Patents by Inventor Gerhard Becker
Gerhard Becker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11576863Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.Type: GrantFiled: March 17, 2014Date of Patent: February 14, 2023Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Markus Rast, Wolfgang Ise, Gerhard Becker, Peter Skufca, Henning Gieseler
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Patent number: 11433029Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.Type: GrantFiled: March 17, 2014Date of Patent: September 6, 2022Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Markus Rast, Wolfgang Ise, Gerhard Becker, Peter Skufca, Henning Gieseler
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Patent number: 9833410Abstract: The present invention relates to aqueous formulations comprising at least 20 mg/ml of a compound neutralizing GM-CSF, a lyoprotectant and an amino acid and/or a buffer. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of lyophilization, storage and reconstruction. In a preferred aspect, the formulation, e.g. after reconstruction, is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided.Type: GrantFiled: October 31, 2013Date of Patent: December 5, 2017Assignees: Takeda GmbH, Amgen Research (Munich) GmbHInventors: Markus Rast, Wolfram Steinhilber, Christian de Muynck, Gerhard Becker, Pernille Dybendal Pedersen, Thomas Urbig, Thomas Boehm
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Patent number: 9614461Abstract: The present invention provides a bidirectional high frequency speed drive configured to connect to a utility grid and an electrical machine. The bidirectional high frequency variable speed drive comprises a plurality of inductors each configured to connect to respective phase outputs of the electrical machine, a first plurality of power switches connected to the plurality of inductors, a second plurality of power switches connected to the plurality of inductors, and a controller connected to the first and second plurality of power switches. The controller can generate control signals based on an operating status and a predetermined operating status of the electrical machine. The first output of the first plurality of power switches can be interleaved to a second output of the second plurality of power switches. The present invention also provides methods for the bidirectional high frequency speed drive and apparatuses used to perform the methods of the present invention.Type: GrantFiled: December 2, 2014Date of Patent: April 4, 2017Assignee: Princeton Power Systems, Inc.Inventor: Martin Gerhard Becker
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Publication number: 20160156291Abstract: The present invention provides a bidirectional high frequency speed drive configured to connect to a utility grid and an electrical machine. The bidirectional high frequency variable speed drive comprises a plurality of inductors each configured to connect to respective phase outputs of the electrical machine, a first plurality of power switches connected to the plurality of inductors, a second plurality of power switches connected to the plurality of inductors, and a controller connected to the first and second plurality of power switches. The controller can generate control signals based on an operating status and a predetermined operating status of the electrical machine. The first output of the first plurality of power switches can be interleaved to a second output of the second plurality of power switches. The present invention also provides methods for the bidirectional high frequency speed drive and apparatuses used to perform the methods of the present invention.Type: ApplicationFiled: December 2, 2014Publication date: June 2, 2016Inventor: Martin Gerhard Becker
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Publication number: 20160022585Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.Type: ApplicationFiled: March 17, 2014Publication date: January 28, 2016Inventors: Markus RAST, Wolfgang ISE, Gerhard BECKER, Peter SKUFCA, Henning GIESELER
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Publication number: 20150342888Abstract: The present invention relates to aqueous formulations comprising at least 20 mg/ml of a compound neutralizing GM-CSF, a lyoprotectant and an amino acid and/or a buffer. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of lyophilisation, storage and reconstruction. In a preferred aspect, the formulation, e.g. after reconstruction, is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided.Type: ApplicationFiled: October 31, 2013Publication date: December 3, 2015Inventors: Markus Rast, Wolfram Steinhilber, Christian de Muynck, Gerhard Becker, Pernille Dybendal Pedersen, Thomas Urbig, Thomas Boehm
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Publication number: 20150266965Abstract: The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof.Type: ApplicationFiled: October 31, 2013Publication date: September 24, 2015Inventors: Markus Rast, Peter Skufca, Wolfram Steinhilber, Gerhard Becker, Jürgen Volz, Wolfgang Ise
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Publication number: 20140271636Abstract: The present invention provides a method for preparation of a lyophilized formulation of an anti-CD 20 antibody as well as to a lyophilized formulation of an anti-CD 20 antibody, comprising an anti-CD 20 antibody and having a residual moisture content in the range of 1% to 10%. The present invention also relates to the reconstituted formulation obtained by the method described herein, the use of said antibody formulation as a medicament, the use of the lyophilized formulation for the preparation of a medicament and a method of treating a patient.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Applicant: Takeda GmbHInventors: Markus RAST, Wolfgang ISE, Gerhard BECKER, Peter SKUFCA, Henning GIESELER
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Publication number: 20140120086Abstract: The present invention provides a method for preparation of a high concentration liquid formulation (HCLF) of an antibody or a fragment thereof. The present invention also relates to a method for stabilizing an anti-CD20 antibody or a fragment thereof in a liquid pharmaceutical formulation. Furthermore, the present invention relates to a liquid pharmaceutical formulation of a veltuzumab antibody or a fragment thereof comprising at least 155 mg/mL of a veltuzumab antibody or a fragment thereof.Type: ApplicationFiled: October 31, 2013Publication date: May 1, 2014Applicant: Takeda GmbHInventors: Markus RAST, Peter SKUFCA, Wolfram STEINHILBER, Gerhard BECKER, Jurgen VOLZ, Wolfgang ISE
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Patent number: 6959634Abstract: The invention concerns a device for die-cutting a stack of sheet-like materials, particularly labels, whereby the stack is pressed into the die-cutter blade by a relative movement of a punching ram and a hollow cylindrical die-cutter blade. For a device such as this, it is proposed that the die-cutter blade 18 is adjustably held in a frame 16, and the frame 16 is accommodated by a receiving apparatus 13 which is mounted in a punch platen 12 and is adjustable relative to it, whereby the frame 16 can be slid in a plane parallel to the punch platen 12, in particular is adjustable in the direction of two major axes that are essentially arranged perpendicular to one another, and can also be tilted out of the plane. Such a device allows for precise orientation of the die-cutter blade relative to the stack to be punched.Type: GrantFiled: May 15, 2001Date of Patent: November 1, 2005Assignee: Adolf Mohr Maschinenfabrik GmbH & Co. KGInventors: Helmut Gross, Werner Bauer, Gerhard Becker, Gerd Gottschalk, Richard Neubauer, Horst Schneider, Frank Stemmer
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Patent number: 6880443Abstract: The invention relates to a device for die cutting a stack consisting of sheet-type materials, in particular labels. According to said method, a movement of a stack to be cut in relation to a hollow cylindrical be pushed into said die-cutter blade. This type of device is characterized in that the die-cutter blade (18) is adjustably mounted in a frame (16), which can be inserted in a holding device (13) perpendicularly to the relative displacement direction (K) of the stacks to be cut (7) and die-cutter blades (18), and can be fixed in a central position. The holding device (13) is mounted in a die-cutter head plate (12), in such a way that it can be adjusted in relation to the latter. A die-cutter device of this type has an extremely compact construction, as a result of the positioning and mounting of the die-cutter blade in the direction of the relative movement of the stack to be cut and the die-cutter blade.Type: GrantFiled: May 15, 2001Date of Patent: April 19, 2005Assignee: Adolf Mohr Maschinenfabrik GmbH & Co. KGInventors: Helmut Gross, Werner Bauer, Gerhard Becker, Gerd Gottschalk, Richard Neubauer, Horst Schneider, Horst Stemmer
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Publication number: 20040255744Abstract: A cutting knife is proposed for the cutting of stacked, sheet-like material. The cutting knife has a wedge shape with one cutting surface and one repelling surface, arranged at the wedge angle to each other, and whose cutting line forms the cutting edge of the knife. According to the invention, the cutting knife is provided with outlet openings for blown air in the region of the repelling surface. In the method for fabrication of the cutting knife, channels are incorporated in the knife holder prior to connecting the knife holder and the hard metal blade of the knife, and due to the arrangement of these parts, the blown air passages are formed in the cutting knife upon connection of knife holder and hard metal blade, emerging into the outlet openings.Type: ApplicationFiled: June 17, 2004Publication date: December 23, 2004Inventor: Gerhard Becker
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Publication number: 20040144228Abstract: The invention concerns a device for die-cutting a stack of sheet-like materials, particularly labels, whereby the stack is pressed into the die-cutter blade by a relative movement of a punching ram and a hollow cylindrical die-cutter blade.Type: ApplicationFiled: February 26, 2004Publication date: July 29, 2004Inventors: Helmut Gross, Werner Bauer, Gerhard Becker, Gerd Gottschalk, Richard Neubauer, Horst Schneider, Frank Stemmer
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Patent number: 6755106Abstract: The invention concerns a device for die-cutting a stack of sheet-like materials, particularly labels, whereby the stack is pressed into the die-cutter blade by a relative movement of a punching ram and a hollow cylindrical die-cutter blade. For such a device, it is proposed that the stack (8) to be punched be positioned between a limiting element (88) and a moveable slide-in unit 21 is positioned against a stop (89), and the limiting element (88) and the stop (89) are moveable. This type of construction of the die-cutting device ensures an optimal positioning of the stack in area of the pinching ram, independent of varying stack sizes.Type: GrantFiled: April 26, 2002Date of Patent: June 29, 2004Assignee: Adolf Mohr Maschinenfabrik GmbH & Co. KGInventors: Helmut Gross, Werner Bauer, Gerhard Becker, Gerd Gottschalk, Richard Neubauer, Horst Schneider, Horst Stemmer
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Publication number: 20040011181Abstract: The invention concerns a device for die-cutting a stack of sheet-like materials, particularly labels, whereby the stack is pressed into the die-cutter blade by a relative movement of a punching ram and a hollow cylindrical die-cutter blade.Type: ApplicationFiled: April 26, 2002Publication date: January 22, 2004Inventors: Helmut Gross, Werner Bauer, Gerhard Becker, Gerd Gottschalk, Richard Neubauer, Horst Schneider, Horst Stemmer
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Publication number: 20030084770Abstract: The invention concerns a device for die-cutting a stack of sheet-like materials, particularly labels, whereby the stack is pressed into the die-cutter blade by a relative movement of a punching ram and a hollow cylindrical die-cutter blade.Type: ApplicationFiled: April 26, 2002Publication date: May 8, 2003Inventors: Helmut Gross, Werner Bauer, Gerhard Becker, Gerd Gottschalk, Richard Neubauer, Horst Schneider, Frank Stemmer
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Publication number: 20020189416Abstract: The invention concerns a device for die-cutting a stack of sheet-like materials, particularly labels, whereby the stack is pressed into the die-cutter blade by a relative movement of a punching ram and a hollow cylindrical die-cutter blade.Type: ApplicationFiled: April 26, 2002Publication date: December 19, 2002Inventors: Helmut Gross, Werner Bauer, Gerhard Becker, Gerd Gottschalk, Richard Neubauer, Horst Schneider, Horst Stemmer
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Patent number: 6143331Abstract: The invention concerns a process for preparing a pharmaceutical composition of thymus factors which displays immunomodulating and anti-inflammatory properties and is stable during storage. The process comprises the extraction of a homogenized thymus tissue and subsequent repeated ultrafiltration via a filter membrane having an exclusion volume of 30 kD. The resultant first ultrafiltrate is then subjected to a second ultrafiltration process on a membrane having an exclusion volume of 3 kD, the retentate being used. A composition prepared in this way, in contrast to the first ultrafiltrate obtained on leukocyte cultures stimulated by phytohaemagglutinin, displays a great increase in the production of anti-inflammatory IL-10 and a reduction in the formation of inflammation-promoting IL-2 and IFN-gamma.Type: GrantFiled: November 25, 1998Date of Patent: November 7, 2000Assignee: Sanorell Pharma GmbH & Co.Inventors: Susanne Koch, Gerhard Becker
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Patent number: 6024964Abstract: According to certain embodiments, the invention relates to a method of producing antibodies employing an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a viral, bacterial, or protoral protein. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunoconjugate for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.Type: GrantFiled: June 6, 1995Date of Patent: February 15, 2000Assignee: Hoechst AktiengesellschaftInventors: Gunther Jung, Karl-Heinz Wiesmuller, Jorg Metzger, Hans-Jorg Buhring, Gerhard Becker, Wolfgang Bessler