Patents by Inventor George T. Gillies
George T. Gillies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9669198Abstract: A system and related method for delivering the anti-tumoral agent carmustine or other types of diagnostic or therapeutic agents into the brain of a patient with a brain tumor includes an insertion device, a skull mount, and a reformulated geometry of the carmustine compound (or other material) optimized for use in the insertion device and for maximized biodegradation time. The insertion device may be front loaded with the carmustine material (or other material) and inserted through the mount on a skull, to the location of the brain tumor, where the carmustine (or other material) is then released. It should be appreciated that the diagnostic and/or therapeutic system and related method thereof are not necessarily limited to the brain of a subject. It may also be used in the organ structures or tubular structures, as well as portions and locations thereof.Type: GrantFiled: July 18, 2007Date of Patent: June 6, 2017Assignees: University of Virginia Patent Foundation, Virginia Commonwealth UniversityInventors: William C. Broaddus, Rahul Mahajan, George T. Gillies
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Patent number: 9642534Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.Type: GrantFiled: May 4, 2012Date of Patent: May 9, 2017Assignee: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies, Jason Tucker-Schwartz
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Patent number: 9636487Abstract: Systems and methods for use in monitoring treatment of pressure-related conditions, such as hydrocephalus, include an implantable vessel, and a meter including one or more microfluidic channels connected to the vessel. The microfluidic channels may be configured to detect at least one of pressure and fluid flow rate through the vessel and to be read out remotely by a wirelessly coupled external device. The meter may include a passive resonant (LC) circuit. A dynamic flap may be included in the microfluidic channel that may act as part of the LC circuit. An external device may also be configured to inductively couple remotely to the LC circuit, with-out physical connections to the implantable vessel or pressure meter, and to display a pressure acting on the pressure meter and/or a fluid flow through the meter.Type: GrantFiled: June 17, 2011Date of Patent: May 2, 2017Assignee: University of Virginia Patent FoundationInventors: Marcel Utz, George T. Gillies, William Broaddus, John A. Jane, Matthew R. Begley
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Publication number: 20170086707Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.Type: ApplicationFiled: October 17, 2016Publication date: March 30, 2017Applicant: University of Virginia Patent FoundationInventors: Srijoy Mahapatra, George T. Gillies, Jason M. Tucker-Schwartz
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Publication number: 20170065814Abstract: A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.Type: ApplicationFiled: September 16, 2016Publication date: March 9, 2017Inventors: Matthew Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
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Publication number: 20160331445Abstract: An electrode catheter for use with an endocardial ablation catheter, wherein the electrode catheter receives the transmitted energy for ablating a portion of the heart. The electrode catheter comprises a proximal portion, a distal portion, and a longitudinal structure there between; and an electrode in communication with said electrode catheter, wherein said electrode receives the transmitted energy from the endocardial ablation catheter, or alternatively an epicardial ablation catheter.Type: ApplicationFiled: December 14, 2015Publication date: November 17, 2016Applicant: University of Virginia Patent FoundationInventors: Srijoy MAHAPATRA, George T. GILLIES
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Patent number: 9486621Abstract: A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.Type: GrantFiled: August 7, 2015Date of Patent: November 8, 2016Assignees: University of Iowa Research Foundation, University of Virginia Patent FoundationInventors: Matthew Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
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Patent number: 9468396Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.Type: GrantFiled: May 4, 2012Date of Patent: October 18, 2016Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Srijoy Mahapatra, George T. Gillies, Jason M Tucker-Schwartz
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Patent number: 9364660Abstract: A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.Type: GrantFiled: November 11, 2011Date of Patent: June 14, 2016Assignees: University of Iowa Research Foundation, University of Virginia Patent FoundationInventors: Matthew Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
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Publication number: 20160100797Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be included with the access needle to provide image data and/or cardiac waveform information of the subject.Type: ApplicationFiled: October 9, 2015Publication date: April 14, 2016Inventors: Srijoy Mahapatra, George T. Gillies, Jason M. Tucker-Schwartz
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Patent number: 9211405Abstract: An electrode catheter for use with an endocardial ablation catheter, wherein the electrode catheter receives the transmitted energy for ablating a portion of the heart. The electrode catheter comprises a proximal portion, a distal portion, and a longitudinal structure there between; and an electrode in communication with said electrode catheter, wherein said electrode receives the transmitted energy from the endocardial ablation catheter, or alternatively an epicardial ablation catheter.Type: GrantFiled: March 20, 2008Date of Patent: December 15, 2015Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Srijoy Mahapatra, George T. Gillies
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Publication number: 20150343205Abstract: A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.Type: ApplicationFiled: August 7, 2015Publication date: December 3, 2015Inventors: Matthew Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robort Shurig
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Patent number: 9192408Abstract: System and method that is directed to medical treatments of organs having anatomical spaces, such as (but not limited to) the heart and the pericardial space. Specifically, an apparatus and method is provided for safely accessing anatomical spaces with surfaces to deliver medical devices or media into such spaces, or to remove fluids from such spaces. The methods and apparatus may include a first elongated member with a sharp tip used to penetrate the surface surrounding the anatomical space with a second elongated member with a helical tine used to engage the surface and lift the surface away from the underlying anatomical space. Once the first elongated member has incised the surface, it is removed, and the incision may be used as a point of entry for delivering media or medical devices into the anatomical space, or for carrying out further medical procedures.Type: GrantFiled: December 8, 2014Date of Patent: November 24, 2015Assignee: University of Virginia Patent FoundationInventors: George T. Gillies, Peter Pollak, Srijoy Mahapatra
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Publication number: 20150238685Abstract: Provided is a method and system for delivering a diagnostic agent to a site in the brain of a subject for imaging at least a portion of the brain site on a medical imaging system. The method and system includes a catheter device with associated lumens having diagnostic agent ports for delivering the diagnostic agent (e.g., infusate) through the lumens and advancing the diagnostic agent so as to exit out from the lumens to at least a portion of the brain site and while sealing a portion of the brain site thereby preventing the exited diagnostic agent from travelling proximally beyond the sealing location, and at the same time imaging at least a portion of the brain site during at least a portion of the sealing duration so that the brain site can be visualized on a medical imaging system. The diagnostic agent (infusate) is able to highlight borders and internal patterns of the deep structures of the brain thereby enabling direct targeting.Type: ApplicationFiled: September 18, 2013Publication date: August 27, 2015Applicant: University of Virginia Patent FoundationInventors: William J. ELIAS, Aaron E. BOND, George T. GILLIES
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Publication number: 20150182253Abstract: System and method that is directed to medical treatments of organs having anatomical spaces, such as (but not limited to) the heart and the pericardial space. Specifically, an apparatus and method is provided for safely accessing anatomical spaces with surfaces to deliver medical devices or media into such spaces, or to remove fluids from such spaces. The methods and apparatus may include a first elongated member with a sharp tip used to penetrate the surface surrounding the anatomical space with a second elongated member with a helical tine used to engage the surface and lift the surface away from the underlying anatomical space. Once the first elongated member has incised the surface, it is removed, and the incision may be used as a point of entry for delivering media or medical devices into the anatomical space, or for carrying out further medical procedures.Type: ApplicationFiled: December 8, 2014Publication date: July 2, 2015Inventors: George T. Gillies, Peter Pollak, Srijoy Mahapatra
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Patent number: 8906056Abstract: System and method that is directed to medical treatments of organs having anatomical spaces, such as (but not limited to) the heart and the pericardial space. Specifically, an apparatus and method is provided for safely accessing anatomical spaces with surfaces to deliver medical devices or media into such spaces, or to remove fluids from such spaces. The methods and apparatus may include a first elongated member with a sharp tip used to penetrate the surface surrounding the anatomical space with a second elongated member with a helical tine used to engage the surface and lift the surface away from the underlying anatomical space. Once the first elongated member has incised the surface, it is removed, and the incision may be used as a point of entry for delivering media or medical devices into the anatomical space, or for carrying out further medical procedures.Type: GrantFiled: April 30, 2010Date of Patent: December 9, 2014Assignee: University of Virginia Patent FoundationInventors: George T. Gillies, Peter Pollak, Srijoy Mahapatra
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Publication number: 20140128955Abstract: A method for treating intractable pain via electrical stimulation of the spinal cord. Remote, non-contact stimulation of a selected region of spinal cord is achieved by placement of a transceiver patch directly on the surface of that region of spinal cord, with said patch optionally being inductively coupled to a transmitter patch of similar size on either the outer or inner wall of the dura surrounding that region of the spinal cord. By inductively exchanging electrical power and signals between said transmitter and transceiver patches, and by carrying out the necessary electronic and stimulus signal distribution functions on the transceiver patch, the targeted dorsal column axons can be stimulated without the unintended stray stimulation of nearby dorsal rootlets. Novel configurations of a pliable surface-sheath and clamp or dentate ligament attachment features which realize undamaging attachment of the patch to the spinal cord are described.Type: ApplicationFiled: November 11, 2011Publication date: May 8, 2014Applicants: University of Virginia Patent Foundation, University of Iowa Research FoundationInventors: Matthew Howard, Timothy Brennan, Brian Dalm, Marcel Utz, George T. Gillies, Steven Scott, Randall S. Nelson, Robert Shurig
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Blood flow bypass catheters and methods for the delivery of medium to the vasculature and body ducts
Patent number: 8655798Abstract: A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion.Type: GrantFiled: July 26, 2012Date of Patent: February 18, 2014Assignee: University of Virginia Patent FoundationInventors: Joseph A. C. Humphrey, George T. Gillies -
Publication number: 20130303967Abstract: Systems and methods for use in monitoring treatment of pressure-related conditions, such as hydrocephalus, include an implantable vessel, and a meter including one or more microfluidic channels connected to the vessel. The microfluidic channels may be configured to detect at least one of pressure and fluid flow rate through the vessel and to be read out remotely by a wirelessly coupled external device. The meter may include a passive resonant (LC) circuit. A dynamic flap may be included in the microfluidic channel that may act as part of the LC circuit. An external device may also be configured to inductively couple remotely to the LC circuit, with-out physical connections to the implantable vessel or pressure meter, and to display a pressure acting on the pressure meter and/or a fluid flow through the meter.Type: ApplicationFiled: June 17, 2011Publication date: November 14, 2013Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Marcel Utz, George T. Gillies, William Broaddus, John A. Jane, Matthew R. Begley
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Publication number: 20130096428Abstract: An access system and method for obtaining access to the interior vascular structures or other regions or collections of fluid or fluid-filled cavities inside the body. The system and method provides for injection of contrast agents (to confirm ideal position or condition), the passage of guide wires, and the eventual catheterization of the heart and other parts of the body via the pathway established through the puncture of a femoral artery. The system and method provides the ability to inject a contrast material and pass a guide wire through the same introducer device simultaneously (without necessarily moving it or removing any parts), with the device designed to prevent the backflow of the contrast material through the guide wire port during the contrast injection process The ideal location of access in the vein or artery can be seen by injecting contrast from a needle inside the structure and then using fluoroscopy.Type: ApplicationFiled: December 21, 2010Publication date: April 18, 2013Applicant: University of Virginia Patent FoundationInventors: George T. Gillies, Srijoy Mahapatra, D. Scott Lim, Michael Ragosta