Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

Abstract: The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37.

Abstract: The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.

Abstract: A method and apparatus for applying nail tabs to roofing and building cover materials involving the steps of depositing tab material onto the surface of the roofing or building cover material, during or after its manufacture, resulting in a plurality of nail tabs from a lamination roll, and bonding the tabs to the surface of the material by pressure between the lamination roll and said surface. The method also encompasses depositing the tab material or pre-formed tads by a pressure roll in contact with said surface. The tabs preferably ate made substantially of a polymer material and may be hardened or cured by ultra-violet or visible light. The tabs may also be pre-formed and have adhesive backing.

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules.

Abstract: The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37.

Abstract: The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37.

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.

Abstract: The present invention is generally directed to novel functionalized biomolecules and methods for generating such biomolecules. Biomolecules may generally include nucleic acids, peptides, multicomponent molecular complexes and/or any other molecular products that may be produced by living organisms. The present invention is further directed to cells and/or organisms manipulated to produce such functionalized biomolecules. The cells contemplated by the present invention include both prokaryotic as well as eukaryotic cells. The functionalized biomolecules are produced via materials introduced into the cell using standard molecular biology techniques or are incorporated within the genomic nucleic acid of a cell by standard recombination techniques. Further contemplated is the use of such cells for sequestration of target molecules within the cells.

Abstract: Molecular probes to particular targets may be nucleic acids that may generally possess resistance to degradation when bound to a target molecule. For example, the molecular probes may be generally resistant to nuclease degradation when bound to their target molecules, and generally not resistant to nuclease degradation when unbound to their target molecules. This may be utilized, for example, to selectively degrade unbound molecular probes while preserving the bound molecular probes, which may thus serve as an indication of the presence of their target molecules in a sample.

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules. The present invention further relates to methods for generating, for example, functional biomolecules, particularly to functional nucleic acids, that bind with functional activity to another biomolecule, such as a receptor molecule. More than one or multiple targets as used herein may generally include different types of targets, and/or may also include a multitude of a singular type of targets at different conditions, such as, for example, temperature, pH, chemical environment, and/or any other appropriate conditions.

Abstract: The present invention is generally directed to novel functionalized biomolecules and methods for generating such biomolecules. Biomolecules may generally include nucleic acids, peptides, multicomponent molecular complexes and/or any other molecular products that may be produced by living organisms. The present invention is further directed to cells and/or organisms manipulated to produce such functionalized biomolecules. The cells contemplated by the present invention include both prokaryotic as well as eukaryotic cells. The functionalized biomolecules are produced via materials introduced into the cell using standard molecular biology techniques or are incorporated within the genomic nucleic acid of a cell by standard recombination techniques. Further contemplated is the use of such cells for sequestration of target molecules within the cells.

Abstract: The present invention is directed to nucleic acid ligands to LL37, methods for producing said nucleic acid ligands, and methods for utilizing said nucleic acid ligands. In one exemplary embodiment, for example, this invention relates to nucleic acid ligands exhibiting high specific binding affinity to LL37 peptides, precursors and/or portions thereof. Further, the nucleic acid ligands may bind competitively with native ligands of LL37 and may also inhibit and/or interfere with LL37 function, such as by binding to LL37.

Abstract: A multi-speed jack, having a pump assembly including a pump block having a first cylinder and a second cylinder defined therein, a piston assembly movable within the pump block, the piston assembly having a first portion configured to sealably engage with the first cylinder and a second portion configured to sealably engage with the second cylinder, a reservoir for storing hydraulic fluid and coupled to the pump block so that when the piston assembly is moved in a first direction, hydraulic fluid in the reservoir is supplied to the first cylinder and the second cylinder, a lifting assembly having a ram chamber and a ram rod, the ram chamber coupled to the pump assembly and configured to receive fluid from the first cylinder and the second cylinder when the piston assembly is moved in a second direction so as to raise the ram rod and a bypass check valve provided in the first cylinder.

Abstract: The present invention is directed to methods and devices for tissue collection and analysis, and particularly to methods and devices for collecting, preserving and analyzing biopsy samples. In one aspect, a method for collecting a tissue sample includes disposing a collection device proximate and/or within a tissue, such as of a body, drawing in at least a portion of the tissue into the collection device, adhering the at least a portion of the tissue to at least a portion of the collection device and separating the sample and collection device from the remainder of the tissue and/or body. In general, the method of adhering the tissue sample to the collection device may also preserve the tissue sample, such as, for example, by altering the temperature of the tissue sample.

Abstract: A putter has an elongated head with a face along a long side of the head and an end surface along a short side of the head. The shaft can be positioned to strike a ball with either the face or the end surface. The end surface may have a loft of 5 degrees or more. The shaft is held in each position such that it does not move appreciably while putting, but can be moved to another position by a golfer, optionally with or without tools. In some embodiments, all contact between the shaft and the head is made through one or more resilient, non-metallic materials such as rubber. In some embodiments, a ball on the end of the shaft is held in a cavity in the head by an annular nut. O-rings or other elements separate the ball from components fixed to the head and the nut can be tightened or loosened to adjust the friction provided by the O-rings or other elements. In some embodiments, the shaft can alternately be made fixable or moveable relative to the head by manipulating, for example twisting, the shaft.

Abstract: A column mounted shoring bracket has a support sub-assembly attached to a column or other supporting surface, a jack sub-assembly attached to the support and a head sub-assembly attached to a part of the jack that varies in height relative to the support. The head has a head base that supports one or more rollers for moving a form. The head also has a supporting plate for supporting the form. The supporting plate is connected to the head base so that it may be slid upwards and fixed in a position where the top of the supporting plate is above the top of the rollers, for example to carry the weight of a slab being built, or slid downwards so that the top of the supporting plate is below the top of the rollers which do not have to carry the weight of the slab being built. The angular position of the rollers may be aligned with an external reference such as the side of a column, a wall, or a jig.

Abstract: An overhang bracket has a top member, a side member and a diagonal member. The side and top member may be connected together through a removable connecter. A guardrail post holder allows a guardrail post to be installed at a variety of angles to the top member. Rotating the side member causes the diagonal member to translate up or down the side member. A side member locator extends upwards from the overhang bracket to indicate the location of the side member. A tie rod holder holds a tie rod in an offset position relative to the side member. The side member locator may extend upwards through further parts of the shoring system or bridge overhang structure, for example a floor of a concrete form or rebar. A worker may adjust the overhang bracket in place from a standing position on a supporting structure or the floor of the form.

Abstract: A bridge overhang bracket includes an elongate top member having inner and outer ends an elongate diagonal member having an inner end and an outer end, the outer end of the diagonal member pivotally attached to the outer end of the top member, upper and lower pivot joints secured to the top member and diagonal member, respectively, adjacent the respective inner ends thereof, and an elongate side member extending between and engaged with the upper and lower pivot joints. At least one of the pivot joints comprises an adjustable axial engagement mechanism for adjusting the position along the length of the side member at which the at least one pivot joint engages the side member.

Abstract: A column mounted shoring bracket has a support sub-assembly attached to a column or other supporting surface, a jack sub-assembly attached to the support and a head sub-assembly attached to a part of the jack that varies in height relative to the support. The head has a head base that supports one or more rollers for moving a form. The head also has a supporting plate for supporting the form. The supporting plate is connected to the head base so that it may be slid upwards and fixed in a position where the top of the supporting plate is above the top of the rollers, for example to carry the weight of a slab being built, or slid downwards so that the top of the supporting plate is below the top of the rollers which do not have to carry the weight of the slab being built. The angular position of the rollers may be aligned with an external reference such as the side of a column, a wall, or a jig.