Abstract: An injection device comprises a housing having a first longitudinal axis (L). The injection device further comprises a medicament cartridge holder and a drive assembly including a drive shaft. The drive shaft is arranged around the first longitudinal axis. The drive assembly is capable of providing an axial force for ejecting a dose of medicament from the injection device. The medicament cartridge holder and at least part of said drive assembly are arranged around a second longitudinal axis (LC) which is substantially parallel to but offset from the first longitudinal axis.

Abstract: Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.

Abstract: A method for recommending modification of user input includes receiving, by a graphical user interface (GUI) provided by a virtual keyboard application, user input representing a first word entered by a user. The virtual keyboard application accesses at least one word entered by the user prior to the entering of the first word. The virtual keyboard application determines an edit distance between the first word and each of a plurality of candidate modifications, based on analyzing the first word, the touchpoint and the at least one word entered prior to the entering of the first word, the plurality of candidate modifications selected from a dictionary in a language matching a language of the first word. The virtual keyboard application identifies a subset of the plurality of candidate modifications. The virtual keyboard application modifies the GUI to display at least one of the identified subset.

Abstract: An apparatus may include: a body defining a flow path; an inlet to the flow path; an outlet to the flow path; a test coupon at least partially disposed within the flow path; a sealing element disposed between the test coupon and the body; and a current source electrically coupled to the test coupon, wherein the inlet and the outlet are in fluid communication through the flow path, and wherein the sealing element electrically insulates the body and the test coupon.

Abstract: The present invention relates to a combination of an anti-toxin, The present invention relates to a combination of an anti-toxin, an immunomodulator and a component that provides energy to mucosal cells, which may be useful for decreasing effects of Clostridia sp. or coccidia sp based diseases or other enteric diseases or by generally improving gastro intestinal health or function.

Abstract: An injection device comprising a housing (12) and a dose selector (16) to set a dose of medicament to be ejected from the injection device. A spring (20) coupled to the dose selector stores energy necessary for ejecting the dose from the injection device. A ratchet (25) arrangement is provided to rotationally couple a ratchet component and an internal surface of the housing in a coupled state and to allow relative rotation between the ratchet component and the internal surface of the housing in an uncoupled state. An over-torque feature (27) located between the dose selector and the spring is actuatable, when the rotation of the dose selector causes the charging force to exceed a defined limit, to reduce the charging force transferred from the dose selector to the spring. Both the ratchet component and the over-torque feature are provided on a single component (28).

Abstract: An injection device comprises a dose selector, rotatable by a user to set a dose to be ejected from the injection device and a drive assembly including a drive shaft (140) and a plunger element (145), the drive assembly being capable of providing an axial force for ejecting a dose of medicament from a medicament container. A dose limit nut (141) is provided which is rotationally coupled to but not axially coupled to said drive shaft. The plunger element is threaded so that the dose limit nut is engaged with said plunger element via said thread, in order to guide relative axial movement between the dose limit nut and the plunger element. The dose limit nut is provided with dose limiting endstops which are capable of limiting axial travel of said dose limit nut with respect to said plunger element, so as to limit maximum and minimum doses of medicament which can be set by the user.

Abstract: The composition of articles can be identified using luminescent codes printed or coated onto the articles (or labels on the articles) by means of an ink which contains long persistence luminescent materials. Radiation is used to excite the luminescent materials and this is then extinguished before the article passes beneath a spectrometer. An infrared beam then strikes the article in order to stimulate emission from the long persistence luminescent materials, via a detrapping mechanism, and the spectrometer detects the emission in order to identify the article.

Abstract: A security system includes a first security badge having a visual portion that varies according to signals provided to the first security badge and an authorization server that periodically provides signals to the first security badge in response to a query of the authorization server by the first security badge while the first security badge remains in a controlled zone, the signals varying independently of reader access of the first security badge. The first security badge may be read by a reader only in connection with initial entry into the controlled zone. Authorization of a user of the first security badge may vary while the user remains in the controlled zone. The first security badge may include a visual image of a user of the first security badge and displays additional information. The additional information may include name and authorization status of the user.

Abstract: A laryngeal mask airway device includes an airway tube and a laryngeal mask placed at a distal end of the airway tube. The distal end of the airway tube opens inside the laryngeal mask. The device includes a connector placed at a proximal end of the airway tube. The connector is in fluid communication with the laryngeal mask through the airway tube and is configured to be connected to a ventilation equipment. The device includes a movable element placed in the laryngeal mask and configured to steer a tip of a catheter passing through the airway tube. The device further includes a control element mounted on the proximal end of the airway tube and a motion transmission device operatively connected to the movable element and to the control element to move the movable element and to steer the tip of the catheter by acting on the control element.

Abstract: The disclosure provides seven integrated methods for the chemical sequestration of carbon dioxide (CO2), nitric oxide (NO), nitrogen dioxide (NO2) (collectively NOx, where x=1, 2) and sulfur dioxide (SO2) using closed loop technology. The methods recycle process reagents and mass balance consumable reagents that can be made using electrochemical separation of sodium chloride (NaCl) or potassium chloride (KCl). The technology applies to marine and terrestrial exhaust gas sources for CO2, NOx and SO2. The integrated technology combines compatible and green processes that capture and/or convert CO2, NOx and SO2 into compounds that enhance the environment, many with commercial value.

Abstract: The disclosure provides a peptide library with increased peptide diversity. The increase in peptide diversity can occur via cleavage of particular amino acids within a peptide. The disclosure further provides a method for promoting folding of a peptide into an active conformation.

Abstract: Compositions and methods for the use of dispersants for carbon nanotube or carbon nanostructure dispersions are provided. In some embodiments the present disclosure provides a composition including a non-aqueous fluid; a carbon nanostructure; a dispersant selected from the group consisting: of a high molecular weight nonylphenol resin, a medium molecular weight nonylphenol resin, a low molecular weight nonylphenol resin, an ethoxylated nonylphenol resins, polyisobutylene succinic anhydride, a calcium overbased sulfonate, N-methyl-2-pyrrolidone (NMP), imidazoline, a derivative of the foregoing, and any combination thereof; and a solvent.

Abstract: The present invention relates to methods, uses, and compositions for the treatment of cancer (e.g., a lung cancer; a cervical cancer; a breast cancer; a head and neck cancer; a liver cancer; a bladder cancer; a gastric cancer; an esophageal cancer; a pancreatic cancer; a kidney or renal cancer; a melanoma; an ovarian cancer; or a colorectal cancer). More specifically, the invention concerns the treatment of patients having cancer with an anti-TIGIT antagonist antibody, including treatment with an anti-TIGIT antagonist antibody in a combination therapy.

Abstract: Providing virtualized credentials of a license holder includes determining contextual data that governs visual information presented on a display and displaying credential data on the display, where visual characteristics of the credential data that is displayed varies according to the contextual data. The display may be a display on a device of the license holder or a display on a device that is viewable by a relying party. The visual characteristics may be modified according to a location of at least some of the credential data on the display on the device of the license holder, a particular font used, a particular color used for text, a color scheme of an existing image and/or a specific image that is independent of the credential data. The visual characteristics may be modified according to the color scheme by changing a background color on the screen of the device of the license holder.

Abstract: A method of forming matched PFET/NFET spacers with differential widths for SG and EG structures and a method of forming differential width nitride spacers for SG NFET and SG PFET structures and PFET/NFET EG structures and respective resulting devices are provided. Embodiments include providing PFET SG and EG structures and NFET SG and EG structures; forming a first nitride layer over the substrate; forming an oxide liner; forming a second nitride layer on sidewalls of the PFET and NFET EG structures; removing horizontal portions of the first nitride layer and the oxide liner over the PFET SG and EG structures; forming RSD structures on opposite sides of each of the PFET SG and EG structures; removing horizontal portions of the first nitride layer and the oxide liner over the NFET SG and EG structures; and forming RSD structures on opposite sides of each of the NFET SG and EG structures.

Abstract: The present disclosure relates to Silstatin compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or pharmaceutical compositions.

Abstract: The present disclosure relates to 4-azapodophylotoxins compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or pharmaceutical compositions.

Abstract: Providing virtualized credentials of a license holder includes determining contextual data that governs visual information presented on a display and displaying credential data on the display, where visual characteristics of the credential data that is displayed varies according to the contextual data. The display may be a display on a device of the license holder or a display on a device that is viewable by a relying party. The visual characteristics may be modified according to a location of at least some of the credential data on the display on the device of the license holder, a particular font used, a particular color used for text, a color scheme of an existing image and/or a specific image that is independent of the credential data. The visual characteristics may be modified according to the color scheme by changing a background color on the screen of the device of the license holder.