitates wound healing for a period of time following said wounding-step.

50. The method of claim 49, wherein said period of time is within about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 7 days, about 10 days, about 11 days, about 14 days, about 17 days, or about 3 weeks.

51. The method of claim 38, wherein said wounded area of the balding scalp is allowed to heal by secondary intention.

52. The method of claim 38, wherein the method is performed on a subject with androgenetic alopecia (AGA), scarring alopecia, male pattern baldness, female pattern baldness, discoid lupus erythematosis, or lichen planopilaris.

53. The method of claim 38, wherein said treatment results in an increase in markers of hair follicle proliferation, hair follicle differentiation or hair follicle embryonic development.

54. The method of claim 38, wherein said treatment results in an increase in the amount of pigmented hair or an increase in hair follicle size.

55. The method of claim 38, wherein said treatment results in differentiation of an uncommitted epidermal cell into a hair follicle cell.

56. The method of claim 38, wherein said treatment results in generation of a hair follicle in the scalp of the subject.

57. The method of claim 38, wherein said wounding does not result in bleeding.

58. A method for treating baldness or a hair loss condition or for stimulating hair growth in a human subject comprising: (a) perforating an area of the balding scalp of said human subject, thereby generating a disrupted epidermis or dermis area of the balding scalp; and (b) contacting the disrupted epidermis or dermis area of the balding scalp with a compound or factor that activates a beta-catenin protein or an inhibitor of a protein that suppresses an activity of the beta-catenin protein and minoxidil.

59. The method of claim 38, wherein said compound or factor is a Wnt7 protein or a nucleic acid molecule encoding said Wnt7 protein.

60. The method of claim 38, wherein the step of disrupting said epidermis comprises the disruption of the basal and suprabasal epidermal layers.