Patents by Inventor Gerald Kleymann

Gerald Kleymann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIFLUOROMETHYL ALCOHOLS AS MODULATORS OF RORyt
    Publication number: 20160122336
    Abstract: The present invention comprises compounds of Formula I. wherein: X, A1, A2, A3, A4, R1, R2, and R3 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
    Type: Application
    Filed: October 30, 2015
    Publication date: May 5, 2016
    Applicant: Janssen Pharmaceutica NV
    Inventors: Steven Goldberg, Hariharan Venkatesan, Virginia Tanis, Olaf Kinzel, Christian Gege, Christoph Steeneck, Gerald Kleymann, Thomas Hoffmann
  • THIAZOLES AS MODULATORS OF RORyt
    Publication number: 20160120850
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R7, R8, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
    Type: Application
    Filed: October 30, 2015
    Publication date: May 5, 2016
    Applicant: Janssen Pharmaceutica NV
    Inventors: Steven Goldberg, Christoph Steeneck, Christian Gege, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann
  • AMIDE SUBSTITUTED THIAZOLES AS MODULATORS OF RORyt
    Publication number: 20160122335
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R5, A1, A2, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
    Type: Application
    Filed: October 30, 2015
    Publication date: May 5, 2016
    Applicant: Janssen Pharmaceutica NV
    Inventors: Steven Goldberg, Hariharan Venkatesan, Virginia Tanis, Maud Urbanski, Aihua Wang, David Kummer, Christoph Steeneck, Christian Gege, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann
  • CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED NITROGEN-CONTAINING 5-MEMBERED HETEROCYCLES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR GAMMA
    Publication number: 20150344423
    Abstract: The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide containing cyclic compounds of Formula (1) to Formula (5) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: May 29, 2013
    Publication date: December 3, 2015
    Inventors: Christian GEGE, Olaf KINZEL, Christoph STEENECK, Gerald KLEYMANN, Thomas HOFFMANN
  • CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA]
    Publication number: 20150175562
    Abstract: The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administering these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1?), (100), (100?), (200) and (200?) and the enantiomers, diastereomers, tautomers, /V-oxides, solvates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: May 29, 2013
    Publication date: June 25, 2015
    Inventors: Christian Gege, Christoph Steeneck, Olaf Kinzel, Gerald Kleymann, Thomas Hoffmann
  • Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-? (ROR-?, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
    Patent number: 8946446
    Abstract: The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: February 3, 2015
    Assignee: Phenex Pharmaceuticals AG
    Inventors: Christoph Steeneck, Olaf Kinzel, Christian Gege, Gerald Kleymann, Thomas Hoffmann
  • Compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (ROR?, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune disease
    Patent number: 8940722
    Abstract: The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: January 27, 2015
    Assignee: Phenex Pharmaceuticals AG
    Inventors: Olaf Kinzel, Christoph Steeneck, Gerald Kleymann, Michael Albers, Thomas Hoffmann, Claus Kremoser, Sanja Perovic-Ottstadt, Thomas Schlüter
  • PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORy, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES
    Publication number: 20140349987
    Abstract: The invention provides modulators for the orphan nuclear receptor ROR? and methods for treating ROR? mediated diseases by administrating these novel ROR? modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo carboxamide compounds of Formula (1) and the enantiomers, diastereomers, N-oxides, tautomers, solvates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: December 3, 2012
    Publication date: November 27, 2014
    Inventors: Christoph Steeneck, Olaf Kinzel, Christian Gege, Gerald Kleymann, Thomas Hoffmann
  • PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (ROR-GAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES
    Publication number: 20140142082
    Abstract: The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: April 13, 2012
    Publication date: May 22, 2014
    Applicant: PHENEX PHARMACEUTICALS AG
    Inventors: Christoph Steeneck, Olaf Kinzel, Christian Gege, Gerald Kleymann, Thomas Hoffmann
  • 2-(3-phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses
    Patent number: 7960387
    Abstract: The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: June 14, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Gerald Kleymann, Thomas Lampe, Susanne Nikolic, Jürgen Reefschläger, Rudolf Schohe-Loop, Frank Süβmeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jörg Keldenich, Thomas Krämer, Peter Nell, Tse-I Lin
  • Topical application of thiazolyl amides
    Patent number: 7883713
    Abstract: The invention relates to the topical application of substituted thiazolyl amides in the treatment of herpes infections in humans, to preparations suitable for the topical application and to the production thereof.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: February 8, 2011
    Assignee: AiCuris GmbH & Co. KG
    Inventors: Ulrich Betz, Tobias Laich, Wolfgang Bender, Ruediger Fischer, Martin Hendrix, Gerald Kleymann
  • 2-(3-Phenyl-2-piperazinyl-3,4-dihydroquinazolin-4-yl)acetic acids as antiviral agents, especially against cytomegaloviruses
    Publication number: 20070066622
    Abstract: The invention relates to dihydroquinazolines and methods for the production thereof, the use thereof in the treatment and/or prophylaxis of diseases, in addition to the use thereof in the production of medicaments in the treatment and/or prophylaxis of diseases, especially for use as anti-viral agents, especially against cytomegalo viruses.
    Type: Application
    Filed: January 29, 2004
    Publication date: March 22, 2007
    Inventors: Tobias Wunberg, Judith Baumeister, Ulrich Betz, Mario Jeske, Gerald Kleymann, Thomas Lampe, Susanne Nikolic, Jurgen Reefshlager, Rudolf Schohe-Loop, Frank Submeier, Holger Zimmermann, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Jorg Keldenich, Thomas Kramer, Peter Nell, Tse-I Lin
  • Method for inhibiting the replication of herpes viruses
    Publication number: 20070004735
    Abstract: The invention relates to a method for inhibiting the replication of herpesviruses, to methods for identifying compounds which inhibit the replication of herpesviruses using this method, to compounds having activity against herpesviruses, to methods for their preparation and to their use for producing medicaments for the treatment of herpes infections.
    Type: Application
    Filed: December 24, 2003
    Publication date: January 4, 2007
    Inventors: Ulrich Betz, Guy Hewlett, Gerald Kleymann, Thomas Lampe, Tse-I Lin, Susanne Nikolic, Jurgen Reefshlager, Tobias Wunberg, Holger Zimmerman, Franz Zumpe, Wolfgang Bender, Kerstin Henninger, Axel Jensen, Jorg Keldenich, Rudolf Schohe-Loop
  • Thiazolyl amide derivatives
    Patent number: 7105553
    Abstract: The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: September 12, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rüdiger Fischer, Gerald Kleymann, Ulrich Betz, Judith Baumeister, Wolfgang Bender, Peter Eckenberg, Gabriele Handke, Martin Hendrix, Kerstin Henninger, Axel Jensen, Jörg Keldenich, Udo Schneider, Olaf Weber
  • Pyridazinone
    Publication number: 20050059658
    Abstract: The invention relates to novel compounds, to a method for the production of said compounds and to the use thereof as medicaments, more particularly as antiviral agents, especially against cytomegalovirus.
    Type: Application
    Filed: June 17, 2002
    Publication date: March 17, 2005
    Inventors: Tobias Wunberg, Ulrich Betz, Sabine Hallenberger, Gerald Kleymann, Thomas Lampe, Susanne Nikolic, Jurgen Reefschlager, Franz Zumpe, Marcus Bauser, Wolfgang Bender, Rolf Grosser, Kerstin Henninger, Guy Hewlett, Axel Jensen, Jorg Keldenich, Holger Zimmermann
  • Thiazolyl amides and their use as antiviral drugs
    Publication number: 20040235916
    Abstract: The invention relates to the novel compounds of formula (I), to a method for producing the same and to their use as drugs, especially as antiviral drugs.
    Type: Application
    Filed: December 19, 2003
    Publication date: November 25, 2004
    Inventors: Rudolf Schohe-Loop, Ulrich Betz, Rudiger Fischer, Martin Hendrix, Gerald Kleymann, Judith Baumeister, Wolfgang Bender, Peter Eckenberg, Gabriele Handke-Erguden, Kerstin Henninger, Axel Jensen, Jorg Keldenich, Udo Schneider, Olaf Weber
  • Topical application of thiazolyl amides
    Publication number: 20040235917
    Abstract: The invention relates to the topical application of substituted thiazolyl amides in the treatment of herpes infections in humans, to preparations suitable for the topical application and to the production thereof.
    Type: Application
    Filed: June 30, 2004
    Publication date: November 25, 2004
    Inventors: Ulrich Betz, Tobias Laich, Wolfgang Bender, Rudiger Fischer, Martin Hendrix, Gerald Kleymann
  • Thiazolyl amide derivatives
    Publication number: 20040006076
    Abstract: The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.
    Type: Application
    Filed: November 12, 2002
    Publication date: January 8, 2004
    Inventors: Rudiger Fischer, Gerald Kleymann, Ulrich Betz, Judith Baumeister, Wolfgang Bender, Peter Eckenberg, Gabriele Handke, Martin Hendrix, Kerstin Henninger, Axel Jensen, Jorg Keldenich, Udo Schneider, Olaf Weber
  • Thiazolyl urea derivatives and their utilization as antiviral agents
    Patent number: 6500817
    Abstract: The present invention relates to thiazolylurea derivatives, a process for their preparation, and their use as pharmaceuticals, in particular as antiviral pharmaceuticals.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: December 31, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rüdiger Fischer, Gerald Kleymann, Judith Baumeister, Wolfgang Bender, Ulrich Betz, Peter Eckenberg, Gabriele Handke, Martin Hendrix, Udo Schneider, Olaf Weber, Kerstin Henninger, Axel Jensen, Jörg Keldenich
  • Uncompetitive inhibitors of helicase-primase
    Publication number: 20020160932
    Abstract: The present invention relates to inhibitors of the viral helicase-primase enzyme complex with anti-herpes activity, and to medicaments containing these compounds in suitable formulation. The invention further describes a method for identifying substances with antiviral activity in order to treat herpes infections in humans and animals.
    Type: Application
    Filed: August 30, 2001
    Publication date: October 31, 2002
    Inventors: Gerald Kleymann, Rudiger Fischer, Martin Hendrix, Guy Hewlett, Veniamin Pevzner, Ulrich Betz, Wolfgang Bender, Peter Eckenberg, Gabriele Handke, Udo Schneider, Olaf Weber, Kerstin Henninger, Axel Jensen, Jorg Keldenich, Judith Baumeister