Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: A spring part, in particular for a driving device, includes a spring body extending around a central axis. The spring body comprises several spring windings which run radially around a spring axis and are made of at least a base material. The base material is surrounded at least by a first protective layer, and the spring body is at least partially covered on the outside by a lubricant. A method for manufacturing a spring part includes the steps of providing a spring body with several spring windings made of a base material and coating the base material at least with a first protective layer. The method includes the step of applying a lubricant formed as a silicone-based lubricant to the outside of the coated spring body.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: The machine tool (10) has an asymmetrically constructed workpiece positioning device (16) which runs on three guide rails (17, 18, 19). It comprises two carriages (20, 45) which are connected together by a workpiece carrier (31) that is mounted so as to be rotatable about the A axis. While the first carriage (20) serves for the longitudinal and rotary positioning of the workpiece carrier (31), the second carriage (45) is provided merely for supplementary weight support. This results in a mechanically slimline, low-weight structure with high positioning accuracy. High dynamic loadability and thus a high machining rate and particularly high vibration resistance is allowed.

Abstract: Provided herein are stem-cell based therapies for the treatment of neurodegenerative diseases and CNS disorder such as Huntington's disease. The therapy improved motor deficits and rescued synaptic alterations. The cells were shown to be electrophysiologically active and that they improved motor and late-stage cognitive impairment.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: This disclosure relates to populations and compositions of purified cell-derived vesicles and uses thereof. One aspect of the disclosure relates to methods for purifying the cell-derived vesicles.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: The machine tool (10) has an asymmetrically constructed workpiece positioning device (16) which runs on three guide rails (17, 18, 19). It comprises two carriages (20, 45) which are connected together by a workpiece carrier (31) that is mounted so as to be rotatable about the A axis. While the first carriage (20) serves for the longitudinal and rotary positioning of the workpiece carrier (31), the second carriage (45) is provided merely for supplementary weight support. This results in a mechanically slimline, low-weight structure with high positioning accuracy. High dynamic loadability and thus a high machining rate and particularly high vibration resistance is allowed.

Abstract: A control unit device for a motor vehicle includes a circuit board, on which a plurality of electronic components are disposed. The electronic components are electrically coupled to one another by conductor tracks on the circuit board. A substantially gas-impermeable cover is materially joined or bonded to the circuit board in such a way that the cover, together with the circuit board, forms a closed cavity in which the electronic components and the associated conductor tracks are located. A method for producing the control unit device is also provided.

Abstract: This disclosure relates to populations and compositions of purified cell-derived vesicles and uses thereof. One aspect of the disclosure relates to methods for purifying the cell-derived vesicles.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: A control unit device for a motor vehicle includes a circuit board, on which a plurality of electronic components are disposed. The electronic components are electrically coupled to one another by conductor tracks on the circuit board. A substantially gas-impermeable cover is materially joined or bonded to the circuit board in such a way that the cover, together with the circuit board, forms a closed cavity in which the electronic components and the associated conductor tracks are located. A method for producing the control unit device is also provided.

Abstract: A control unit for use in the engine compartment or in the transmission of a motor vehicle. The control unit has a line section for an engine or transmission fluid, a circuit carrier, and a base plate. The base body is mounted on the base plate. The circuit carrier is arranged between the base body and the base plate. The base body has a plurality of parallel channels each having a respective outlet. At least one of the plurality of parallel channels forms a portion of the line section. A separate cover is mounted on the base body, the cover having a single inlet coupled to the plurality of parallel channels. The cover is, other than only the inlet, connected to the base body in a fluid-tight manner, and the inlet is the only fluid passage through the cover.

Abstract: A planetary stage of a planetary gear unit with a gearbox housing includes a ring gear, at least one planet gear, and a sun gear, which are rotatably positioned. The ring gear is connected via a tappet to a sun gear shaft of an upstream planetary gear stage, and is rotatably mounted in the gearbox housing. The planetary gear unit exhibits increased robustness by connecting the ring gear on a side opposite the tappet to a ring gear support that is seated in the gearbox housing.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi; and an expression control element that regulates expression of the nucleic acid encoding the CCR5 RNAi element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding TRIM5 alpha and HIV TAR decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides. The vectors are combined with packaging plasmid and envelope plasmids and optionally conjugated to cell-specific targeting antibodies. Diagnostic and therapeutic methods for using the compositions are further provided herein.

Abstract: A paper product comprising a planar fibrous cellulose substrate, and a coating composition disposed on a surface of said substrate comprising an interpolymer prepared by the emulsion polymerization of (i) one or more vinyl ester monomers; (ii) ethylene; (iii) an unsaturated silane co-monomer; and (iv) one or more emulsion-stabilizing ionic co-monomers comprising one or more of unsaturated, substituted sulfonic acid, one or more of an unsaturated phosphonic acid, or an ester of one of those acids, in the presence of (v) a stabilizing system which comprises one or more anionic and/or nonionic surfactants but less than about 1 pphm of any protective colloid material; and (v) water.

Abstract: A planet stage of an epicyclic gearing includes a gearing housing with a ring gear arranged in a fixed position, at least two planet wheels mounted in a planet web that has at least one cheek, and a sun wheel. The planet web is connected to an input shaft, and there is a connection between the input shaft and a component of a further planet stage. The planet stage of the epicyclic gearing, in particular the planet web, has a reduced torsional loading. The reduced torsional loading is achieved in that the connection is a connecting web which is connected to that cheek of the planet web which is acted upon by an admission of load/moment, and is arranged in the region between two planet wheels and within the ring gear.