Patents by Inventor Gerald J. Tanoury

Gerald J. Tanoury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES AND INTERMEDIATES
    Publication number: 20100063252
    Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.
    Type: Application
    Filed: April 27, 2009
    Publication date: March 11, 2010
    Inventors: Gerald J. Tanoury, Minzhang Chen, John E. Cochran, Adam Looker, Valdas Jurkauskas
  • Formoterol Tartrate Process and Polymorph
    Publication number: 20090156862
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 18, 2009
    Applicant: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Processes and intermediates
    Publication number: 20090048429
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Application
    Filed: March 7, 2008
    Publication date: February 19, 2009
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Formoterol tartrate process and polymorph
    Patent number: 7479572
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: January 20, 2009
    Assignee: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayaka, Donald W. Kessler
  • Processes and intermediates
    Patent number: 7381827
    Abstract: The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 3, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Gerald J. Tanoury, Minzhang Chen, Andrew D. Jones, Philip L. Nyce, Martin Trudeau, David J. Guerin, John R. Snoonian
  • Formoterol tartrate process and polymorph
    Patent number: 7342132
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: March 11, 2008
    Assignee: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Formoterol tartrate polymorph
    Patent number: 7145036
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: December 5, 2006
    Assignee: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Method of resolving amlodipine racemate
    Patent number: 6822099
    Abstract: The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,N′-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: November 23, 2004
    Assignee: Sepracor, Inc.
    Inventors: Chris H. Senanayake, Gerald J. Tanoury, Harold S. Wilkinson, Roger P. Bakale, Andrei A. Zlota
  • Formoterol tartrate polymorph
    Publication number: 20040176450
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Application
    Filed: March 23, 2004
    Publication date: September 9, 2004
    Applicant: SEPRACOR INC.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Formoterol tartrate polymorph
    Patent number: 6720453
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: April 13, 2004
    Assignee: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W Kessler
  • Formoterol tartrate polymorph
    Publication number: 20030149304
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Application
    Filed: September 10, 2002
    Publication date: August 7, 2003
    Applicant: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W. Kessler
  • Method of resolving amlodipine racemate
    Publication number: 20030130321
    Abstract: The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,N′-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.
    Type: Application
    Filed: December 20, 2002
    Publication date: July 10, 2003
    Applicant: Sepracor, Inc.
    Inventors: Chris H. Senanayake, Gerald J. Tanoury, Harold S. Wilkinson, Roger P. Bakale, Andrei A. Zlota
  • Formoterol tartrate process and polymorph
    Patent number: 6472563
    Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: October 29, 2002
    Assignee: Sepracor Inc.
    Inventors: Gerald J. Tanoury, Chris H. Senanayake, Donald W Kessler
  • 2R,4S,S,S- and 2S,4R,S,S-hydroxyitraconazole
    Patent number: 6455530
    Abstract: A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (S,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: September 24, 2002
    Assignee: Sepracor Inc.
    Inventors: Patrick Koch, John R. McCullough, Chris H. Senanayake, Gerald J. Tanoury, Yaping Hong
  • 2R, 4S, R, S- and 2S, 4R, R, S-hydroxyitraconazole
    Patent number: 6166018
    Abstract: A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (R,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and their use for the treatment of fungal infection are also disclosed.
    Type: Grant
    Filed: June 14, 1999
    Date of Patent: December 26, 2000
    Assignee: Sepracor Inc.
    Inventors: John R. McCullough, Chris H. Senanayake, Gerald J. Tanoury, Yaping Hong, Patrick Koch
  • 2R,4S,R, S- and 2S,4R,R,S-hydroxyitraconazole
    Patent number: 5952502
    Abstract: A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (R,S)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: September 14, 1999
    Assignee: Sepracor Inc.
    Inventors: John R. McCullough, Chris H. Senanayake, Gerald J. Tanoury, Yaping Hong, Patrick Koch