Patents by Inventor Gerald J. Tanoury

Gerald J. Tanoury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS OF PRODUCING CYCLOALKYLCARBOXAMIDO-INDOLE COMPOUNDS
    Publication number: 20130324743
    Abstract: The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.
    Type: Application
    Filed: April 21, 2011
    Publication date: December 5, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Daniel T. Belmont, Cristian Harrison, Robert Michael Hughes, Young Chun Jung, Elaine Chungmin Lee, Benjamin Joseph Littler, Peter Jamison Rose, David Andrew Siesel, Gerald J. Tanoury
  • PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
    Publication number: 20130303764
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Application
    Filed: July 12, 2013
    Publication date: November 14, 2013
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcik, Beatriz Dominguez Olmo
  • Processes and intermediates for producing azaindoles
    Patent number: 8513414
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: August 20, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcik, Beatriz Dominguez Olmo
  • PROCESSES AND INTERMEDIATES FOR PRODUCING AZAINDOLES
    Publication number: 20130102782
    Abstract: The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of Janus kinases (JAK).
    Type: Application
    Filed: July 3, 2012
    Publication date: April 25, 2013
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Young Chun Jung, Derek Magdziak, Adam Looker, Billie J. Kline, Václav Jurcík, Beatriz Dominguez Olmo
  • Processes and intermediates
    Patent number: 8399615
    Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: March 19, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, John E. Cochran, Adam Looker, Valdas Jurkauskas
  • Processes and intermediates for preparing steric compounds
    Patent number: 8383858
    Abstract: This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R1, R?1 and R2 are defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: February 26, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Young Chun Jung, Raymond E. Forslund
  • Processes and intermediates
    Patent number: 8293929
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: October 23, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Deuterated hepatitis C protease inhibitors
    Patent number: 8247532
    Abstract: This invention relates to processes and intermediates for the preparation of salts of deuterated, enantiomericallv enriched alpha-amino beta-hydroxy acids of Formula 1 wherein the variables R1,R?1 and R?2 are defined herein, and wherein the process may comprise the steps of forming a salt of a compound of Formula 1, and crystallizing said salt to give a compound of greater than 55% enantiomeric excess.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: August 21, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Robert B. Perni, Youssef Bennani, Gregor Zlokarnik, Gerald J. Tanoury, Minzhang Chen, Young Chun Jung, Raymond E. Forslund, Francois Maltais
  • FORMOTEROL TARTRATE PROCESS AND POLYMORPH
    Publication number: 20120108670
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Application
    Filed: January 4, 2012
    Publication date: May 3, 2012
    Applicant: SUNOVION PHARMACEUTICALS INC.
    Inventors: Gerald J. TANOURY, Chris H. SENANAYAKE, Donald W. KESSLER
  • Formoterol tartrate process and polymorph
    Patent number: 8110706
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: February 7, 2012
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Formoterol tartrate process and polymorph
    Patent number: 7964753
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: June 21, 2011
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • DEUTERATED HEPATITIS C PROTEASE INHIBITORS
    Publication number: 20110071074
    Abstract: A deuterated ?-ketoamido steric specific compound of the formula wherein D denotes a deuterium atom on a steric specific carbon atom.
    Type: Application
    Filed: November 24, 2010
    Publication date: March 24, 2011
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Robert B. Perni, Youssef Bennani, Gregor Zlokarnik, Gerald J. Tanoury, Minzhang Chen, Young Chun Jung, Raymond E. Forslund, Francois Maltais
  • Processes and Intermediates
    Publication number: 20110071298
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Application
    Filed: October 12, 2010
    Publication date: March 24, 2011
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Processes and intermediates for preparing steric compounds
    Publication number: 20100298568
    Abstract: This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R1, R?1 and R2 are defined herein and the compound of Formula 1 has an enantiomeric excess (ee) of 55% or greater.
    Type: Application
    Filed: August 4, 2010
    Publication date: November 25, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Young Chun Jung, Raymond E. Forslund
  • Processes and intermediates
    Patent number: 7834200
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 16, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Formoterol Tartrate Process and Polymorph
    Publication number: 20100249459
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Application
    Filed: June 7, 2010
    Publication date: September 30, 2010
    Applicant: SEPRACOR INC.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Processes and intermediates
    Patent number: 7776887
    Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: August 17, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, John E. Cochran, Valdas Jurkauskas
  • Formoterol Tartrate Process and Polymorph
    Publication number: 20100204336
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Application
    Filed: April 26, 2010
    Publication date: August 12, 2010
    Applicant: SEPRACOR INC.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Processes and intermediates
    Publication number: 20100174077
    Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.
    Type: Application
    Filed: March 15, 2010
    Publication date: July 8, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, John E. Cochran, Valdas Jurkauskas
  • Formoterol tartrate process and polymorph
    Patent number: 7732641
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: June 8, 2010
    Assignee: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler