Patents by Inventor George T. Gillies
George T. Gillies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11951303Abstract: The epicardial pacing system and related method includes an epicardial catheter configured to be disposed in the middle mediastinum of the thorax of a subject for use in electrical pacing of the heart at one or more locations on the epicardial surface. The epicardial pacing catheter may include at least one electrode whereby the electrode is insulated on at least one side to allow pacing of the heart without damage to adjacent anatomical structures.Type: GrantFiled: April 23, 2018Date of Patent: April 9, 2024Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies
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Patent number: 11937872Abstract: An aspect of various embodiments of the present invention system and method provide, but not limited thereto, a novel means for epicardial ablation using a double-curve steerable sheath and a double-curve deflectable open irrigated-tip/suction catheter that can be guided around the apex of the heart and adjusted so as to position the distal tip optimally. The catheter can also both deliver fluid to and withdraw fluid from the pericardial space. Access to the epicardial surface of the heart is via a subxiphoid entry. The method and means presented include, but are not limited to, steering, energy delivery, bipolar mapping, placement and use of electrodes, irrigation, suction of irrigation fluid, and other details of the subject invention.Type: GrantFiled: December 31, 2018Date of Patent: March 26, 2024Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies
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Publication number: 20220362542Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.Type: ApplicationFiled: August 1, 2022Publication date: November 17, 2022Applicants: University of Iowa Research Foundation, University of Virginia Patend FoundationInventors: Matthew A. Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
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Patent number: 11413449Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.Type: GrantFiled: February 13, 2020Date of Patent: August 16, 2022Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, University of Virginia Patent FoundationInventors: Matthew A. Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
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Patent number: 11241526Abstract: Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting.Type: GrantFiled: November 6, 2018Date of Patent: February 8, 2022Assignee: University of Virginia Patent FoundationInventors: William J. Elias, Aaron E. Bond, George T. Gillies
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Patent number: 11083381Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which conditions at the location of an access needle may be determined according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject, and the pressure frequency information may be segmented based on the cardiac waveform information. Conditions at the current location of the needle may be determined based on an algorithm including the segmented pressure frequency information and the cardiac waveform information.Type: GrantFiled: May 8, 2017Date of Patent: August 10, 2021Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies, Jason Tucker-Schwartz
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Patent number: 11058354Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be included with the access needle to provide image data and/or cardiac waveform information of the subject.Type: GrantFiled: October 9, 2015Date of Patent: July 13, 2021Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies, Jason M. Tucker-Schwartz
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Patent number: 11013428Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.Type: GrantFiled: October 17, 2016Date of Patent: May 25, 2021Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies, Jason M. Tucker-Schwartz
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Patent number: 10702335Abstract: An electrode catheter for use with an endocardial ablation catheter, wherein the electrode catheter receives the transmitted energy for ablating a portion of the heart. The electrode catheter comprises a proximal portion, a distal portion, and a longitudinal structure there between; and an electrode in communication with said electrode catheter, wherein said electrode receives the transmitted energy from the endocardial ablation catheter, or alternatively an epicardial ablation catheter.Type: GrantFiled: December 14, 2015Date of Patent: July 7, 2020Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies
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Publication number: 20200179684Abstract: This invention provides an device for electrical stimulation of the spinal cord. The device has an electrode assembly with a sufficiently thin profile to be implanted between the pial surface of the spinal cord and the dura mater, and secured to the dura. Electrodes on the electrode assembly are directed towards the surface of the spinal cord, and connected through the dura to a signal generator located outside the dura. Following implantation, the subject is treated by transmitting electrical signals from the signal generator through the leads to the electrodes, stimulating the subject's spinal cord.Type: ApplicationFiled: February 13, 2020Publication date: June 11, 2020Applicants: Universty of Iowa Research Foundation, University of Virginia Patent FoundationInventors: Matthew A. Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
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Publication number: 20190274757Abstract: An aspect of various embodiments of the present invention system and method provide, but not limited thereto, a novel means for epicardial ablation using a double-curve steerable sheath and a double-curve deflectable open irrigated-tip/suction catheter that can be guided around the apex of the heart and adjusted so as to position the distal tip optimally. The catheter can also both deliver fluid to and withdraw fluid from the pericardial space. Access to the epicardial surface of the heart is via a subxiphoid entry. The method and means presented include, but are not limited to, steering, energy delivery, bipolar mapping, placement and use of electrodes, irrigation, suction of irrigation fluid, and other details of the subject invention.Type: ApplicationFiled: December 31, 2018Publication date: September 12, 2019Inventors: Srijoy Mahapatra, George T. Gillies
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Publication number: 20190070356Abstract: Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting.Type: ApplicationFiled: November 6, 2018Publication date: March 7, 2019Applicant: University of Virginia Patent FoundationInventors: William J. Elias, Aaron E. Bond, George T. Gillies
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Patent number: 10166066Abstract: An aspect of various embodiments of the present invention system and method provide, but not limited thereto, a novel means for epicardial ablation using a double-curve steerable sheath and a double-curve deflectable open irrigated-tip/suction catheter that can be guided around the apex of the heart and adjusted so as to position the distal tip optimally. The catheter can also both deliver fluid to and withdraw fluid from the pericardial space. Access to the epicardial surface of the heart is via a subxiphoid entry. The method and means presented include, but are not limited to, steering, energy delivery, bipolar mapping, placement and use of electrodes, irrigation, suction of irrigation fluid, and other details of the subject invention.Type: GrantFiled: March 13, 2008Date of Patent: January 1, 2019Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies
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Patent number: 10159782Abstract: Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting.Type: GrantFiled: September 18, 2013Date of Patent: December 25, 2018Assignee: University of Virginia Patent FoundationInventors: William J. Elias, Aaron E. Bond, George T. Gillies
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Publication number: 20180361145Abstract: The epicardial pacing system and related method includes an epicardial catheter configured to be disposed in the middle mediastinum of the thorax of a subject for use in electrical pacing of the heart at one or more locations on the epicardial surface. The epicardial pacing catheter may include at least one electrode whereby the electrode is insulated on at least one side to allow pacing of the heart without damage to adjacent anatomical structures.Type: ApplicationFiled: April 23, 2018Publication date: December 20, 2018Inventors: Srijoy Mahapatra, George T. Gillies
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Patent number: 10071240Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.Type: GrantFiled: February 21, 2017Date of Patent: September 11, 2018Assignees: University of Iowa Research Foundation, University of Virgina Patent FoundationInventors: Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy, George T. Gillies
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Publication number: 20170238823Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which conditions at the location of an access needle may be determined according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject, and the pressure frequency information may be segmented based on the cardiac waveform information. Conditions at the current location of the needle may be determined based on an algorithm including the segmented pressure frequency information and the cardiac waveform information.Type: ApplicationFiled: May 8, 2017Publication date: August 24, 2017Inventors: Srijoy Mahapatra, George T. Gillies, Jason Tucker-Schwartz
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Publication number: 20170224968Abstract: Systems and methods for use in monitoring treatment of pressure-related conditions, such as hydrocephalus, include an implantable vessel, and a meter including one or more microfluidic channels connected to the vessel. The microfluidic channels may be configured to detect at least one of pressure and fluid flow rate through the vessel and to be read out remotely by a wirelessly coupled external device. The meter may include a passive resonant (LC) circuit. A dynamic flap may be included in the microfluidic channel that may act as part of the LC circuit. An external device may also be configured to inductively couple remotely to the LC circuit, with-out physical connections to the implantable vessel or pressure meter, and to display a pressure acting on the pressure meter and/or a fluid flow through the meter.Type: ApplicationFiled: April 26, 2017Publication date: August 10, 2017Inventors: Marcel Utz, George T. Gillies, William Broaddus, John A. Jane, Matthew R. Begley
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Publication number: 20170157390Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.Type: ApplicationFiled: February 21, 2017Publication date: June 8, 2017Inventors: Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy, George T. Gillies
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Patent number: 9669198Abstract: A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof.Type: GrantFiled: July 18, 2007Date of Patent: June 6, 2017Assignees: University of Virginia Patent Foundation, Virginia Commonwealth UniversityInventors: William C. Broaddus, Rahul Mahajan, George T. Gillies