Abstract: A composition comprising a cell or a population thereof, wherein the cell comprises a polynucleotide encoding an antibody or a fragment thereof that binds CD269 (BCMA), wherein the binding to CD269 (BCMA) disrupts the interaction between CD269 and its native ligands (BAFF and APRIL). Also disclosed is treatment of plasma cell-mediated diseases such as multiple myeloma and autoimmune diseases.

Abstract: A composition comprising a cell or a population thereof, wherein the cell comprises a polynucleotide encoding an antibody or a fragment thereof that binds CD269 (BCMA), wherein the binding to CD269 (BCMA) disrupts the interaction between CD269 and its native ligands (BAFF and APRIL). Also disclosed is treatment of plasma cell-mediated diseases such as multiple myeloma and autoimmune diseases.

Abstract: The invention relates to antibodies or antibody fragments that bind CD269 (BCMA), thereby disrupting the interaction between CD269 and its native ligands (BAFF and APRIL), and their use in the treatment of plasma cell-mediated diseases such as multiple myeloma and autoimmune diseases.

Abstract: The invention relates to antibodies or antibody fragments that bind CD269 (BCMA), thereby disrupting the interaction between CD269 and its native ligands (BAFF and APRIL), and their use in the treatment of plasma cell-mediated diseases such as multiple myeloma and autoimmune diseases.

Abstract: The invention relates to antibodies or antibody fragments that bind CD269 (BCMA), thereby disrupting the interaction between CD269 and its native ligands (BAFF and APRIL), and their use in the treatment of plasma cell-mediated diseases such as multiple myeloma and autoimmune diseases.

Abstract: A method for producing printed textiles for motor vehicles, the textiles having a polyester-based top material and a bottom material, introduces at least a thickener and a UV absorber into the top material in a foulard process. The top material is dried, a digital printing process is carried out on the dried top material, and the printed top material is laminated with the bottom material. Dyes are applied such that the dyes are especially abrasion resistant. This is achieved in that, in the foulard process, a hydrophilizing agent is introduced into the top material.

Abstract: The invention relates to antibodies or antibody fragments that bind CD269 (BCMA), thereby disrupting the interaction between CD269 and its native ligands (BAFF and APRIL), and their use in the treatment of plasma cell-mediated diseases such as multiple myeloma and autoimmune diseases.

Abstract: An electric switch is disclosed, in particular an electric circuit breaker. In at least one example embodiment, the switch includes a measuring channel for measuring an electric measured variable and is switched off when the result of a measurement reaches or exceeds a limit value. To test the mode of operation of the measuring channel, the electric measured variable is switched to a reference channel and a reference signal source is switched to the measuring channel and the reference result obtained via the measuring channel is compared with a reference setpoint. The switch is also tripped if, to test the mode of operation of the measuring channel, the electric measured variable is switched to the reference channel and the result obtained via the reference channel reaches or exceeds the limit value.

Abstract: A power circuit breaker is disclosed wherein an electric current is monitored by an electronic trip unit in order to detect an electrical fault. In an embodiment, a first magnetic device of the power circuit breaker, in the event of a fault being detected, is configured to be excited which, when it is excited, trips a trip mechanism via a plunger. As a result of tripping, the trip mechanism disconnects two contacts via which the current flows. The power circuit breaker of an embodiment includes a second magnetic device which is likewise able to be excited by the ETU and by which the trip mechanism is likewise able to be tripped.

Abstract: A method is disclosed for testing the functionality of the electromagnetic tripping of a switch, in particular of a circuit breaker for low voltages, which has switching contacts which are opened with the aid of a tripping shaft, which is held prestressed by a switching mechanism and is unlatched by a tripping magnet which for this purpose has a winding through which a current is sent for tripping. In order to test the functionality with relatively little effort, it is proposed in at least one embodiment that the winding is connected as an inductance in a resonant circuit, the resonant frequency of the resonant circuit is detected, and the functionality of the tripping magnet is assessed on the basis of the detected resonant frequency.

Abstract: A switch and a method for testing the power transformers of a power supply of the switch are provided, wherein each power transformer generates an analog transformer voltage corresponding to the alternating current, wherein an electronic trip unit, to which each transformer voltage is applied, compares a current derived from each transformer voltage with a current condition, and wherein a rectifier circuit connected to the power transformer charges a capacitor which feeds the power supply of the trip unit. A switching device short-circuits each rectifier circuit when a predefined capacitor voltage is reached. To provide the protective function of the switch, a monostable multivibrator is connected to one pole of each power transformer, wherein each monostable multivibrator is set by the respective transformer voltage and reset after a predefined time, and wherein the level at the output of each monostable multivibrator is used to test the respective power transformer.

Abstract: A power circuit breaker is disclosed wherein an electric current is monitored by an electronic trip unit in order to detect an electrical fault. In an embodiment, a first magnetic device of the power circuit breaker, in the event of a fault being detected, is configured to be excited which, when it is excited, trips a trip mechanism via a plunger. As a result of tripping, the trip mechanism disconnects two contacts via which the current flows. The power circuit breaker of an embodiment includes a second magnetic device which is likewise able to be excited by the ETU and by which the trip mechanism is likewise able to be tripped.

Abstract: A switch and a method for testing the power transformers of a power supply of the switch are provided, wherein each power transformer generates an analog transformer voltage corresponding to the alternating current, wherein an electronic trip unit, to which each transformer voltage is applied, compares a current derived from each transformer voltage with a current condition, and wherein a rectifier circuit connected to the power transformer charges a capacitor which feeds the power supply of the trip unit. A switching device short-circuits each rectifier circuit when a predefined capacitor voltage is reached. To provide the protective function of the switch, a monostable multivibrator is connected to one pole of each power transformer, wherein each monostable multivibrator is set by the respective transformer voltage and reset after a predefined time, and wherein the level at the output of each monostable multivibrator is used to test the respective power transformer.

Abstract: There is described a control device of a machine, an engineering system and a method for operating said control device. Said control device is used to control and/or regulate the machine and is used to carry out at least one user program which is used to at least perform one function, and said control device comprises a debug function. The functionality of the debug function is limited in large user programs due to the high complexity and the unclearness thereof. According to the invention, in order to improve said function, the user program comprises stop points for the debug function and said stop points can be activated and/or deactivated.

Abstract: A method is disclosed for testing the functionality of the electromagnetic tripping of a switch, in particular of a circuit breaker for low voltages, which has switching contacts which are opened with the aid of a tripping shaft, which is held prestressed by a switching mechanism and is unlatched by a tripping magnet which for this purpose has a winding through which a current is sent for tripping. In order to test the functionality with relatively little effort, it is proposed in at least one embodiment that the winding is connected as an inductance in a resonant circuit, the resonant frequency of the resonant circuit is detected, and the functionality of the tripping magnet is assessed on the basis of the detected resonant frequency.

Abstract: There is described a control device of a machine, an engineering system and a method for operating said control device. Said control device is used to control and/or regulate the machine and is used to carry out at least one user program which is used to at least perform one function, and said control device comprises a debug function. The functionality of the debug function is limited in large user programs due to the high complexity and the unclearness thereof. According to the invention, in order to improve said function, the user program comprises stop points for the debug function and said stop points can be activated and/or deactivated.

Abstract: An at least partially implantable hearing system comprising at least one electromechanical output transducer; a micromanipulator for positioning the transducer and for fixing the transducer in a position set by the micromanipulator, the micromanipulator being adapted to be fixedly attached by fixing means to a skull cap; and a releasable coupling unit disposed between the transducer and the micromanipulator, said coupling unit, in an assembled state, fixing the transducer with respect to the micromanipulator, and, in a released state, permitting removal of the transducer from the micromanipulator.

Abstract: A fixation element for an implantable microphone is disclosed. In a preferred embodiment the fixation element comprises an essentially cylindrical portion adapted to be inserted into a bore which crosses a wall of the auditory canal of a user, said cylindrical portion, at least in an implanted state of the fixation element, surrounding an outer circumferential portion of a housing part of the microphone, which housing part is provided with a sound receiving member. The cylindrical portion includes at least one elastic region of increased diameter, said elastic region contacting, in the implanted state of the fixation element, a wall of said bore and providing, by elastic restoring forces, for a friction which is sufficiently high to fix said cylindrical portion in at least one of the two axial directions of said bore.

Abstract: The invention relates to a tri-color lamp for generating white light comprising a phosphor composition comprising a phosphor of general formula (Ba1-x-y-z-SrxCay)2SiO4:Euz, wherein 0?x?1, 0?y?1 and 0<z<1. The phosphor composition may also comprise a red phosphor. The two phosphors can absorb radiation emitted by a light emitting diode, particularly a blue LED. This arrangement provides a mixing of three light sources—light emitted from the two phosphors and unabsorbed light from the LED. The invention also relates to an alternative to a green LED comprising a single green phosphor of general formula (Ba1-x-y-z-SrxCay)2SiO4:Euz, wherein 0?x?1, 0?y?1 and 0<z<1, that absorbs radiation from a blue LED. A resulting device provides green light of high absorption efficiency and high luminous equivalent values.

Abstract: The invention relates to 17-methylene steroids, process for their production and pharmaceutical compositions that contain these compounds. The compounds according to the invention have a hybrid-type profile of action in the sense that they act as inhibitors of 5?-reductase and simultaneously as gestagens. They are therefore suitable for treating diseases that are the result of elevated androgen levels in certain organs and tissues in men and women. Together with other hormonal substances, such as an estrogen, testosterone or a strong androgen, the compounds according to the invention are suitable as contraceptive agents for women and for men.