Abstract: The present invention relates to methods for treating patients having cancer or a premalignant or neoplastic condition. It is based, at least in part, on the discovery that a genome editing technique that specifically targets a fusion gene can induce cell death in a cancer cell other than a prostate cancer cell, e.g., a hepatocellular cancer cell, having the fusion gene. The present invention provides methods for treating cancer patients that include performing a genome editing technique targeting a fusion gene present within one or more cells of a subject to produce an anti-cancer effect.

Abstract: The present invention relates to methods of treating cancer patients carrying one or more specific fusion genes. It is based, at least in part, on the discovery that the protein encoded by the MAN2A1-FER fusion gene exhibits kinase activity and the use of tyrosine kinase inhibitors targeting MAN2A1-FER in a cancer other than prostate, for example hepatocellular cancer, led to dramatic improvement of survival of animals xenografted with the cancer.

Abstract: The present invention relates to methods of treating cancer patients carrying one or more specific fusion genes. It is based, at least in part, on the discovery that the protein encoded by the MAN2A1-FER fusion gene exhibits kinase activity and the use of tyrosine kinase inhibitors targeting MAN2A1-FER in a cancer other than prostate, for example hepatocellular cancer, led to dramatic improvement of survival of animals xenografted with the cancer.

Abstract: A pet training pad includes a central absorbent pad on top of a waterproof bottom layer. The waterproof bottom layer covers one side of the central absorbent pad. The pet training pad also includes a wicking material around a periphery of the central absorbent pad and/or one or more fringe barriers around a periphery of the central absorbent pad. A pet training pad manufacturing method involves cutting a bottom waterproof plastic layer, placing die-cut absorbent layers on the bottom plastic layer and laminating or adhering the absorbent layers to the bottom waterproof plastic layer to keep the absorbent layers together and positioned, layering roll cut first fringe borders and wicking edges on the bottom waterproof plastic layer around borders of the absorbent layers and securing them in place, and cutting to create a final shape.

Abstract: A method for effective delivery of vitamin B12 to a human being involves positioning a delivery device containing a mixture comprising a form of vitamin B12 and water such that, when activated, the delivery device places at least a portion of the mixture inside of a users mouth in a form suitable for inhalation, and activating the delivery device while or before the user inhales. The form of vitamin B12 may be cyanocobalamin, methylcobalamin, hydroxocobalamin, and/or adenosylcobalamin. The delivery device may be an aerosolizer, atomizer, vaporizer, or humidifier. The mixture may also include flavorings. Water may be 20% or less of the mixture by volume. The mixture may contain no nicotine, propylene glycol, or diacetyl. A method for vitamin B12 supplementation includes determining that a person has a disorder causing the person to have a reduced ability to process B-vitamins and administering methylcobalamin by inhalation.

Abstract: The present invention relates to methods for determining whether a subject having prostate cancer is at an increased risk for relapse or rapid relapse. It is based, at least in part, on the results of a comprehensive genome analysis of 273 prostate cancer samples, which indicate that the percentage of large size CNVs predicts prostate cancer relapse. In certain embodiments, a method for determining whether a prostate cancer patient has an increased risk of suffering a relapse or a rapid relapse comprises determining the number and size of CNVs in a sample and determining a large size ratio, where if the large size ratio exceeds a particular threshold, the patient is deemed to be at an increased risk for relapse or rapid relapse.

Abstract: A sanitary wipe is provided, including a pad that is contained beneath or as part of an adhesive sticker or otherwise attachable body that is releasably secured at any convenient point on a surface of a container or containment vessel, such as the side or top of the containment vessel. The pad can be provided with or without a cleaning substance. For use, the user simply pulls the adhesive sticker or attachable body free of the container, and uses the wipe part or pad of the sticker or body to clean and remove contamination wherever contamination is suspected or at any other desired location, like on the lid of the containment vessel.

Abstract: A portable container base for use with a powered lifting device is provided. The portable container base includes a main body to secure a bottom surface of a container such as a trash can, a plurality of wheels on a lower surface of the main body, each providing independent rotation for moving the main body and container across a surface, and a loading tube on a lower surface of the main body to slidably receive a loading spike of a lifting device, transfer a lifting force from the loading spike to the main body for lifting the container, and restrict movement of the main body around the loading spike during lifting by an interference fit between a circumferential shape of the loading tube and the loading spike, such that a drive mechanism can lift and tilt the container to easily transfer contents from the lifted container to a receiving container.

Abstract: The present invention relates to methods of treating cancer patients carrying one or more specific fusion genes. It is based, at least in part, on the discovery that the protein encoded by the MAN2A1-FER fusion gene exhibits kinase activity and the use of tyrosine kinase inhibitors targeting MAN2A1-FER in a cancer other than prostate, for example hepatocellular cancer, led to dramatic improvement of survival of animals xenografted with the cancer.

Abstract: A portable container base for use with a powered lifting device is provided. The portable container base includes a main body to secure a bottom surface of a container such as a trash can, a plurality of wheels on a lower surface of the main body, each providing independent rotation for moving the main body and container across a surface, and a loading tube on a lower surface of the main body to slidably receive a loading spike of a lifting device, transfer a lifting force from the loading spike to the main body for lifting the container, and restrict movement of the main body around the loading spike during lifting by an interference fit between a circumferential shape of the loading tube and the loading spike, such that a drive mechanism can lift and tilt the container to easily transfer contents from the lifted container to a receiving container.

Abstract: The present invention relates to methods for treating patients having cancer or a premalignant or neoplastic condition. It is based, at least in part, on the discovery that a genome editing technique that specifically targets a fusion gene can induce cell death in a cancer cell other than a prostate cancer cell, e.g., a hepatocellular cancer cell, having the fusion gene. The present invention provides methods for treating cancer patients that include performing a genome editing technique targeting a fusion gene present within one or more cells of a subject to produce an anti-cancer effect.

Abstract: A powered, waste container lifting and tilting device is provided with a plurality of braces that can be universally attached to any receiving container, a retractable loading spike and strap that can be universally attached to any trash can, and a drive mechanism that can lift and tilt a trash can to easily transfer contents from the lifted trash can to the receiving container.

Abstract: A powered, waste container lifting and tilting device is provided with a plurality of braces that can be universally attached to any receiving container, a retractable loading spike and strap that can be universally attached to any trash can, and a drive mechanism that can lift and tilt a trash can to easily transfer contents from the lifted trash can to the receiving container.

Abstract: A device for preventing intrusion of collected water into a vehicle is provided, defined by a water diverter configured and dimensioned to divert water from at least a vehicle-rearward edge of a roof panel aperture provided for a vehicle sun roof/moon roof assembly. The water diverter further includes end portions configured and dimensioned to divert water from at least a portion of opposed vehicle-outboard edges of the roof panel aperture.

Abstract: A device for preventing intrusion of collected water into a vehicle is provided, defined by a water diverter configured and dimensioned to divert water from at least a vehicle-rearward edge of a roof panel aperture provided for a vehicle sun roof/moon roof assembly. The water diverter further includes end portions configured and dimensioned to divert water from at least a portion of opposed vehicle-outboard edges of the roof panel aperture.

Abstract: The present invention relates to methods for determining whether a subject having prostate cancer is at an increased risk for relapse or rapid relapse. It is based, at least in part, on the results of a comprehensive genome analysis of 273 prostate cancer samples, which indicate that the percentage of large size CNVs predicts prostate cancer relapse. In certain embodiments, a method for determining whether a prostate cancer patient has an increased risk of suffering a relapse or a rapid relapse comprises determining the number and size of CNVs in a sample and determining a large size ratio, where if the large size ratio exceeds a particular threshold, the patient is deemed to be at an increased risk for relapse or rapid relapse.

Abstract: A powered, waste container lifting and tilting device is provided with a plurality of braces that can be universally attached to any receiving container, a retractable loading spike and strap that can be universally attached to any trash can, and a drive mechanism that can lift and tilt a trash can to easily transfer contents from the lifted trash can to the receiving container.

Abstract: A powered, waste container lifting and tilting device is provided with a plurality of braces that can be universally attached to any receiving container, a retractable loading spike and strap that can be universally attached to any trash can, and a drive mechanism that can lift and tilt a trash can to easily transfer contents from the lifted trash can to the receiving container.

Abstract: A motor vehicle has a body including a header margin at least partially defining a body side opening. The motor vehicle further includes a first door received in and closing at least a first portion of the body side opening and a drip resistant textured-paint surface feature provided along the header margin above the first door.

Abstract: A motor vehicle has a body including a header margin at least partially defining a body side opening. The motor vehicle further includes a first door received in and closing at least a first portion of the body side opening and a drip resistant textured surface feature provided along the header margin above the first door.