Abstract: The present invention relates to a clinical support system and a corresponding clinical support method. The system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining current patient data descriptive of a patient, for whom a recommendation for a transition from a current care levels to one or more other care levels shall be provided, in the current care level, obtaining historic patient data of the patient obtained earlier in the current and/or other care levels.

Abstract: In summary the invention relates stimuli control system 100 configured for finding ambient stimuli from a database 120 in a way so that the ambient stimuli having the most promising effect on stress reduction is selected. The selection may be performed based on a probability distribution created for describing how likely it is that a given ambient stimuli has a positive effect on the stress level for a given patient or other user. The database is a multiuser database which may be updated based on experiences from uses already registered ambient stimuli.

Abstract: A healthcare support system and healthcare support method for scheduling a clinical visit of a patient are presented. The healthcare support system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining clinical patient data descriptive of a clinical condition of the patient, obtaining psycho-social-assessment data of the patient, and scheduling a clinical visit for the patient based on said clinical patient data and said psycho-social-assessment data. Further, the present invention relates to a computer-readable non-transitory storage medium and a computer program. The proposed system assists in determining the need of a clinical visit, the urgency of a clinical visit and the nature of this visit in terms of required procedures and tests, topics to be discussed and professionals to be seen.

Abstract: A healthcare support system for determining care for a patient and a corresponding healthcare support method are presented. The healthcare support system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining patient data, assessing a clinical need of the patient, proposing a clinical outcome, and determining a service to be provided to the patient for said clinical need and said proposed clinical outcome based on a service-outcome-need model. Further, the present invention relates to a computer-readable non-transitory storage medium and a computer program.

Abstract: The invention relates to a process for the isomerization of unsaturated fatty acids or esters or amides thereof, said process comprising reacting: (a) an unsaturated fatty acid or ester or amide thereof; (b) a source of Pd; (c) a bidentate diphosphine of formula I, R1R2>P1-R—P2<R3R4??(I) wherein P1 and P2 represent phosphorus atoms; R1, R2, R3 and R4 represent tert-butyl; and wherein R represents an optionally substituted aromatic group spanning P1 and P2; (d) a lower alcohol; and (e) an acid co-catalyst, under conditions for isomerization to take place. The process is particularly advantageous for the isomerization of substituted alkenes harboring a hydroxy group when the desired end product has a keto group, such as ricinoleic acid or ester thereof.

Abstract: The invention relates to a process for the isomerization of unsaturated fatty acids or esters or amides thereof, said process comprising reacting: (a) an unsaturated fatty acid or ester or amide thereof; (b) a source of Pd; (c) a bidentate diphosphine of formula I, R1R2>P1-R-P2<R3R4??(I) wherein P1 and P2 represent phosphorus atoms; R1, R2, R3 and R4 represent tert-butyl; and wherein R represents an optionally substituted aromatic group spanning P1 and P2; (d) a lower alcohol; and (e) an acid co-catalyst, under conditions for isomerization to take place. The process is particularly advantageous for the isomerization of substituted alkenes harbouring a hydroxy group when the desired end product has a keto group, such as ricinoleic acid or ester thereof.

Abstract: The present invention relates to a clinical support system and a corresponding clinical support method. The system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining a health score curve over time of a patient, for whom a recommendation for a moment of discharge from a medical facility shall be provided, obtaining a reference curve to the health score curve, wherein said reference curve indicates a patient stabilization over time, computing a difference between the health score curve and said reference curve, and computing a recommended moment of discharge from the medical facility based on the difference between said health score curve and said reference curve. Further, the present invention relates to a computer-readable non-transitory storage medium and a computer program.

Abstract: The invention relates to a carbonylation process for the preparation of an alkanoic acid ester comprising reacting: (a) an alkene; (b) a source of Pd; (c) a bidentate phosphine ligand of formula I; R1R2P—R3—R—R4—PR5R6??(I) wherein P represents a phosphorus atom; R1, R2, R5 and R6 can independently represent the same or different optionally substituted organic groups containing a tertiary carbon atom through which the group is linked to the phosphorus atom; R3 and R4 independently represent optionally substituted lower alkylene groups and R represents an optionally substituted aromatic group; (d) a source of anions derived from an acid with a pKa<3; (e) carbon monoxide; and (f) an alkanol; characterized in that the process is performed in the presence of between 0.1 and 3 wt water.

Abstract: A method of adapting an environment of a terminal (2) includes: —receiving data (27) from an external source at the terminal (2); —receiving monitoring data from a system for monitoring at least one user in the environment; and —controlling at least one output device for providing an output perceptible in the environment, the output being adjusted in dependence on the monitoring data. At least one segment including data pertaining to at least one mental state is retrieved from the data (27) from the external source, and the adjustment in dependence on the monitoring data is effected at least partly on the basis of the data pertaining to the at least one mental state.

Abstract: The present invention relates to a stress-measuring device (10) and method for determining a level (15) of stress of a user (1), in particular long-term stress. The stress-measuring device (10) comprises an input interface (12) for receiving a skin conductance signal (11) indicating the skin conductance of the user (1), the skin conductance signal (11) over time forming skin conductance trace data (13). The stress-measuring device (10) further comprises a processing unit (14) for processing the skin conductance trace data (13), the processing unit (14) adapted to determine, over at least a portion of the skin conductance trace data (13), values of a rise time (tr) between at least two different points of the skin conductance trace data (13), to determine a frequency distribution of the rise time (tr) values, and to determine the level (15) of stress of the user (1) based on the determined frequency distribution.

Abstract: A process for producing furfural and levulinic acid from lignocellulose-comprising biomass is disclosed. The biomass is slurried using water and optionally an acid, subjected to hydrolysis, and then subjected to a solid/liquid separation to yield at least an aqueous fraction comprising C5 and C6 sugars and a solid fraction comprising cellulose and lignin. Furfural is obtained by adding an organic solvent to the aqueous fraction, heating at 120-220° C. for a sufficient time to form furfural, cooling, and separating an organic phase comprising at least part of the furfural from an aqueous phase. Levulinic acid is obtained by suspending the solid fraction in water and optionally an acid, heating the suspension to 140-220° C., and separating an aqueous fraction comprising the levulinic acid from a solid fraction.

Abstract: A method of selecting a solution, comprises identifying a set of performance indicators that are correlated with a quality indicator. A target value is set for at least one of the performance indicators, based on a target in respect of the quality indicator. A plurality of solutions is selected, wherein a solution is associated with an effect on said at least one of the performance indicators for which a target value was set. At least one solution is selected of the plurality of solutions based on the target value of said at least one of the performance indicators and the effect of the selected at least one solution on said at least one of the performance indicators. A scenario is simulated with a particular value of at least one of the performance indicators, to obtain a predicted value of the quality indicator.

Abstract: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3-6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).

Abstract: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).

Abstract: Stimulation system for indicating stimulation signals to a user, provided with at least one heart beat sensor for converting measured heart beats into a signal, a processing circuit configured to process the measured heart beat signals, a user interface configured to indicate stimulation signals to a user, wherein the processing circuit is configured to calculate intervals between the detected heart beats and register a predetermined number of successive intervals, predict a time interval between a detected heart beat and a predicted future heart beat based on the registered intervals, and instruct the user interface to indicate a stimulation signal to a user non-simultaneously with the predicted heart beat at the end of the predicted time interval so as to change the heart rate and/or heart coherence of the user.

Abstract: The present invention relates to a method for preparing caprolactone, comprising converting 5-hydroxymethyl-2-furfuraldehyde by hydrogenation into at least one intermediate compound selected from the group of 2,5-tetrahydrofuran-dimethanol, 1,6-hexanediol and 1,2,6-hexanetriol,and preparing caprolactone from said intermediate compound. Further, the invention relates to a method for preparing 1,2,6-hexanetriol comprising preparing 5-hydroxymethyl-2-furfaldehyde from a renewable source, converting 5-hydroxymethyl-2-furfaldehyde into 2,5-tetrahydrofuran-dimethanol and converting 2,5-tetrahydrofuran-dimethanol into 1,2,6-hexanetriol. Further, the invention relates to a method for preparing 1,6-hexanediol from 1,2,6-hexanetriol, wherein 1,2,6-hexanetriol is subjected to a ring closure reaction, thereby forming (tetrahydro-2H-pyran-2-yl)methanol, and the (tetrahydro-2H-pyran-2-yl)methanol is hydrogenated, thereby forming 1,6-hexane diol.

Abstract: A method of signal processing, includes obtaining at least one physiological signal from a system (9-12) arranged to monitor at least one user. Data at least based on data representative of at least one characteristic of electrical current drawn by at least one appliance (23,24,28) in an environment in which the at least one user is present is obtained. This data is used to determine an output based on the at least one physiological signal.

Abstract: A method of adapting an environment of a terminal (2) includes: —receiving data (27) from an external source at the terminal (2); —receiving monitoring data from a system for monitoring at least one user in the environment; and —controlling at least one output device for providing an output perceptible in the environment, the output being adjusted in dependence on the monitoring data. At least one segment including data pertaining to at least one mental state is retrieved from the data (27) from the external source, and the adjustment in dependence on the monitoring data is effected at least partly on the basis of the data pertaining to the at least one mental state.

Abstract: Stimulation system for indicating stimulation signals to a user, provided with at least one heart beat sensor for converting measured heart beats into a signal, a processing circuit configured to process the measured heart beat signals, a user interface configured to indicate stimulation signals to a user, wherein the processing circuit is configured to calculate intervals between the detected heart beats and register a predetermined number of successive intervals, predict a time interval between a detected heart beat and a predicted future heart beat based on the registered intervals, and instruct the user interface to indicate a stimulation signal to a user non-simultaneously with the predicted heart beat at the end of the predicted time interval so as to change the heart rate and/or heart coherence of the user.

Abstract: Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).