Abstract: Enhanced capabilities within a telephone network are made accessible to a telecommunications device. The telecommunications device is used to dial a sequence. A network server receives and identifies the sequence invokes an advanced network function. A advanced network function server in communication with the network server provides instructions as to how the network server is to provide the advanced network function. The network server processes the call in accordance with the received instructions to provide the particular advanced network function.

Abstract: A computer assisted facility monitoring method provides users with predefined operating procedures that are recommended for addressing one or more alarms acknowledged by the user. The predefined operating procedures are created and stored prior to the occurrence of the alarms. In some examples, after acknowledging an alarm occurrence, the user may be provided with an option for bypassing or disregarding the alarm, as some such acknowledgements may have been for false alarms. In some examples, the predefined operating procedure may specify multiple action steps for addressing an alarm. In such examples, the user can close out or settle an alarm incident even without completing all of the action steps, provided the user enters a valid reason for doing so. In some examples, a user can batch-select a group of alarms, wherein perhaps only some of the acknowledged alarms in the group have corresponding predefined operating procedures.

Abstract: The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti-PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: An intraocular lens, wherein an outer periphery of an optic portion has a peripheral surface, and a radially inner portion of a peripheral portion of the IOL has an inner surface, wherein the peripheral surface is directly adjacent to the inner surface, and wherein the peripheral surface does not directly extend (coupled to or integrally formed therewith) from the inner surface, and wherein the peripheral surface and the inner surface are configured so that the peripheral portion is stabilized in at least one of, and optionally both of, the proximal and distal directions relative to the optic portion.

Abstract: An intraocular lens, wherein an outer periphery of an optic portion has a peripheral surface, and a radially inner portion of a peripheral portion of the IOL has an inner surface, wherein the peripheral surface is directly adjacent to the inner surface, and wherein the peripheral surface does not directly extend (coupled to or integrally formed therewith) from the inner surface, and wherein the peripheral surface and the inner surface are configured so that the peripheral portion is stabilized in at least one of, and optionally both of, the proximal and distal directions relative to the optic portion.

Abstract: A computer assisted facility monitoring method provides users with predefined operating procedures that are recommended for addressing one or more alarms acknowledged by the user. The predefined operating procedures are created and stored prior to the occurrence of the alarms. In some examples, after acknowledging an alarm occurrence, the user may be provided with an option for bypassing or disregarding the alarm, as some such acknowledgements may have been for false alarms. In some examples, the predefined operating procedure may specify multiple action steps for addressing an alarm. In such examples, the user can close out or settle an alarm incident even without completing all of the action steps, provided the user enters a valid reason for doing so. In some examples, a user can batch-select a group of alarms, wherein perhaps only some of the acknowledged alarms in the group have corresponding predefined operating procedures.

Abstract: A computer assisted facility monitoring method provides users with predefined operating procedures that are recommended for addressing one or more alarms acknowledged by the user. The predefined operating procedures are created and stored prior to the occurrence of the alarms. In some examples, after acknowledging an alarm occurrence, the user may be provided with an option for bypassing or disregarding the alarm, as some such acknowledgements may have been for false alarms. In some examples, the predefined operating procedure may specify multiple action steps for addressing an alarm. In such examples, the user can close out or settle an alarm incident even without completing all of the action steps, provided the user enters a valid reason for doing so. In some examples, a user can batch-select a group of alarms, wherein perhaps only some of the acknowledged alarms in the group have corresponding predefined operating procedures.

Abstract: The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more genes of a pantumor inflammation gene panel. In some aspects, the method further comprises administering an I-O therapy to the subject. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSFIR. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: The present disclosure provides methods of identifying a subject suitable for an immuno-oncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSF1R. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: Certain aspects of the present disclosure provide techniques for predicting a likelihood of future failure of components in an ophthalmic medical device and performing preventative maintenance on the ophthalmic medical device. An example method generally includes receiving, from an ophthalmic medical device, measurements of one or more operational parameters associated with the ophthalmic medical device. Using one or more models, a future failure of the ophthalmic medical is predicted. The predictions are generated based, at least in part, on the received measurements of the one or more operational parameters. One or more actions are taken to perform preventative maintenance on the ophthalmic medical device based on the predicted future failure of the ophthalmic medical device.

Abstract: A computer assisted facility monitoring method provides users with predefined operating procedures that are recommended for addressing one or more alarms acknowledged by the user. The predefined operating procedures are created and stored prior to the occurrence of the alarms. In some examples, after acknowledging an alarm occurrence, the user may be provided with an option for bypassing or disregarding the alarm, as some such acknowledgements may have been for false alarms. In some examples, the predefined operating procedure may specify multiple action steps for addressing an alarm. In such examples, the user can close out or settle an alarm incident even without completing all of the action steps, provided the user enters a valid reason for doing so. In some examples, a user can batch-select a group of alarms, wherein perhaps only some of the acknowledged alarms in the group have corresponding predefined operating procedures.

Abstract: A computer assisted facility monitoring method provides users with predefined operating procedures that are recommended for addressing one or more alarms acknowledged by the user. The predefined operating procedures are created and stored prior to the occurrence of the alarms. In some examples, after acknowledging an alarm occurrence, the user may be provided with an option for bypassing or disregarding the alarm, as some such acknowledgements may have been for false alarms. In some examples, the predefined operating procedure may specify multiple action steps for addressing an alarm. In such examples, the user can close out or settle an alarm incident even without completing all of the action steps, provided the user enters a valid reason for doing so. In some examples, a user can batch-select a group of alarms, wherein perhaps only some of the acknowledged alarms in the group have corresponding predefined operating procedures.

Abstract: The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti-PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: The disclosure provides a method for treating a subject afflicted with a tumor derived from a non-small cell lung cancer (NSCLC) comprising administering to the subject a therapeutically effective amount of (a) an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof and (b) an anti-CTLA-4 antibody or an antigen binding portion thereof, wherein the tumor has a high tumor mutation burden (TMB) status. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

Abstract: An intraocular lens, wherein an outer periphery of an optic portion has a peripheral surface, and a radially inner portion of a peripheral portion of the IOL has an inner surface, wherein the peripheral surface is directly adjacent to the inner surface, and wherein the peripheral surface does not directly extend (coupled to or integrally formed therewith) from the inner surface, and wherein the peripheral surface and the inner surface are configured so that the peripheral portion is stabilized in at least one of, and optionally both of, the proximal and distal directions relative to the optic portion.

Abstract: A business intelligence (BI) document preserves references to identities and formats of remote data sources and allows a local computing device to offload analytical operations to remote data sources. The BI document specifies a graph of entities connected by directed edges from the output of one entity to an input of another entity. An entity, for example, can represent without limitation a data structure, an external data source, a control element, an external event source, a visualization, or an update service. The entities of a BI document at a local computing device can reference data at an original data source—rather than extracting data from the original data source to a preferred local datastore. An entity of the BI document can direct a remote data source to execute transformations on the remote data before returning a solution to the local computing device.

Abstract: A business intelligence document provides functionality for testing a hypothesis on aggregated data in a business intelligence document (e.g., a spreadsheet-like document), wherein one or more of the input data values and transformation properties are designated as constrained (e.g., invariant or constrained within a range, set, enumeration, or domain). The hypothesis, which is articulated as a data mining assertion, is input through the user interface of the business intelligence document (e.g., via an expression interface or properties of a row, column, or cell) and solved over the aggregated data. The solution is then presented through the user interface of the spreadsheet-like document, such as in a table, graph, histogram, etc.

Abstract: A composite material, the composite material comprising at least one prepreg, said prepreg comprising at least one polymeric resin and at least one fibrous reinforcement; and conducting particles dispersed in the polymeric resin.

Abstract: A business intelligence document provides functionality for testing a hypothesis on aggregated data in a business intelligence document (e.g., a spreadsheet-like document), wherein one or more of the input data values and transformation properties are designated as constrained (e.g., invariant or constrained within a range, set, enumeration, or domain). The hypothesis, which is articulated as a data mining assertion, is input through the user interface of the business intelligence document (e.g., via an expression interface or properties of a row, column, or cell) and solved over the aggregated data. The solution is then presented through the user interface of the spreadsheet-like document, such as in a table, graph, histogram, etc.