Abstract: Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi; and an expression control element that regulates expression of the nucleic acid encoding the CCR5 RNAi element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding TRIM5 alpha and HIV TAR decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides. The vectors are combined with packaging plasmid and envelope plasmids and optionally conjugated to cell-specific targeting antibodies. Diagnostic and therapeutic methods for using the compositions are further provided herein.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: A control unit for use in the engine compartment or in the transmission of a motor vehicle. The control unit has a line section for an engine or transmission fluid, a circuit carrier, and a base plate. The base body is mounted on the base plate. The circuit carrier is arranged between the base body and the base plate. The base body has a plurality of parallel channels each having a respective outlet. At least one of the plurality of parallel channels forms a portion of the line section. A separate cover is mounted on the base body, the cover having a single inlet coupled to the plurality of parallel channels. The cover is, other than only the inlet, connected to the base body in a fluid-tight manner, and the inlet is the only fluid passage through the cover.

Abstract: A planet stage of an epicyclic gearing includes a gearing housing with a ring gear arranged in a fixed position, at least two planet wheels mounted in a planet web that has at least one cheek, and a sun wheel. The planet web is connected to an input shaft, and there is a connection between the input shaft and a component of a further planet stage. The planet stage of the epicyclic gearing, in particular the planet web, has a reduced torsional loading. The reduced torsional loading is achieved in that the connection is a connecting web which is connected to that cheek of the planet web which is acted upon by an admission of load/moment, and is arranged in the region between two planet wheels and within the ring gear.

Abstract: Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi; and an expression control element that regulates expression of the nucleic acid encoding the CCR5 RNAi element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding TRIM5 alpha and HIV TAR decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides. The vectors are combined with packaging plasmid and envelope plasmids and optionally conjugated to cell-specific targeting antibodies. Diagnostic and therapeutic methods for using the compositions are further provided herein.

Abstract: A flexible printed circuit board, in particular for the spatial connection of electronic components, includes a carrier foil (1), several bonding surfaces (10) arranged on a solder side (4) of the carrier foil (1), and several soldering surfaces (2) arranged on a bonding side (12) of the carrier foil (1) opposite the solder side. The soldering surfaces (2) are connected to the bonding surfaces (10) via electrical strip conductors, and a stiffening plate (3) is inseparably connected to the carrier foil (1) on the solder side thereof.

Abstract: A planetary gear set with a planet stage revolving in a gear set housing has a planet carrier which is connected in particular to a rotor and has planet web cheeks which are connected to one another by means of webs, and a plurality of planet gears which are mounted in planet gear bearings, which are connected to the planet carrier, and are in engagement on one side with a sun gear and on the other side with a ring gear. The gear set housing is provided with an oil supply channel which is connected to at least one oil-guiding channel in the planet carrier. The lubrication of the meshing engagements is facilitated in the planetary gear set by providing dry sump lubrication. This is achieved in that at least one channel connected to the oil-guiding channel is embedded in each web, said channel being aligned with the meshing engagements between sun gear and planet gear and/or planet gear and ring gear.

Abstract: A planetary stage of a planetary gear unit with a gearbox housing includes a ring gear, at least one planet gear, and a sun gear, which are rotatably positioned. The ring gear is connected via a tappet to a sun gear shaft of an upstream planetary gear stage, and is rotatably mounted in the gearbox housing. The planetary gear unit exhibits increased robustness by connecting the ring gear on a side opposite the tappet to a ring gear support that is seated in the gearbox housing.

Abstract: A gear transmission having at least one gear wheel stage, wherein at least one of the gear wheels is fastened coaxially on a hollow shaft that is rotatably mounted in a transmission housing via at least two shaft bearings. An outside-radial stage offset is formed on the hollow shaft as a seat for a broad rim gear wheel that approaches the plant radially on the inside.

Abstract: Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi; and an expression control element that regulates expression of the nucleic acid encoding the CCR5 RNAi element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding TRIM5 alpha and HIV TAR decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides. The vectors are combined with packaging plasmid and envelope plasmids and optionally conjugated to cell-specific targeting antibodies. Diagnostic and therapeutic methods for using the compositions are further provided herein.

Abstract: This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165A isoform VEGF protein and a promoter that regulates expression of the nucleic acid encoding the VEGF.

Abstract: Planetary gearing, in particular multistage planetary gearing, is disclosed. The planetary gearing includes at least one drive shaft, an output shaft, a sun wheel, a ring gear, planet wheels assigned to the planetary gear train, a gear casing, in particular a multipart gear casing, a planetary gear train, in particular the second planetary gear train, comprising a planet wheel arm immovably arranged in a casing. The construction of such a planetary gearing is simplified compared to the prior art, thereby saving costs. This is achieved in that the planet wheel arm is integrally formed with a casing.

Abstract: A power-distributed wind turbine transmission for transmitting a torque generated by a rotor hub to an output pinion rotating with increased speed compared to the former to drive an electric generator, wherein at least two parallel-connected planetary stages are provided for power-distributed speed increase internal to the transmission, wherein further coupling of the rotor hub is carried out by means of a connection ring element on the input side of the transmission, which is rotatably supported by a large roller bearing at a fixed transmission housing, and which transmits the force flow in a power-distributed manner to the hollow gears of the parallel-connected planetary stages by means of cardan-like decoupling means formed thereon.

Abstract: Planetary gearing, in particular multistage planetary gearing, is disclosed. The planetary gearing includes at least one drive shaft, an output shaft, a sun wheel, a ring gear, planet wheels assigned to the planetary gear train, a gear casing, in particular a multipart gear casing, a planetary gear train, in particular the second planetary gear train, comprising a planet wheel arm immovably arranged in a casing. The construction of such a planetary gearing is simplified compared to the prior art, thereby saving costs. This is achieved in that the planet wheel arm is integrally formed with a casing.

Abstract: A drive train between a rotor and a transmission having a torque support for a wind turbine generator system, including a rotor shaft extending from the rotor and supported in this area by a first rotor shaft bearing and extending to the transmission for converting the rotor speed into a desired generator speed, wherein the rotor shaft is supported by a second rotor shaft bearing formed in the manner of a moment bearing which is arranged on the input side within the transmission in order to receive the partial rotor forces, moments and weight forces and to directly pass them on to the torque support.

Abstract: Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a CCR5 RNAi; and an expression control element that regulates expression of the nucleic acid encoding the CCR5 RNAi element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding TRIMS alpha and HIV TAR decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides. The vectors are combined with packaging plasmid and envelope plasmids and optionally conjugated to cell-specific targeting antibodies. Diagnostic and therapeutic methods for using the compositions are further provided herein.

Abstract: A planetary gear set with a planet stage revolving in a gear set housing has a planet carrier which is connected in particular to a rotor and has planet web cheeks which are connected to one another by means of webs, and a plurality of planet gears which are mounted in planet gear bearings, which are connected to the planet carrier, and are in engagement on one side with a sun gear and on the other side with a ring gear. The gear set housing is provided with an oil supply channel which is connected to at least one oil-guiding channel in the planet carrier. The lubrication of the meshing engagements is facilitated in the planetary gear set by providing dry sump lubrication. This is achieved in that at least one channel connected to the oil-guiding channel is embedded in each web, said channel being aligned with the meshing engagements between sun gear and planet gear and/or planet gear and ring gear.

Abstract: The invention relates to a gear transmission having at least one gear wheel stage (1), wherein at least one of the gear wheels (2a; 2b) is fastened coaxially on a hollow shaft (3) that is rotatably mounted in a transmission housing (5) via at least two shaft bearings (4a, 4b). An outside-radial stage offset (8) is formed on the hollow shaft (3) as a seat for a broad rim gear wheel (2a) that approaches the plant radially on the inside.

Abstract: Flexible printed board, in particular for the spatial connection of electronic components, comprising a carrier foil (1), several bonding surfaces (10) arranged on the carrier foil (1), several soldering surfaces (2) arranged on the carrier foil (1), which soldering surfaces (2) are connected to the bonding surfaces (10) via electrical strip conductors, and a stiffening plate (3) that is inseparably connected to the carrier foil (1), wherein the soldering surfaces (2) and the stiffening plate (3) are arranged on a solder side (4) of the carrier foil (1) and the bonding surfaces (10) are arranged on a bonding side (12) that is arranged opposite the solder side (4).

Abstract: A power-distributed wind turbine transmission for transmitting a torque generated by a rotor hub (1) to an output pinion (12) rotating with increased speed compared to the former to drive an electric generator, wherein at least two parallel-connected planetary stages (10a, 10b) are provided for power-distributed speed increase internal to the transmission, wherein further coupling of the rotor hub (1) is carried out by means of a connection ring element (2) on the input side of the transmission, which is rotatably supported by a large roller bearing (5) at a fixed transmission housing (3), and which transmits the force flow in a power-distributed manner to the hollow gears (6a, 6b) of the parallel-connected planetary stages (10a, 10b) by means of cardan-like decoupling means formed thereon.