Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring of formula II, process for their production and pharmaceutical preparations that contain these compounds as well as 17&agr;-cyanomethylated estra-1,3,5(10)-trienes, which produce intermediate products on the way to the 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols. The 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols produce novel selective estrogens, which contrast to standard estrogens, such as estradiol, show a preference for one of the two known estrogen receptors, estrogen receptor alpha.

Abstract: Wheel, in particular, for a motor vehicle with a rim and a spider, where a bolted connection is provided in the area of transition from the rim to the spider, in which a bolt head or a nut on the outside acts in conjunction with a contact surface on the spider, where the bolted connection includes a spacer sleeve which, with one of its sides, acts in conjunction with the bolt head or the nut and, with its other side, with the contact surface in such a way that the bolt head or the nut projects above the outer surface of the spider.

Abstract: This invention describes the use of estrogen receptor (ER)&bgr;-selective agonists for the production of a pharmaceutical agent for triggering somatotropic and/or organotropic effects in the CNS, the circulatory system, the skeletal system and/or the immune system in the aging male and female organism (anticatabolic therapy).

Abstract: The invention relates to new C13-substituted estra-1,3,5(10)-trien-3-yl sulfamates of general formula I, wherein R1 represents an acyl residue, oxycarbonyl residue, aminocarbonyl residue, sulfonyl residue, or aminosulfonyl residue, and R15 represents ethyl, methods of preparing same, and pharmaceutical compositions containing these compounds. The compounds of the invention of general formula I inhibit the activity of steroid sulfatase (EC 3.1.6.2) and do not exhibit any estrogenic effect.

Abstract: This invention relates to new 19-nor-17&agr;-pregna-1,3,5(10)-trien-17&bgr;-ols with a 21,16&agr;-lactone ring of formula II, 1

Abstract: The invention relates to 17-methylene steroids, process for their production and pharmaceutical compositions that contain these compounds.

Abstract: The present invention relates to a novel process for the production of sequences of interference layers composed of layers i of prescribed thicknesses d(i) and refractive indices n(i). In this process a stack of at least two layers i of glasses having refractive indices n(i) and thicknesses d0(i), which are each larger than the predetermined thicknesses d(i) by the same multiplying factor, is provided. The stack is heated to a temperature above the transformation temperature of the glasses and during or after heating, the stack is drawn in such a manner that the individual layers obtain the prescribed thicknesses d(i). After this the drawn stack is cooled.

Abstract: A permanently implantable positioning and fixing system for positioning and fixing of an implantable device relative to a human body, including a plate member constructed to affix to the human body a ball-and-socket joint having a socket attached to the fixing member and a ball positionably mounted in the socket, a clamp mechanism cooperating with the ball-and-socket joint for selectively fixing the ball relative to the socket, a guide rail which is fixed to the ball of the ball-and-socket joint, the guide rail including outer guide surfaces, a threaded spindle having an outer thread, the threaded spindle being mounted to rotate relative to the guide rail and to prevent axial movement of the threaded spindle, a carriage with a feed nut having an inner thread that is engaged by the outer thread of the threaded spindle in a manner that the carriage is freely positionable along the guide rail by turning the threaded spindle, the carriage including inner guide surfaces that slidingly engage the outer guide surfac

Abstract: Wheel, in particular, for a motor vehicle with a rim and a spider, where a bolted connection is provided in the area of transition from the rim to the spider, in which a bolt head or a nut on the outside acts in conjunction with a contact surface on the spider, where the bolted connection includes a spacer sleeve which, with one of its sides, acts in conjunction with the bolt head or the nut and, with its other side, with the contact surface in such a way that the bolt head or the nut projects above the outer surface of the spider.

Abstract: A protective device for a repeatedly rechargeable electrochemical battery (10) with a battery housing (12), the protective device having at least one switching element (86) which can be activated by a detector element (62) and which is designed or adjusted to prevent recharging and/or discharging of the battery (10) in an impermissible operating state thereof. The protective device has a hermetically sealed protective housing (54) which holds the battery housing (12). An impermissible operating state of the battery (10) causes a change in shape (deflection) to be impressed on the detector element (62). Preferably, the at least one switching element (86) is made as a make contact which electrically short circuits a recharging circuit supplied by a charging device when a predetermined expansion in the volume of the battery housing (12) and/or gas escape therefrom occurs. The protective device is part of an implantable device, such as a hearing aid.

Abstract: The 17.alpha.-cyanomethylestra-4,9-diene derivative compounds are of formula I: ##STR1## wherein R.sub.1 is an alkyl group having from 1 to 2 carbon atoms; R.sub.2 is an alkyl group with 1 to 10 carbon atoms, an acyl group with 1 to 10 carbon atoms or a trialkylsilyl group; and R.sub.3 is an oxygen atom or a R--O--N group, wherein R is a hydrogen atom, an acyl group with 1 to 10 carbon atoms, an alkyl group with 1 to 10 carbon atoms, a sulfamoyl group, an alkylsilyl group or a trialkylsilyl group. These compounds, particularly in combination with at least one suitable estrogen, are suitable for treatment of endometrioses or gestagen-dependent tumors and for hormonal contraception and climacteric hormone replacement therapy (HRT). Processes for making the new steroids are described as well as methods of making the pharmaceutical compositions containing them.

Abstract: Implantable microphone for implantable hearing aids, which is used for excitation of hearing, such as cochlear implants or hearing aids with mechanical stimulation of the middle or inner ear, with a microphone capsule which is accommodated in a hermetically sealed housing, and with an electrical lead-in wire connector for connecting an implant line to the microphone module. The housing has at least two legs which are oriented at an angle relative to one another, one leg holding the microphone capsule and being provided with a sound inlet membrane, and the other leg containing the electrical lead-in wire connector.

Abstract: A permanently implantable, fixable positioning system (1) for stationary attachment to a human body, without play, preferably to the human skull. It has ball-and-socket joint (3), linear axle (4) fixed stationary to it, and a carriage (5) which is guided on the linear axle for accommodating an implantable actuator or sensor device (6). The combination of the axial degree of freedom of the linear axle (4) with three degrees of rotational freedom of the ball-and-socket joint (3) allows a surgeon four-axis, in-situ positioning of the implantable means especially in the middle ear and mastoid cavities. By using the positioning system, precise positioning of a free active end (16) of the implantable device (6) relative to sensitive anatomical structures of the human body is enabled while avoiding risky relative movements between the implantable device and the body of the patient. The positioning system is thus used more or less as a "tremor-free artificial hand" of the surgeon.

Abstract: The polymerization of tetrafluoroethylene in aqueous suspension can be carried out with high conversion if the medium is thoroughly mixed using an axially conveying stirrer element in such a manner that a cone forms at least as far as the vicinity of the stirrer element. In the region of this stirrer element there are expediently arranged baffles which extend only over a part of the filling height of the reactor.

Abstract: The unsaturated 17.alpha.-cyanomethyl-17.beta.-hydroxy steroids of the formula I, ##STR1## in which R.sub.1 =Me, Eth; R.sub.2 =H, Me; R.sub.3 =H, OH, an acetoxy or alkoxy group; R.sub.4 =H, R.sub.5 =OH, an acetoxy, alkoxy group of R.sub.4 and R.sub.5 together represent a keto- or ketal group and double bonds are contained in the basic structure of the steroid, particularly between the 15 and 16 position in the steroid ring, from unsaturated 17-ketosteroids of the general formula II as described herein with the aforementioned meanings of R.sub.1 to R.sub.5 by reacting the unsaturated 17-ketosteroids with LiCH.sub.2 CN and subsequently hydrolyzing.The compounds of formula I are pharmacologically interesting steroid compounds or also intermediate products for the synthesis of highly-effective steroid products which can be used in human and veterinary medicine for the treatment of endocrine disorders and for reproductive control based on their specific hormonal/anti-hormonal actions.

Abstract: In an internal combustion engine with a positive displacement charger having a charger housing adjacent to the engine cylinder(s), the gas exchange control element for the combustion chamber inlet is a functional part of the charger, preferably designed as a rotary piston charger. An internal combustion engine comprising at least one set of three cylinders having a combustion space is provided with an outlet gap at its lower end. The outlet gap is controlled by a stroke piston. There is at least one rotary piston charger in constant driving connection with a crank shaft. The charger has an outlet opening forming an inlet opening of one combustion space. The opening is capable of being closed off by a gas exchange control element that is separate from the stroke piston.

Abstract: In the illustrative embodiments described, a double tube shock absorber is provided with a continuously open throttling fluid passage device both on the piston valve unit and the bottom valve unit. The continuously open fluid passage device comprises a fluid passage chamber defined by a first wall member and a second wall member. The fluid passage chamber is connected to a first fluid chamber of the shock absorber by a first axially directed opening and to a second fluid chamber of the shock absorber by a second radially directed opening. The second radially directed opening is located radially outward of said first opening. The axial height of the fluid passage chamber continuously decreases in radial direction between said first opening and said second opening.

Abstract: Glass compositions useful for passivating silicon semiconductor elements or bodies and to semiconductor elements or bodies coated by such glass compositions. The glass compositions are applied onto the surface of the semiconductor in the form of a finely ground powder and thereafter fused on at least a portion of the semiconductor element. The compositions comprise: (A) glass and (B) powdered cordierite in an amount effective to provide a coefficient of thermal expansion of up to 40 .times. 10.sup.-7 /.degree. C for said composition within the temperature range of 20.degree.-300.degree. C. The compositions are compatible with the thermal expansion of the silicon semiconductor and capable of adhering to the silicon in layers greater than 10 .mu.m without the formation of cracks.