Patents by Inventor George Fromm

George Fromm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPIES COMPRISING SIRP ALPHA-BASED CHIMERIC PROTEINS
    Publication number: 20200071380
    Abstract: The present invention relates to, inter alia, combinations of compositions which include chimeric proteins that find use in methods for treating disease, such as immunotherapies for cancer and autoimmunity.
    Type: Application
    Filed: September 16, 2019
    Publication date: March 5, 2020
    Inventors: Taylor SCHREIBER, George FROMM, Suresh DE SILVA
  • VSIG8-BASED CHIMERIC PROTEINS
    Publication number: 20200071378
    Abstract: The present invention relates, in part, to, chimeric proteins which include the extracellular domain of V-set and immunoglobulin domain-containing protein 8 (VSIG8) and their use in the treatment of diseases, such as immunotherapies for cancer and/or inflammatory diseases.
    Type: Application
    Filed: October 28, 2019
    Publication date: March 5, 2020
    Inventors: Taylor SCHREIBER, George FROMM, Suresh DE SILVA
  • FLT3L-BASED CHIMERIC PROTEINS
    Publication number: 20200069733
    Abstract: The present invention relates, inter alia, to compositions and methods, including chimeric proteins comprising an extracellular domain of FMS like tyrosine kinase 3 ligand (FLT3L) and an extracellular domain of a Type II transmembrane protein that find use in the treatment of disease, such as cancer.
    Type: Application
    Filed: September 13, 2019
    Publication date: March 5, 2020
    Inventors: Taylor SCHREIBER, George FROMM, Suresh DE SILVA
  • Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
    Patent number: 10543253
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: January 28, 2020
    Assignee: Heat Biologics, Inc.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
    Patent number: 10525102
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: January 7, 2020
    Assignee: Heat Biologics, Inc.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • CSF1R-based chimeric proteins
    Patent number: 10513548
    Abstract: The present invention relates, in part, to, chimeric proteins which include the extracellular domain of colony stimulating factor 1 receptor (CSF1R) and their use in the treatment of diseases, such as immunotherapies for cancer and/or an inflammatory disease.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: December 24, 2019
    Assignee: Shattuck Labs, Inc.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • CSF1R-BASED CHIMERIC PROTEINS
    Publication number: 20190382466
    Abstract: The present invention relates, in part, to, chimeric proteins which include the extracellular domain of colony stimulating factor 1 receptor (CSF1R) and their use in the treatment of diseases, such as immunotherapies for cancer and/or an inflammatory disease.
    Type: Application
    Filed: February 27, 2018
    Publication date: December 19, 2019
    Inventors: Taylor SCHREIBER, George FROMM, Suresh DE SILVA
  • VSIG8-BASED CHIMERIC PROTEINS
    Publication number: 20190367581
    Abstract: The present invention relates, in part, to, chimeric proteins which include the extracellular domain of V-set and immunoglobulin domain-containing protein 8 (VSIG8) and their use in the treatment of diseases, such as immunotherapies for cancer and/or inflammatory diseases.
    Type: Application
    Filed: February 27, 2018
    Publication date: December 5, 2019
    Inventors: Taylor SCHREIBER, George FROMM, Suresh DE SILVA
  • TIGIT- AND LIGHT-BASED CHIMERIC PROTEINS
    Publication number: 20190367579
    Abstract: The present invention relates, inter alia, to compositions and methods, including TIGIT- and/or LIGHT-based chimeric proteins that find use in the treatment of disease, such as cancer and an inflammatory disease.
    Type: Application
    Filed: February 27, 2018
    Publication date: December 5, 2019
    Inventors: Taylor SCHREIBER, George FROMM, Suresh DE SILVA
  • Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
    Patent number: 10493128
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: December 3, 2019
    Assignee: Heat Biologics, Inc.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
    Patent number: 10449233
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 22, 2019
    Assignee: Heat Biologics, Inc.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva, Neal Schilling
  • CSF1R-BASED CHIMERIC PROTEINS
    Publication number: 20190169249
    Abstract: The present invention relates, in part, to, chimeric proteins which include the extracellular domain of colony stimulating factor 1 receptor (CSF1R) and their use in the treatment of diseases, such as immunotherapies for cancer and/or an inflammatory disease.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 6, 2019
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • COMPOSITIONS AND METHODS FOR ADJOINING TYPE I AND TYPE II EXTRACELLULAR DOMAINS AS HETEROLOGOUS CHIMERIC PROTEINS
    Publication number: 20190151413
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Application
    Filed: November 28, 2018
    Publication date: May 23, 2019
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
    Patent number: 10188701
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: January 29, 2019
    Assignee: HEAT BIOLOGICS, INC.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
    Patent number: 10183060
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: January 22, 2019
    Assignee: HEAT BIOLOGICS, INC.
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva
  • VECTOR CO-EXPRESSING VACCINE AND COSTIMULATORY MOLECULES
    Publication number: 20190000967
    Abstract: Compositions and methods for co-expressing a secretable vaccine protein (such as gp96-Ig) and T-cell co-stimulatory molecules from a single vector, among others, are provided herein. Materials and methods for using gp96-Ig vaccination and T-cell co-stimulation to treat a clinical condition (e.g., cancer) in a subject also are provided.
    Type: Application
    Filed: June 25, 2018
    Publication date: January 3, 2019
    Inventors: Taylor Schreiber, George Fromm
  • VECTOR CO-EXPRESSING VACCINE AND COSTIMULATORY MOLECULES
    Publication number: 20180360955
    Abstract: Compositions and methods for co-expressing a secretable vaccine protein (such as gp96-Ig) and T-cell co-stimulatory molecules from a single vector, among others, are provided herein. Materials and methods for using gp96-Ig vaccination and T-cell co-stimulation to treat a clinical condition (e.g., cancer) in a subject also are provided.
    Type: Application
    Filed: June 25, 2018
    Publication date: December 20, 2018
    Inventors: Taylor Schreiber, George Fromm
  • COMPOSITIONS AND METHODS FOR ADJOINING TYPE I AND TYPE II EXTRACELLULAR DOMAINS AS HETEROLOGOUS CHIMERIC PROTEINS
    Publication number: 20180326007
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Application
    Filed: June 29, 2018
    Publication date: November 15, 2018
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva, Neal Schilling
  • COMPOSITIONS AND METHODS FOR ADJOINING TYPE I AND TYPE II EXTRACELLULAR DOMAINS AS HETEROLOGOUS CHIMERIC PROTEINS
    Publication number: 20180326008
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Application
    Filed: June 29, 2018
    Publication date: November 15, 2018
    Inventors: Taylor SCHREIBER, George FROMM, Suresh DE SILVA, Neal SCHILLING
  • COMPOSITIONS AND METHODS FOR ADJOINING TYPE I AND TYPE II EXTRACELLULAR DOMAINS AS HETEROLOGOUS CHIMERIC PROTEINS
    Publication number: 20180326005
    Abstract: The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
    Type: Application
    Filed: June 29, 2018
    Publication date: November 15, 2018
    Inventors: Taylor Schreiber, George Fromm, Suresh De Silva, Neal Schilling