Patents by Inventor George Michalopoulos

George Michalopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160101671
    Abstract: A motor vehicle has a body including a header margin at least partially defining a body side opening. The motor vehicle further includes a first door received in and closing at least a first portion of the body side opening and a drip resistant textured surface feature provided along the header margin above the first door.
    Type: Application
    Filed: October 8, 2014
    Publication date: April 14, 2016
    Inventor: George Michalopoulos
  • Publication number: 20150283589
    Abstract: A sanitary wipe is provided, including a pad that is contained beneath or as part of an adhesive sticker or otherwise attachable body that is releasably secured at any convenient point on a surface of a container or containment vessel, such as the side or top of the containment vessel. The pad can be provided with or without a cleaning substance. For use, the user simply pulls the adhesive sticker or attachable body free of the container, and uses the wipe part or pad of the sticker or body to clean and remove contamination wherever contamination is suspected or at any other desired location, like on the lid of the containment vessel.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 8, 2015
    Inventors: Taso Georgas, George Michalopoulos
  • Publication number: 20140143028
    Abstract: Embodiments disclosed herein provide systems and methods that allow users to self-organize and build self-governed online communities around any topic or genre of interest, such as sports, news, politics, science, and/or broader or more specific topics. The online communities may be groups of like-minded individuals who can govern themselves by democratically selecting leaders and rules. The selection process for leaders and/or rule may be automatic using algorithms, based on voting, or a combination of both.
    Type: Application
    Filed: November 16, 2013
    Publication date: May 22, 2014
    Applicant: Eunum, LLC
    Inventors: William Howe, George Michalopoulos, Chhay Tea
  • Publication number: 20040151729
    Abstract: The present invention relates to long-term, three-dimensional cultures of cells in a horizontally-rotating vessel and methods for producing the cultures and using the cultures as explants to treat various conditions.
    Type: Application
    Filed: November 4, 2003
    Publication date: August 5, 2004
    Inventors: George Michalopoulos, William C. Bowen
  • Patent number: 6737270
    Abstract: A method is provided for long term culture of proliferating hepatocytes that retain hepatic function to produce a hepatic cell culture. Hepatocytes and nonparenchymal cells are co-cultured ex vivo on a matrix coated with a molecule that promotes cell adhesion, proliferation or survival, in the presence of growth factors, resulting in a long-term culture of proliferating hepatocytes that retain hepatic function. The co-culturing method results in the formation of matrix/hepatic cell clusters that may be mixed with a second structured or scaffold matrix that provides a three-dimensional structural support to form structures analogous to liver tissue counterparts. The method can be used to form bio-articial livers through which a subjects blood is perfused.
    Type: Grant
    Filed: December 7, 1999
    Date of Patent: May 18, 2004
    Assignee: University of Pittsburgh of the Commonwealth System of Higher Education
    Inventors: George Michalopoulos, William C. Bowen
  • Publication number: 20030096411
    Abstract: The present invention relates to a novel tissue culture system that provides for the long term culture of proliferating hepatocytes that retain hepatic function. Disclosed are methods and compositions for ex vivo culturing of hepatocytes and nonparenchymal cells on a matrix coated with a molecule that promotes cell adhesion, proliferation or survival, in the presence of growth factors, resulting in a long-term culture of proliferating hepatocytes that retain hepatic function. The co-culturing method results in the formation of matrix/hepatic cell clusters that may be mixed with a second structured or scaffold matrix that provides a three-dimensional structural support to form structures analogous to liver tissue counterparts. The hepatic cell culture system can be used to form bio-artificial livers through which a subjects blood is perfused. Alternatively, the novel hepatic cell culture system may be implanted into the body of a recipient host having a hepatic disorder.
    Type: Application
    Filed: October 28, 2002
    Publication date: May 22, 2003
    Inventors: George Michalopoulos, William C. Bowen