Patents by Inventor Gerald Kleymann

Gerald Kleymann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DEUTERATED AMINOTHIAZOLE COMPOUNDS AS ANTIVIRAL COMPOUNDS
    Publication number: 20230391738
    Abstract: The invention relates to novel deuterated compounds of Formula (I) to a process for their preparation and to their use as medicament, in particular as antiviral medicament.
    Type: Application
    Filed: October 28, 2021
    Publication date: December 7, 2023
    Inventors: Christian Gege, Gerald Kleymann
  • Enantiomers Of Substituted Thiazoles As Antiviral Compounds
    Publication number: 20220152008
    Abstract: The present invention relates to novel antiviral compounds with specific stereoconfiguration, especially to specific novel enantiomers, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Application
    Filed: January 21, 2022
    Publication date: May 19, 2022
    Inventors: Gerald Kleymann, Christian Gege
  • Enantiomers of substituted thiazoles as antiviral compounds
    Patent number: 11278534
    Abstract: The present invention relates to novel antiviral compounds with specific stereoconfiguration, especially to specific novel enantiomers, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: March 22, 2022
    Assignee: Innovative Molecules GmbG
    Inventors: Gerald Kleymann, Christian Gege
  • Helicase Primase Inhibitors For Treating Cancer In A Combination Therapy With Oncolytic Viruses
    Publication number: 20210401810
    Abstract: The present invention relates to the novel use of antiviral compounds, which act as helicase primase inhibitors in a combination therapy with oncolytic viruses for treating tumors, cancer or neoplasia.
    Type: Application
    Filed: November 27, 2019
    Publication date: December 30, 2021
    Inventors: Gerald Kleymann, Christian Gege
  • Substituted N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
    Patent number: 11078168
    Abstract: The invention provides modulators of indoleamine 2,3-dioxygenase (IDO1) and their use in the prophylaxis and/or treatment of IDO1-mediated diseases. Specifically, the present invention provides compounds according to Formula (I) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: August 3, 2021
    Assignee: Phenex Discovery Verwaltungs-GmbH
    Inventors: Christoph Steeneck, Olaf Kinzel, Simon Anderhub, Martin Hornberger, Gerald Kleymann, Thomas Hoffmann
  • Enantiomers Of Substituted Thiazoles As Antiviral Compounds
    Publication number: 20200289486
    Abstract: The present invention relates to novel antiviral compounds with specific stereoconfiguration, especially to specific novel enantiomers, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Application
    Filed: October 4, 2018
    Publication date: September 17, 2020
    Inventors: Gerald Kleymann, Christian Gege
  • Aminothiazole Derivatives Useful As Antiviral Agents
    Publication number: 20200148652
    Abstract: The invention relates to novel compounds of the Formula (I) to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Application
    Filed: January 20, 2020
    Publication date: May 14, 2020
    Inventors: Gerald Kleymann, Christian Gege
  • Aminothiazole derivatives useful as antiviral agents
    Patent number: 10590094
    Abstract: The invention relates to novel compounds of the Formula (I), to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 17, 2020
    Assignee: Innovative Molecules GmbH
    Inventors: Gerald Kleymann, Christian Gege
  • SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE
    Publication number: 20190292160
    Abstract: The invention provides modulators of indoleamine 2,3-dioxygenase (IDO1) and their use in the prophylaxis and/or treatment of IDO1-mediated diseases. Specifically, the present invention provides compounds according to Formula (I) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 26, 2019
    Applicant: PHENEX DISCOVERY VERWALTUNGS-GMBH
    Inventors: Christoph Steeneck, Olaf Kinzel, Simon Anderhub, Martin Hornberger, Gerald Kleymann, Thomas Hoffmann
  • Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[?]
    Patent number: 10301272
    Abstract: The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1?), (100), (100?), (200) and (200?) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: May 28, 2019
    Assignee: Phenex Pharmaceuticals AG
    Inventors: Christian Gege, Christoph Steeneck, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann
  • Aminothiazole Derivatives Useful As Antiviral Agents
    Publication number: 20190112285
    Abstract: The invention relates to novel compounds of the Formula (I), to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Application
    Filed: April 5, 2017
    Publication date: April 18, 2019
    Inventors: Gerald Kleymann, Christian Gege
  • Trifluoromethyl alcohols as modulators of ROR?t
    Patent number: 10150762
    Abstract: The present invention comprises methods of making 5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2-hydroxy-2-methylpropyl)-4-(R1-1-carbonyl)thiazole-2-carboxamide, wherein R1 is defined in the specification.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: December 11, 2018
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Steven Goldberg, Hariharan Venkatesan, Olaf Kinzel, Christian Gege, Christoph Steeneck, Gerald Kleymann, Thomas Hoffmann
  • Thiazoles as modulators of ROR?t
    Patent number: 10080744
    Abstract: The present invention comprises compounds of Formula I wherein: R1, R2, R3, R4, R5, R7, R8, and {circle around (A)} are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: September 25, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Steven Goldberg, Christoph Steeneck, Christian Gege, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann, Anne M. Fourie, Xiaohua Xue
  • THIAZOLES AS MODULATORS OF RORyt
    Publication number: 20180064690
    Abstract: The present invention comprises compounds of Formula I wherein: R1, R2, R3, R4, R5, R7, R8, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
    Type: Application
    Filed: November 14, 2017
    Publication date: March 8, 2018
    Inventors: Steven Goldberg, Christoph Steeneck, Christian Gege, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann, Anne M. Fourie, Xiaohua Xue
  • Thiazoles as modulators of ROR?t
    Patent number: 9861618
    Abstract: The present invention comprises compounds of Formula I wherein: R1, R2, R3, R4, R5, R7, R8, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 9, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Steven Goldberg, Christoph Steeneck, Christian Gege, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann
  • Trifluoromethyl alcohols as modulators of ROR?t
    Patent number: 9850236
    Abstract: The present invention comprises compounds of Formula I. wherein: X, A1, A2, A3, A4, R1, R2, and R3 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: December 26, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Steven Goldberg, Hariharan Venkatesan, Virginia Tanis, Olaf Kinzel, Christian Gege, Christoph Steeneck, Gerald Kleymann, Thomas Hoffmann, Anne M. Fourie, Xiaohua Xue
  • Amide substituted thiazoles as modulators of RORyt
    Patent number: 9845319
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R5, A1, A2, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: December 19, 2017
    Assignee: Janssen Pharmaceutiuca NV
    Inventors: Steven Goldberg, Hariharan Venkatesan, Virginia Tanis, Maud Urbanski, Aihua Wang, David Kummer, Christoph Steeneck, Christian Gege, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann, Anne M. Fourie, Xiaohua Xue
  • TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt
    Publication number: 20170327492
    Abstract: The present invention comprises methods of making 5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2-hydroxy-2-methylpropyl)-4-(R1-1-carbonyl)thiazole-2-carboxamide, wherein R1 is defined in the specification.
    Type: Application
    Filed: July 31, 2017
    Publication date: November 16, 2017
    Applicant: Janssen Pharmaceutica NV
    Inventors: Steven Goldberg, Hariharan Venkatesan, Olaf Kinzel, Christian Gege, Christoph Steeneck, Gerald Kleymann, Thomas Hoffmann
  • Pyrrolo carboxamides as modulators of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR?, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
    Patent number: 9815851
    Abstract: The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: November 14, 2017
    Assignee: Phenex Pharmaceuticals AG
    Inventors: Christoph Steeneck, Olaf Kinzel, Christian Gege, Gerald Kleymann, Thomas Hoffmann
  • Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor ROR?
    Patent number: 9458104
    Abstract: The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide containing cyclic compounds of Formula (1) to Formula (5) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: October 4, 2016
    Assignee: Phenex Pharmaceuticals AG
    Inventors: Christian Gege, Olaf Kinzel, Christoph Steeneck, Gerald Kleymann, Thomas Hoffmann