Abstract: The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

Abstract: A method for dynamic pixel mass spectrometric imaging, or dynamic pixel imaging is disclosed. The method includes striking a sample to be scanned with a laser beam so that the laser beam releases analytes from the sample. The laser beam and the sample are then displaced relative to one another so that the laser beam substantially continuously traces a predefined path on the sample to release analytes from the sample along the predefined path. A mass analysis of the released analytes is performed.

Abstract: A process of producing a filter tube comprises the steps of cutting a paper segment of given length and width from an endless paper supply. Next, a filter segment of cellulose acetate tow, for example, is centrally positioned on the paper segment. Opposed tube forming rollers engage the ends of the filter segment, and as these rollers rotate, the paper segment is formed into a tube shape. Overlapping portions of the paper segment are secured together, and the tube forming rollers are withdrawn from the tube to thereby complete the forming operation.

Abstract: A method and apparatus is provided to assure transformations between applications in an integration project. This assurance of transformations between applications includes mapping one or more related fields from a set of fields between the one or more source applications and the one or more target applications according to a set of integration objectives, checking a type compatibility for each of the one or more related fields mapped between the one or more source applications and the one or more target applications and indicating a mapping status according to the type compatibility between the source applications and the target applications.

Abstract: Process and apparatus for the mass production of compound cigarette filters function to deposit granular filter material into the open ends of vertically oriented filter tubes. Predetermined amounts of diverse granular material are withdrawn by suction from sources of such material, and these amounts are deposited into the tubes. Solid filter segments seal the granular material within the tube. After one half of each filter tube is filled with granular material and sealed, the tube is inverted and the opposite end is filled in substantially the same manner. When cut in half each filter tube produces two cigarette filters.

Abstract: A process of impregnating fine adsorbent particles such as carbon dust or APS silica gel powder into the micro-cavities of shaped fibers comprises the steps of continuously conveying shaped fibers with micro-cavities to a reservoir of the fine adsorbent particles. The fibers pass through the reservoir to thereby produce relative motion between the fibers and the particles. Additionally, impact forces are created between the shaped fibers and the fine particles to assist in impregnating the particles into the micro-cavities of the fibers. Any excess particles are removed from the fibers outside the reservoir, and subsequently the shaped fibers impregnated with fine adsorbent particles are collected for later use in filter applications such as cigarette filter and air filter applications, for example.

Abstract: A variable ratio drive belt system is used to drive the water pump. The variable ratio drive belt system comprises a variable pitch water pump pulley, or driven pulley, a variable pitch crankshaft pulley, or driver pulley, and a drive belt that is coupled between a water pump and an engine crankshaft. By increasing and decreasing the size of the variable pitch water pump pulley and increasing the size of the variable pitch crankshaft pulley as a function of engine speed, the water pump speed can be increased at low engine speed to provide improved coolant flow and decreased at higher engine speeds to prevent pump cavitation.

Abstract: A laparoscopic netting assembly is provided for conducting a gallbladder or bile duct procedure through one of the throughbores in a carrier sheath, which in turn may be positioned within a laparoscopic port. The carrier sheath includes at least one through channel for conducting a frame control rod, and optionally a deployment rod. The netting assembly includes a collapsible and expandable frame and a fluid permeable netting, which is preferably comprises a plurality of netting layers, suspended on the frame for collecting stones released from the gallbladder or bile duct. The frame is sized to also collect the gallbladder. The carrier sheath may also include one or more through channels for a cutting instrument.

Abstract: A device for the prevention or treatment of ulcers includes an absorbent layer 20 and an upper layer 30, 84 which may be transparent or opaque, and is preferably curved downward to engage the absorbent layer and minimize contact to the ulcer. A sensor or signaling member is provided for outputting an electrical signal in response to the flexible deformation of the upper layer indicative of the excessive pressure. A warning member, such as a light or alarm, is responsive to the signaling member for notifying the patient or caregiver of excessive pressure. In another embodiment, the device includes a plurality of shear detector sensors for outputting an electrical signal in response to shear movement between the absorbent layer and the patient's skin.

Abstract: An in vitro method for the differentiation of functionally mature neutrophils from stem cells is disclosed. Also disclosed are methods of producing genetically modified neutrophils in vitro and methods of using the neutrophils produced according to the invention.

Abstract: A pulse free escalator system has two spaced apart pulse free turnaround sections and at least one pulse-free transition zone. A method of designing the turnaround sections and the at least one transition zone is described herein. The escalator system has a pair of guide tracks and a pair of linkage assemblies, each comprising a plurality of links joined together. Each linkage assembly has a plurality of rollers for supporting the linkage assembly which travel in a respective one of the guide tracks. Each guide track has two spaced apart turnaround portions with each turnaround portion defining a travel path for each roller having a linear entry section, a linear exit section, and a pulse-free section intermediate the two sections.

Abstract: An assembly for positioning and removably supporting cargo on the exterior of a vehicle, wherein the cargo is preferably mounted on a mobile carrier assembly such as a hand truck. A hoist assembly includes a winch and lifting cable and is concurrently supported, along with the mobile carrier, on a base which is removably secured to a hitch structure mounted on the vehicle. A support assembly is secured to the base and is structured to independently but concurrently support both the hoist assembly and the mobile carrier, with or without the cargo thereon. Upon removal of the mobile carrier from the vehicle, the cargo supported thereon can be transported over the ground or other support surface to an intended location for use without requiring repeated loading and unloading of the cargo from the mobile carrier.

Abstract: The present invention relates to a pulse free escalator system having two spaced apart pulse free turnaround sections and at least one pulse-free transition zone and to a method of designing the turnaround sections and the at least one transition zone. The escalator system has a pair of guide tracks and a pair of linkage assemblies, each comprising a plurality of links joined together. Each linkage assembly has a plurality of rollers for supporting the linkage assembly which travel in a respective one of the guide tracks. Each guide track has two spaced apart turnaround portions with each turnaround portion defining a travel path for each roller having a linear entry section, a linear exit section, and a pulse-free section intermediate said two sections.

Abstract: In a system for mooring offshore drilling units, a first mooring assembles installed at a first drilling venue, after which the mobile offshore drilling unit is moored by connection to the mooring lines. A second mooring assembly is installed at a second drilling venue while drilling operations are carried out at the first drilling venue. In this manner the mobile offshore drilling unit can be relocated between successive drilling venues with minimum down time. Less than complete mooring assemblies can be used to temporarily secure the mobile offshore drilling unit.